Computational selection of RNA aptamer against angiopoietin-2 and experimental evaluation.

abstract：:Lung cancer is one of the most malignant tumors in the world. Early diagnosis and treatment of lung cancer are vitally important to reduce the mortality of lung cancer patients. In the present study, we attempt to identify the candidate biomarkers for lung cancer by weighted gene co-expression network analysis (WGCNA)...

journal_title：BioMed research international

authors： Xu X,Xu L,Huang H,Li J,Dong S,Jin L,Ma Z,Li L

更新日期：2020-06-10 00:00:00

abstract：:Coronary artery diseases (CAD) and heart failure have high mortality rate in the world, although much progress has been made in this field in last two decades. There is still a clinical need for a novel diagnostic approach and a therapeutic strategy to decrease the incidence of CAD. MicroRNAs (miRNAs) are highly conse...

journal_title：BioMed research international

authors： Nishiguchi T,Imanishi T,Akasaka T

更新日期：2015-01-01 00:00:00

abstract：:Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS. In this study, we aimed to explore the regulatory mechanisms of mi...

journal_title：BioMed research international

authors： Zhang YH,Chen AL,Yu RQ,Jia BB,Ye DN,Wang M,Mei YZ,Fang GD,Jiang SY,Zhou Q,Zhang B

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologou...

journal_title：BioMed research international

authors： Jiménez-Hernández E,Dueñas-González MT,Arellano-Galindo J,Medrano-Ortíz-De-Zárate ME,Bekker-Méndez VC,Berges-García A,Solís-Labastida K,Sánchez-Jara B,Tiznado-García HM,Jaimes-Reyes EZ,García-Jiménez X,Espinoza-Hernández L,Núñez-

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To investigate if software simulation is practical for quantifying random error (RE) in phantom dosimetry. MATERIALS AND METHODS:We applied software error simulation to an existing dosimetry study. The specifications and the measurement values of this study were brought into the software (R version 3.0.2) to...

journal_title：BioMed research international

authors： Hoogeveen RC,Martens EP,van der Stelt PF,Berkhout WE

更新日期：2015-01-01 00:00:00

abstract：:Any bioassay to test new chemically synthesized larvicides or phytolarvicides against Culicidae and more harmful mosquito species, such as Aedes aegypti and Aedes albopictus, which specifically transmit dengue, yellow fever, chikungunya viral fevers as well as Zika virus, or Anopheles gambiae, a vector for malaria and...

journal_title：BioMed research international

authors： Fontana JD,Ferreira RL,Zuccolotto T,de Borba Dallagassa C,Wielewski LP,Chalcoski BMS,da Silva MAN,Richardi VS,Golart J,de Melo Rodovalho C

更新日期：2020-08-29 00:00:00

abstract：:Stimuli responsive pH- and temperature-sensitive hydrogel drug delivery systems, as those based on N-isopropylacrylamide (NiPAAm) and itaconic acid (IA), have been attracting much of the attention of the scientific community nowadays, especially in the field of drug release. By adjusting comonomer composition, the mat...

journal_title：BioMed research international

authors： Milašinović N,Knežević-Jugović Z,Milosavljević N,Lučić Škorić M,Filipović J,Kalagasidis Krušić M

更新日期：2014-01-01 00:00:00

abstract：:Viscosupplementation with hyaluronic acid is safe and effective in the management of osteoarthritis, but its use in the treatment of tendon disorders has received less attention. The aim of this review is to summarize the current knowledge on this topic, evaluating experimental and clinical trials. A search of English...

journal_title：BioMed research international

authors： Abate M,Schiavone C,Salini V

更新日期：2014-01-01 00:00:00

abstract：:The objective of the present investigation was to study the effect of combination of telmisartan with cisplatin in oral cancer cachexia induced by applying 0.5% 4-nitroquinoline-1-oxide (4-NQO) in propylene glycol to tongue, thrice a week for 8 weeks. From 8th to 22nd week, cisplatin (0.23 mg/kg, i.v.) was administere...

journal_title：BioMed research international

authors： Patel BM,Damle D

更新日期：2013-01-01 00:00:00

abstract：:Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by an impairment of corneal sensory innervation, characterized by decreased or absent corneal sensitivity resulting in epithelial keratopathy, ulceration, and perforation. The aetiopathogenesis of corneal sensory innervation impairment in ...

journal_title：BioMed research international

authors： Mantelli F,Nardella C,Tiberi E,Sacchetti M,Bruscolini A,Lambiase A

更新日期：2015-01-01 00:00:00

abstract：:It is increasingly affirmed that most of the long-term consequences of TBI are due to molecular and cellular changes occurring during the acute phase of the injury and which may, afterwards, persist or progress. Understanding how to prevent secondary damage and improve outcome in trauma patients, has been always a tar...

