Abstract:
:Multiple sclerosis (MS) is a central nervous system (CNS) disease resulting from a targeted autoimmune-mediated attack on myelin proteins in the CNS. The release of Th1 inflammatory mediators in the CNS activates macrophages, antibodies, and microglia resulting in myelin damage and the induction of neuropathic pain (NPP). Molecular signaling through fractalkine (CX3CL1), a nociceptive chemokine, via its receptor (CX3CR1) is thought to be associated with MS-induced NPP. An experimental autoimmune encephalomyelitis (EAE) model of MS was utilized to assess time dependent gene and protein expression changes of CX3CL1 and CX3CR1. Results revealed significant increases in mRNA and the protein expression of CX3CL1 and CX3CR1 in the dorsal root ganglia (DRG) and spinal cord (SC) 12 days after EAE induction compared to controls. This increased expression correlated with behavioural thermal sensory abnormalities consistent with NPP. Furthermore, this increased expression correlated with the peak neurological disability caused by EAE induction. This is the first study to identify CX3CL1 signaling through CX3CR1 via the DRG/SC anatomical connection that represents a critical pathway involved in NPP induction in an EAE model of MS.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Zhu W,Acosta C,MacNeil B,Cortes C,Intrater H,Gong Y,Namaka Mdoi
10.1155/2013/480702subject
Has Abstractpub_date
2013-01-01 00:00:00pages
480702eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract:Purpose:To study the effect of duodenal-jejunal omega switch (DJOS) in combination with different dietary patterns on the retinol-binding protein (RBP4), fetuin-A, and fibroblast growth factor 21 (FGF21) plasma levels and their hepatic gene expressions in rats. Methods:A high-fat diet (HF) was given to 28 rats and 28 ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3472190
更新日期:2018-08-16 00:00:00
abstract::Cancer and diabetes are among the most common diseases in western societies. Epidemiological studies have shown that diabetic patients have a significantly higher risk of developing a number of different types of cancers and that individuals with comorbidity (cancer and diabetes/prediabetes) have a poorer prognosis re...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/165105
更新日期:2015-01-01 00:00:00
abstract::The biological age (BA) equation is a prediction model that utilizes an algorithm to combine various biological markers of ageing. Different from traditional concepts, the BA equation does not emphasize the importance of a golden index but focuses on using indices of vital organs to represent the senescence of whole b...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/4697017
更新日期:2016-01-01 00:00:00
abstract::To overcome the issues connected to the use of autologous vascular grafts and artificial materials for reconstruction of small diameter (<6 mm) blood vessels, this study aimed to develop acellular matrix- (AM-) based vascular grafts. Rat iliac arteries were decellularized by a detergent-enzymatic treatment, whereas en...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/685426
更新日期:2014-01-01 00:00:00
abstract::Objective. Our objective is to develop a computerized scheme for liver tumor segmentation in MR images. Materials and Methods. Our proposed scheme consists of four main stages. Firstly, the region of interest (ROI) image which contains the liver tumor region in the T1-weighted MR image series was extracted by using se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3219068
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:This study investigated whether the 1 : 2 ω-3/ω-6 ratio may reduce proinflammatory response in human alveolar cells (A549) exposed to an ex vivo inflammatory stimulus (bronchoalveolar lavage fluid (BALF) of acute respiratory distress syndrome (ARDS) patients). Methods. We exposed A549 cells to the BALF colle...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/642520
更新日期:2015-01-01 00:00:00
abstract::Curcumin is a bright yellow compound found in Curcuma longa L., a member of the family Zingiberaceae. In the present study, we determined whether curcumin protects against oxidative stress in liver and brain in mice fed excessive alcohol. BALB/c mice were administered 20% alcohol (16 g/kg body weight) with or without ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/242671
更新日期:2013-01-01 00:00:00
abstract::Tobacco smoking continues to be a leading cause of disease and mortality. Recent research has confirmed the important role of nicotinic acetylcholine receptor (nAChR) gene cluster on chromosome 15q 24-25 in nicotine dependence and smoking. In this study we tested the association of smoking initiation, age at onset of ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/350348
更新日期:2015-01-01 00:00:00
abstract::Effects of in ovo injection of Q10 on hatchability, performance (feed intake (FI), body weight gain (BWG), feed/gain ratio (F/G)) traits, and immune status of Ross × Ross 308 broiler chicks, hatched from eggs laid by a 38-week-old breeder flock, were determined through 42 days after hatch. Eggs containing live embryos...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7167525
更新日期:2019-02-04 00:00:00
abstract::The purpose of the study is to evaluate the relationship between NIH-CPSI and IIEF-5 in Chinese men with CP/CPPS. A large cross-sectional and multicenter survey was conducted from July 2012 to January 2014. Men were recruited from urology clinics which were located at the five cities in China. All men participated in ...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2015/560239
更新日期:2015-01-01 00:00:00
abstract::Introduction. The aim of this study was to investigate the utility of ultrasonography (US) for predicting and assessing the effectiveness of extracorporeal shock wave therapy (ESWT) in insertional Achilles tendinopathy (IAT). Methods. A total of 42 patients with an established diagnosis of chronic IAT were examined by...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/2580969
更新日期:2016-01-01 00:00:00
abstract::Diabetic patients are at risk for spontaneous foot ulcers, chronic wounds, infections, and tissue necrosis. Current theories suggest that the development and progression of diabetic foot ulcers are mainly caused by arteriosclerosis and peripheral neuropathy. Tissue necrosis plays a primordial role in the progression o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/490964
更新日期:2013-01-01 00:00:00
