Gene Alterations of N6-Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study.

Abstract:

:N6-methyladenosine (m6A) plays an important role in many cancers. However, few studies have examined the role of m6A in colorectal CRC. To examine the effect of m6A on CRC, we studied the genome of 591 CRC cases from The Cancer Genome Atlas (TCGA). The relationship between the messenger RNA (mRNA) expression, copy number variation (CNVs), and mutations of m6A "Writers," "Readers," and "Erasers," prognosis, immune cell infiltration, and genetic mutations in CRC cases were analyzed. CNVs and mutations were found in thirteen m6A regulators. As expected, gain and amplification of m6A regulators increased the mRNA expression of these regulators, while deletion led to reduction in the mRNA expression. Moreover, CNVs and mutation of these regulators were significantly associated with APC, TP53, and microsatellite instability (MSI) status (p < 0.001, p < 0.001, and p = 0.029, respectively). CNVs of m6A regulators also correlated with inferred immune cell infiltration in CRC tissues, especially in colon tissues. Additionally, alterations of RBM15, YTHDF2, YTHDC1, YTHDC2, and METTL14 genes were related to the worse overall survival and disease-free survival (DFS) of CRC patients. Specifically, the deletion status of "Writers" was also correlated to the DFS of CRC patients (p = 0.02). Gene set enrichment analysis found that FTO was involved in mRNA 3' end processing, polyubiquitin binding, and RNA polymerase promoter elongation, while YTHDC1 was related to interferon-alpha and gamma response. In conclusion, a novel relationship was identified between CNVs and mutations of m6A regulators with prognosis and inferred immune function of CRC. These findings will improve the understanding of the relationship of m6A in CRC.

journal_name

Biomed Res Int

authors

Zhang Q,Cai Y,Kurbatov V,Khan SA,Lu L,Zhang Y,Johnson CH

doi

10.1155/2020/8826456

subject

Has Abstract

pub_date

2020-12-19 00:00:00

pages

8826456

eissn

2314-6133

issn

2314-6141

journal_volume

2020

pub_type

杂志文章
  • Effect of Glucocorticoids on Ultrastructure of Myocardial Muscle in the Course of Experimentally Induced Acute Myocardial Ischemia.

    abstract::The search for effective methods of myocardial cytoprotection against ischemia is the most significant issue in modern cardiology and cardiac surgery. Glucocorticoids are deemed very strong modulators of inflammatory response and thus can potentially protect heart muscle from postreperfusion injury and myocardial isch...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2108497

    authors: Kuropka P,Dobrzyński M,Gamian A,Gostomska-Pampuch K,Kuryszko J,Całkosiński I

    更新日期:2017-01-01 00:00:00

  • Modeling Clinical States and Metabolic Rhythms in Bioarcheology.

    abstract::Bioarcheology is cross disciplinary research encompassing the study of human remains. However, life's activities have, up till now, eluded bioarcheological investigation. We hypothesized that growth lines in hair might archive the biologic rhythms, growth rate, and metabolism during life. Computational modeling predic...

    journal_title:BioMed research international

    pub_type: 历史文章,杂志文章

    doi:10.1155/2015/818724

    authors: Qualls C,Bianucci R,Spilde MN,Phillips G,Wu C,Appenzeller O

    更新日期:2015-01-01 00:00:00

  • Cartilage Regeneration in Human with Adipose Tissue-Derived Stem Cells: Current Status in Clinical Implications.

    abstract::Osteoarthritis (OA) is one of the most common debilitating disorders among the elderly population. At present, there is no definite cure for the underlying causes of OA. However, adipose tissue-derived stem cells (ADSCs) in the form of stromal vascular fraction (SVF) may offer an alternative at this time. ADSCs are on...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/4702674

    authors: Pak J,Lee JH,Kartolo WA,Lee SH

    更新日期:2016-01-01 00:00:00

  • Platelet rich plasma and knee surgery.

    abstract::In orthopaedic surgery and sports medicine, the knee joint has traditionally been considered the workhorse. The reconstruction of every damaged element in this joint is crucial in achieving the surgeon's goal to restore the knee function and prevent degeneration towards osteoarthritis. In the last fifteen years, the f...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/890630

    authors: Sánchez M,Delgado D,Sánchez P,Fiz N,Azofra J,Orive G,Anitua E,Padilla S

    更新日期:2014-01-01 00:00:00

  • Efficacy of Sucralfate-Combined Quadruple Therapy on Gastric Mucosal Injury Induced by Helicobacter pylori and Its Effect on Gastrointestinal Flora.

