Abstract:
:Schistosomiasis, caused by infection with Schistosoma species, remains an important parasitic zoonosis. Thioredoxin glutathione reductase of Schistosoma japonicum (SjTGR) plays an important role in the development of the parasite and for its survival. Here we present a recombinant plasmid DNA vaccine, pVAX1/SjTGR, to estimate its protection against S. japonicum in BALB/c mice. The DNA vaccine administrated by particle bombardment induced higher protection than by intramuscular injection. All animals vaccinated with pVAX1/SjTGR developed significant specific anti-SjTGR antibodies than control groups. Moreover, animals immunized by gene gun exhibited a splenocyte proliferative response, with an increase in IFN- γ and IL-4. The recombinant plasmid administrated by gene gun achieved a medium protective efficacy of 27.83-38.83% (P < 0.01) of worm reduction and 40.38-44.51% (P < 0.01) of liver egg count reduction. It suggests that different modes of administering a DNA vaccine can influence the protective efficacy induced by the vaccine. Interestingly, from the enzymatic activity results, we found that worms obtained from pVAX1/SjTGR-vaccinated animals expressed lower enzymatic activity than the control group and the antibodies weakened the enzymatic activity of SjTGR in vitro, too. It implies that the high-level antibodies may contribute to the protective effects.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Cao Y,Zhao B,Han Y,Zhang J,Li X,Qiu C,Wu X,Hong Y,Ai D,Lin J,Fu Zdoi
10.1155/2013/952416subject
Has Abstractpub_date
2013-01-01 00:00:00pages
952416eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
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journal_title:BioMed research international
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doi:10.1155/2018/6075705
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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doi:10.1155/2015/319589
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doi:10.1155/2020/3807234
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doi:10.1155/2018/9483928
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2013/121794
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pub_type: 杂志文章
doi:10.1155/2018/3059478
更新日期:2018-10-09 00:00:00
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pub_type: 杂志文章
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journal_title:BioMed research international
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4042509
更新日期:2017-01-01 00:00:00