Abstract:
:In consequence of the key role of factor Xa in the clotting cascade and absence of its activity in the processes that do not affect coagulation, this protein is an attractive target for development of new blood coagulation inhibitors. Factor Xa is more effective and convenient target for creation of anticoagulants than thrombin, inhibition of which may cause some side effects. This study is aimed at finding new inhibitors of factor Xa by molecular computer modeling including docking SOL and postdocking optimization DISCORE programs. After validation of molecular modeling methods on well-known factor Xa inhibitors the virtual screening of NCI Diversity and Voronezh State University databases of ready-made low molecular weight species has been carried out. Seventeen compounds selected on the basis of modeling results have been tested experimentally in vitro. It has been found that 12 of them showed activity against factor Xa (IC50 = 1.8-40 μM). Based on analysis of the results, the new original compound was synthesized and experimentally verified. It shows activity against factor Xa with IC50 value of 0.7 μM.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Sulimov VB,Gribkova IV,Kochugaeva MP,Katkova EV,Sulimov AV,Kutov DC,Shikhaliev KS,Medvedeva SM,Krysin MY,Sinauridze EI,Ataullakhanov FIdoi
10.1155/2015/120802subject
Has Abstractpub_date
2015-01-01 00:00:00pages
120802eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract::Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The h...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/236745
更新日期:2015-01-01 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease characterized by variable expressivity, age penetrance, and a high heterogeneity. The transcriptional profile (miRNAs, mRNAs), epigenetic modifications, and posttranslational modifications seem to be highly relevant for the onset of the disease. miRNAs...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/983290
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship of delivery type, maternal anesthesia, feeding modalities, and first feeding and meconium passage times with early bilirubin levels of healthy infants. METHODS:Cord, 24 hours' and 48 hours' total bilirubin levels were measured in 388 study infants. RESULTS:Infants born with c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/316430
更新日期:2013-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are al...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4574509
更新日期:2020-04-06 00:00:00
abstract::Retinoblastoma protein (pRB) interacts with E2F and other protein factors to play a pivotal role in regulating the expression of target genes that induce cell cycle arrest, apoptosis, and differentiation. pRB controls the local promoter activity and has the ability to change the structure of nucleosomes and/or chromos...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/5959721
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of docetaxel plus oxaliplatin and capecitabine (DOX) in the first line treatment of advanced gastric adenocarcinoma. METHODS:A total of 37 patients were enrolled into this study, and they received DOX regimen (docetaxel 75 mg/m² and oxaliplatin 130 mg/m² intravenous infusi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/971096
更新日期:2013-01-01 00:00:00
abstract::Quantitative magnetic resonance imaging (qMRI) is a promising approach to detect early cartilage degeneration. However, there is no consensus on which cartilage component contributes to the tissue's qMRI signal properties. T1, T1ρ, and T2⁎ maps of cartilage samples (n = 8) were generated on a clinical 3.0-T MRI system...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9460456
更新日期:2018-05-15 00:00:00
abstract::Background. It has been suggested that, during pregnancy, endometriosis can cause a variety of disease-related complications. Objectives. The purpose of the study was to find out if women with histologically confirmed endometriosis do have a higher risk of adverse pregnancy outcome and if they suffer from a higher rat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8271452
更新日期:2016-01-01 00:00:00
abstract::Acute leukemias are the most frequent childhood malignancies worldwide and remain a leading cause of morbidity and mortality of relapsed patients. While remarkable progress has been made in characterizing genetic aberrations that may control these hematological disorders, it has also become clear that abnormalities in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/846724
更新日期:2013-01-01 00:00:00
abstract::Cancer and diabetes are among the most common diseases in western societies. Epidemiological studies have shown that diabetic patients have a significantly higher risk of developing a number of different types of cancers and that individuals with comorbidity (cancer and diabetes/prediabetes) have a poorer prognosis re...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/165105
更新日期:2015-01-01 00:00:00
abstract::Due to expanding applications of positron emission tomography (PET) there is a demand for developing new techniques to introduce fluorine-18 (t 1/2 = 109.8 min). Considering that most novel PET tracers are sensitive biomolecules and that direct introduction of fluorine-18 often needs harsh conditions, the insertion of...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/361329
更新日期:2014-01-01 00:00:00
abstract::Surgical flaps are frequently affected by ischemia/reperfusion (I/R) injury. Calcium-sensing receptor (CaSR) and stromal cell-derived factor-1α (SDF-1α) are closely associated with myocardial I/R injury. This study was performed to evaluate the feasibility of applying SDF-1α to counteract CaSR activation-mediated I/R ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8945850
更新日期:2018-01-11 00:00:00
abstract::Human epididymis protein 4 (HE4) is an available tumor biomarker mainly for detecting ovarian cancer. However, it is unknown whether it can be a novel indicator for diagnosis of diabetic kidney disease (DKD). The aim of this study was to investigate the possibility of serum HE4 as a novel biomarker for DKD in patients...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4831459
更新日期:2019-11-11 00:00:00
abstract::Liver regeneration after partial hepatectomy (PH) is a highly orchestrated biological process in which synchronized hepatocyte proliferation is induced after massive liver mass loss. Hepatocyte proliferation could be regulated by multiple signals, such as miRNAs and autophagy, but underlying mechanism remains unclear....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3817057
