Variants of SCARB1 and VDR Involved in Complex Genetic Interactions May Be Implicated in the Genetic Susceptibility to Clear Cell Renal Cell Carcinoma.

abstract：Background:Although both nonfunctional paraganglioma of the bladder (NPB) and urothelial carcinoma of the bladder (UCB) are subtypes of bladder tumors, they are entirely different entities with distinct tissue origins and anatomical locations. However, NPB is frequently misdiagnosed as UCB chiefly due to the similariti...

journal_title：BioMed research international

authors： Male M,Ye T,Tao J,Chen ZQ,Peng E

更新日期：2019-11-06 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease characterized by variable expressivity, age penetrance, and a high heterogeneity. The transcriptional profile (miRNAs, mRNAs), epigenetic modifications, and posttranslational modifications seem to be highly relevant for the onset of the disease. miRNAs...

journal_title：BioMed research international

authors： Roma-Rodrigues C,Raposo LR,Fernandes AR

更新日期：2015-01-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in TNFSF4 and ANKRD55 genes have been shown to be associated with several autoimmune diseases, although whether these genes are susceptibility genes for dermatomyositis/polymyositis (DM/PM) has, to date, not been reported. This study aimed to investigate the potential association...

journal_title：BioMed research international

authors： Li L,Chen S,Wen X,Wang Q,Lv G,Li J,Yang F,Zhang F,Li Y

更新日期：2017-01-01 00:00:00

abstract：Background:According to several studies, the autoimmune response may lead to osteoarthritis and dyslipidemia and may affect the homeostasis of the human body's internal environment and then cause its own immune regulation. Consequently, the risk of osteoarthritis might be increased by dyslipidemia, but this association...

journal_title：BioMed research international

authors： Xiong J,Long J,Chen X,Li Y,Song H

更新日期：2020-02-15 00:00:00

abstract：:Tomatoes and tomato based-foods contain beneficial microorganisms and various organic acids that have important nutritional values for human. The objective of this study was to access the physiochemical properties of fermented tomatoes juices and to evaluate the competitiveness of lactic acid bacteria (LAB) against Li...

journal_title：BioMed research international

authors： Bah A,Albano H,Barbosa JB,Fhoula I,Gharbi Y,Najjari A,Boudabous A,Teixeira P,Ouzari HI

更新日期：2019-02-26 00:00:00

abstract：:T. reesei is an efficient cellulase producer and biomass degrader. To improve xylitol production in Trichoderma reesei strains by genetic engineering, two approaches were used in this study. First, the presumptive D-xylulokinase gene in T. reesei (xyiH), which has high homology to known fungi D-xylulokinase genes, was...

journal_title：BioMed research international

authors： Hong Y,Dashtban M,Kepka G,Chen S,Qin W

更新日期：2014-01-01 00:00:00

abstract：:Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense infiltrati...

journal_title：BioMed research international

authors： Correa MA,Borrego A,Jensen JR,Cabrera WHK,Barros M,Katz ISS,Canhamero T,Spadafora-Ferreira M,Fernandes JG,Starobinas N,Ribeiro OG,Ibañez OM,De Franco M

更新日期：2018-10-08 00:00:00

abstract：:The treatment of traumatic low-degree vertebral compression fracture remains in a wide range between functional treatment, bracing, vertebroplasty, kyphoplasty, and even surgical fixation. The objective was to assess the innovation of instrumented kyphoplasty and to report the early and mid-term functional and radiolo...

journal_title：BioMed research international

authors： Descamps J,Lamerain M,Chenguel Z,Jubert P,Rousseau MA

更新日期：2019-12-10 00:00:00

abstract：:Introduction. Luteolin, a falconoid compound in many Chinese herbs and formula, plays important roles in cardiovascular diseases. The underlying mechanism of luteolin remains to be further elaborated. Methods. A model of hydrogen peroxide- (H2O2-) induced H9C2 cells apoptosis was established. Cell viabilities were exa...

journal_title：BioMed research international

authors： Chang H,Li C,Huo K,Wang Q,Lu L,Zhang Q,Wang Y,Wang W

更新日期：2016-01-01 00:00:00

abstract：:Objectives. To investigate the potential association of a set of serum cytokines with the severity of coronary artery disease (CAD). Methods. A total of 201 patients who underwent coronary angiography for chest discomfort were enrolled. The concentrations of serum IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-9, and IL-17...

journal_title：BioMed research international

authors： Min X,Lu M,Tu S,Wang X,Zhou C,Wang S,Pang S,Qian J,Ge Y,Guo Y,Xu D,Cao K

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologou...

