Abstract:
:Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats. Three-week-old male rats were randomly divided into 2 groups: control (C; n = 14) and fructose fed (FF; n = 18), with a fructose enriched drink (20-25% w/v fructose in water) for 21 weeks. Systolic blood pressure, fasting glycemia, and bodyweight were regularly measured. Glucose tolerance was evaluated three times using an oral glucose tolerance test. Insulin levels were measured concomitantly and insulin resistance markers were evaluated (HOMA 2-IR, Insulin Sensitivity Index for glycemia (ISI-gly)). Lipids profile was evaluated on plasma. This fructose supplementation resulted in the early induction of hypertension without renal failure (stable theoretical creatinine clearance) and in the progressive development of fasting hyperglycemia and insulin resistance (higher HOMA 2-IR, lower ISI-gly) without modification of glucose tolerance. FF rats presented dyslipidemia (higher plasma triglycerides) and early sign of liver malfunction (higher liver weight). Although abdominal fat weight was increased in FF rats, no significant overweight was found. In Wistar rats, 21 weeks of fructose supplementation induced a metabolic syndrome (hypertension, insulin resistance, and dyslipidemia) but not T2D.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Dupas J,Feray A,Goanvec C,Guernec A,Samson N,Bougaran P,Guerrero F,Mansourati Jdoi
10.1155/2017/2494067subject
Has Abstractpub_date
2017-01-01 00:00:00pages
2494067eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract::The Purkinje network is a specialized conduction system within the heart that ensures the proper activation of the ventricles to produce effective contraction. Its role during ventricular arrhythmias is less clear, but some experimental studies have suggested that the Purkinje network may significantly affect the gene...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/621034
更新日期:2015-01-01 00:00:00
abstract::Sentinel lymph node biopsy (SLNB) emerged in the 1990s as a new technique in the surgical management of the axilla for patients with early breast cancer, resulting in lower complication rates and better quality of life than axillary lymph node dissection (ALND). Today SLNB is firmly established in the armamentarium of...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/405949
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To evaluate tumor structure in children with diffuse intrinsic pontine glioma (DIPG) using histogram analyses of mean diffusivity (MD), determine potential treatment and corticosteroid-related effects on MD, and monitor changes in MD distributions over time. MATERIALS AND METHODS:DTI was performed on a 1.5T GE...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/647356
更新日期:2014-01-01 00:00:00
abstract::Toxoplasma gondii (T. gondii) can be transmitted by blood transfusion. We determined the prevalence of T. gondii infection in healthy blood donors in Hermosillo city, Mexico, and the association of infection with T. gondii with the sociodemographic, clinical, and behavioral characteristics of blood donors. Four hundre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9597276
更新日期:2016-01-01 00:00:00
abstract::Human epididymis protein 4 (HE4) is an available tumor biomarker mainly for detecting ovarian cancer. However, it is unknown whether it can be a novel indicator for diagnosis of diabetic kidney disease (DKD). The aim of this study was to investigate the possibility of serum HE4 as a novel biomarker for DKD in patients...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4831459
更新日期:2019-11-11 00:00:00
abstract::The aim of this study was to evaluate a novel composite material for tracheal reconstruction in an ovine model. A polymer containing various forms of carbon fibers (roving, woven, and nonwoven fabric) impregnated with polysulfone (PSU) was used to create cylindrical tracheal implants, 3 cm in length and 2.5 cm in diam...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2610637
更新日期:2018-10-17 00:00:00
abstract:PURPOSE OF THE REPORT:There is a paucity of data on correlation of various imaging modalities with clinical findings in craniosynostosis. Moreover, no study has specifically reported the role of (99m)Tc-ECD SPECT in a large number of subjects with craniosynostosis. MATERIALS AND METHODS:We prospectively analyzed a coh...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/172646
更新日期:2014-01-01 00:00:00
abstract:Purpose:The aim of this study is to evaluate the effectiveness of laboratory serum tests in the diagnosis of infected nonunion. Methods:Forty-two patients suspected of having infected nonunion were investigated in the study. The serum levels of white blood-cell count (WBC), C-reactive protein (CRP), erythrocyte sedime...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9146317
更新日期:2017-01-01 00:00:00
abstract::Bacterial infections are the most common cause of purulent soft tissue inflammations in the head and neck area. These bacteria are also responsible for the majority of inflammatory complications after third molar removal. The key to success of antibacterial treatment in both cases is the use of an appropriate antibact...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2010453
更新日期:2019-10-07 00:00:00
abstract::A familiarity with the anatomy of some types of bone anomalies is necessary for clinicians involved in many medical areas. The aim of this paper is to review the newest literature concerning the morphology, embryology, clinical image, and therapeutic methods of the cervical ribs in the humans. The incidence of cervica...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/8034613
更新日期:2016-01-01 00:00:00
abstract::Spinal cord stimulation has been utilized for decades in the treatment of numerous conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer pain, and others. The placement of the stimulating electrode array was originally subdural but, to minimize surgical complexity and reduce the risk...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/989175
更新日期:2014-01-01 00:00:00
abstract::The uncertain position of lung tumor during radiotherapy compromises the treatment effect. To effectively control respiratory motion during radiotherapy of lung cancer without any side effects, a novel control scheme, hypnosis, has been introduced in lung cancer treatment. In order to verify the suggested method, six ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/574934
更新日期:2013-01-01 00:00:00
abstract:Results:In 221 cycles from 138 patients (104 cycles requiring HLA matching), 90.5% had embryo(s) biopsied for genetic testing. There were 119 embryo transfers for thalassemia (76) and thalassemia-HLA cases (43), respectively, resulting in overall clinical pregnancy rates of 54.6%, implantation rates of 45.7%, and live ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5292090
