Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release.

Abstract:

:Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

journal_name

Biomed Res Int

authors

Lu J,Li Y,Hu D,Chen X,Liu Y,Wang L,Zhao Y

doi

10.1155/2015/236745

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

236745

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章
  • Acinetobacter baumannii Infection in Transfusion Dependent Thalassemia Patients with Sepsis.

    abstract:PURPOSE:To identify the Acinetobacter baumannii infection among transfusion dependent thalassemia patients. METHODS:A quantitative approach was employed to assess Acinetobacter baumannii infection in transfusion dependent thalassemia patients. Samples were collected from 916 patients, which have shown bacterial growth...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2351037

    authors: Abdul Rasheed M,Alzahrani FM,Sattar Shaikh S

    更新日期:2017-01-01 00:00:00

  • The effect of created local hyperosmotic microenvironment in microcapsule for the growth and metabolism of osmotolerant yeast Candida krusei.

    abstract::Candida krusei is osmotolerant yeast used for the production of glycerol. Addition of osmolyte such as NaCl into culture medium can increase the production of glycerol from glucose, but osmolytes may burden the glycerol separation. A coencapsulation method was suggested to create local extracellular hyperosmotic stres...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/467263

    authors: Chen G,Yao S

    更新日期:2013-01-01 00:00:00

  • Influence of Induced Blood Pressure Variability on the Assessment of Cerebral Autoregulation in Patients after Cardiac Arrest.

    abstract:Objective:To determine if increasing variability of blood pressure influences determination of cerebral autoregulation. Methods:A prospective observational study was performed at the ICU of a university hospital in the Netherlands. 13 comatose patients after cardiac arrest underwent baseline and intervention (tilting ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8153241

    authors: van den Brule JMD,van Kaam CR,van der Hoeven JG,Claassen JAHR,Hoedemaekers CWE

    更新日期:2018-06-06 00:00:00

  • ADC Benchmark Range for Correct Diagnosis of Primary and Recurrent Middle Ear Cholesteatoma.

    abstract:Objectives:Magnetic resonance imaging (MRI) and in particular diffusion-weighted imaging (DWI) have been broadly proven to be the reference imaging method to discriminate between cholesteatoma and noncholesteatomatous middle ear lesions, especially when high tissue specificity is required. The aim of this study is to d...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7945482

    authors: Russo C,Elefante A,Di Lullo AM,Carotenuto B,D'Amico A,Cavaliere M,Iengo M,Brunetti A

    更新日期:2018-04-24 00:00:00

  • The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease. NAFLD encompasses a wide range of pathologies, from simple steatosis to steatosis with inflammation to fibrosis. The pathogenesis of NAFLD progression has not been completely elucidated, and different liver cells could be imp...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/768071

    authors: Almeda-Valdes P,Aguilar Olivos NE,Barranco-Fragoso B,Uribe M,Méndez-Sánchez N

    更新日期:2015-01-01 00:00:00

  • Quantitative Motion Analysis of Tai Chi Chuan: The Upper Extremity Movement.

    abstract::The quantitative and reproducible analysis of the standard body movement in Tai Chi Chuan (TCC) was performed in this study. We aimed to provide a reference of the upper extremities for standardizing TCC practice. Microsoft Kinect was used to record the motion during the practice of TCC. The preparation form and eight...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2538765

    authors: Ho TJ,Chou KT,Li CH,Kuo BC,Huang TC

    更新日期:2018-01-29 00:00:00

  • Resistance exercise with older fallers: its impact on intermuscular adipose tissue.

    abstract:OBJECTIVE:Greater skeletal muscle fat infiltration occurs with age and contributes to numerous negative health outcomes. The primary purpose was to determine whether intermuscular adipose tissue (IMAT) can be influenced by an exercise intervention and if a greater reduction in IMAT occurs with eccentric versus traditio...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/398960

    authors: Jacobs JL,Marcus RL,Morrell G,LaStayo P

    更新日期:2014-01-01 00:00:00

  • The Role of Biologically Active Ingredients from Natural Drug Treatments for Arrhythmias in Different Mechanisms.

