Abstract:
:The present work reports the anticancer, antioxidant, lipo-protective, and anti-HIV activities of phytoconstituents present in P. hysterophorus leaf. Dried leaf samples were sequentially extracted with nonpolar and polar solvents. Ethanol fraction showed noticeable cytotoxic activity (81-85%) in SRB assay against MCF-7 and THP-1 cancer cell lines at 100 μg/ml concentration, while lower activity was observed with DU-145 cell line. The same extract exhibited 17-98% growth inhibition of HL-60 cancer cell lines in MTT assay, showing concentration dependent response. Ethanol extract caused 12% reduction in mitochondrial membrane potential and 10% increment in sub G1 population of HL-60 cell lines. Several leaf fractions, namely, ethyl acetate, ethanol, and aqueous fractions exhibited considerable reducing capability at higher concentrations. Most of the extracts demonstrated appreciable (>75%) metal ion chelating and hydroxyl radical scavenging activities at 200 µg/ml. All the extracts except aqueous fraction accounted for about 70-80% inhibition of lipid peroxidation in rat liver homogenate indicating protective response against membrane damage. About 40% inhibition of reverse transcriptase (RT) activity was observed in hexane fraction in anti-HIV assay at 6.0 µg/ml concentration. The study showed that phytochemicals present in P. hysterophorus leaf have considerable potential as cytotoxic and antioxidant agents with low to moderate anti-HIV activity.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Kumar S,Chashoo G,Saxena AK,Pandey AKdoi
10.1155/2013/810734subject
Has Abstractpub_date
2013-01-01 00:00:00pages
810734eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
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pub_type: 杂志文章,评审
doi:10.1155/2013/571912
更新日期:2013-01-01 00:00:00
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doi:10.1155/2015/513906
更新日期:2015-01-01 00:00:00
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doi:10.1155/2015/319589
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doi:10.1155/2018/4014021
更新日期:2018-01-16 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/763715
更新日期:2015-01-01 00:00:00
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doi:10.1155/2017/9567498
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1155/2014/196837
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,meta分析
doi:10.1155/2017/3803457
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2159739
更新日期:2017-01-01 00:00:00