    abstract:Background:This study explored the therapeutic efficacy of standard triple therapy combined with sucralfate suspension gel as well as the mechanisms of action in mouse models of H. pylori infection. Materials and Methods:C57BL/6J mice were randomly divided into 5 groups: NC (natural control), HP (H. pylori infection),...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4936318

    authors: Teng G,Liu Y,Wu T,Wang W,Wang H,Hu F

    更新日期:2020-08-31 00:00:00

  • A Combination of UTMD-Mediated HIF-1α shRNA Transfection and TAE in the Treatment of Hepatic Cancer.

    abstract::To explore the antitumor effect of hypoxia-inducible factor-1α short hairpin RNA (HIF-1α shRNA) delivered by ultrasound targeted microbubble destruction (UTMD) and transcatheter arterial embolization (TAE) on rats with hepatic cancer. After the models of transplantation hepatoma were established, Wistar rats were rand...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1937460

    authors: Liao Y,Luo H,He Z,Kuang Y,Chen P,Zhang X,Chen J,Wen Q,Xie Y,Ding S

    更新日期:2019-02-19 00:00:00

  • Lack of association between JAK3 gene polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis.

    abstract::Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/318364

    authors: García-Bermúdez M,López-Mejías R,Genre F,Castañeda S,Corrales A,Llorca J,González-Juanatey C,Ubilla B,Miranda-Filloy JA,Pina T,Gómez-Vaquero C,Rodríguez-Rodríguez L,Fernández-Gutiérrez B,Balsa A,Pascual-Salcedo D,López-Long

    更新日期:2015-01-01 00:00:00

  • LAP TGF-Beta Subset of CD4(+)CD25(+)CD127(-) Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients.

    abstract::Lung cancer is the leading cause of cancer death worldwide. Adenocarcinoma, the most commonly diagnosed histologic type of lung cancer, is associated with smoking. Cigarette smoke promotes inflammation on the airways, which might be mediated by Th17 cells. This inflammatory environment may contribute to tumor developm...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/430943

    authors: Islas-Vazquez L,Prado-Garcia H,Aguilar-Cazares D,Meneses-Flores M,Galicia-Velasco M,Romero-Garcia S,Camacho-Mendoza C,Lopez-Gonzalez JS

    更新日期:2015-01-01 00:00:00

  • Influence of heavy metal stress on antioxidant status and DNA damage in Urtica dioica.

    abstract::Heavy metals have the potential to interact and induce several stress responses in the plants; thus, effects of heavy metal stress on DNA damages and total antioxidants level in Urtica dioica leaves and stems were investigated. The samples are sampled from areas with different metal exposition. Metal content was analy...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/276417

    authors: Gjorgieva D,Kadifkova Panovska T,Ruskovska T,Bačeva K,Stafilov T

    更新日期:2013-01-01 00:00:00

  • Identification of Peptide Antagonists to Thioredoxin Glutathione Reductase of Schistosoma japonicum.

    abstract::Schistosomiasis is one of the world's major public health problems. Praziquantel is currently the only effective drug against schistosomiasis. As resistance of praziquantel has emerged in some endemic areas, development of new antischistosomal agents should be a high priority. In this study, a phage display peptide li...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9483928

    authors: Song LJ,Li JH,Yin XR,Zhang W,Jin Y,Gao H,Wang J,Yu CX,Hua ZC

    更新日期:2018-06-05 00:00:00

  • Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release.

    abstract::Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The h...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/236745

    authors: Lu J,Li Y,Hu D,Chen X,Liu Y,Wang L,Zhao Y

    更新日期:2015-01-01 00:00:00

  • Measurement of the silver ion concentration in wound fluids after implantation of silver-coated megaprostheses: correlation with the clinical outcome.

    abstract:BACKGROUND:Tumor patients and patients after traumas are endangered by a reduced immune defense, and a silver coating on their megaprostheses may reduce their risks of infection. The aim of this study was to determine the silver ion concentration directly measured from the periprosthetic tissue and the influence on the...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/763096

    authors: Hussmann B,Johann I,Kauther MD,Landgraeber S,Jäger M,Lendemans S

    更新日期:2013-01-01 00:00:00

  • Antiadherent and antibiofilm activity of Humulus lupulus L. derived products: new pharmacological properties.