    abstract::Arrhythmia is a disease that is caused by abnormal electrical activity in the heart rate or rhythm. It is the major cause of cardiovascular morbidity and mortality. Although several antiarrhythmic drugs have been used in clinic for decades, their application is often limited by their adverse effects. As a result, natu...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/4615727

    authors: Li J,Hu D,Song X,Han T,Gao Y,Xing Y

    更新日期:2017-01-01 00:00:00

  • A Retrospective Study on the Morphology of Posterior Malleolar Fractures Based on a CT Scan: Whether We Ignore the Importance of Fracture Height.

    abstract:Objective:The aim of this study was to investigate the respective correlation between the height (H) of a posterior malleolar fracture (PMF) and the involved area (S) of an articular surface and the presence of "die-punch." Methods:Patients with closed posterior malleolar fractures admitted to our hospital from Januar...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2903537

    authors: Wang Z,Yuan C,Zhu G,Geng X,Zhang C,Huang J,Ma X,Wang X

    更新日期:2020-07-29 00:00:00

  • Behavioral Medicine Methods in Treatment of Somatic Conditions.

    abstract:Background:The aim of this article is to present a short review of noninvasive, nonpharmacological treatment methods used in somatic illnesses that fall under the umbrella of approach called behavioral medicine. Methods:The narrative review method was applied in the study. Science paper databases, including PubMed, ha...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/5076516

    authors: Białkowska J,Juranek J,Wojtkiewicz J

    更新日期:2020-11-03 00:00:00

  • Transforaminal Percutaneous Endoscopic Lumbar Decompression by Using Rigid Bendable Burr for Lumbar Lateral Recess Stenosis: Technique and Clinical Outcome.

    abstract:Background:Open laminectomy has been regarded as the standard surgical procedure for lumbar lateral recess stenosis during the last decades. Although percutaneous endoscopic lumbar decompression has led to successful results comparable with open decompression, its application in LSS with is still challenging and techni...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2601232

    authors: Tang S,Jin S,Liao X,Huang K,Luo J,Zhu T

    更新日期:2018-11-26 00:00:00

  • Chromatographic fingerprint analysis and effects of the medicinal plant species Mitracarpus frigidus on adult Schistosoma mansoni worms.

    abstract::The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile. For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different conce...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/941318

    authors: Fabri RL,Aragão DM,Florêncio JR,Pinto Nde C,Mattos AC,Coelho PM,Castañon MC,Vasconcelos EG,Pinto Pde F,Scio E

    更新日期:2014-01-01 00:00:00

  • Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China.

    abstract::Human papillomavirus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinomas (OPSCC). Our study investigates the prevalence, prognostic, and clinicopathologic features of HPV-related oropharyngeal cancer in Northeast China and elucidates the involvement of p16 in the tumorigenesis and progressio...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9594568

    authors: Meng HX,Miao SS,Chen K,Li HN,Yao G,Geng J,Wang H,Shi QT,He J,Mao X,Tong FJ,Wei LL,Sun J,Tan D,You Q,Li X,Geng JS

    更新日期:2018-09-17 00:00:00

  • Associations between Physical Fitness, Bone Mass, and Structure in Older People.

    abstract::The main aim was to analyse the associations between several physical fitness variables and bone parameters in a sample of elderly people. 129 participants (94 females and 35 males, 76.2 ± 5.4 y) from the EXERNET cohort of Zaragoza (Spain) were included in the study. Physical fitness was assessed using the Senior Fitn...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6930682

    authors: Moradell A,Gómez-Cabello A,Gómez-Bruton A,Muniz-Pardos B,Puyalto JM,Matute-Llorente A,Gónzalez-Agüero A,Ara I,Casajús JA,Vicente-Rodríguez G

    更新日期:2020-07-15 00:00:00

  • EMRlog method for computer security for electronic medical records with logic and data mining.

    abstract::The proper functioning of a hospital computer system is an arduous work for managers and staff. However, inconsistent policies are frequent and can produce enormous problems, such as stolen information, frequent failures, and loss of the entire or part of the hospital data. This paper presents a new method named EMRlo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/542016

    authors: Martínez Monterrubio SM,Frausto Solis J,Monroy Borja R

    更新日期:2015-01-01 00:00:00

  • Tanshinone IIA Attenuates Renal Fibrosis after Acute Kidney Injury in a Mouse Model through Inhibition of Fibrocytes Recruitment.

