Abstract:
BACKGROUND:The deregulated tumorigenic long non-coding RNA (lncRNA) has been reported in several malignancies. However, there is still no comprehensive study on tongue squamous cell carcinoma (SCC). METHODS:Functional reannotation for the human lncRNA was carried out by ncFANs. Real-time quantitative PCR was used to validate the identified lncRNAs. RESULTS:Using the functional annotation algorithm from ncFANs, 8 differentially expressed lncRNAs were identified. Lnc-PPP2R4-5, lnc-SPRR2D-1, lnc-MAN1A2-1, lnc-FAM46A-1, lnc-MBL2-4:1, and lnc-MBL2-4:3 were upregulated in the microdissected tongue SCC tissues. In comparison, lnc-AL355149.1-1 and lnc-STXBP5-1 showed significant downregulation. High level of lnc-MBL2-4:3 was significantly associated with the node positive tongue SCC patients. Further, patients with advanced T-stage demonstrated a further reduction of lnc-AL355149.1-1 in the tumor tissues. Treatment of tongue SCC cells with 5-fluorouracil and paclitaxel can reserve the expression patterns observed in the tongue SCC tissues. Further, changes of lnc-MBL2-4:3 and lnc-AL355149.1-1 expression levels were noticed in the cisplatin-resistant tongue SCC cells. CONCLUSIONS:Our results demonstrated that functional reannotation allows us to identify novel lncRNAs using the existing gene expression array dataset. The association of lncRNA with the T-stage and nodal status of tongue SCC patients suggested that lncRNA deregulation was involved in the pathogenesis of tongue SCC.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Gao W,Chan JY,Wong TSdoi
10.1155/2014/405860subject
Has Abstractpub_date
2014-01-01 00:00:00pages
405860eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/480702
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/648040
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4147932
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abstract::Diabetes-triggered apoptosis of Schwann cells (SC) contributes to the degradation of diabetic peripheral neuropathy (DNP). In recent years, mesenchymal stem cells (MSC) were applied to DPN repair and it was demonstrated that paracrine secretion played a key role in neuroprotection exerted by MSC. Erythropoietin (EPO) ...
journal_title:BioMed research international
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更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/913235
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/860405
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/730535
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2020/3105248
更新日期:2020-02-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2021/6230826
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/910260
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3501827
更新日期:2018-03-20 00:00:00
abstract::Selenium is an essential trace element, which has certain antioxidant properties. Na2SeO3 is toxic, and its use is limited. SeMet, as an organic selenium, is less toxic than Na2SeO3. In this experiment, different concentrations of Na2SeO3 and SeMet were added to MEA and PDA media to observe the effect of selenium on t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2368245
更新日期:2020-04-26 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/760963
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/621481
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2019/4985121
更新日期:2019-04-10 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/919374
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2019-05-19 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7698038
更新日期:2019-01-09 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3817057
更新日期:2018-07-31 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8329513
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/849080
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8978906
更新日期:2019-01-02 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5201879
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3061742
更新日期:2018-11-01 00:00:00