Asiatic Acid Interferes with Invasion and Proliferation of Breast Cancer Cells by Inhibiting WAVE3 Activation through PI3K/AKT Signaling Pathway.

Abstract:

Objective:To explore the ability of asiatic acid to interfere with the invasion and proliferation of breast cancer cells by inhibiting WAVE3 expression and activation through the PI3K/AKT signaling pathway. Methods:The MDA-MB-231 cells with strong invasiveness were screened by transwell assay, and plasmids with high expression of WAVE3 were constructed for transfection. The transfection effect and protein expression level of plasmids were verified by PCR and WB. The effects of asiatic acid on cell proliferation and invasion were investigated by flow cytometry. The xenografted tumor models in nude mice were established to study the antitumor activity of asiatic acid. Results:Asiatic acid significantly inhibited the activity of MDA-MB-231 cells, and the expression level of WAVE3 increased significantly in the tissue of ductal carcinoma in situ and was lower than that in the metastasis group. After plasmid transfection, the mRNA and protein expression of WAVE3 increased significantly in the cells. Asiatic acid at different concentrations had an impact on cell apoptosis and invasion and could significantly inhibit the expression of WAVE3, P53, p-PI3K, p-AKT, and other proteins. The T/C(%) of asiatic acid (50 mg/kg) for MDA-MB-231(F10) xenografted tumor in nude mice was 46.33%, with a tumor inhibition rate of 59.55%. Asiatic acid could significantly inhibit the growth of MDA-MB-231 (F10) xenografted tumors in nude mice (p < 0.05). Conclusions:Asiatic acid interferes with the ability of breast cancer cells to invade and proliferate by inhibiting WAVE3 expression and activation and the mechanism of action may be related to the PI3K/AKT signaling pathway.

journal_name

Biomed Res Int

authors

Gou XJ,Bai HH,Liu LW,Chen HY,Shi Q,Chang LS,Ding MM,Shi Q,Zhou MX,Chen WL,Zhang LM

doi

10.1155/2020/1874387

subject

Has Abstract

pub_date

2020-02-10 00:00:00

pages

1874387

eissn

2314-6133

issn

2314-6141

journal_volume

2020

pub_type

杂志文章
  • Comparison of three multiple allergen simultaneous tests: RIDA allergy screen, MAST optigen, and polycheck allergy.

    abstract::We compared the performances of 3 Multiple Allergen Simultaneous Test (MAST) assays: RIDA Allergy Screen (R-Biopharm, Darmstadt, Germany), MAST Optigen allergy system (Hitachi Chemical Diagnostics, Mountain View, CA), and Polycheck Allergy (Biocheck GmbH, Munster, Germany). Forty sera that tested positive with the RID...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2013/340513

    authors: Han M,Shin S,Park H,Park KU,Park MH,Song EY

    更新日期:2013-01-01 00:00:00

  • Improvement in the Detection of Cystic Metastatic Papillary Thyroid Carcinoma by Measurement of Thyroglobulin in Aspirated Fluid.

    abstract::Cystic change in metastatic lymph nodes of papillary thyroid carcinoma (PTC) is a diagnostic challenge for fine needle aspiration (FNA) because of the scant cellularity. The aim of this study was to evaluate the measurement of thyroglobulin in fine needle aspirate (Tg-FNA) for detecting metastatic PTC in patients with...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8905916

    authors: Wang Y,Zhao H,Wang YX,Wang MJ,Zhang ZH,Zhang L,Zhang B,Ahuja AT,Zhou CW,Jiang YX,Guo HQ

    更新日期:2016-01-01 00:00:00

  • Quality and Brands of Amoxicillin Formulations in Nairobi, Kenya.

    abstract::Antibiotics are among the most counterfeited anti-infectious medicines in developing countries. Amoxicillin is one of the commonly prescribed, affordable, and easily accessible antibiotic in Kenya. It is a broad-spectrum antibiotic hence commonly used in chemotherapy. This study sought to determine the quality and ide...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7091278

    authors: Koech LC,Irungu BN,Ng'ang'a MM,Ondicho JM,Keter LK

    更新日期:2020-06-12 00:00:00

  • Modern Family Planning Utilization and Its Associated Factors among Currently Married Women in Rural Eastern Ethiopia: A Community-Based Study.

