Abstract:
PURPOSE:To identify the Acinetobacter baumannii infection among transfusion dependent thalassemia patients. METHODS:A quantitative approach was employed to assess Acinetobacter baumannii infection in transfusion dependent thalassemia patients. Samples were collected from 916 patients, which have shown bacterial growth on MacConkey and blood agar culture media. A. baumannii strains were identified by microbiological methods and Gram's staining. API 20 E kit (Biomerieux, USA) was used for final identification. RESULTS:From 916 cultured blood specimens, 107 (11.6%) showed growth of A. baumannii. Serum ferritin in thalassemic patients without bacterial infections was 3849.5 ± 1513.5 µg/L versus 6413.5 ± 2103.9 µg/L in those with bacterial infections (p = 0.0001). Acinetobacter baumannii infected patients have shown higher serum ferritin levels (p = 0.0001). Serum ferritin in thalassemic patients was 3849.5 ± 1513.5 µg/L versus 6413.5 ± 2103.9 µg/L in those with bacterial infections (p = 0.0001). Acinetobacter baumannii infected patients showed high serum ferritin levels (p = 0.0001). The clinical symptoms have been found with A. baumannii +ve with a mean and standard deviation of 47 (5.1%) and A. baumannii -ve with mean and standard deviation of 60 (6.5%). CONCLUSION:Isolation of asymptomatic A. baumannii from the thalassemia patients shows an alarming situation of bacterial infections. A continuous surveillance of transfusion dependent thalassemia patients is recommended for bacterial sepsis.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Abdul Rasheed M,Alzahrani FM,Sattar Shaikh Sdoi
10.1155/2017/2351037subject
Has Abstractpub_date
2017-01-01 00:00:00pages
2351037eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract::Feature selection has become the essential step in biomarker discovery from high-dimensional genomics data. It is recognized that different feature selection techniques may result in different set of biomarkers, that is, different groups of genes highly correlated to a given pathological condition, but few direct comp...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/387673
更新日期:2013-01-01 00:00:00
abstract::Impact of bone mesenchymal stem cell (BMSC) transfusion on chronic smoking-induced lung inflammation is poorly understood. In this study, a rat model of smoking-related lung injury was induced and the rats were treated with vehicle or BMSCs for two weeks. Different subsets of CD4+ T cells, cytokines, and anti-elastin ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/932923
更新日期:2015-01-01 00:00:00
abstract::The polarization of macrophages and its anti-inflammatory and proinflammatory properties play a significant role in host response after implant placement to determine the outcome of osseointegration and long-term survival. In the previous study, we immobilized an antimicrobial peptide, GL13K, onto titanium surfaces to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2327034
更新日期:2020-07-24 00:00:00
abstract::Microalgae are a promising source of omega-3. The purpose of this study was to extract lipid with a relatively high content of eicosapentaenoic acid (EPA) from Nannochloropsis gaditana using subcritical water extraction (SWE). The effects of different temperatures (156.1-273.9°C), extraction times (6.6-23.4 minutes), ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8273581
更新日期:2018-12-27 00:00:00
abstract::Beyond hemostasis and thrombosis, an increasing number of studies indicate that platelets play an integral role in intercellular communication, mediating inflammatory and immunomodulatory activities. Our knowledge about how platelets modulate inflammatory and immunity has greatly improved in recent years. In this revi...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/9060143
更新日期:2016-01-01 00:00:00
abstract::High-dose melphalan (200 mg/m(2)) as conditioning regimen followed by autologous stem cell transplantation (ASCT) rescue has been established as a standard treatment for patients with multiple myeloma (MM) younger than 65 years of age. However, the role of ASCT in elderly patients older than 65 years remains controver...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/394792
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:The present study investigated which type of adenocarcinoma with BAC features was prone to be false-negative on 18F-FDG PET/CT. MATERIALS AND METHODS:A retrospective study was performed on 51 consecutive patients with localized adenocarcinoma with BAC features. CT and PET were assessed for lesion size, GGO per...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/243681
更新日期:2015-01-01 00:00:00
