Abstract:
:The objective of the present investigation was to study the effect of combination of telmisartan with cisplatin in oral cancer cachexia induced by applying 0.5% 4-nitroquinoline-1-oxide (4-NQO) in propylene glycol to tongue, thrice a week for 8 weeks. From 8th to 22nd week, cisplatin (0.23 mg/kg, i.v.) was administered once in three weeks and telmisartan (5 mg/kg/day, p.o.) was administered daily. 4-NQO produced significant decrease in food intake, body weight, hyperglycemia, dyslipidemia, hypertension, and bradycardia, worsened hemodynamics, increased cachexia markers like insulin, C-reactive protein, and interleukin-6, and increased tumor markers like lactate dehydrogenase and γ -glutamyl transferase.Treatment with combination of telmisartan with cisplatin produced significant increase in food intake and body weight and controlled hyperglycaemia and dyslipidemia, preserved hemodynamic function, and decreased the cachexia markers while cisplatin alone did not produce any increase in food intake and body weight. Further, the combination of telmisartan with cisplatin significantly reduced tumor marker levels. Combination of telmisartan with cisplatin prevented 4-NQO induced oxidative stress, hyperplasia and hyperkeratosis, premalignant dysplasia, and invasive squamous cell carcinoma in the tongue. Our data suggests that combination of telmisartan with cisplatin treatment is beneficial in controlling cancer cachexia. Telmisartan can be used as an add-on therapy with cisplatin or other traditional chemotherapeutic agents.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Patel BM,Damle Ddoi
10.1155/2013/642848subject
Has Abstractpub_date
2013-01-01 00:00:00pages
642848eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
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journal_title:BioMed research international
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2019-07-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:BioMed research international
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/917968
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2020-12-09 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00