Abstract:
:Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become bioactive at human body, these polyphenols must undergo diverse intestinal transformations, due to the action of digestive enzymes, but also by the action of microbiota metabolism. After elimination of sugar tailoring (generating the corresponding aglycons) and diverse hydroxyl moieties, as well as further backbone reorganizations, the final absorbed compounds enter the portal vein circulation towards liver (where other enzymatic transformations take place) and from there to other organs, including behind the digestive tract or via blood towards urine excretion. During this transit along diverse tissues and organs, they are able to carry out strong antiviral, antibacterial, and antiparasitic activities. This paper revises and discusses these antimicrobial activities of dietary polyphenols and their relevance for human health, shedding light on the importance of polyphenols structure recognition by specific enzymes produced by intestinal microbial taxa.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Marín L,Miguélez EM,Villar CJ,Lombó Fdoi
10.1155/2015/905215subject
Has Abstractpub_date
2015-01-01 00:00:00pages
905215eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
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doi:10.1155/2014/405860
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pub_type: 临床试验,杂志文章,随机对照试验
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doi:10.1155/2018/8153241
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