journal_title：BioMed research international

authors： Mangiola A,Vigo V,Anile C,De Bonis P,Marziali G,Lofrese G

更新日期：2015-01-01 00:00:00

abstract：:Polyketide belongs to a family of abundant natural products typically produced by the filamentous soil bacteria Streptomyces. Similar to the biosynthesis of most secondary metabolites produced in the Streptomyces species, polyketide compounds are synthesized through tight regulatory networks in the cell, and thus extr...

journal_title：BioMed research international

authors： Nah JH,Kim HJ,Lee HN,Lee MJ,Choi SS,Kim ES

更新日期：2013-01-01 00:00:00

abstract：:Purpose. To compare the results of extracorporeal shock wave therapy (ESWT) for insertional Achilles tendinopathy (IAT) with or without Haglund's deformity. Methods. Between September 2014 and May 2015, all patients who underwent ESWT were retrospectively enrolled in this study. A total of 67 patients were available f...

journal_title：BioMed research international

authors： Wu Z,Yao W,Chen S,Li Y

更新日期：2016-01-01 00:00:00

abstract：:Vitamin D deficiency is common in pregnant women and infants. The present study aimed to investigate the effects of vitamin D restricted diet on the Wistar rats offspring penis morphology. Mother rats received either standard diet (SC) or vitamin D restricted (VitD) diet. At birth, offspring were divided into SC/SC (f...

journal_title：BioMed research international

authors： Fernandes-Lima F,Gregório BM,Nascimento FAM,Costa WS,Gallo CBM,Sampaio FJB

更新日期：2018-04-23 00:00:00

abstract：:Introduction and Objectives. Neutrophil-to-lymphocyte ratio (NLR) has been suggested to be a simple marker of the systemic inflammatory response in critical care patients. We previously assessed the utility of NLR as a biomarker to predict tumor recurrence and cancer death in bladder cancer patients who underwent radi...

journal_title：BioMed research international

authors： Ohtake S,Kawahara T,Kasahara R,Ito H,Osaka K,Hattori Y,Teranishi JI,Makiyama K,Mizuno N,Umemoto S,Miyoshi Y,Nakaigawa N,Miyamoto H,Yao M,Uemura H

更新日期：2016-01-01 00:00:00

abstract：Background:Physical activity has been found to maintain and improve cognitive function and consequently improve health-related quality of life (HRQoL). The relationships between different types of physical activities, cognitive function, and HRQoL have not been studied sufficiently and compared in different age and gen...

journal_title：BioMed research international

authors： Alsubaie SF,Alkathiry AA,Abdelbasset WK,Nambi G

更新日期：2020-12-18 00:00:00

abstract：:The utility of various regions of the ribosomal repeat unit for phylogenetic analysis was examined in 16 species representing four families, nine genera, and two orders of the subclass Copepoda (Crustacea). Fragments approximately 2000 bp in length containing the ribosomal DNA (rDNA) 18S and 28S gene fragments, the 5....

journal_title：BioMed research international

authors： Zagoskin MV,Lazareva VI,Grishanin AK,Mukha DV

更新日期：2014-01-01 00:00:00

abstract：:Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the...

journal_title：BioMed research international

authors： Rowdhwal SSS,Chen J

更新日期：2018-02-22 00:00:00

abstract：PURPOSE OF THE REPORT:There is a paucity of data on correlation of various imaging modalities with clinical findings in craniosynostosis. Moreover, no study has specifically reported the role of (99m)Tc-ECD SPECT in a large number of subjects with craniosynostosis. MATERIALS AND METHODS:We prospectively analyzed a coh...

journal_title：BioMed research international

authors： Barik M,Bajpai M,Das RR,Malhotra A,Panda SS,Sahoo MK,Dwivedi S

更新日期：2014-01-01 00:00:00

abstract：:N6-methyladenosine (m6A) plays an important role in many cancers. However, few studies have examined the role of m6A in colorectal CRC. To examine the effect of m6A on CRC, we studied the genome of 591 CRC cases from The Cancer Genome Atlas (TCGA). The relationship between the messenger RNA (mRNA) expression, copy num...

journal_title：BioMed research international

authors： Zhang Q,Cai Y,Kurbatov V,Khan SA,Lu L,Zhang Y,Johnson CH

更新日期：2020-12-19 00:00:00

abstract：:Spinocerebellar ataxia-3 (SCA3) is the most common dominant inherited ataxia worldwide and is caused by an unstable CAG trinucleotide expansion mutation within the ATXN3 gene, resulting in an expanded polyglutamine tract within the ATXN3 protein. Many in vitro studies have examined the role of autophagy in neurodegene...