    abstract:Background:The use of modern family planning methods among women of reproductive age (15-49 years) is of public health importance in Ethiopia. Nationally, modern family planning method use remains as low as 35%. Understanding factors associated with the use of modern family planning methods may help to improve maternal...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6096280

    authors: Mulatu T,Sintayehu Y,Dessie Y,Deressa M

    更新日期:2020-12-29 00:00:00

  • Pulsed Electromagnetic Field Inhibits Synovitis via Enhancing the Efferocytosis of Macrophages.

    abstract::Synovitis plays an important role in the pathogenesis of arthritis, which is closely related to the joint swell and pain of patients. The purpose of this study was to investigate the anti-inflammatory effects of pulsed electromagnetic fields (PEMF) on synovitis and its underlying mechanisms. Destabilization of the med...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4307385

    authors: Ouyang J,Zhang B,Kuang L,Yang P,Du X,Qi H,Su N,Jin M,Yang J,Xie Y,Tan Q,Chen H,Chen S,Jiang W,Liu M,Luo X,He M,Ni Z,Chen L

    更新日期:2020-05-26 00:00:00

  • A fast, reliable, and sensitive method for detection and quantification of Listeria monocytogenes and Escherichia coli O157:H7 in ready-to-eat fresh-cut products by MPN-qPCR.

    abstract::In the present work we developed a MPN quantitative real-time PCR (MPN-qPCR) method for a fast and reliable detection and quantification of Listeria monocytogenes and Escherichia coli O157:H7 in minimally processed vegetables. In order to validate the proposed technique, the results were compared with conventional MPN...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/608296

    authors: Russo P,Botticella G,Capozzi V,Massa S,Spano G,Beneduce L

    更新日期:2014-01-01 00:00:00

  • Antioxidant, lipid lowering, and membrane stabilization effect of sesamol against doxorubicin-induced cardiomyopathy in experimental rats.

    abstract::The present study was designed to evaluate the cardioprotective effect of sesamol against doxorubicin-induced cardiomyopathy in rats. In this study, the cardioprotective effect of sesamol against doxorubicin induced cardiomyopathy in experimental rats was evaluated at the dosage of 50 mg/kg bw. Doxorubicin was adminis...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/934239

    authors: Chennuru A,Saleem MT

    更新日期:2013-01-01 00:00:00

  • Microarray Based Functional Analysis of Myricetin and Proteomic Study on Its Anti-Inflammatory Property.

    abstract::Myricetin has been reported as a promising chemopreventive compound with multiple biofunctions. To evaluate its influence on gene expressions in genome-wide set and further investigate its anti-inflammatory property, the present study performed Gene Ontology and Ingenuity Pathway Analysis (IPA) to describe the basic g...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/3746326

    authors: Li T,Zhu J,Deng F,Wu W,Zheng Z,Lv C,Li Y,Xiang W,Lu X,Qin S

    更新日期:2019-03-07 00:00:00

  • The Efficacy of Programmed Intermittent Epidural Bolus for Postoperative Analgesia after Open Gynecological Surgery: A Randomized Double-Blinded Study.

    abstract:Background:It is well known that the programmed intermittent epidural bolus (PIEB) technique effectively provides epidural anesthesia in labor. This randomized double-blind trial compared the postoperative analgesic efficacy of PIEB with that of continuous epidural infusion (CEI) in patients undergoing gynecological su...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/6297247

    authors: Satomi S,Kakuta N,Murakami C,Sakai Y,Tanaka K,Tsutsumi YM

    更新日期:2018-05-15 00:00:00

  • Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease.