    abstract::New antimicrobial properties of products derived from Humulus lupulus L. such as antiadherent and antibiofilm activities were evaluated. The growth of gram-positive but not gram-negative bacteria was inhibited to different extents by these compounds. An extract of hop cones containing 51% xanthohumol was slightly less...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/101089

    authors: Rozalski M,Micota B,Sadowska B,Stochmal A,Jedrejek D,Wieckowska-Szakiel M,Rozalska B

    更新日期:2013-01-01 00:00:00

  • Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties.

    abstract::Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/905215

    authors: Marín L,Miguélez EM,Villar CJ,Lombó F

    更新日期:2015-01-01 00:00:00

  • Antimalarial Properties of Isoquinoline Derivative from Streptomyces hygroscopicus subsp. Hygroscopicus: An In Silico Approach.

    abstract::Malaria is one of the life-threatening diseases in the world. The spread of resistance to antimalarial drugs is a major challenge, and resistance to artemisinin has been reported in the Southeast Asian region. In the previous study, the active compound of Streptomyces hygroscopicus subsp. Hygroscopicus (S. hygroscopic...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6135696

    authors: Nugraha RY,Faratisha IF,Mardhiyyah K,Ariel DG,Putri FF,Nafisatuzzamrudah,Winarsih S,Sardjono TW,Fitri LE

    更新日期:2020-01-09 00:00:00

  • The importance of the ionic product for water to understand the physiology of the acid-base balance in humans.

    abstract::Human plasma is an aqueous solution that has to abide by chemical rules such as the principle of electrical neutrality and the constancy of the ionic product for water. These rules define the acid-base balance in the human body. According to the electroneutrality principle, plasma has to be electrically neutral and th...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/695281

    authors: Adeva-Andany MM,Carneiro-Freire N,Donapetry-García C,Rañal-Muíño E,López-Pereiro Y

    更新日期:2014-01-01 00:00:00

  • Syn-lethality: an integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies.

    abstract::Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells. While numerous SL...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/196034

    authors: Li XJ,Mishra SK,Wu M,Zhang F,Zheng J

    更新日期:2014-01-01 00:00:00

  • Misleading Westerns: Common Quantification Mistakes in Western Blot Densitometry and Proposed Corrective Measures.

    abstract::Densitometry data generated for Western blots are commonly used to compare protein abundance between samples. In the last decade, it has become apparent that assumptions underpinning these comparisons are often violated in studies reporting Western blot data in the literature. These violations can lead to erroneous in...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5214821

    authors: Butler TAJ,Paul JW,Chan EC,Smith R,Tolosa JM

    更新日期:2019-01-21 00:00:00

  • Optimized periocular template selection for human recognition.

    abstract::A novel approach for selecting a rectangular template around periocular region optimally potential for human recognition is proposed. A comparatively larger template of periocular image than the optimal one can be slightly more potent for recognition, but the larger template heavily slows down the biometric system by ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/481431

    authors: Bakshi S,Sa PK,Majhi B

    更新日期:2013-01-01 00:00:00

  • Nonalcoholic Fatty Liver Disease Aggravated the Severity of Acute Pancreatitis in Patients.

    abstract:Background and Aim:The incidence of nonalcoholic fatty liver disease (NAFLD) as a metabolic disease is increasing annually. In the present study, we aimed to explore the influence of NAFLD on the severity of acute pancreatitis (AP). Methods:The severity of AP was diagnosed and analyzed according to the 2012 revised At...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9583790

    authors: Wu D,Zhang M,Xu S,Wu K,Wang N,Wang Y,Wu J,Lu G,Gong W,Ding Y,Xiao W

    更新日期:2019-01-22 00:00:00

  • Analysis of Synonymous Codon Usage Bias in Flaviviridae Virus.

    abstract:Background:Flaviviridae viruses are single-stranded, positive-sense RNA viruses, which threat human constantly mediated by mosquitoes, ticks, and sandflies. Considering the recent increase in the prevalence of the family virus and its risk potential, we investigated the codon usage pattern to understand its evolutionar...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5857285

    authors: Yao H,Chen M,Tang Z

    更新日期:2019-06-27 00:00:00

  • Advanced extrauterine pregnancy at 33 weeks with a healthy newborn.

