Abstract:
:Resveratrol has recently been used as a supplemental treatment for several neurological and nonneurological diseases. It is not known whether resveratrol has neuroprotective effect on amyotrophic lateral sclerosis (ALS). To assess the effect of resveratrol on the disease, we tested this agent on an ALS model of SOD1(G93A) transgenic mouse. Rotarod measurement was performed to measure the motor function of the ALS mice. Nissl staining and SMI-32 immunofluorescent staining were used to determine motor neurons survival in the spinal cord of the ALS mice. Hematoxylin-eosin (H&E), succinic dehydrogenase (SDH), and cytochrome oxidase (COX) staining were applied to pathologically analyze the skeletal muscles of the ALS mice. We found that resveratrol treatment significantly delayed the disease onset and prolonged the lifespan of the ALS mice. Furthermore, resveratrol treatment attenuated motor neuron loss, relieved muscle atrophy, and improved mitochondrial function of muscle fibers in the ALS mice. In addition, we demonstrated that resveratrol exerted these neuroprotective effects mainly through increasing the expression of Sirt1, consequently suppressing oxidative stress and downregulating p53 and its related apoptotic pathway. Collectively, our findings suggest that resveratrol might provide a promising therapeutic intervention for ALS.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Song L,Chen L,Zhang X,Li J,Le Wdoi
10.1155/2014/483501subject
Has Abstractpub_date
2014-01-01 00:00:00pages
483501eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章,收录出版abstract:Background:Large scalp defects, especially those complicated by calvarial defects, titanium mesh exposure, or cerebrospinal fluid (CSF) leak, pose a challenge for the neurosurgeon and plastic surgeon. Here, we describe our experience of reconstructing the complex scalp defect with free flap transfer. Methods:From Octo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2748219
更新日期:2020-01-10 00:00:00
abstract::Metabolic syndrome (MetS) is a steering force for the cardiovascular diseases epidemic in Asia. This study aimed to compare the prevalence of MetS in Malaysian adults using NCEP-ATP III, IDF, and JIS definitions, identify the demographic factors associated with MetS, and determine the level of agreement between these ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/760963
更新日期:2013-01-01 00:00:00
abstract::Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/905215
更新日期:2015-01-01 00:00:00
abstract::The present work reports the anticancer, antioxidant, lipo-protective, and anti-HIV activities of phytoconstituents present in P. hysterophorus leaf. Dried leaf samples were sequentially extracted with nonpolar and polar solvents. Ethanol fraction showed noticeable cytotoxic activity (81-85%) in SRB assay against MCF-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/810734
更新日期:2013-01-01 00:00:00
abstract::Periodontal remodeling and alveolar bone resorption and formation play essential roles during orthodontic tooth movement (OTM). In the process, human periodontal ligament cells (HPDLCs) sense and respond to orthodontic forces, contributing to the alveolar bone formation. However, the underlying mechanism in this proce...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2174824
更新日期:2018-11-05 00:00:00
abstract::Mixed-phase TiO2 nanocomposite thin films consisting of anatase and rutile prepared on commercially pure Ti sheets via the electrochemical anodization and annealing treatments were investigated in terms of their photocatalytic activity for antibacterial use around dental implants. The resulting films were characterize...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/705871
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Vasculogenic mimicry (VM) was related to invasion and metastasis of head and neck squamous cell carcinoma (HNSCC) patients. This study was designed to investigate the role of EphA2 in VM formation of HNSCC. METHODS:The SiRNA technique was used to knock down the expression of EphA2 in vitro. The ability of cell...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/803914
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. METHODS:Young children (≤ 5 years) with suspected TB were prospectively enrolled at a tertiary hospital...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/783698
更新日期:2013-01-01 00:00:00
abstract::Ouabain, a cardiac glycoside found in plants, is primarily used in the treatment of congestive heart failure and arrhythmia because of its ability to inhibit Na(+)/K(+)-ATPase pump. Recently ouabain has been shown to exert anticancer effects but the underlying mechanism is not clear. Here, we explored the molecular me...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/537136
更新日期:2015-01-01 00:00:00
abstract:Background:In addition to the widely known effect of vitamin D3 (vitD3) on the skeleton, its role in the regulation of the immune response was also confirmed. Aim:The assessment of biochemical and densitometric markers of calcium-phosphate metabolism in the groups of patients with relapsing-remitting multiple sclerosi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9329123
更新日期:2018-08-23 00:00:00
abstract::Schistosomiasis is the most prevalent tropical disease in the world after malaria. According to the World Health Organization, the disease afflicts more than 240 million people in about 80 countries. Recently, an epidemiological surveillance study performed between 1997 and 2010 by the European Network for Tropical Me...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/8257310
更新日期:2017-01-01 00:00:00
abstract::This study evaluated the potential relationship between exosomal miRNAs and clinical symptoms in patients with multiple myeloma (MM). Forty-eight newly diagnosed myeloma patients and sixteen normal donors were enrolled in the study. The results showed that the relative expression levels of let-7c-5p, let-7d-5p, miR-14...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1575468
更新日期:2019-12-14 00:00:00
abstract::The prediction of RNA-binding proteins is one of the most challenging problems in computation biology. Although some studies have investigated this problem, the accuracy of prediction is still not sufficient. In this study, a highly accurate method was developed to predict RNA-binding proteins from amino acid sequence...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/425810
更新日期:2015-01-01 00:00:00