abstract::Heteronemin is a bioactive marine sesterterpene isolated from the sponge Hyrtios sp. Previous reports have shown that heteronemin possesses anticancer activity. Here, heteronemin displayed cytotoxic effects against three human cancer cell lines (A549, ACHN, and A498) and exhibited potent activity in A498 human renal c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/738241
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:There are some theoretical concerns for the use of intraoperative cell salvage (ICS) in patients with ectopic pregnancy. This study aimed to observe the impact of ICS on the coagulation function and clinical outcomes of patients with ruptured ectopic pregnancy and severe blood loss. METHODS:This was a retro...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7501807
更新日期:2017-01-01 00:00:00
abstract::In vivo confocal microscopy (IVCM) of the living human cornea offers the ability to perform repeated imaging without tissue damage. Studies using corneal IVCM have led to significant contributions to scientific and clinical knowledge of the living cornea in health and pathological states. Recently the application of c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/951081
更新日期:2015-01-01 00:00:00
abstract::Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and a major cause of nonrelapse mortality after allo-HSCT. A conditioning regimen plays a pivotal role in the development of aGVHD. To provide a platform for studying aGVHD and evaluating t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3071214
更新日期:2016-01-01 00:00:00
abstract::The current data are still inconclusive in terms of a genetic component involved in the susceptibility to renal cell carcinoma. Our aim was to evaluate 40 selected candidate polymorphisms for potential association with clear cell renal cell carcinoma (ccRCC) based on independent group of 167 patients and 200 healthy c...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/860405
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:While studies using various materials to overcome ischemia-reperfusion (IR) injury are becoming increasingly common, studies on the effects of botulinum toxin A (BoTA) on IR injury in musculocutaneous flaps are still limited. The purpose of this study was to examine our hypotheses that BoTA provide protect...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1074178
更新日期:2017-01-01 00:00:00
abstract:Background:Glucagon-like peptide 1 (GLP-1) hormone is an incretin hormone that is secreted in the ileum and plays a role in the pancreas to increase insulin secretion, stimulate proliferation, and prevent pancreatic β-cell apoptosis. Currently, diabetes mellitus (DM) treatment based on GLP-1 work is being developed, fo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8724824
更新日期:2019-11-11 00:00:00
abstract::Among other diseases characterized by the onset of cachexia, congestive heart failure takes a place of relevance, considering the high prevalence of this pathology in most European countries and in the United States, and is undergoing a rapid increase in developing countries. Actually, only few models of cardiac cache...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9549036
更新日期:2016-01-01 00:00:00
abstract::In clinical endodontics, preoperative estimation of root canal curvature is crucial regarding the prevention of iatrogenic errors. Reproduction of the two-dimensional radiographic images causes certain proximal view curvatures not seen. Therefore, the present study is aimed at investigating the degree of root canal cu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2021/6699635
更新日期:2021-01-13 00:00:00
abstract::Neutrophils comprise the first line of innate immune defense during a host-pathogen interaction. They attack microorganisms directly through three different methods, of which, phagocytosis and degranulation have been known and well-studied for decades. The formation of neutrophil extracellular traps (NETs) is the thir...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4192745
更新日期:2020-02-01 00:00:00
abstract::Fibroblast growth factor 21 (FGF21) is a metabolic hormone with multiple beneficial effects on lipid and glucose homeostasis. Previous study demonstrated that FGF21 might be one of the Sp1 target genes. However, the transcriptional role of Sp1 on FGF21 in adipose tissue and liver has not been reported. In this study, ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8402035
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to determine the capacity of biofilm formation of atypical enteropathogenic Escherichia coli (aEPEC) strains on abiotic and biotic surfaces. Ninety-one aEPEC strains, isolated from feces of children with diarrhea, were analyzed by the crystal violet (CV) assay on an abiotic surface after 24 h...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/845147
