Abstract:
:Angiogenesis and lymphangiogenesis are important in the proliferation and survival of the malignant hematopoietic neoplasms, including non-Hodgkin's lymphomas (NHLs). Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) play an important role in the initiation of angiogenesis. Both VEGF and bFGF have been reported to have prognostic significance in NHL. The present study aimed to determine an association between the VEGF and bFGF gene polymorphisms and disease susceptibility and progression. VEGF (rs3025039; 936 C>T) and bFGF (rs308395, -921 G>C) variants were determined in 78 NHL patients and 122 healthy individuals by PCR-RFLP technique. The presence of the VEGF 936T allele was found to significantly associate with worse prognosis of the disease (expressed by the highest International Prognostic Index (IPI)) (0.41 versus 0.20, P = 0.044 for IPI 4 among patients having and lacking the T allele). The VEGF 936T variant was also more frequent among patients with IPI 4 than in controls (OR = 3.37, P = 0.029). The bFGF -921G variant was more frequently detected among patients with aggressive as compared to those with indolent histological subtype (0.37 versus 0.18, P = 0.095) and healthy individuals (0.37 versus 0.19, OR = 2.51, P = 0.038). These results imply that VEGF and bFGF gene polymorphisms have prognostic significance in patients with NHL.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Wróbel T,Mazur G,Dzietczenia J,Gębura K,Kuliczkowski K,Bogunia-Kubik Kdoi
10.1155/2013/159813subject
Has Abstractpub_date
2013-01-01 00:00:00pages
159813eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract::Background. Acute graft-versus-host disease (aGVHD) involving skin is one of the most frequent complications of allogeneic hematopoietic stem cell transplantation (alloHSCT), usually diagnosed based on clinical manifestations. So far, skin biopsy with histopathological evaluation is the only method to confirm the diag...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4535717
更新日期:2016-01-01 00:00:00
abstract::Polyketide belongs to a family of abundant natural products typically produced by the filamentous soil bacteria Streptomyces. Similar to the biosynthesis of most secondary metabolites produced in the Streptomyces species, polyketide compounds are synthesized through tight regulatory networks in the cell, and thus extr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/549737
更新日期:2013-01-01 00:00:00
abstract::Although extensive studies have identified large number of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in ischemic stroke, the RNA regulation network response to focal ischemia remains poorly understood. In this study, we simultaneously interrogate the expression profiles of lncRNAs, miRNAs, and mRNAs changes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8354350
更新日期:2018-01-08 00:00:00
abstract:Aim:The aim of this study is to detect the prevalence of substance use among tenth-grade students; their thoughts, attitudes, behaviors, and tendencies towards substance use; and risk factors of substance use in tenth-grade students in general. Methods:This study is descriptive and cross-sectional conducted between Ap...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1407649
更新日期:2018-03-15 00:00:00
abstract::[This retracts the article DOI: 10.1155/2019/5879089.]. ...
journal_title:BioMed research international
pub_type: 撤回出版物
doi:10.1155/2020/5014928
更新日期:2020-08-26 00:00:00
abstract::As the heart transitions from one exercise intensity to another, changes in cardiac output occur, which are modulated by alterations in force development and calcium handling. Although the steady-state force-calcium relationship at various heart rates is well investigated, regulation of these processes during transiti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/468548
更新日期:2015-01-01 00:00:00
abstract::The etiology of nephrotic syndrome is complex and ranges from primary glomerulonephritis to secondary forms. Patients with nephrotic syndrome often need immunosuppressive treatment with its side effects and may progress to end stage renal disease. This review focuses on recent advances in the treatment of primary caus...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/7689254
更新日期:2017-01-01 00:00:00
abstract:Background:The use of modern family planning methods among women of reproductive age (15-49 years) is of public health importance in Ethiopia. Nationally, modern family planning method use remains as low as 35%. Understanding factors associated with the use of modern family planning methods may help to improve maternal...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6096280
更新日期:2020-12-29 00:00:00
abstract::Microgravity influences cell differentiation by modifying the morphogenetic field in which stem cells are embedded. Preliminary data showed indeed that stem cells are committed to selective differentiation when exposed to real or simulated microgravity. Our study provides evidence that a similar event occurs when canc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/470253
更新日期:2014-01-01 00:00:00
abstract::Toonaciliatin K is a natural limonoid purified from the Toona ciliata Roem. var. ciliata (Meliaceae). This study is to reveal the inflammatory suppression effect of toonaciliatin K and further the intrinsic mechanism. Firstly, anti-inflammatory effect of toonaciliatin K was evaluated in lipopolysaccharide- (LPS-) indu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9436280
更新日期:2017-01-01 00:00:00
abstract::A novel approach for selecting a rectangular template around periocular region optimally potential for human recognition is proposed. A comparatively larger template of periocular image than the optimal one can be slightly more potent for recognition, but the larger template heavily slows down the biometric system by ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/481431
更新日期:2013-01-01 00:00:00
abstract::Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling pathways. In vitro...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/202905
更新日期:2013-01-01 00:00:00
abstract::Pinelliae Rhizoma Praeparatum Cum Alumine (PRPCA) is useful for eliminating dampness and phlegm in clinical settings, targeting the main mechanisms of insomnia as defined in traditional Chinese medicine. However, little is known regarding the sedative and hypnotic effects of PRPCA. In the present study, we examined th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6198067
更新日期:2019-04-28 00:00:00
abstract::Besides the pinpointing of individual disease-related genes, associating protein complexes to human inherited diseases is also of great importance, because a biological function usually arises from the cooperative behaviour of multiple proteins in a protein complex. Moreover, knowledge about disease-related protein co...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/732650