abstract:Background:Large scalp defects, especially those complicated by calvarial defects, titanium mesh exposure, or cerebrospinal fluid (CSF) leak, pose a challenge for the neurosurgeon and plastic surgeon. Here, we describe our experience of reconstructing the complex scalp defect with free flap transfer. Methods:From Octo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2748219
更新日期:2020-01-10 00:00:00
abstract::Mesenchymal stem cells (MSCs) therapy has been applied to a wide range of diseases with excessive immune response, including inflammatory bowel disease (IBD), owing to its powerful immunosuppression and its ability to repair tissue lesions. Different sources of MSCs show different therapeutic properties. Engineering m...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/9652817
更新日期:2018-12-26 00:00:00
abstract::The AT-hook transcription factor, AKNA, is a nuclear protein that affects a few physiological and pathological processes including cancer. Here, we investigated the role of AKNA in gastric cancer (GC). By using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays, AKNA was found deregulat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6726759
更新日期:2020-05-13 00:00:00
abstract::Medicinal plants have played an important role in the treatment of many diseases. Medicinal plants are believed to be well appropriate with the human body and to produce less side influences than the pharmaceuticals. Kingdom of Saudi Arabia has abundant and wide variety of medicinal plants whose therapeutic effects ha...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3596287
更新日期:2019-02-27 00:00:00
abstract:Objective:We identified differentially expressed microRNAs (DEMs) between esophageal carcinoma (ESCA) tissues and normal esophageal tissues. We then constructed a novel three-miRNA signature to predict the prognosis of ESCA patients using bioinformatics analysis. Materials and Methods. We combined two microarray profil...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5973082
更新日期:2020-02-10 00:00:00
abstract::Almost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/143109
更新日期:2015-01-01 00:00:00
abstract::Preeclampsia (PE) is a unique complication of pregnancy, the pathogenesis of which has been generally accepted to be associated with the dysfunctions of extravillous trophoblast (EVT) including proliferation, apoptosis, and migration and invasion. Decorin (DCN) has been proved to be a decidua-derived TGF-binding prote...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/201629
更新日期:2015-01-01 00:00:00
abstract:Background:The use of modern family planning methods among women of reproductive age (15-49 years) is of public health importance in Ethiopia. Nationally, modern family planning method use remains as low as 35%. Understanding factors associated with the use of modern family planning methods may help to improve maternal...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6096280
更新日期:2020-12-29 00:00:00
abstract::Cardiac computed tomography angiography (CCTA) is widely used as a diagnostic tool for evaluation of coronary artery disease (CAD). Despite the excellent capability to rule-out CAD, CCTA may overestimate the degree of stenosis; furthermore, CCTA analysis can be time consuming, often requiring advanced postprocessing t...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6649410
更新日期:2020-12-16 00:00:00
abstract::The anaerobic batch test (45 days at 37°C) was performed to describe the effect of thermal pretreatment at moderate temperatures (60, 80, and 100°C) over durations of 10 and 20 minutes on the enhancement of biogas production using hotel food waste from city of Jaipur, India. The results showed that the total cumulativ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9416249
更新日期:2018-09-16 00:00:00
abstract::Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/720514
更新日期:2013-01-01 00:00:00
abstract::The incidence of postoperative nausea and vomiting (PONV) is 30-50% after surgery. PONV occurs frequently, especially after craniotomy. In this study, we investigated the preventive effects on PONV in a randomized study by comparing patients who had been administered fosaprepitant, a neurokinin-1 (NK1) receptor antago...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/307025
更新日期:2014-01-01 00:00:00
abstract:CONTEXT:The 7th (2009) edition of the AJCC melanoma staging system incorporates tumor (Breslow) thickness, MR, and ulceration in stratifying T1 primary melanomas. Compared to the prior 6th (2001) edition, MR has replaced CL for thin melanomas. OBJECTIVE:We sought to identify and report differences of the classificatio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/898719
更新日期:2013-01-01 00:00:00
abstract:Objective:Primary headache and obesity are highly prevalent disorders in the general population. Although many studies have reported an association between the two, there is still no overall comprehension about this relationship. To gain a more accurate understanding in this regard, we analyzed data from a 2011 cross-s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4630490
更新日期:2019-04-15 00:00:00
abstract::In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6452965
更新日期:2018-10-25 00:00:00
abstract::Background. The chronic recommendation of pediatric drugs could exhibit erosive and cariogenic problems. Objective. To evaluate the effects of different pediatric drugs on the color stability of various restorative materials. Methods. Five specimens (1 mm × 3 mm) were prepared and immersed in ten different pediatric d...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9684193
更新日期:2017-01-01 00:00:00
abstract::Although the dynamic motions and peptidyl transferase activity seem to be embedded in the rRNAs, the ribosome contains more than 50 ribosomal proteins (r-proteins), whose functions remain largely elusive. Also, the precise forms of some of these r-proteins, as being part of the ribosome, are not structurally solved du...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/539238
更新日期:2015-01-01 00:00:00
abstract::Protein phosphorylation is catalyzed by kinases which regulate many aspects that control death, movement, and cell growth. Identification of the phosphorylation site-specific kinase-substrate relationships (ssKSRs) is important for understanding cellular dynamics and provides a fundamental basis for further disease-re...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1826496
更新日期:2017-01-01 00:00:00