Abstract:
:Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management. A deeper understanding of the immunological basis and other potential mechanisms of action together with new dosing schedules and/or routes of administration may potentiate its clinical benefit. Newer forms of taxanes, with better safety profiles and higher intratumoural cytotoxicity, have yet to demonstrate clinical superiority over the parent compound.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Kampan NC,Madondo MT,McNally OM,Quinn M,Plebanski Mdoi
10.1155/2015/413076subject
Has Abstractpub_date
2015-01-01 00:00:00pages
413076eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract::Ampelopsis brevipedunculata (Maxim.) Trautv. (AB), a traditional East Asian medicine, exhibits protective effects against several inflammatory diseases. Our search for an inhibitor of IL-6-induced JAK2/STAT3 activation revealed that AB ethanolic extract (ABE) had a significant inhibitory effect on IL-6-induced STAT3 e...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3684845
更新日期:2018-06-10 00:00:00
abstract::The incidence of acute kidney injury induced by contrast media (CI-AKI) is the third cause of AKI in hospitalized patients. Contrast media cause relevant alterations both in renal hemodynamics and in renal tubular cell function that lead to CI-AKI. The vasoconstriction of intrarenal vasculature is the main hemodynamic...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/578974
更新日期:2014-01-01 00:00:00
abstract::Abnormal expression of neuroepithelial cell transforming gene 1 (NET1) has been authenticated in many human cancers, including lung cancer. We have previously reported that NET1 functioned as an oncogene and promoted human non-small-cell lung cancer (NSCLC) growth and migration. However, the correlation between NET1 a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1648419
更新日期:2020-01-11 00:00:00
abstract::Angiogenesis and lymphangiogenesis are important in the proliferation and survival of the malignant hematopoietic neoplasms, including non-Hodgkin's lymphomas (NHLs). Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) play an important role in the initiation of angiogenesis. Both VEGF ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/159813
更新日期:2013-01-01 00:00:00
abstract::The present study is designed to determine potential target genes involved in hepatocellular carcinoma (HCC) and provide possible underlying mechanisms of action. Several studies (GSE112790, GSE87630, and GSE56140) from the GEO database looking at molecular characteristics in HCC were screened and analyzed by GEO2R, w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7042124
更新日期:2020-10-05 00:00:00
abstract::The objective and quantitative analysis of longitudinal single photon emission computed tomography (SPECT) images are significant for the treatment monitoring of brain disorders. Therefore, a computer aided analysis (CAA) method is introduced to extract a change-rate map (CRM) as a parametric image for quantifying the...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1962181
更新日期:2017-01-01 00:00:00
abstract::Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and maternal milk reduce behavioral indicators of experimental anxiety in adult Wistar rats. Unknown, however, is whether the anxiolytic-like effects of fatty acids provide a natural mechanism against anxiety in young offspring. The present study assessed ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8798546
更新日期:2017-01-01 00:00:00
abstract::Cardiotonic drugs mainly include digitalis, catecholamines, phosphodiesterase inhibitors, and calcium sensitizers, which have been successively discovered and applied in clinical practice. However, there are only a few new drugs available in this field, and the selection is very limited. Digitalis, catecholamines, and...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/9731467
更新日期:2019-09-19 00:00:00
abstract::The aim of the present study was to evaluate the antitumor potential of iminoflavones in in vitro and in vivo anticancer models. Preliminary screening in various cancer cell lines revealed four potential iminoflavones out of which IMF-8 was taken based on its activity against colon cancer cells. This was further confi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/569130
更新日期:2014-01-01 00:00:00
abstract::For the induction of robust humoral and cellular immune responses, a strong rationale exists to use vaccine-adjuvant combinations possessing both immune modulatory and enhanced delivery capabilities. Herein, we evaluated the combination of 2 different adjuvants, a TLR9 agonist, composed of synthetic oligodeoxynucleoti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/636847
更新日期:2013-01-01 00:00:00
abstract::Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/905215
更新日期:2015-01-01 00:00:00
abstract::Family planning coverage has improved in Ethiopia in the last decade, though fertility is still about 5.8 in the rural setup. In this paper, the major structural determinants of family planning service were analyzed using a multilevel model from 8906 individual women observation in the 2011 EDHS data. The results show...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/495745
更新日期:2015-01-01 00:00:00
abstract:Background:Fibroid is the most common benign tumor of the uterus and if associated with pregnancy may adversely affect the outcome of pregnancy. Objective of the present study was to assess the obstetric outcome (maternal and fetal) in pregnancy with fibroid. Methods:A prospective observational study was performed ove...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8367068
更新日期:2018-03-26 00:00:00
abstract::This study evaluated the potential relationship between exosomal miRNAs and clinical symptoms in patients with multiple myeloma (MM). Forty-eight newly diagnosed myeloma patients and sixteen normal donors were enrolled in the study. The results showed that the relative expression levels of let-7c-5p, let-7d-5p, miR-14...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1575468
更新日期:2019-12-14 00:00:00
abstract::Cancer cells acquire unique secretome compositions that contribute to tumor development and metastasis. The aim of our study was to elucidate the biological processes involved in cervical cancer, by performing a proteomic analysis of the secretome from the following informative cervical cell lines: SiHa (HPV16+), HeLa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4180703
更新日期:2017-01-01 00:00:00
abstract::Adipose-derived stem cells (ADSCs) are an abundant cell source and provide an easy way to harvest mesenchymal stem cells, which are the focus of considerable attention in regenerative medicine. Electric fields (EF) play roles in many biological events and have been reported to promote cell proliferation, migration, an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7134719
更新日期:2020-11-06 00:00:00
abstract::Triple-negative breast cancer (TNBC) is a very aggressive malignant type of tumor that currently lacks effective targeted therapies. In hematological malignancies, chimeric antigen receptor T (CAR-T) cells have shown very significant antitumor ability; however, in solid tumors, the efficacy is poor. In order to apply ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4795171
更新日期:2020-01-02 00:00:00
abstract::Advancement in the gene delivery system have resulted in clinical successes in gene therapy for patients with several genetic diseases, such as immunodeficiency diseases, X-linked adrenoleukodystrophy (X-ALD) blindness, thalassemia, and many more. Among various delivery systems, liposomal mediated gene delivery route ...
