Abstract:
:New and innovative treatment strategies for cancer patients in the fields of immunotherapy and radiotherapy are rapidly developing in parallel. Among the most promising preclinical treatment approaches is combining immunotherapy with radiotherapy where early data suggest synergistic effects in several tumor model systems. These studies demonstrate that radiation combined with immunotherapy can result in superior efficacy for local tumor control. More alluring is the emergence of data suggesting an equally profound systemic response also known as "abscopal" effects with the combination of radiation and certain immunotherapies. Studies addressing optimal radiation dose, fractionation, and modality to be used in combination with immunotherapy still require further exploration. However, recent anecdotal clinical reports combining stereotactic or hypofractionated radiation regimens with immunotherapy have resulted in dramatic sustained clinical responses, both local and abscopal. Technologic advances in clinical radiation therapy has made it possible to deliver hypofractionated regimens anywhere in the body using stereotactic radiation techniques, facilitating further clinical investigations. Thus, stereotactic radiation in combination with immunotherapy agents represents an exciting and potentially fruitful new space for improving cancer therapeutic responses.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Zeng J,Harris TJ,Lim M,Drake CG,Tran PTdoi
10.1155/2013/658126subject
Has Abstractpub_date
2013-01-01 00:00:00pages
658126eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章,评审abstract:Objective:To explore the ability of asiatic acid to interfere with the invasion and proliferation of breast cancer cells by inhibiting WAVE3 expression and activation through the PI3K/AKT signaling pathway. Methods:The MDA-MB-231 cells with strong invasiveness were screened by transwell assay, and plasmids with high e...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1874387
更新日期:2020-02-10 00:00:00
abstract::The availability of fluorescent dyes and the advances in the optical systems for in vivo imaging have stimulated an increasing interest in developing new methodologies to study and quantify the biodistribution of labeled agents. However, despite these great achievements, we are facing significant challenges in determi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/196837
更新日期:2014-01-01 00:00:00
abstract::The palmaris longus is considered a phylogenetic degenerate metacarpophalangeal joint flexor muscle in humans, a small vestigial forearm muscle; it is the most variable muscle in humans, showing variation in position, duplication, slips and could be reverted. It is frequently studied in papers about human anatomical v...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/178906
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Anaemia with an estimated prevalence of 35-75% among pregnant women is a major cause of maternal deaths in Nigeria. objective: To determine the prevalence of anaemia, associated sociodemographic factors and red cell morphological pattern among pregnant women during booking at the University Teaching Hospital...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/849080
更新日期:2014-01-01 00:00:00
abstract:Background:In peritoneal dialysis (PD) patients, whether angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) could protect residual renal function is still controversial. To assess the effects of ACEIs and ARBs on the residual renal function and cardiovascular (CV) events in perito...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6762029
更新日期:2020-09-23 00:00:00
abstract:PURPOSE:In order to establish inspection routines for individual intraocular lenses (IOLs), their surfaces have to be measured separately. Currently available measurement devices lack this functionality. The purpose of this study is to evaluate a new topography measurement device based on wavefront analysis for measuri...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/363742
更新日期:2013-01-01 00:00:00
abstract::In clinical endodontics, preoperative estimation of root canal curvature is crucial regarding the prevention of iatrogenic errors. Reproduction of the two-dimensional radiographic images causes certain proximal view curvatures not seen. Therefore, the present study is aimed at investigating the degree of root canal cu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2021/6699635
更新日期:2021-01-13 00:00:00
abstract::Diarrhea is a major clinical problem affecting foals up to 3 months of age. The aim of this study was to identify enteric microorganisms involved in monoinfections and coinfections and the associated virulence factors in healthy and diarrheic foals. Diarrheic (D) (n = 56) and nondiarrheic (ND) foals (n = 60) up to thr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1512690
更新日期:2016-01-01 00:00:00
abstract::Preformulation is an important step in the rational formulation of an active pharmaceutical ingredient (API). Micromeritics properties: bulk density (BD) and tapped density (TD), compressibility index (Carr's index), Hauser's ratio (H), and sieve analysis were performed in order to determine the best excipients to be ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/307032
更新日期:2015-01-01 00:00:00
abstract::Using the dual-process model of assimilative-tenacity (TGP) and accommodative-flexibility (FGA), the study aims to identify trajectories of TGP and FGA over five time points within a 9-year period, explore the relationships between the trajectories of TGP and FGA, and explore if participants from distinct TGP and FGA ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8017541
更新日期:2017-01-01 00:00:00
abstract::Pediatric myelodysplastic syndrome (MDS) is an uncommon disease and little is known about the molecular alterations of its development and evolution to acute myeloid leukemia (AML). The Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PCR2). It is a histone methyltransferas...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2019/3176565
更新日期:2019-12-10 00:00:00
abstract::Stem cells are biological cells that can self-renew and can differentiate into multiple cell lineages. Stem cell-based therapy is emerging as a promising alternative therapeutic option for various disorders. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are isolated from various tissues and can b...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/6104738
更新日期:2019-01-29 00:00:00
abstract:BACKGROUND:Recently antiangiogenic therapy with bevacizumab has shown a high but transient efficacy in glioblastoma (GBM). Indeed, GBM is one of the most angiogenic human tumors and endothelial proliferation is a hallmark of the disease. We therefore hypothesized that tumor cells may participate in endothelial prolifer...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/827327
更新日期:2014-01-01 00:00:00