    abstract::Abdominal pregnancy is a very rare form of ectopic pregnancy, associated with high morbidity and mortality for both fetus and mother. It is, and often, seen in poor resource nations, where early diagnosis is often a major challenge due to poor prenatal care and lack of medical resources. An advanced abdominal pregnanc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/102479

    authors: Dabiri T,Marroquin GA,Bendek B,Agamasu E,Mikhail M

    更新日期:2014-01-01 00:00:00

  • Corrigendum to "Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly".

    abstract::[This corrects the article DOI: 10.1155/2014/169203.]. ...

    journal_title:BioMed research international

    pub_type: 已发布勘误

    doi:10.1155/2020/9175369

    authors: Arosio B,D'Addario C,Gussago C,Casati M,Tedone E,Ferri E,Nicolini P,Rossi PD,Maccarrone M,Mari D

    更新日期:2020-09-07 00:00:00

  • Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot.

    abstract:Objective:The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at p...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6383906

    authors: Cui M,Gao Y,Zhao Y,Pang H,Chen L,Wang Z,Zhao L,Li M

    更新日期:2020-06-21 00:00:00

  • Prognostic value of combined aquaporin 3 and aquaporin 5 overexpression in hepatocellular carcinoma.

    abstract:BACKGROUND:Aquaporin (AQP) 3 and AQP 5 are involved in tumorigenesis and tumor progression of several tumor types. AIM:To investigate expression patterns and clinical significance of AQP3 and AQP5 in hepatocellular carcinoma (HCC). METHODS:Immunohistochemistry was performed to detect the expression of AQP3 and AQP5 i...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/206525

    authors: Guo X,Sun T,Yang M,Li Z,Li Z,Gao Y

    更新日期:2013-01-01 00:00:00

  • Colorectal Cancer: From the Genetic Model to Posttranscriptional Regulation by Noncoding RNAs.

    abstract::Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death. In this review, we first focus on colorectal carcinogenesis and on the genetic and epigenetic alterations involved...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/7354260

    authors: Lizarbe MA,Calle-Espinosa J,Fernández-Lizarbe E,Fernández-Lizarbe S,Robles MÁ,Olmo N,Turnay J

    更新日期:2017-01-01 00:00:00

  • Alteration of basilar artery rho-kinase and soluble guanylyl cyclase protein expression in a rat model of cerebral vasospasm following subarachnoid hemorrhage.

    abstract:BACKGROUND AND PURPOSE:The vasoconstrictor endothelin-1 (ET-1) has been implicated in the pathogenesis of cerebral vasospasm following subarachnoid hemorrhage (SAH). Previous results showed that CGS 26303, an endothelin converting enzyme (ECE) inhibitor, effectively prevented and reversed arterial narrowing in animal m...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/531508

    authors: Wang CJ,Lee PY,Wu BN,Wu SC,Loh JK,Tsai HP,Chung CL,Kassell NF,Kwan AL

    更新日期:2014-01-01 00:00:00

  • mTOR in viral hepatitis and hepatocellular carcinoma: function and treatment.

    abstract::As the fifth most common cancer in men and the eighth most common cancer in women, hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, with standard chemotherapy and radiation being minimally effective in prolonging survival. Virus hepatitis, particularly HBV and HCV infection is th...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/735672

    authors: Wang Z,Jin W,Jin H,Wang X

    更新日期:2014-01-01 00:00:00

  • Predominance of Abdominal Visceral Adipose Tissue Reflects the Presence of Aortic Valve Calcification.

    abstract::Background. Aortic valve calcification (AVC) is a common feature of aging and is related to coronary artery disease. Although abdominal visceral adipose tissue (VAT) plays fundamental roles in coronary artery disease, the relationship between abdominal VAT and AVC is not fully understood. Methods. We investigated 259 ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2174657

    authors: Oikawa M,Owada T,Yamauchi H,Misaka T,Machii H,Yamaki T,Sugimoto K,Kunii H,Nakazato K,Suzuki H,Saitoh S,Takeishi Y

    更新日期:2016-01-01 00:00:00

  • Socioeconomic Factors in Patients with Ulnar Nerve Compression at the Elbow: A National Registry-Based Study.

    abstract:Aims:To investigate demographics and socioeconomic status in patients with ulnar nerve compression and the influence of socioeconomic factors on patient-reported outcome measurements (PROM) as evaluated by QuickDASH (short version of Disabilities of Arm, Shoulder and Hand) after surgery for ulnar nerve compression at t...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5928649

    authors: Zimmerman M,Nyman E,Steen Carlsson K,Dahlin LB

    更新日期:2020-12-18 00:00:00