Abstract:
BACKGROUND:Tumor patients and patients after traumas are endangered by a reduced immune defense, and a silver coating on their megaprostheses may reduce their risks of infection. The aim of this study was to determine the silver ion concentration directly measured from the periprosthetic tissue and the influence on the clinical outcome. MATERIAL AND METHODS:Silver ions were evaluated in 5 mL wound fluids two days postoperatively and in blood patients 7 and 14 days after surgery using inductively coupled plasma emission spectrometry in 18 patients who underwent total joint replacement with a silver-coated megaendoprosthesis. RESULTS:The concentration of silver ions averaged 0.08 parts per million. Patients who showed an increased silver concentration in the blood postoperatively presented a lower silver concentration in the wound fluids and a delayed decrease in C-reactive protein levels. There were significantly fewer reinfections and shorter hospitalization in comparison with a group that did not receive a silver-coated megaprosthesis. CONCLUSION:An increased concentration of silver in the immediate surroundings of silver-coated prostheses was demonstrated for the first time in cohorts of patients with trauma or tumors. An elevated concentration of silver ions in the direct periprosthetic tissue may have reduced the infection rate.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Hussmann B,Johann I,Kauther MD,Landgraeber S,Jäger M,Lendemans Sdoi
10.1155/2013/763096subject
Has Abstractpub_date
2013-01-01 00:00:00pages
763096eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
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