abstract::Purpose. To report pilot data from a novel image analysis software "RetiView," to highlight clinically relevant information in RetCam images of infants with aggressive posterior retinopathy of prematurity (APROP). Methods. Twenty-three imaging sessions of consecutive infants of Asian Indian origin with clinically diag...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/898197
更新日期:2015-01-01 00:00:00
abstract::Intervertebral disk disease (IVDD) is a major spine disorder in canines that causes neurological dysfunction, particularly in the thoracolumbar area. Analgesic and anti-inflammatory drugs are typically used to reduce nociceptive signals to decrease canine suffering. Bee venom (BV) has been reported to exert anti-infla...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/363801
更新日期:2015-01-01 00:00:00
abstract:Objective:Biomaterial research for soft tissue augmentation is an increasing topic in aesthetic medicine. Hyaluronic acid (HA) fillers are widely used for their low invasiveness and easy application to correct aesthetic defects or traumatic injuries. Some complications as acute or chronic inflammation can occur in pati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8676343
更新日期:2020-05-21 00:00:00
abstract:Introduction:Rapid eye movement sleep behavior disorder (RBD) is characterized by dream-enacting behavior (shouting, punching, and falling out of bed) related to unpleasant dreams and loss of normal rapid eye movement (REM) sleep muscle atonia. Rapid eye movement sleep enhances learning and memory by regulating neurona...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1810836
更新日期:2020-05-15 00:00:00
abstract::Previously, a novel technique was proposed to quantify the relationship between the muscle stiffness and its nonfatigue contraction intensity. The method extended the measured range of isometric contraction to 100% maximum voluntary contraction (MVC) using an ultrasonic shear wave measurement setup. Yet, it has not be...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9469548
更新日期:2017-01-01 00:00:00
abstract::Objective. To evaluate the efficacy of bundle intervention on healthcare-associated (HA) methicillin-resistant Staphylococcus Aureus (MRSA) infection in the neonatal intensive care unit (NICU). Methods. In this study, 11,277 infants having undergone treatment at the NICU in Xiamen, China, from January 2014 to February...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5490413
更新日期:2019-07-10 00:00:00
abstract::Angiogenesis plays a decisive role in the growth and spread of cancer and angiopoietin-2 (Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. The aim of this study was to introduce a computational simulation approach to screen aptamers with high binding ability for Ang2. We carried out...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/658712
更新日期:2015-01-01 00:00:00
abstract:Background:The chromobox (CBX) proteins CBX2, CBX4, CBX6, CBX7, and CBX8, also known as Polycomb (Pc) proteins, are canonical components of the Polycomb repressive complex 1 (PRC1). Abundant evidence indicates that abnormal expression of Pc proteins is associated with a variety of tumors, but their role in the pathogen...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2019/6436825
更新日期:2019-05-09 00:00:00
abstract::Objective. Our objective is to develop a computerized scheme for liver tumor segmentation in MR images. Materials and Methods. Our proposed scheme consists of four main stages. Firstly, the region of interest (ROI) image which contains the liver tumor region in the T1-weighted MR image series was extracted by using se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3219068
更新日期:2016-01-01 00:00:00
abstract::Effective alteration of the recalcitrance properties like crystallization of cellulose, lignin shield, and interlinking of lignocellulosic biomass is an ideal way to utilize the full-scale potential for biofuel production. This study exhibited three different pretreatment effects to enhance the digestibility of corn s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2786598
更新日期:2016-01-01 00:00:00
abstract::CA-125 has been a valuable marker for the follow-up of ovarian cancer patients but it is not sensitive enough to be used as diagnostic marker. We had already used secretomic methods to identify proteins differentially secreted by serous ovarian cancer cells compared to healthy ovarian cells. Here, we evaluated the sec...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/208017
更新日期:2015-01-01 00:00:00
abstract::Little is known about how prenatal maternal stress (PNMS) influences risks of asthma in humans. In this small study, we sought to determine whether disaster-related PNMS would predict asthma risk in children. In June 1998, we assessed severity of objective hardship and subjective distress in women pregnant during the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/201717
更新日期:2014-01-01 00:00:00
abstract::This study shows that membrane-associated cytoskeletal protein structures and the erythrocyte morphology undergo profound changes during hypoxia. Hypoxia also intensified oxidative processes in the lipid phase of the bilayer of red blood cell membranes. Sodium nitroprusside impaired the morphology of red blood cells a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6758017
更新日期:2019-12-07 00:00:00
abstract::Nematodes infections are responsible for debilitating conditions and economic losses in domestic animals as well as livestock and are considered an important public health problem due to the high prevalence in humans. The nematode resistance for drugs has been reported for livestock, highlighting the importance for de...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/879263
更新日期:2015-01-01 00:00:00
abstract:Aims:The purpose of this study was to describe the challenge of cross-cultural care encounters from perspective of imported nurses in Lhasa, Tibet, as well as investigate the relationship of cross-cultural care encounters and its influencing factors. Methods:A cross-sectional survey was designed among 300 imported nur...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3159178
更新日期:2020-04-08 00:00:00
abstract:Background:The use of modern family planning methods among women of reproductive age (15-49 years) is of public health importance in Ethiopia. Nationally, modern family planning method use remains as low as 35%. Understanding factors associated with the use of modern family planning methods may help to improve maternal...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6096280
更新日期:2020-12-29 00:00:00
abstract::Dietary polyphenols present in a broad range of plant foods have been related to beneficial health effects. This review aims to update the current information about the modulation of the gut microbiota by dietary phenolic compounds, from a perspective based on the experimental approaches used. After referring to gener...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/850902
更新日期:2015-01-01 00:00:00