Roles of pRB in the Regulation of Nucleosome and Chromatin Structures.

Abstract:

:Retinoblastoma protein (pRB) interacts with E2F and other protein factors to play a pivotal role in regulating the expression of target genes that induce cell cycle arrest, apoptosis, and differentiation. pRB controls the local promoter activity and has the ability to change the structure of nucleosomes and/or chromosomes via histone modification, epigenetic changes, chromatin remodeling, and chromosome organization. Functional inactivation of pRB perturbs these cellular events and causes dysregulated cell growth and chromosome instability, which are hallmarks of cancer cells. The role of pRB in regulation of nucleosome/chromatin structures has been shown to link to tumor suppression. This review focuses on the ability of pRB to control nucleosome/chromatin structures via physical interactions with histone modifiers and chromatin factors and describes cancer therapies based on targeting these protein factors.

journal_name

Biomed Res Int

authors

Uchida C

doi

10.1155/2016/5959721

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

5959721

eissn

2314-6133

issn

2314-6141

journal_volume

2016

pub_type

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