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:Perimesencephalic nonaneurysmal subarachnoid hemorrhage (PM-NASAH) is characterized by a benign course compared with aneurysmal SAH. While vasospasm (VS) after aneurysmal SAH is considered responsible for serious complications, VS post-PM-NASAH is not well documented. Our purpose was to characterize the inci...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/371063
更新日期:2013-01-01 00:00:00
abstract::Dietary polyphenols present in a broad range of plant foods have been related to beneficial health effects. This review aims to update the current information about the modulation of the gut microbiota by dietary phenolic compounds, from a perspective based on the experimental approaches used. After referring to gener...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/850902
更新日期:2015-01-01 00:00:00
abstract::The purpose of the study is to evaluate the relationship between NIH-CPSI and IIEF-5 in Chinese men with CP/CPPS. A large cross-sectional and multicenter survey was conducted from July 2012 to January 2014. Men were recruited from urology clinics which were located at the five cities in China. All men participated in ...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2015/560239
更新日期:2015-01-01 00:00:00
abstract::The use of endotamponade agents has gained a major role in the management of macular complications of high myopia. Myopic foveoschisis and macular hole are the main macular complication of pathologic myopia, this growing condition that is a main cause of visual loss, especially in patients at a younger age. We discuss...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/420380
更新日期:2014-01-01 00:00:00
abstract::The objective of this study was to investigate the effects of selective inducible nitric oxide synthase and neuronal nitric oxide synthase inhibitors on cartilage regeneration. The study involved 27 Wistar rats that were divided into five groups. On Day 1, both knees of 3 rats were resected and placed in a formalin so...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7857345
更新日期:2016-01-01 00:00:00
abstract::Information and communications technology (ICT) could support ambient assisted living (AAL) based interventions to provide support to informal caregivers of people with dementia, especially when they need to cope with their feelings of overburden or isolation. An e-learning platform (understAID application) was tested...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2016/5726465
更新日期:2016-01-01 00:00:00
abstract:Objectives:To evaluate the role of short-term low-dose glucocorticoids in mild COVID-19 patients. Methods:We conducted a retrospective, cross-sectional, single-center study in Kunming, China. A total of 33 mild COVID-19 cases were divided into two treatment groups (with and without glucocorticoids, methylprednisolone,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2854186
更新日期:2020-09-23 00:00:00
abstract::Lipids have been widely used as main constituents in various drug delivery systems, such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-based lyotropic liquid crystals. Among them, lipid-based lyotropic liquid crystals have highly ordered, thermodynamically stable internal nanostruct...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/815981
更新日期:2014-01-01 00:00:00
abstract::Background. It has been suggested that, during pregnancy, endometriosis can cause a variety of disease-related complications. Objectives. The purpose of the study was to find out if women with histologically confirmed endometriosis do have a higher risk of adverse pregnancy outcome and if they suffer from a higher rat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8271452
更新日期:2016-01-01 00:00:00
abstract::Studies pertaining to trans fatty acids (TFA), which have been implicated in development of chronic diseases, are more relevant in developing countries where nutrition transition is changing traditional habits and practices. Measuring TFA is an arduous task because of the need for fat biopsies. This study identifies a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/276174
更新日期:2013-01-01 00:00:00
abstract::Three bioactive fractions, extracellular laccase (ex-LAC), crude endopolysaccharides (c-EPL), and a low molecular subfraction of secondary metabolites (ex-LMS), were isolated from the idiophasic cultures of the white rot fungus Cerrena unicolor. For the first time, we determined the antioxidant properties of these sam...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/497492
更新日期:2013-01-01 00:00:00
abstract::The research was performed on male Wistar rats based on assumptions that new microelement preparations containing metal nanoparticles and their agglomerates had potential. Morphological and functional changes in tissues in the injection site and dynamics of chemical element metabolism (25 indicators) in body were asse...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/243173
更新日期:2015-01-01 00:00:00
abstract::Angiopoietin-like protein 4 (ANGPTL4) is widely known as a key regulator of lipid metabolism. We investigated the relationship between ANGPTL4 expression in serum or urine and blood lipid or urine protein levels of patients with hyperlipidemia- (HL-) related proteinuria. Sixty-eight patients with HL-related proteinuri...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5281251
更新日期:2020-03-23 00:00:00
abstract::Purpose. This meta-analysis is to assess the effectiveness of teriparatide in fracture healing and clinical function improvement of the osteoporotic patients. Methods. We searched PubMed, Embase, Web of Science, and the Cochrane databases for randomized and quasi-randomized controlled trials comparing teriparatide to ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/6040379
更新日期:2016-01-01 00:00:00
abstract:Materials and Methods:Various aqueous extracts were prepared from this plant and preadministered per os to albino mice 3 h before APAP administration, once daily for one week. Animals from the normal group were given only distilled water while those from negative control received only APAP 250 mg/kg. After treatment, m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3807234
更新日期:2020-08-31 00:00:00
abstract::This study described a TaqMan based real-time fluorescent quantitative PCR (qPCR) method to detect porcine cytomegalovirus (PCMV) infection, targeting the conserved region of the DNA polymerase (DPOL) gene. The standard curve showed a linear regression relationship with a coefficient of 0.999 and a slope of y = -3.249...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5673145
更新日期:2020-01-10 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/5760612.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/7108272
更新日期:2018-01-08 00:00:00