    abstract::This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitin...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/6915789

    authors: Lee JH,Kim SJ,Park SI,Ko YG,Choi D,Hong MK,Jang Y

    更新日期:2016-01-01 00:00:00

  • Advances in Exosomes Derived from Different Cell Sources and Cardiovascular Diseases.

    abstract::Exosomes can reach distant tissues through blood circulation to communicate directly with target cells and rapidly regulate intracellular signals. Exosomes play an important role in cardiovascular pathophysiology. Different exosomes derived from different sources, and their cargos have different mechanisms of action. ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/7298687

    authors: Liang B,He X,Zhao YX,Zhang XX,Gu N

    更新日期:2020-07-07 00:00:00

  • Chronic Hypoxia-Induced Microvessel Proliferation and Basal Membrane Degradation in the Bone Marrow of Rats Regulated through the IL-6/JAK2/STAT3/MMP-9 Pathway.

    abstract::Chronic hypoxia (CH) is characterized by long-term hypoxia that is associated with microvessel proliferation and basal membrane (BM) degradation in tissues. The IL-6/JAK2/STAT3/MMP-9 pathway has been described in a variety of human cancers and plays an essential role in microvessel proliferation and BM degradation. Th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9204708

    authors: Zhu M,Yang M,Yang Q,Liu W,Geng H,Pan L,Wang L,Ge R,Ji L,Cui S,Li Z

    更新日期:2020-01-23 00:00:00

  • Onlay Repair Technique for the Management of Ureteral Strictures: A Comprehensive Review.

    abstract::Ureteroplasty using onlay grafts or flaps emerged as an innovative procedure for the management of proximal and midureteral strictures. Autologous grafts or flaps used commonly in ureteroplasty include the oral mucosae, bladder mucosae, ileal mucosae, and appendiceal mucosae. Oral mucosa grafts, especially buccal muco...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/6178286

    authors: Xiong S,Wang J,Zhu W,Yang K,Ding G,Li X,Eun DD

    更新日期:2020-07-27 00:00:00

  • The Hip Morphology Changes with Ageing in Asian Population.

    abstract:Objectives:This study aims to determine the changing in hip anatomy parameters with age and reveals the reason for the extorsion of lower extremity in the aged. Design:Retrospective study. Participants:One hundred and forty patients who had received imaging check of the femur and acetabulum between October 2013 and O...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/1507979

    authors: Yin Y,Zhang R,Jin L,Li S,Hou Z,Zhang Y

    更新日期:2018-09-27 00:00:00

  • Abdominal Hernias, Giant Colon Diverticulum, GIST, Intestinal Pneumatosis, Colon Ischemia, Cold Intussusception, Gallstone Ileus, and Foreign Bodies: Our Experience and Literature Review of Incidental Gastrointestinal MDCT Findings.

    abstract::Incidental gastrointestinal findings are commonly detected on MDCT exams performed for various medical indications. This review describes the radiological MDCT spectrum of appearances already present in the past literature and in today's experience of several gastrointestinal acute conditions such as abdominal hernia,...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5716835

    authors: Di Grezia G,Gatta G,Rella R,Donatello D,Falco G,Grassi R,Grassi R

    更新日期:2017-01-01 00:00:00

  • Correlations of Expression Levels of a Panel of Genes (IRF5, STAT4, TNFSF4, MECP2, and TLR7) and Cytokine Levels (IL-2, IL-6, IL-10, IL-12, IFN-γ, and TNF-α) with Systemic Lupus Erythematosus Outcomes in Jordanian Patients.

    abstract::Systemic lupus erythematosus (SLE) is characterized by systemic end-organ damage. We investigated the involvement of IRF5, TLR-7, MECP2, STAT4, and TNFSF4 genes and TNF-α, IFN-γ, IL-2, IL-12, IL-6, and IL-10 cytokines in SLE pathogenesis and in organ damage in Jordanian patients. Blood was collected from 51 patients a...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1703842

    authors: Uzrail AH,Assaf AM,Abdalla SS

    更新日期:2019-11-29 00:00:00

  • Inhibitory Effects of Compounds and Extracts from Ampelopsis brevipedunculata on IL-6-Induced STAT3 Activation.