journal_title：BioMed research international

authors： Ou Z,Luo M,Niu X,Chen Y,Xie Y,He W,Song B,Xian Y,Fan D,OuYang S,Sun X

更新日期：2016-01-01 00:00:00

abstract：Purpose:β-Defensin 118 (DEFB118) is a novel host defense peptide (HDP) identified in humans. To evaluate its potentials for future utilization, the DEFB118 gene was expressed in Escherichia coli (E. coli) and the recombinant protein was fully characterized. Methods:The DEFB118 protein was obtained by heterologous expr...

journal_title：BioMed research international

authors： Lin Q,Xie K,Chen D,Yu B,Mao X,Yu J,Luo J,Zheng P,Luo Y,Yan H,He J

更新日期：2020-11-09 00:00:00

abstract：:The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field and made it possible to carry out functional studies on model organisms. Insects including Drosophila are classical and still popular models to study autophagy, starting from the 1960s. This rev...

journal_title：BioMed research international

authors： Mulakkal NC,Nagy P,Takats S,Tusco R,Juhász G,Nezis IP

更新日期：2014-01-01 00:00:00

abstract：:Hepatitis B virus- (HBV-) associated hepatocellular carcinoma (HCC) is the most common type of liver cancer. However, the underlying mechanism of HCC tumorigenesis is very complicated and HBV-encoded X protein (HBx) has been reported to play the most important role in this process. Activation of downstream signal path...

journal_title：BioMed research international

authors： Hung CM,Huang WC,Pan HL,Chien PH,Lin CW,Chen LC,Chien YF,Lin CC,Leow KH,Chen WS,Chen JY,Ho CY,Hou PS,Chen YJ

更新日期：2014-01-01 00:00:00

abstract：:Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin cancers. In the treatment of cSCC, it is necessary to remove it completely, and reconstructive surgery, such as a skin graft or a local or free flap, will be required, depending on the size, with donor-site morbidity posing a burden to the patient...

journal_title：BioMed research international

authors： Mitsui T,Morimoto N,Mahara A,Notodihardjo SC,Le TM,Munisso MC,Kakudo N,Yamaoka T,Kusumoto K

更新日期：2020-03-07 00:00:00

abstract：:Healthcare professionals undergo high levels of occupational stress as a result of their working conditions. Thus, the aim of this study is to develop a model that focuses on healthcare professionals so as to analyze the influence that job demands, control, social support, and recognition have on the likelihood that a...

journal_title：BioMed research international

authors： García-Herrero S,Lopez-Garcia JR,Herrera S,Fontaneda I,Báscones SM,Mariscal MA

更新日期：2017-01-01 00:00:00

abstract：:Lung cancer consists of two main subtypes: small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) that are classified according to their physiological phenotypes. In this study, we have developed a network-based approach to identify molecular biomarkers that can distinguish SCLC from NSCLC. By identifyin...

journal_title：BioMed research international

authors： Long F,Su JH,Liang B,Su LL,Jiang SJ

更新日期：2015-01-01 00:00:00

abstract：:The aims of the present research are to investigate the possible predictors of pancreatic cancer, in particular smoking status, alcohol consumption, hypercholesterolemia, and diabetes mellitus, in patients with histologically confirmed pancreatic carcinoma and to examine the synergism between risk factors. A case-cont...

journal_title：BioMed research international

authors： La Torre G,Sferrazza A,Gualano MR,de Waure C,Clemente G,De Rose AM,Nicolotti N,Nuzzo G,Siliquini R,Boccia A,Ricciardi W

更新日期：2014-01-01 00:00:00

abstract：:Exosomes can reach distant tissues through blood circulation to communicate directly with target cells and rapidly regulate intracellular signals. Exosomes play an important role in cardiovascular pathophysiology. Different exosomes derived from different sources, and their cargos have different mechanisms of action. ...

journal_title：BioMed research international

authors： Liang B,He X,Zhao YX,Zhang XX,Gu N

更新日期：2020-07-07 00:00:00

abstract：:Coconut palm (Cocos nucifera) is an important commercial crop in many tropical countries, but its industry generates large amounts of residue. One way to address this problem is to use this residue, coconut husk, to produce second-generation (2G) ethanol. The aim of this review is to describe the methods that have bee...

journal_title：BioMed research international

authors： Bolivar-Telleria M,Turbay C,Favarato L,Carneiro T,de Biasi RS,Fernandes AAR,Santos AMC,Fernandes PMB

更新日期：2018-09-27 00:00:00