Abstract:
:Little is known about the clinical value of the Hadlock and INTERGROWTH-21st EFW standards for predicting adverse perinatal outcomes (APOs) in the third trimester. The purpose of this study was to study the association between low estimated fetal weight percentile (EFWc) in the third trimester and the risk of APOs and compare predictions of APOs between Hadlock and INTERGROWTH-21st EFW standards. A prospective cohort of 690 singleton pregnancies with ultrasonography performed in the third trimester between March 2015 and March 2016 in China was conducted. EFW and the corresponding EFWc were measured using the Hadlock and INTERGROWTH-21st standards, respectively. Cox proportional hazard models were used to assess the relationship between low EFWc (i.e., <5 percentile, P5) and the risk of APOs. Compared with fetuses with ≥P5 of the EFWc, fetuses with journal_name journal_title authors doi subject pub_date pages eissn issn journal_volume pub_type
abstract::Data on genotypic diversity of Mycobacterium tuberculosis complex (MTBC) is important to understand its epidemiology, human adaptation, clinical phenotypes, and drug resistance. This study aimed to characterize MTBC clinical isolates circulating in a predominantly pastoralist area in Ethiopia, a country where tubercul...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/238532
更新日期:2014-01-01 00:00:00
abstract::The energy generated by an extremely low frequency electromagnetic field (ELF-EMF) is too weak to directly induce genotoxicity. However, it is reported that an extremely low frequency magnetic field (ELF-MF) is related to DNA strand breakage and apoptosis. The testes that conduct spermatogenesis through a dynamic cell...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/567183
更新日期:2014-01-01 00:00:00
abstract::Cardiotonic drugs mainly include digitalis, catecholamines, phosphodiesterase inhibitors, and calcium sensitizers, which have been successively discovered and applied in clinical practice. However, there are only a few new drugs available in this field, and the selection is very limited. Digitalis, catecholamines, and...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/9731467
更新日期:2019-09-19 00:00:00
abstract::Acute kidney injury (AKI) is associated with an increased risk of developing advanced chronic kidney disease (CKD). Yet, effective interventions to prevent this conversion are unavailable for clinical practice. In this study, we examined the beneficial effects of Tanshinone IIA on renal fibrosis in a mouse model of fo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/867140
更新日期:2015-01-01 00:00:00
abstract::Aims. We describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantify and compare simultaneously global methylation and hydroxymethylation in human DNA of different tissues. Materials and Methods. Blood and saliva DNA from fourteen volunteers was processed for epigenetic endpoints using LC-M...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/845041
更新日期:2015-01-01 00:00:00
abstract::Beta-1,3-glucanosyltransferase (Gas1p) plays important roles in cell wall biosynthesis and morphogenesis and has been implicated in DNA damage responses and cell cycle regulation in fungi. Yeast Gas1p has also been reported to participate in endoplasmic reticulum (ER) stress responses. However, the precise roles and m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1238581
更新日期:2019-06-02 00:00:00
abstract::Postoperative cognitive dysfunction (POCD) is a kind of serious neurologic complications and dexmedetomidine has a certain effect on POCD. However, functional mechanism of dexmedetomidine on POCD still remains unclear, so the research mainly studied the effect of dexmedetomidine on cognitive function and protein expre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4014021
更新日期:2018-01-16 00:00:00
abstract:Background:Inflammation is the major risk factor for the progression of hepatocellular carcinoma (HCC), and the nuclear factor-κB (NF-κB) signaling plays the central role in the inflammation process. However, the activated mechanism of NF-κB signaling in HCC is unclear. Methods:The expression of PHF5A is examined by q...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1621854
更新日期:2019-01-15 00:00:00
abstract:Background:In resource limited settings, HIV/AIDS patients lack access to sufficient nutritious foods, which poses challenges to the success of antiretroviral therapy. HIV/AIDS and malnutrition are still major public health problems in Ethiopia. Though measuring nutritional status is an essential part of ART program, l...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1913534
更新日期:2018-05-06 00:00:00
abstract:Background:This study is aimed at identifying unknown clinically relevant genes involved in colorectal cancer using bioinformatics analysis. Methods:Original microarray datasets GSE107499 (ulcerative colitis), GSE8671 (colorectal adenoma), and GSE32323 (colorectal cancer) were downloaded from the Gene Expression Omnib...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1204605
更新日期:2020-05-23 00:00:00
abstract::Nematodes infections are responsible for debilitating conditions and economic losses in domestic animals as well as livestock and are considered an important public health problem due to the high prevalence in humans. The nematode resistance for drugs has been reported for livestock, highlighting the importance for de...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/879263
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:This study was designed to evaluate the role of maintenance therapy with partially hydrolyzed guar gum (PHGG) after topical application of glyceryl trinitrate (GTN) in the conservative treatment of chronic anal fissure (CAF). METHODS:From all the patients with CAF observed during the study period, 165 subjects...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/964942
更新日期:2014-01-01 00:00:00
abstract::Background and Purposes. The 320-detector row CT scanner enables visualization of whole-brain hemodynamic information (dynamic CT angiography (CTA) derived from CT perfusion scans). However, arterial image quality in dynamic CTA (dCTA) is inferior to arterial image quality in standard CTA. This study evaluates whether...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/603173
更新日期:2014-01-01 00:00:00