    abstract::Ampelopsis brevipedunculata (Maxim.) Trautv. (AB), a traditional East Asian medicine, exhibits protective effects against several inflammatory diseases. Our search for an inhibitor of IL-6-induced JAK2/STAT3 activation revealed that AB ethanolic extract (ABE) had a significant inhibitory effect on IL-6-induced STAT3 e...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3684845

    authors: Jang HJ,Lee SJ,Lim HJ,Jung K,Lee S,Park CS,Lee SW,Rho MC

    更新日期:2018-06-10 00:00:00

  • Immunoregulation of Bone Marrow-Derived Mesenchymal Stem Cells on the Chronic Cigarette Smoking-Induced Lung Inflammation in Rats.

    abstract::Impact of bone mesenchymal stem cell (BMSC) transfusion on chronic smoking-induced lung inflammation is poorly understood. In this study, a rat model of smoking-related lung injury was induced and the rats were treated with vehicle or BMSCs for two weeks. Different subsets of CD4+ T cells, cytokines, and anti-elastin ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/932923

    authors: Li X,Wang J,Cao J,Ma L,Xu J

    更新日期:2015-01-01 00:00:00

  • Diagnostic Potential of Evaluation of SDF-1α and sRAGE Levels in Threatened Premature Labor.

    abstract::Preterm birth remains the most prevalent cause of neonatal morbidity. This study aimed to evaluate the diagnostic value of SDF-1α, resistin, secretory RAGE (sRAGE), and endogenous secretory RAGE (esRAGE) in preterm labor. A total of 211 pregnant women participated in the study. Group A contained 72 women between 22 an...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2719460

    authors: Rzepka R,Dołęgowska B,Rajewska A,Sałata D,Budkowska M,Kwiatkowski S,Torbé A

    更新日期:2016-01-01 00:00:00

  • Retracted: Long Noncoding RNA KIAA0125 Potentiates Cell Migration and Invasion in Gallbladder Cancer.

    abstract::[This retracts the article DOI: 10.1155/2015/108458.]. ...

    journal_title:BioMed research international

    pub_type: 杂志文章,撤回出版物

    doi:10.1155/2017/3471417

    authors: International BR

    更新日期:2017-01-01 00:00:00

  • Analysis of Self-Adhesive Resin Cement Microshear Bond Strength on Leucite-Reinforced Glass-Ceramic with/without Pure Silane Primer or Universal Adhesive Surface Treatment.

    abstract:OBJECTIVE:To evaluate the microshear bond strength (μSBS) of self-adhesive resin (SA) cement on leucite-reinforced glass-ceramic using silane or universal adhesive. MATERIALS AND METHODS:Ceramic blocks were etched with 9.5% hydrofluoric acid and divided into three groups (n = 16): (1) negative control (NC) without tre...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/361893

    authors: Lee Y,Kim JH,Woo JS,Yi YA,Hwang JY,Seo DG

    更新日期:2015-01-01 00:00:00

  • Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: susceptibility to head and neck cancers.

    abstract::The occurrence of head and neck cancer (HNC) is associated with smoking and alcohol drinking. Tobacco smoking exposes smokers to a series of carcinogenic chemicals. Cytochrome P450 enzymes (CYP450s), such as CYP1A1, CYP1B1, and CYP2D6, usually metabolize carcinogens to their inactive derivatives, but they occasionally...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/582768

    authors: Khlifi R,Messaoud O,Rebai A,Hamza-Chaffai A

    更新日期:2013-01-01 00:00:00

  • Colorectal Cancer: From the Genetic Model to Posttranscriptional Regulation by Noncoding RNAs.

    abstract::Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death. In this review, we first focus on colorectal carcinogenesis and on the genetic and epigenetic alterations involved...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/7354260

    authors: Lizarbe MA,Calle-Espinosa J,Fernández-Lizarbe E,Fernández-Lizarbe S,Robles MÁ,Olmo N,Turnay J