journal_title：BioMed research international

authors： Jiménez-Hernández E,Dueñas-González MT,Arellano-Galindo J,Medrano-Ortíz-De-Zárate ME,Bekker-Méndez VC,Berges-García A,Solís-Labastida K,Sánchez-Jara B,Tiznado-García HM,Jaimes-Reyes EZ,García-Jiménez X,Espinoza-Hernández L,Núñez-

更新日期：2015-01-01 00:00:00

abstract：:Candida krusei is osmotolerant yeast used for the production of glycerol. Addition of osmolyte such as NaCl into culture medium can increase the production of glycerol from glucose, but osmolytes may burden the glycerol separation. A coencapsulation method was suggested to create local extracellular hyperosmotic stres...

journal_title：BioMed research international

authors： Chen G,Yao S

更新日期：2013-01-01 00:00:00

abstract：Background:Doublecortin-like kinase 1 (DCLK1) has been universally identified as a cancer stem cell (CSC) marker and is found to be overexpressed in many types of cancers including breast cancer. However, there is little data regarding the functional role of DCLK1 in breast cancer metastasis. In the present study, we s...

journal_title：BioMed research international

authors： Liu H,Wen T,Zhou Y,Fan X,Du T,Gao T,Li L,Liu J,Yang L,Yao J,Ge Y,An G

更新日期：2019-05-15 00:00:00

abstract：:Background. Aortic valve calcification (AVC) is a common feature of aging and is related to coronary artery disease. Although abdominal visceral adipose tissue (VAT) plays fundamental roles in coronary artery disease, the relationship between abdominal VAT and AVC is not fully understood. Methods. We investigated 259 ...

journal_title：BioMed research international

authors： Oikawa M,Owada T,Yamauchi H,Misaka T,Machii H,Yamaki T,Sugimoto K,Kunii H,Nakazato K,Suzuki H,Saitoh S,Takeishi Y

更新日期：2016-01-01 00:00:00

abstract：Background:Reproductive system cancer is an important cause of morbidity and mortality worldwide which threatens women's health and lives. Breast, cervical, and ovarian cancer have the higher incidence and mortality among a series of gynecology malignant tumor. We aimed to compare and assess the temporal trends of comm...

journal_title：BioMed research international

authors： Wang J,Lv H,Xue Z,Wang L,Bai Z

更新日期：2018-03-21 00:00:00

abstract：Background:Thyroid cancer is the most common endocrine malignancy, with a recent global increase of 20% in age-related incidence. Ultrasonography and ultrasonography-guided fine-needle aspiration biopsy (FNAB) are the most widely used diagnostic tests for thyroid nodules; however, it is estimated that up to 25% of thyr...

journal_title：BioMed research international

authors： Nan BY,Xiong GF,Zhao ZR,Gu X,Huang XS

更新日期：2021-01-12 00:00:00

abstract：Objective:The aim of this study is to compare the clinical outcomes of two-level percutaneous endoscopic lumbar discectomy (PELD) and foraminoplasty PELD in treating highly migrated lumbar disc herniations. Methods:Patients with highly migrated lumbar disc herniations were enrolled from May 2014 to June 2016. Low back...

journal_title：BioMed research international

authors： Wu X,Fan G,He S,Gu X,Yang Y

更新日期：2019-10-13 00:00:00

abstract：:Schistosomiasis, caused by infection with Schistosoma species, remains an important parasitic zoonosis. Thioredoxin glutathione reductase of Schistosoma japonicum (SjTGR) plays an important role in the development of the parasite and for its survival. Here we present a recombinant plasmid DNA vaccine, pVAX1/SjTGR, to ...

journal_title：BioMed research international

authors： Cao Y,Zhao B,Han Y,Zhang J,Li X,Qiu C,Wu X,Hong Y,Ai D,Lin J,Fu Z

更新日期：2013-01-01 00:00:00

abstract：:Resveratrol has recently been used as a supplemental treatment for several neurological and nonneurological diseases. It is not known whether resveratrol has neuroprotective effect on amyotrophic lateral sclerosis (ALS). To assess the effect of resveratrol on the disease, we tested this agent on an ALS model of SOD1(G...

journal_title：BioMed research international

authors： Song L,Chen L,Zhang X,Li J,Le W

更新日期：2014-01-01 00:00:00

abstract：:Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence o...

journal_title：BioMed research international

authors： Dakouane-Giudicelli M,Alfaidy N,de Mazancourt P

更新日期：2014-01-01 00:00:00

abstract：Background and Aims:The value of hepatocyte regeneration in predicting the outcomes of hepatitis B-related acute-on-chronic liver failure (HBV-ACLF) is not fully assessed. The present study was aimed at establishing a novel scoring system to predict patients' outcomes within 3 months by applying serological indicators ...