journal_title:BioMed research international
pub_type: 杂志文章,收录出版,评审
doi:10.1155/2014/934605
更新日期:2014-01-01 00:00:00
abstract:Purpose:Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9765162
更新日期:2020-02-22 00:00:00
abstract::The purpose of this study was to investigate the impact of polishing methods on the bonding effectiveness and durability of different resin cements to dentin. The dentin surfaces were either treated with a fine-grit diamond bur (polishing A) or further polished by polishing disks (polishing B), and then they were bond...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9189354
更新日期:2018-02-28 00:00:00
abstract::Catalases are widely used in many scientific areas. A catalase gene (Kat) from Geobacillus sp. CHB1 encoding a monofunctional catalase was cloned and recombinant expressed in Escherichia coli (E. coli), which was the first time to clone and express this type of catalase of genus Geobacillus strains as far as we know. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7535604
更新日期:2016-01-01 00:00:00
abstract::Cabbages (Brassica oleracea L.) are an important vegetable crop around world, and cold temperature is among the most significant abiotic stresses causing agricultural losses, especially in cabbage crops. Plant bZIP transcription factors play diverse roles in biotic/abiotic stress responses. In this study, 119 putative...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4376598
更新日期:2016-01-01 00:00:00
abstract::Vocal tract morphology is an important factor in voice production. Its analysis has potential implications for educational matters as well as medical issues like voice therapy. The knowledge of the complex adjustments in the spatial geometry of the vocal tract during phonation is still limited. For a major part, this ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/906356
更新日期:2015-01-01 00:00:00
abstract::Hemoglobin, which widely exists in all vertebrates and in some invertebrates, is possibly a precursor of antimicrobial peptides (AMPs). However, AMPs in the hemoglobin of invertebrates have been rarely investigated. This study is the first to report the full-length cDNA, prokaryotic expression, and antimicrobial activ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5683026
更新日期:2016-01-01 00:00:00
abstract::Two field isolates of Rhizoctonia solani were isolated from infected paddy plants in Malaysia. These isolates were verified via ITS-rDNA analysis that yielded ~720 bp products of the ITS1-5.8S-ITS4 region, respectively. The sequenced products showed insertion and substitution incidences which may result in strain dive...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/434257
更新日期:2014-01-01 00:00:00
abstract::The current developments of the new biological drugs targeting interleukin 5 (IL-5) and IL-5 receptor allowed to expand the treatment options for severe hypereosinophilic asthma. Clinicians will then be able to choose between antibodies targeting either circulating IL-5 or its receptor expressed on eosinophils and bas...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/5698212
更新日期:2018-11-05 00:00:00
abstract:AIM:Gastrointestinal mucositis is a frequent complication of antineoplastic chemotherapy, but the effects of chemotherapy on mucosal defense mechanisms remain poorly understood. We studied the effects of cisplatin on mucin, one of the principal defense factors of the gastrointestinal mucosa, and evaluated the efficacy ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/276186
更新日期:2013-01-01 00:00:00
abstract::Previous studies indicated that intracerebroventricular administration of nerve growth factor (NGF) leads to massive Schwann cell hyperplasia surrounding the medulla oblongata and spinal cord. This study was designed to characterize the proliferation of peripheral glial cells, that is, Schwann and satellite cells, in ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/704259
更新日期:2014-01-01 00:00:00
abstract::The epilepsies are a heterogeneous group of neurological disorders and syndromes characterised by recurrent, involuntary, paroxysmal seizure activity, which is often associated with a clinicoelectrical correlate on the electroencephalogram. The diagnosis of epilepsy is usually made by a neurologist but can be difficul...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/986736
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alzheimer's disease (ADAD) participating in the Dominantly Inherited Alzheimer Network (DIAN). METHODS:The baseline sample of 18...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2015/828120
更新日期:2015-01-01 00:00:00