更新日期:2018-07-31 00:00:00
abstract::The goal of the present study were (1) to investigate the pathological characteristics of gastrocnemius muscle (GM) and quantitatively assess GM tissue stiffness in rat models with spinal cord injury (SCI) and (2) to explore the correlation between pathological characteristics changes and Young's modulus value of GM. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5387948
更新日期:2017-01-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are involved in the remodeling of extracellular matrix in various tissues. Their functioning could be related to the formation of complexes, containing MMP9, MMP2, tissue inhibitor of metalloproteinases type 1 (TIMP1), and neutrophil gelatinase-associated lipocalin (NGAL). Such complex...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/283856
更新日期:2013-01-01 00:00:00
abstract::So far, there is no report regarding the micro-Raman vibrational fingerprint of the bonds between 10-methacryloyloxy-decyl dihydrogen phosphate (10-MDP) and zirconia ceramics. Thus, the aim of this study was to identify the Raman vibrational peaks related to the bonds of 10-MDP with zirconia, as well as the influence ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8756396
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:The aim of this report is to study the graft and patient survival in a large cohort of recipients with an analysis of factors that may affect the final outcomes. METHODS:Between March 1976 and March 2008, 1967 consecutive live-donor renal transplants were carried out. Various variables that may have an im...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/912413
更新日期:2013-01-01 00:00:00
abstract::The release of ATP from the urothelium in response to stretch during filling demonstrates the importance of the purinergic system for the physiological functioning of the bladder. This study examined the effect of P2 receptor agonists on ATP release from two urothelial cell lines (RT4 and UROtsa cells). Hypotonic Kreb...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/830374
更新日期:2014-01-01 00:00:00
abstract::1-Deoxynojirimycin (DNJ), the main hypoglycemic constituent in mulberry (Morus alba) latex, has been extensively researched. Although there is considerable interest in the biological effects of DNJ, the roles of 1-deoxynojirimycin (DNJ) in glycometabolism and energy metabolism in insects have received little attention...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4676505
更新日期:2016-01-01 00:00:00
abstract::Heart failure (HF) is associated with mitochondrial dysfunction and energy metabolism impairment. MicroRNAs are implicated in the development of heart failure. However, the mitochondria enriched microRNA during heart failure remains elusive. Here, we generated a pressure overload-induced early and late stage heart fai...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4042509
更新日期:2017-01-01 00:00:00
abstract::Although ginseng has long been broadly used in clinical settings around the world, few clinical trials on ginseng have been conducted. The objective of this study was to provide a comprehensive evaluation of the characteristics of ginseng clinical trials registered in the WHO International Clinical Trials Registry Pla...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1843142
更新日期:2018-02-06 00:00:00
abstract::The endoscopic and histopathological findings detected in Sparus aurata experimentally infected with third-stage Anisakis larvae without intermediate host are evaluated and discussed. In six fish, live nematode larvae were introduced by gastroscopy into the stomach. The first observation by endoscope, 15 days after ch...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/701828
更新日期:2013-01-01 00:00:00
abstract::Electrospun scaffolds provide a dense framework of nanofibers with pore sizes and fiber diameters that closely resemble the architecture of native extracellular matrix. However, it generates limited three-dimensional structures of relevant physiological thicknesses. 3D printing allows digitally controlled fabrication ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6956794
更新日期:2017-01-01 00:00:00
abstract::TAL effectors (TALEs) contain a modular DNA-binding domain that is composed of tandem repeats. In all naturally occurring TALEs, the end of tandem repeats is invariantly a truncated half repeat. To investigate the potential role of the last half repeat in TALEs, we performed comparative molecular dynamics simulations ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8036450
更新日期:2016-01-01 00:00:00
abstract::Ricin is a potential biothreat agent with no approved antidote available for ricin poisoning. The aim of this study was to develop potent antibody-based antiricin antidotes. Four strong ricin resistant hybridoma clones secreting antiricin monoclonal antibodies (mAbs) were developed. All four mAbs are bound to conforma...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/471346
更新日期:2013-01-01 00:00:00
abstract:Aims:We aimed to summarize available lines of evidence about intraoperative and postoperative donor outcomes following robotic-assisted laparoscopic donor nephrectomy (RALDN) as well as outcomes of graft and recipients. Methods:A systematic review of PubMed/Medline, ISI Web of Knowledge, and Scopus databases was perfo...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/1729138
更新日期:2019-04-22 00:00:00
abstract:OBJECTIVE:This study aims to explore the usage of intraocular pressure measurements as the early indicator of the increase in intra-abdominal pressure. METHODS:In this prospective study, 40 patients undergoing elective surgery were included. Patients were divided into four groups of 10 patients. The control group (Gro...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/986895
更新日期:2015-01-01 00:00:00
abstract::The biological age (BA) equation is a prediction model that utilizes an algorithm to combine various biological markers of ageing. Different from traditional concepts, the BA equation does not emphasize the importance of a golden index but focuses on using indices of vital organs to represent the senescence of whole b...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/4697017
更新日期:2016-01-01 00:00:00
abstract::To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/782490
更新日期:2014-01-01 00:00:00