更新日期:2014-01-01 00:00:00
abstract::Adverse drug reactions (ADRs) are responsible for drug candidate failure during clinical trials. It is crucial to investigate biological pathways contributing to ADRs. Here, we applied a large-scale analysis to identify overrepresented ADR-pathway combinations through merging clinical phenotypic data, biological pathw...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/670949
更新日期:2015-01-01 00:00:00
abstract::Coronal decompensation is a common complication in Lenke 1 or 2 AIS patients after selective thoracic fusion (STF). However, the majority who developed immediately postoperative coronal decompensation experienced improvement and the related factors are not fully understood. The aim of this retrospective study was to i...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/3476425
更新日期:2018-12-09 00:00:00
abstract::In consequence of the key role of factor Xa in the clotting cascade and absence of its activity in the processes that do not affect coagulation, this protein is an attractive target for development of new blood coagulation inhibitors. Factor Xa is more effective and convenient target for creation of anticoagulants tha...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/120802
更新日期:2015-01-01 00:00:00
abstract::The ability of Aspergillus niger strain to reduce organic and mineral pollution as well as the toxicity of two tannery wastewaters, the unhairing effluent (UE) and the final effluent (FE), taken from a local Tunisian tannery and under nonsterile conditions, was studied. Raw effluents show alkaline pH ≥11; thus experim...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9020178
更新日期:2019-06-03 00:00:00
abstract::Hitherto, limited clinical impact has been achieved in the treatment of glioblastoma (GBMs). Although phytochemicals found in medicinal herbs can provide mankind with new therapeutic remedies, single agent intervention has failed to bring the expected outcome in clinical trials. Therefore, combinations of several agen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/260210
更新日期:2014-01-01 00:00:00
abstract::Aim. The aim of this study was to describe PCa characteristics and long-term outcomes in young men aged ≤55 years after radical prostatectomy (RP) and to compare them with older men cohort. Methods. Among 2,200 patients who underwent RP for clinically localized PCa at our centre between 2001 and 2015, 277 (10.3%) men ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9858923
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The vasoconstrictor endothelin-1 (ET-1) has been implicated in the pathogenesis of cerebral vasospasm following subarachnoid hemorrhage (SAH). Previous results showed that CGS 26303, an endothelin converting enzyme (ECE) inhibitor, effectively prevented and reversed arterial narrowing in animal m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/531508
更新日期:2014-01-01 00:00:00
abstract::Taking into account that there are controversial antioxidative effects of inhalational anesthetics isoflurane and sevoflurane and absence of comparison of genotoxicity of both anesthetics in animal model, the aim of this study was to compare DNA damage and antioxidant status in Wistar rats exposed to a single time to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/264971
更新日期:2015-01-01 00:00:00
abstract:Objective:This study evaluated the bioactivity and physicochemical properties of three commercial calcium silicate-based endodontic materials (MTA, EndoSequence Root Repair Material putty, and Biodentine™). Material and Methods. Horizontal sections of 3 mm thickness from 18 root canals of human teeth were subjected to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9576930
更新日期:2020-05-22 00:00:00
abstract::The aim was to evaluate three different biodegradable polylactic acid- (PLA-) based osteosynthesis materials (OM). These OM (BioSorb, LactoSorb, and Delta) were used in 64 patients of whom 55 (85.9%) had fractures of the zygoma, five (7.8%) in the LeFort II level, two of the frontal bone (3.1%), and two of the maxilla...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/621481
更新日期:2015-01-01 00:00:00
abstract::Introduction. The lateral lumbar interbody fusion (LLIF) surgical approach has potential advantages over other approaches but is associated with some unique neurologic risks due to the proximity of the lumbosacral plexus. The present study analyzed complications following LLIF surgical approach using a novel single fl...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2016/8450712
更新日期:2016-01-01 00:00:00