Abstract:
:Molecular imaging based personalized therapy has been a fascinating concept for individualized therapeutic strategy, which is able to attain the highest efficacy and reduce adverse effects in certain patients. Theranostics, which integrates diagnostic testing to detect molecular targets for particular therapeutic modalities, is one of the key technologies that contribute to the success of personalized medicine. Although the term "theranostics" was used after the second millennium, its basic principle was applied more than 70 years ago in the field of thyroidology with radioiodine molecular imaging. Differentiated thyroid cancer, which arises from follicular cells in the thyroid, is the most common endocrine malignancy, and theranostic radioiodine has been successfully applied to diagnose and treat differentiated thyroid cancer, the applications of which were included in the guidelines published by various thyroid or nuclear medicine societies. Through better pathophysiologic understanding of thyroid cancer and advancements in nuclear technologies, theranostic radioiodine contributes more to modern tailored personalized management by providing high therapeutic effect and by avoiding significant adverse effects in differentiated thyroid cancer. This review details the inception of theranostic radioiodine and recent radioiodine applications for differentiated thyroid cancer management as a prototype of personalized medicine based on molecular imaging.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Ahn BCdoi
10.1155/2016/1680464subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1680464eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
杂志文章,评审abstract:Background:Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectab...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6278403
更新日期:2018-08-27 00:00:00
abstract::[This corrects the article DOI: 10.1155/2014/169203.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2020/9175369
更新日期:2020-09-07 00:00:00
abstract::In continuance of our search for anticancer agents, we report herein the synthesis and anticancer activity of some novel oxadiazole analogues. The compounds were screened for anticancer activity as per National Cancer Institute (NCI US) protocol on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and br...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/814984
更新日期:2014-01-01 00:00:00
abstract::We aimed to predict the ten-year cardiovascular disease (CVD) risk among low-income urban dwellers of metropolitan Malaysia. Participants were selected from a cross-sectional survey conducted in Kuala Lumpur. To assess the 10-year CVD risk, we employed the Framingham risk scoring (FRS) models. Significant determinants...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/516984
更新日期:2015-01-01 00:00:00
abstract::Alzheimer's disease affects millions of people worldwide and incidence is expected to rise as the population ages, but no effective therapies exist despite decades of research and more than 20 known disease markers. Research has shown that Alzheimer's disease's missing heritability remains extensive with an estimated ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/870123
更新日期:2015-01-01 00:00:00
abstract::Although ginseng has long been broadly used in clinical settings around the world, few clinical trials on ginseng have been conducted. The objective of this study was to provide a comprehensive evaluation of the characteristics of ginseng clinical trials registered in the WHO International Clinical Trials Registry Pla...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1843142
更新日期:2018-02-06 00:00:00
abstract::Natural plant extracts contain a variety of phenolic compounds which are assigned various biological activities. Our work aims to make a quantitative and qualitative characterization of the Zest (ZL) and the Flesh (FL) of lemon (Citrus limon), to valorize the pharmacological uses of lemon, by evaluating in vitro activ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6251546
更新日期:2018-01-15 00:00:00
abstract:Introduction:Limitations in breeding source reduction practices, development of insecticide resistance in mosquitoes, and ill effects of chemical controlling methods on human and ecosystem health have motivated Sri Lankan authorities working for dengue control to seek for alternative, ecofriendly, and sustainable appro...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8759459
更新日期:2018-12-03 00:00:00
abstract::Iron deficiency anemia has been a widespread disease. As an effective and stable iron supplement, the physiochemical properties of the polysaccharide iron complex have been widely studied. In this study, we characterized a novel polysaccharide-iron(III) complex extracted in an edible fungal species Auricularia auricul...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6416941
更新日期:2019-06-11 00:00:00
abstract:BACKGROUND:Anaemia with an estimated prevalence of 35-75% among pregnant women is a major cause of maternal deaths in Nigeria. objective: To determine the prevalence of anaemia, associated sociodemographic factors and red cell morphological pattern among pregnant women during booking at the University Teaching Hospital...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/849080
更新日期:2014-01-01 00:00:00
abstract::Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB). The association between HBV infection and human leukocyte antigen- (HLA-) DQ polymorphism (rs2856718 and rs7453920) has been demonstrated in other studies; however, the results were controversial or inconclusive. Therefore,...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2017/9679843
更新日期:2017-01-01 00:00:00
abstract::The intra- and extracellular accumulation of misfolded and aggregated amyloid proteins is a common feature in several neurodegenerative diseases, which is thought to play a major role in disease severity and progression. The principal machineries maintaining proteostasis are the ubiquitin proteasomal and lysosomal aut...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/495091
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/673018
更新日期:2015-01-01 00:00:00
abstract::Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death. In this review, we first focus on colorectal carcinogenesis and on the genetic and epigenetic alterations involved...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/7354260