    abstract::Acute kidney injury (AKI) is associated with an increased risk of developing advanced chronic kidney disease (CKD). Yet, effective interventions to prevent this conversion are unavailable for clinical practice. In this study, we examined the beneficial effects of Tanshinone IIA on renal fibrosis in a mouse model of fo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/867140

    authors: Jiang C,Shao Q,Jin B,Gong R,Zhang M,Xu B

    更新日期:2015-01-01 00:00:00

  • Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications.

    abstract::Electrospun scaffolds provide a dense framework of nanofibers with pore sizes and fiber diameters that closely resemble the architecture of native extracellular matrix. However, it generates limited three-dimensional structures of relevant physiological thicknesses. 3D printing allows digitally controlled fabrication ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/6956794

    authors: Mellor LF,Huebner P,Cai S,Mohiti-Asli M,Taylor MA,Spang J,Shirwaiker RA,Loboa EG

    更新日期:2017-01-01 00:00:00

  • Pathologic Assessment of Rectal Carcinoma after Neoadjuvant Radio(chemo)therapy: Prognostic Implications.

    abstract::Neoadjuvant radio(chemo)therapy is increasingly used in rectal cancer and induces a number of morphologic changes that affect prognostication after curative surgery, thereby creating new challenges for surgical pathologists, particularly in evaluating morphologic changes and tumour response to preoperative treatment. ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/574540

    authors: Hav M,Libbrecht L,Ferdinande L,Geboes K,Pattyn P,Cuvelier CA

    更新日期:2015-01-01 00:00:00

  • Polymorphisms in the Osteopontin Are Associated with Susceptibility to Ankylosing Spondylitis in a Han Chinese Population.

    abstract::The aim of this study was to investigate whether osteopontin (OPN) variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population. Polymorphisms at the 9175th position in exon 7 of OPN and rs17524488 were genotyped using direct sequencing in 186 unrelated AS patients and 188 ethnica...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3458439

    authors: Li J,Cai Y,Wang Z,Deng A,Yang G

    更新日期:2018-01-18 00:00:00

  • Antipsychotic Drugs Inhibit Platelet Aggregation via P2Y 1 and P2Y 12 Receptors.

    abstract::Antipsychotic drugs (APDs) used to treat clinical psychotic syndromes cause a variety of blood dyscrasias. APDs suppress the aggregation of platelets; however, the underlying mechanism remains unknown. We first analyzed platelet aggregation and clot formation in platelets treated with APDs, risperidone, clozapine, or ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2532371

    authors: Wu CC,Tsai FM,Chen ML,Wu S,Lee MC,Tsai TC,Wang LK,Wang CH

    更新日期:2016-01-01 00:00:00

  • Accuracy on Scanned Images of Full Arch Models with Orthodontic Brackets by Various Intraoral Scanners in the Presence of Artificial Saliva.

    abstract:Aim:This study aims to evaluate the accuracy of scanned images of 4 clinically used intraoral scanners (CS3600, i500, Trios3, Omnicam) when scanning the surface of full arch models with various kinds of orthodontic brackets in the presence of artificial saliva. Materials and Methods. Four study models were prepared; bo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2920804

    authors: Song J,Kim M

    更新日期:2020-02-27 00:00:00

  • Functional Activation-Informed Structural Changes during Stroke Recovery: A Longitudinal MRI Study.

    abstract:Objective:Neuroimaging studies revealed the functional reorganization or the structural changes during stroke recovery. However, previous studies did not combine the functional and structural information and the results might be affected by heterogeneous lesion. This study aimed to investigate functional activation-inf...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/4345205

    authors: Wu Z,Cheng L,Yang GY,Tong S,Sun J,Miao F

    更新日期:2017-01-01 00:00:00

  • Correlations of Expression Levels of a Panel of Genes (IRF5, STAT4, TNFSF4, MECP2, and TLR7) and Cytokine Levels (IL-2, IL-6, IL-10, IL-12, IFN-γ, and TNF-α) with Systemic Lupus Erythematosus Outcomes in Jordanian Patients.

