ACE-I/ARB therapy prior to contrast exposure: what should the clinician do?

Abstract:

:Contrast-induced nephropathy (CIN) is now one of the three leading causes of acute kidney injury in the world. A lot is known about the risk factors of CIN, yet it remains a major cause of morbidity, end stage renal disease, prolonged hospital stay, and increased costs as well as a high mortality. Many patients undergoing contrast-based radiological investigations are treated with angiotensin converting inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs) for their cardiac and renal benefits and their known mortality benefits. However, controversy exists among clinicians as to whether ACE-Is and ARBs should be continued or discontinued prior to contrast media exposure. In this paper we review the current evidence on ACE-I/ARB therapy for patients undergoing procedures involving use of contrast media and provide recommendations as to whether these drugs should be continued or held prior to contrast exposure.

journal_name

Biomed Res Int

authors

Kalyesubula R,Bagasha P,Perazella MA

doi

10.1155/2014/423848

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

423848

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

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