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to determine the capacity of biofilm formation of atypical enteropathogenic Escherichia coli (aEPEC) strains on abiotic and biotic surfaces. Ninety-one aEPEC strains, isolated from feces of children with diarrhea, were analyzed by the crystal violet (CV) assay on an abiotic surface after 24 h...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/845147
更新日期:2014-01-01 00:00:00
abstract::Detecting breast cancer at early stages can be challenging. Traditional mammography and tissue microarray that have been studied for early breast cancer detection and prediction have many drawbacks. Therefore, there is a need for more reliable diagnostic tools for early detection of breast cancer due to a number of fa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/781618
更新日期:2013-01-01 00:00:00
abstract:Background:In peritoneal dialysis (PD) patients, whether angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) could protect residual renal function is still controversial. To assess the effects of ACEIs and ARBs on the residual renal function and cardiovascular (CV) events in perito...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6762029
更新日期:2020-09-23 00:00:00
abstract::The pathogenesis of intractable epilepsy is not fully clear. In recent years, both animal and clinical trials have shown that the expression of ATP-binding cassette (ABC) transporters is increased in patients with intractable epilepsy; additionally, epileptic seizures can lead to an increase in the number of sites tha...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/194541
更新日期:2015-01-01 00:00:00
abstract::Numerous studies have reported that mesenchymal stem cells (MSCs) can ameliorate neurological deficits in ischemic stroke models. Among the various hypotheses that have been suggested to explain the therapeutic mechanism underlying these observations, neurogenesis is thought to be critical. To enhance the therapeutic ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/129145
更新日期:2014-01-01 00:00:00
abstract::Experimental animal models improve our understanding of technical problems in peritoneal dialysis PD, and such studies contribute to solving crucial clinical problems. We established an acute and chronic PD model in nonuremic and uremic rats. We observed that kinetics of PD in rats change as the animals are aging, and...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/261813
更新日期:2015-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the first most common neurodegenerative disease. Despite a large amount of research, the pathogenetic mechanism of AD has not yet been clarified. The two hallmarks of the pathology of AD are the extracellular senile plaques (SPs) of aggregated amyloid-beta (Aβ) peptide and the accumulation ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/796869
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:In the process of care for disorders of sex development (DSD), clinical decisions should focus on the long-term quality of life (QOL). We sought to investigate the QOL of patients with DSD in China. DESIGN:Case-control study was carried out. PATIENTS:90 patients of DSD participated in the study. Finally, 87...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/342420
更新日期:2015-01-01 00:00:00
abstract::To evaluate the role of Cystatin C (Cys-C) in tumorigenesis and progression of prostate cancer (PCa), we retrospectively collected the clinical information from the records of 492 benign prostatic hyperplasia (BPH), 48 prostatic intraepithelial neoplasia (PIN), and 173 PCa patients, whose disease was newly diagnosed a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7450459
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To estimate localization and the period up to the appearance of small hyperreflective round-shaped droplets using spectral-domain optical coherence tomography (SD-OCT) after pars plana vitrectomy with silicone oil tamponade. METHODS:A retrospective observational study included 24 patients who had undergone par...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/372045
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To determine interfractional changes of lung tumor centroid position and tumor regression during stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS:34 patients were treated by SBRT in 4-5 fractions to a median dose of 50 Gy. The CT scans acquired for verification were registered with simulation ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/372738
更新日期:2014-01-01 00:00:00
abstract::We evaluated the effects of mechanical stimulation on the osteogenic differentiation of human intraoral mesenchymal stem and progenitor cells (MSPCs) using the Flexcell FX5K Tension System that mediated cyclic tensile stretch on the cells. MSPCs were isolated from human mandibular retromolar bones and characterized us...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/189516
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The presence of common risk factors suggests that there is a relationship between osteoporosis and cardiovascular disease, possibly via dyslipidemia and inflammation. We investigated the relationships among the lipid profile, the inflammation marker high-sensitivity C-reactive protein (hsCRP), bone turnover ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/398397
更新日期:2014-01-01 00:00:00
abstract:Background:This study is aimed at identifying unknown clinically relevant genes involved in colorectal cancer using bioinformatics analysis. Methods:Original microarray datasets GSE107499 (ulcerative colitis), GSE8671 (colorectal adenoma), and GSE32323 (colorectal cancer) were downloaded from the Gene Expression Omnib...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1204605
更新日期:2020-05-23 00:00:00
abstract:Background:Ischemic heart disease (IHD) is the major cause of death in patients with cardiovascular disease. Cardiac remodeling is a common pathological change following myocardial infarction (MI), and cardiomyocyte apoptosis plays a key role in this change. Transcription factor recombination signal-binding protein-J (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5207031
更新日期:2018-07-03 00:00:00
abstract:Introduction:To investigate the clinical results of arthroscopic management for the unstable inferior leaf of the lateral meniscus anterior horn and associated cysts through an inframeniscal portal. Methods:From March 2005 to October 2014, 64 patients with an unstable inferior leaf of the lateral meniscus anterior hor...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9264907
更新日期:2017-01-01 00:00:00