    abstract::Systemic lupus erythematosus (SLE) is characterized by systemic end-organ damage. We investigated the involvement of IRF5, TLR-7, MECP2, STAT4, and TNFSF4 genes and TNF-α, IFN-γ, IL-2, IL-12, IL-6, and IL-10 cytokines in SLE pathogenesis and in organ damage in Jordanian patients. Blood was collected from 51 patients a...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1703842

    authors: Uzrail AH,Assaf AM,Abdalla SS

    更新日期:2019-11-29 00:00:00

  • Construction of Protein-related Risk Score Model in Bladder Urothelial Carcinoma.

    abstract:Background:Though there are several prognostic models, there is no protein-related prognostic model. The aim of this study is to identify possible prognostic-related proteins in bladder urothelial carcinoma and to try to predict the prognosis of bladder urothelial carcinoma based on these proteins. Methods:Profile dat...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7147824

    authors: Luo Q,Zhang X

    更新日期:2020-07-31 00:00:00

  • The Effect of Omega-3 Docosahexaenoic Acid Supplementation on Gestational Length: Randomized Trial of Supplementation Compared to Nutrition Education for Increasing n-3 Intake from Foods.

    abstract:OBJECTIVE:DHA supplementation was compared to nutrition education to increase DHA consumption from fish and DHA fortified foods. DESIGN:This two-part intervention included a randomized double-blind placebo controlled DHA supplementation arm and a nutrition education arm designed to increase intake of DHA from dietary ...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2015/123078

    authors: Harris MA,Reece MS,McGregor JA,Wilson JW,Burke SM,Wheeler M,Anderson JE,Auld GW,French JI,Allen KG

    更新日期:2015-01-01 00:00:00

  • Retracted: Leaf Rolling and Stem Fasciation in Grass Pea (Lathyrus sativus L.) Mutant Are Mediated through Glutathione-Dependent Cellular and Metabolic Changes and Associated with a Metabolic Diversion through Cysteine during Phenotypic Reversal.

    abstract::[This retracts the article DOI: 10.1155/2014/479180.]. ...

    journal_title:BioMed research international

    pub_type: 撤回出版物

    doi:10.1155/2016/4938464

    authors: BioMed Research International

    更新日期:2016-01-01 00:00:00

  • Secondary bacterial infections in patients with seasonal influenza A and pandemic H1N1.

    abstract::The aim of the present study is to analyse the secondary bacterial infections in a large group of patients with seasonal influenza A and influenza A(H1N1) pdm09. Patients diagnosed with seasonal influenza A and influenza A(H1N1) pdm09 between 2005 and 2009 were enrolled in the study. Data was retrieved from medical re...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/376219

    authors: Liderot K,Ahl M,Ozenci V

    更新日期:2013-01-01 00:00:00

  • How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective.

    abstract::The use of in vitro metabolism data to predict human clearance has become more significant in the current prediction of large scale drug clearance for all the drugs. The relevant information (in vitro metabolism data and in vivo human clearance values) of thirty-five drugs that satisfied the entry criteria of probe dr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/857327

    authors: Wang L,Chiang C,Liang H,Wu H,Feng W,Quinney SK,Li J,Li L

    更新日期:2015-01-01 00:00:00

  • Fracture Strength and Stress Distribution in Premolars Restored with Cast Post-and-Cores or Glass-Fiber Posts Considering the Influence of Ferule.

    abstract:Objectives:The aim of this study was to evaluate the influence of ferule and the post type on the fracture strength and stress distribution in premolars. Materials and Methods:Forty human mandibular premolars were decoronated, allocated in four groups, and restored as follows: CPC-NF: cast post-and-core and absence of...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2196519

    authors: Bacchi A,Caldas RA,Schmidt D,Detoni M,Matheus Albino Souza,Cecchin D,Farina AP

    更新日期:2019-01-03 00:00:00

  • Pandemic Avian Influenza and Intra/Interhaemagglutinin Subtype Electrostatic Variation among Viruses Isolated from Avian, Mammalian, and Human Hosts.

    abstract::Host jump can result in deadly pandemic events when avian influenza A viruses broaden their host specificity and become able to infect mammals, including humans. Haemagglutinin-the major capsid protein in influenza A viruses-is subjected to high rate mutations, of which several occur at its "head": the receptor-bindin...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3870508

    authors: Righetto I,Filippini F

    更新日期:2018-05-17 00:00:00