更新日期:2017-01-01 00:00:00
abstract:Background:Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which plays a significant role in cell proliferation and tumor progression. The relationship between YAP1 and gastrointestinal cancer has been explored in many previous studies. We conducted a meta-analysis to explore the prognostic effect of Y...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2018/4039173
更新日期:2018-11-14 00:00:00
abstract:Background:The aims of this study were to explore the characteristics of left ventricular (LV) functional changes in subjects with or without acute mountain sickness (AMS) and their associations with AMS incidence. Methods:A total of 589 healthy men were enrolled and took a trip from Chengdu (500 m, above sea level (a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6028747
更新日期:2020-11-10 00:00:00
abstract::This study applies the environmental Kuznets curve to test the relationship between the regional economic growth and the different types of agricultural nonpoint source pollution loads in the Ningxia Yellow River irrigation area by using the Johnes export coefficient method. Results show that the pollution load genera...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/267968
更新日期:2013-01-01 00:00:00
abstract::We evaluated single nucleotide polymorphism (SNP) detection via a target-capture, C-probe ligation, and RAM assay in a single-blind comparison to clinical samples that had been tested with FDA-cleared tests for up to 4 different vascular disease-related SNPs. In the RAM assay circulizable linear probes (C- or padlock ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/641090
更新日期:2014-01-01 00:00:00
abstract::Stem cell-based therapy has been considered as a promising option in the treatment of ischemic heart disease. Although stem cell administration resulted in the temporary improvement of myocardial contractility in the majority of studies, the formation of new cardiomyocytes within the injured myocardium has not been co...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/7874109
更新日期:2020-03-03 00:00:00
abstract::Pediatric myelodysplastic syndrome (MDS) is an uncommon disease and little is known about the molecular alterations of its development and evolution to acute myeloid leukemia (AML). The Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PCR2). It is a histone methyltransferas...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2019/3176565
更新日期:2019-12-10 00:00:00
abstract::The selection of the most relevant molecular descriptors to describe a target variable in the context of QSAR (Quantitative Structure-Activity Relationship) modelling is a challenging combinatorial optimization problem. In this paper, a novel software tool for addressing this task in the context of regression and clas...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2905203
更新日期:2019-02-17 00:00:00
abstract::The use of modern surgical dressings to prevent wound complications and surgical site infection (SSI) after minimally invasive total knee arthroplasty (MIS-TKA) is lacking. In a prospective, randomized, controlled study, 240 patients were randomized to receive either AQUACEL Ag Surgical dressing (study group) or a sta...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/1262108
更新日期:2017-01-01 00:00:00
abstract::Porcine circovirus virus type II (PCV2) is the etiology of postweaning multisystemic wasting syndrome (PMWS), porcine dermatitis, nephropathy syndrome (PDNS), and necrotizing pneumonia. Rapid diagnosis tool for detection of PCV2 plays an important role in the disease control and eradication program. Recombinase polyme...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8403642
更新日期:2017-01-01 00:00:00
abstract::Previously, a novel technique was proposed to quantify the relationship between the muscle stiffness and its nonfatigue contraction intensity. The method extended the measured range of isometric contraction to 100% maximum voluntary contraction (MVC) using an ultrasonic shear wave measurement setup. Yet, it has not be...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9469548
更新日期:2017-01-01 00:00:00
abstract::Studies of aseptic loosening showed an influence of calcitonin and α-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) with the time to asept...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3687415
更新日期:2018-06-05 00:00:00
abstract:OBJECTIVE:This study mainly aimed to explore the association between brain-derived neurotropic factor (BDNF) Val66Met polymorphism and posttraumatic stress disorder (PTSD) among flood survivors in China. METHODS:Individuals who experienced the 1998 Dongting Lake flood in Southeast Huarong, China, were enrolled in this...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/4569698
更新日期:2017-01-01 00:00:00
abstract:Background:Health workers are one of the most important building blocks of the health system. High turnover rate contribute to the shortfalls and unbalanced distribution of health personnel in the health workforce. Turnover intention is the strongest predictor of actual turnover. Objective:To assess the magnitude of t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3165379
更新日期:2018-12-23 00:00:00
abstract::Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management. A deeper understanding of the immunological basis and other potential mechanisms of action together with new dosing schedules and/or routes of administr...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/413076
更新日期:2015-01-01 00:00:00
abstract::Intestinal parasites of dogs and cats are cosmopolitan pathogens with zoonotic potential for humans. Our investigation considered their diffusion in dogs and cats from northern Italy areas, specifically the metropolitan area of Milan and two micropolitan areas of neighboring provinces. It included the study of the lev...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/696508
更新日期:2014-01-01 00:00:00
abstract::Cancer cells acquire unique secretome compositions that contribute to tumor development and metastasis. The aim of our study was to elucidate the biological processes involved in cervical cancer, by performing a proteomic analysis of the secretome from the following informative cervical cell lines: SiHa (HPV16+), HeLa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4180703
更新日期:2017-01-01 00:00:00