abstract:Results:The VMAT plans showed superior to PTV dose conformity index (CI), homogeneity index (HI), protection of the ipsilateral lung, monitor units (MUs), and maximum dose (Dmax) to the contralateral breast compared with TSP and 9FIMRT plans. The TSP provided better protection for Dmean of the heart and left ventricle ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2020/7131590
更新日期:2020-03-26 00:00:00
abstract:Background:The reliability of blood pressure (BP) measurement in hospitalized patients is a topic of debate and the therapeutic implication of the routinely collected BP profiles is probably overestimated. When measurements are performed in elderly patients, further potential sources of misinterpretation occur. Method...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6274545
更新日期:2019-04-01 00:00:00
abstract::This study aimed to examine the expression of and the relationship between CD44V6, CDH11, and β-catenin. The expression of these cell adhesion molecules was detected in 90 osteosarcoma and 20 osteochondroma specimens using immunohistochemistry. Associations between these parameters and clinicopathological data were al...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/496193
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2014/169203.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2020/9175369
更新日期:2020-09-07 00:00:00
abstract::This study described a TaqMan based real-time fluorescent quantitative PCR (qPCR) method to detect porcine cytomegalovirus (PCMV) infection, targeting the conserved region of the DNA polymerase (DPOL) gene. The standard curve showed a linear regression relationship with a coefficient of 0.999 and a slope of y = -3.249...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5673145
更新日期:2020-01-10 00:00:00
abstract::N6-methyladenosine (m6A) plays an important role in many cancers. However, few studies have examined the role of m6A in colorectal CRC. To examine the effect of m6A on CRC, we studied the genome of 591 CRC cases from The Cancer Genome Atlas (TCGA). The relationship between the messenger RNA (mRNA) expression, copy num...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8826456
更新日期:2020-12-19 00:00:00
abstract::Cancer related fatigue (CRF) is a common and debilitating symptom that can influence quality of life (QoL) in cancer patients. The increase in survival times stresses for a better understanding of how CRF affects patients' QoL. This was a cross-sectional descriptive study with 148 randomly recruited prostate cancer pa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3989286
更新日期:2016-01-01 00:00:00
abstract::The prospect of biomaterial hypersensitivity developing in response to joint implant materials was first presented more than 30 years ago. Many studies have established probable causation between first-generation metal-on-metal hip implants and hypersensitivity reactions. In a limited patient population, implant failu...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2015/137287
更新日期:2015-01-01 00:00:00
abstract::The efficiency of oat bran and barley bran in lowering the induced hyperlipidemia and hypercholesterolemia in blood of male Albino rats (Rattus rattus) was studied. Twenty rats were divided into four groups each consisted of five rats and fed the specified test diets for eight weeks. The first group (G1) is the negati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/263594
更新日期:2013-01-01 00:00:00
abstract::Within-litter birth weight variation in multiparous animals has become a big issue due to high incidence of low birth weight neonates, which gives rise to high preweaning mortality and morbidity. Foetus with various birth weights is the outcome of diverse embryos competence which is affected by oocyte quality. Glucosa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1630890
更新日期:2020-01-08 00:00:00
abstract:PURPOSE:This study aimed to investigate the shear displacement between the body and backrest/seat, range of motion (ROM), and force acting on the lower limb joints during sit-stand-sit transitions by operating an electric-powered standing wheelchair. METHODS AND MATERIALS:The amounts of sliding along the backrest and ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/236486
更新日期:2014-01-01 00:00:00
abstract::The total knee arthroplasty (TKA) is the gold standard for patients with an advanced symptomatic gonarthrosis. However, there are very few publications dealing with the primary TKA for patients with a proximal tibia fracture. In our retrospective study we evaluated 30 patients treated with a TKA for a proximal tibia f...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6047876
更新日期:2016-01-01 00:00:00
abstract::Falls are an important health concern among older adults due to age-related changes in the body. Having a medical history of chronic health condition may pose even higher risk of falling. Only few studies have assessed a number of chronic health conditions as risk factor for falls over a large nationally representativ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5146378
更新日期:2017-01-01 00:00:00
abstract:Background:The purpose of this study was to evaluate the association between the non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio and the risk of coronary artery disease (CAD). We also explored the potential role of non-HDL-C/HDL-C in the prognosis of CAD. Meth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7146028
更新日期:2020-03-07 00:00:00
abstract::The research was performed on male Wistar rats based on assumptions that new microelement preparations containing metal nanoparticles and their agglomerates had potential. Morphological and functional changes in tissues in the injection site and dynamics of chemical element metabolism (25 indicators) in body were asse...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/243173
更新日期:2015-01-01 00:00:00
abstract::In the present study, we explored SA's activity against DOX-induced cardiotoxicity and revealed its underlying mechanisms. Male Wistar rats (weight, 190-210g; n = 6) were randomly divided into four groups: group I, normal control; group II, DOX 15 mg/kg via intraperitoneal (ip) route; group III, administered DOX+SA 20...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3921796
更新日期:2020-03-10 00:00:00
abstract::Although triacylglycerol, the major component for lipid storage, is essential for normal physiology, its excessive accumulation causes obesity in adipose tissue and is associated with organ dysfunction in nonadipose tissue. Here, we focused on the Drosophila model to develop therapeutics for preventing obesity. The br...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6293163
更新日期:2016-01-01 00:00:00