    更新日期:2017-01-01 00:00:00

  • Using ecological momentary assessment to evaluate current physical activity.

    abstract:OBJECTIVE:The purpose of this study was to assess the value of ecological momentary assessment in evaluating physical activity among children, adolescents, and adults. It also determines whether ecological momentary assessment fulfills the criteria of validity, reliability, objectivity, norms, and standardization appli...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/915172

    authors: Marszalek J,Morgulec-Adamowicz N,Rutkowska I,Kosmol A

    更新日期:2014-01-01 00:00:00

  • Bioactivity and Physicochemical Properties of Three Calcium Silicate-Based Cements: An In Vitro Study.

    abstract:Objective:This study evaluated the bioactivity and physicochemical properties of three commercial calcium silicate-based endodontic materials (MTA, EndoSequence Root Repair Material putty, and Biodentine™). Material and Methods. Horizontal sections of 3 mm thickness from 18 root canals of human teeth were subjected to ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9576930

    authors: Talabani RM,Garib BT,Masaeli R

    更新日期:2020-05-22 00:00:00

  • Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis.

    abstract::Despite remarkable therapeutic advances have been made in the last few decades, non-small cell lung cancer (NSCLC) is still one of the leading causes of death worldwide. Brain metastases are a common complication of a wide range of human malignancies and in particular NSCLC. Brain-derived neurotrophic factor (BDNF), b...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4193541

    authors: Lombardi M,D'Ascanio M,Scarpino S,Scozzi D,Giordano M,Costarelli L,Raj ER,Mancini R,Cardillo G,Cardaci V,Innammorato M,Vecchione A,Ricci A

    更新日期:2020-11-17 00:00:00

  • Oral Streptococci Biofilm Formation on Different Implant Surface Topographies.

    abstract::The establishment of the subgingival microbiota is dependent on successive colonization of the implant surface by bacterial species. Different implant surface topographies could influence the bacterial adsorption and therefore jeopardize the implant survival. This study evaluated the biofilm formation capacity of five...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/159625

    authors: Pita PP,Rodrigues JA,Ota-Tsuzuki C,Miato TF,Zenobio EG,Giro G,Figueiredo LC,Gonçalves C,Gehrke SA,Cassoni A,Shibli JA

    更新日期:2015-01-01 00:00:00

  • Acinetobacter baumannii Infection in Transfusion Dependent Thalassemia Patients with Sepsis.

    abstract:PURPOSE:To identify the Acinetobacter baumannii infection among transfusion dependent thalassemia patients. METHODS:A quantitative approach was employed to assess Acinetobacter baumannii infection in transfusion dependent thalassemia patients. Samples were collected from 916 patients, which have shown bacterial growth...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2351037

    authors: Abdul Rasheed M,Alzahrani FM,Sattar Shaikh S

    更新日期:2017-01-01 00:00:00

  • Heteronemin, a Spongean Sesterterpene, Induces Cell Apoptosis and Autophagy in Human Renal Carcinoma Cells.

    abstract::Heteronemin is a bioactive marine sesterterpene isolated from the sponge Hyrtios sp. Previous reports have shown that heteronemin possesses anticancer activity. Here, heteronemin displayed cytotoxic effects against three human cancer cell lines (A549, ACHN, and A498) and exhibited potent activity in A498 human renal c...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/738241

    authors: Wu SY,Sung PJ,Chang YL,Pan SL,Teng CM

    更新日期:2015-01-01 00:00:00

  • Design of CGMP production of 18F- and 68Ga-radiopharmaceuticals.

    abstract:OBJECTIVE:Radiopharmaceutical production process must adhere to current good manufacturing process (CGMP) compliance to ensure the quality of precursor, prodrug (active pharmaceutical ingredient, API), and the final drug product that meet acceptance criteria. We aimed to develop an automated system for production of CG...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/680195

    authors: Chi YT,Chu PC,Chao HY,Shieh WC,Chen CC

    更新日期:2014-01-01 00:00:00