abstract::Presynaptic and postsynaptic neurotoxins are proteins which act at the presynaptic and postsynaptic membrane. Correctly predicting presynaptic and postsynaptic neurotoxins will provide important clues for drug-target discovery and drug design. In this study, we developed a theoretical method to discriminate presynapti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3267325
更新日期:2017-01-01 00:00:00
abstract:Objective:To investigate the effects of electroacupuncture (EA) at "Zusanli" (ST36) and "Shangjuxu"(ST37) on reducing inflammatory reaction and improving intestinal dysfunction in patients with sepsis-induced intestinal dysfunction with syndrome of obstruction of the bowels Qi. Methods:A total of 71 patients with seps...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/8293594
更新日期:2018-06-26 00:00:00
abstract::Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling pathways. In vitro...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/202905
更新日期:2013-01-01 00:00:00
abstract::Gremlin is a developmental gene upregulated in human chronic kidney disease and in renal cells in response to transforming growth factor-β (TGF-β). Epithelial mesenchymal transition (EMT) is one process involved in renal fibrosis. In tubular epithelial cells we have recently described that Gremlin induces EMT and acts...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/802841
更新日期:2014-01-01 00:00:00
abstract::The application of chemotherapeutic drug adriamycin (ADR) in cancer therapy is limited by its side effects like high toxicity and insolubility. Nanomedicine offers new hope for overcoming the shortcomings. But how to increase in vivo stability and to control intracellular drug release is a key issue for nano-based for...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/987404
更新日期:2015-01-01 00:00:00
abstract::Although neurological ailments continue to be some of the main causes of disease burden in the world, current therapies such as pharmacological agents have limited potential in the restoration of neural functions. Cell therapies, firstly applied to treat different hematological diseases, are now being investigated in ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/417091
更新日期:2014-01-01 00:00:00
abstract::Myopia is the most common ocular abnormality. Its high and growing prevalence has contributed to a recent surge in surgical interest in the disorder, since retinal detachment in eyes with high myopia differs from that in emmetropic eyes or eyes with low myopia. The myopic eye, because of its specific anatomy, poses sp...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/618382
更新日期:2014-01-01 00:00:00
abstract::The early diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI) is very important for treatment research and patient care purposes. Few biomarkers are currently considered in clinical settings, and their use is still optional. The objective of this work was to determine whether multimodal and nonpr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/961314
更新日期:2015-01-01 00:00:00
abstract::Trypanosoma cruzi causes a cardiac infection characterized by an inflammatory imbalance that could become the inciting factor of the illness. To this end, we evaluated the role of carvedilol, a beta-blocker with potential immunomodulatory properties, on the immune response in C57BL/6 mice infected with VL-10 strain of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9205062
更新日期:2017-01-01 00:00:00
abstract::Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective effects of freeze-dr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/693613
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:To study whether weaker self-esteem in adolescence is connected with smoking behavior in adulthood. METHODS:An age cohort born in 1979 responded to the Lawrence Self-Esteem Questionnaire (LAWSEQ) at the age of 16 (n = 1,072). Respondents' smoking behavior was monitored annually during adolescence and 75.3% ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/687541
更新日期:2015-01-01 00:00:00
abstract::New and innovative treatment strategies for cancer patients in the fields of immunotherapy and radiotherapy are rapidly developing in parallel. Among the most promising preclinical treatment approaches is combining immunotherapy with radiotherapy where early data suggest synergistic effects in several tumor model syst...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/658126
更新日期:2013-01-01 00:00:00
abstract::Emerging evidence shows that microRNAs (miRNAs) play important roles in the regulation of various biological and pathologic processes in human cancers and the aberrant expression of miRNAs contributes to the tumor development. In this study, our findings indicate that miR-451 is significantly overexpressed in pancreat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2381482
更新日期:2017-01-01 00:00:00
abstract::Molecular imaging based personalized therapy has been a fascinating concept for individualized therapeutic strategy, which is able to attain the highest efficacy and reduce adverse effects in certain patients. Theranostics, which integrates diagnostic testing to detect molecular targets for particular therapeutic moda...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/1680464
更新日期:2016-01-01 00:00:00
abstract::Mexico has one of the highest incidences of childhood leukemia worldwide and significantly higher mortality rates for this disease compared with other countries. One possible cause is the high prevalence of gene rearrangements associated with the etiology or with a poor prognosis of childhood acute lymphoblastic leuke...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2014/210560
更新日期:2014-01-01 00:00:00
abstract::Tsetse flies (Glossina spp.) are the primary vectors of trypanosomes, which can cause human and animal African trypanosomiasis in Sub-Saharan African countries. The objective of this study was to explore the genome of Glossina morsitans morsitans for evidence of horizontal gene transfer (HGT) from microorganisms. We e...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3164624
更新日期:2016-01-01 00:00:00
abstract::Eccentric exercise is characterized by initial unfavorable effects such as subcellular muscle damage, pain, reduced fiber excitability, and initial muscle weakness. However, stretch combined with overload, as in eccentric contractions, is an effective stimulus for inducing physiological and neural adaptations to train...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/193741
更新日期:2015-01-01 00:00:00