Abstract:
:Cardiotonic drugs mainly include digitalis, catecholamines, phosphodiesterase inhibitors, and calcium sensitizers, which have been successively discovered and applied in clinical practice. However, there are only a few new drugs available in this field, and the selection is very limited. Digitalis, catecholamines, and phosphodiesterase inhibitors increase myocardial contractility by increasing intracellular concentrations of cyclic adenosine monophosphate (cAMP) and Ca2+, and this increase in intracellular calcium ion concentration enhances myocardial oxygen consumption and causes arrhythmia. For these reasons, the research focus on positive inotropic agents has shifted from calcium mobilization to calcium sensitization. Intracellular calcium sensitizers are more effective and safer drugs because they do not increase the intracellular concentration of calcium ions. However, only three calcium sensitizers have been fully developed and used in the past three decades. One of these drugs, levosimendan, has multiple molecular targets and exerts its pharmacological effects by not only increasing myocardial contractility, but also enhancing respiratory muscle function and liver and kidney protection, and it is useful for patients with severe sepsis and septic shock. Recently, more than 60 randomized controlled clinical trials of levosimendan have been reported; however, these clinical trials have occasionally shown different findings. This article reviews the research progress of levosimendan in critical illnesses in recent years.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Pan J,Yang YM,Zhu JY,Lu YQdoi
10.1155/2019/9731467subject
Has Abstractpub_date
2019-09-19 00:00:00pages
9731467eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章,评审abstract::Coronary heart disease (CHD) has become one of the leading causes of death and functional impairment in the world. Hyperglycemia is associated with an increased risk of cardiovascular disease. It was speculated that miRNAs in peripheral blood were a primary parameter in discriminating CHD. The biological characteristi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9192575
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journal_title:BioMed research international
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/480702
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2018-06-13 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/178906
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/196894
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8812157
更新日期:2020-11-05 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/305367
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/7298687
更新日期:2020-07-07 00:00:00
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pub_type: 杂志文章
doi:10.1155/2018/3870508
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doi:10.1155/2020/4671989
更新日期:2020-05-09 00:00:00
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pub_type: 临床试验,杂志文章
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doi:10.1155/2018/1070645
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/673682
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