journal_title：BioMed research international

authors： Wang X,Sun M,Yang X,Gao L,Weng M,Yang D,Li H,Zhou X,Li J,Qin S,Zhou D,Wu X,Tang S,Zeng W

更新日期：2020-08-06 00:00:00

abstract：:There is an emerging body of evidence that chemoresistance and minimal residual disease result from selective resistance of a cell subpopulation from the original tumor that is molecularly and phenotypically distinct. These cells are called "cancer stem cells" (CSCs). In this review, we analyze the potential targeting...

journal_title：BioMed research international

authors： Paldino E,Tesori V,Casalbore P,Gasbarrini A,Puglisi MA

更新日期：2014-01-01 00:00:00

abstract：Background:Large scalp defects, especially those complicated by calvarial defects, titanium mesh exposure, or cerebrospinal fluid (CSF) leak, pose a challenge for the neurosurgeon and plastic surgeon. Here, we describe our experience of reconstructing the complex scalp defect with free flap transfer. Methods:From Octo...

journal_title：BioMed research international

authors： Chen F,Ju H,Huang A,Yi Y,Cao Y,Xie W,Wang X,Fu G

更新日期：2020-01-10 00:00:00

abstract：:Toll-like receptors (TLRs), a critical family of pattern recognition receptors (PRRs), are responsible for the innate immune responses via signalling pathways to provide effective host defence against pathogen infections. However, TLR-signalling pathways are also likely to stringently regulate tissue maintenance and h...

journal_title：BioMed research international

authors： He X,Jing Z,Cheng G

更新日期：2014-01-01 00:00:00

abstract：:ADP-glucose pyrophosphorylase (AGPase) is the first rate limiting enzyme of starch biosynthesis pathway and has been exploited as the target for greater starch yield in several plants. The structure-function analysis and substrate binding specificity of AGPase have provided enormous potential for understanding the rol...

journal_title：BioMed research international

authors： Sarma K,Sen P,Barooah M,Choudhury MD,Roychoudhury S,Modi MK

更新日期：2014-01-01 00:00:00

abstract：:The etiology of nephrotic syndrome is complex and ranges from primary glomerulonephritis to secondary forms. Patients with nephrotic syndrome often need immunosuppressive treatment with its side effects and may progress to end stage renal disease. This review focuses on recent advances in the treatment of primary caus...

journal_title：BioMed research international

authors： Königshausen E,Sellin L

更新日期：2017-01-01 00:00:00

abstract：Purpose:Computer-aided diagnosis (CAD) can aid in improving diagnostic level; however, the main problem currently faced by CAD is that it cannot obtain sufficient labeled samples. To solve this problem, in this study, we adopt a generative adversarial network (GAN) approach and design a semisupervised learning algorith...

journal_title：BioMed research international

authors： Zheng G,Han G,Soomro NQ,Ma L,Zhang F,Zhao Y,Zhao X,Zhou C

更新日期：2019-04-15 00:00:00

abstract：:Significant positive effects, particularly on psychological state in patients who completed the follow-up pulmonary rehabilitation programs, are indicated by a large number of studies. Yet, a remarkable proportion of selected patients drop out from these programs. In this study, we investigated existing differences on...

journal_title：BioMed research international

authors： Tselebis A,Kosmas E,Bratis D,Pachi A,Ilias I,Harikiopoulou M,Theodorakopoulou E,Velentzas K,Dumitru S,Moussas G,Siafakas N,Tzanakis N

更新日期：2014-01-01 00:00:00

abstract：:A new exopolysaccharide preparation isolated from stationary cultures of the white rot fungus Ganoderma applanatum (GpEPS) was tested in terms of its bioactive properties including its cytotoxic and immunostimulatory effect. The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/m...

journal_title：BioMed research international

authors： Osińska-Jaroszuk M,Jaszek M,Mizerska-Dudka M,Błachowicz A,Rejczak TP,Janusz G,Wydrych J,Polak J,Jarosz-Wilkołazka A,Kandefer-Szerszeń M

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To identify the Acinetobacter baumannii infection among transfusion dependent thalassemia patients. METHODS:A quantitative approach was employed to assess Acinetobacter baumannii infection in transfusion dependent thalassemia patients. Samples were collected from 916 patients, which have shown bacterial growth...

journal_title：BioMed research international

authors： Abdul Rasheed M,Alzahrani FM,Sattar Shaikh S

更新日期：2017-01-01 00:00:00