Abstract:
Objective:Neuroimaging studies revealed the functional reorganization or the structural changes during stroke recovery. However, previous studies did not combine the functional and structural information and the results might be affected by heterogeneous lesion. This study aimed to investigate functional activation-informed structural changes during stroke recovery. Methods:MRI data of twelve stroke patients were collected at four consecutive time points during the first 3 months after stroke onset. Functional activation during finger-tapping task was used to inform the analysis of structural changes of activated brain regions. Correlation between structural changes in motor-related activated brain regions and motor function recovery was estimated. Results:The averaged gray matter volume (aGMV) of contralesional activated brain regions and laterality index of gray matter volume (LIGMV) increased during stroke recovery, and LIGMV was positively correlated with Fugl-Meyer Index (FMI) at initial stage after stroke. The aGMV of bilateral activated brain regions was negatively correlated with FMI during the stroke recovery. Conclusion:This study demonstrated that combining the stroke-induced functional reorganization and structural change provided new insights into the underlying innate plasticity process during stroke recovery. Significance:This study proposed a new approach to integrate functional and structural information for investigating the innate plasticity after stroke.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Wu Z,Cheng L,Yang GY,Tong S,Sun J,Miao Fdoi
10.1155/2017/4345205subject
Has Abstractpub_date
2017-01-01 00:00:00pages
4345205eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract::A familiarity with the anatomy of some types of bone anomalies is necessary for clinicians involved in many medical areas. The aim of this paper is to review the newest literature concerning the morphology, embryology, clinical image, and therapeutic methods of the cervical ribs in the humans. The incidence of cervica...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/8034613
更新日期:2016-01-01 00:00:00
abstract::Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. AS patients also display a high prevalence of features clustered under the name of metabolic syndrome (MeS). Anti-TNF- α therapy was found to be effecti...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/860651
更新日期:2014-01-01 00:00:00
abstract::Initiation and maintenance of atrial fibrillation (AF) is often associated with pharmacologically or pathologically induced bradycardic states. Even drugs specifically developed in order to counteract cardiac arrhythmias often combine their action with bradycardia and, in turn, with development of AF, via still largel...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/496418
更新日期:2015-01-01 00:00:00
abstract:UNLABELLED:Ehlers-Danlos syndrome hypermobility type a. k. a. joint hypermobility syndrome (JHS/EDS-HT) is a hereditary musculoskeletal disorder associating generalized joint hypermobility with chronic pain. Anecdotal reports suggest a prominent role for kinesiophobia in disease manifestations, but no study has systema...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/580460
更新日期:2013-01-01 00:00:00
abstract::External focus of attention (EFA) and internal focus of attention (IFA) represent commonly used strategies to instruct subjects during exercise. Several studies showed EFA to be more effective than IFA to improve motor performance and learning. To date the role of these strategies on motor performance during finger mo...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/2946465
更新日期:2017-01-01 00:00:00
abstract::Growing evidence indicates that immune-related biomarkers play an important role in tumor processes. This study investigates immune-related gene expression and its prognostic value in lung squamous cell carcinoma (LUSC). A cohort of 493 samples of patients with LUSC was collected and analyzed from data generated by th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5024942
更新日期:2020-06-27 00:00:00
abstract::Because of their high incidence and mortality solid cancers are a major health problem worldwide. Although several new biomarkers and potential targets for therapy have been identified through biomolecular research in the last years, the effects on patients' outcome are still unsatisfactory. Increasing evidence indica...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/896432
更新日期:2015-01-01 00:00:00
abstract::Maintaining regular blood pressure control usually requires multidrug regimens rather than monotherapy. The objective of this study was to describe the effectiveness and safety of an angiotensin-converting enzyme inhibitor and a nondihydropyridine calcium channel blocker in a single-tablet combination in patients with...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2123601
更新日期:2020-09-05 00:00:00
abstract:Introduction:To investigate the clinical results of arthroscopic management for the unstable inferior leaf of the lateral meniscus anterior horn and associated cysts through an inframeniscal portal. Methods:From March 2005 to October 2014, 64 patients with an unstable inferior leaf of the lateral meniscus anterior hor...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9264907
更新日期:2017-01-01 00:00:00
abstract::Epigenetic changes have major role in the normal development and programming of gene expression. Aberrant methylation results in carcinogenesis. The primary objective of our study is to determine whether primary tumor tissue and cultured tumor cells in 2D and 3D tissue culture systems have the same methylation signatu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1407167
更新日期:2019-01-17 00:00:00
abstract::Hepatitis B virus- (HBV-) associated hepatocellular carcinoma (HCC) is the most common type of liver cancer. However, the underlying mechanism of HCC tumorigenesis is very complicated and HBV-encoded X protein (HBx) has been reported to play the most important role in this process. Activation of downstream signal path...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/827415
更新日期:2014-01-01 00:00:00
abstract::Objectives. To construct a frailty index from next-of-kin information of the last year of life of community-dwelling 50 years old or older adults and test its association with health services utilization. Methods. Cross-sectional analysis from next-of-kin data available from the last wave of the Mexican Health and Agi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6069374
更新日期:2017-01-01 00:00:00
abstract::In the present study, we explored SA's activity against DOX-induced cardiotoxicity and revealed its underlying mechanisms. Male Wistar rats (weight, 190-210g; n = 6) were randomly divided into four groups: group I, normal control; group II, DOX 15 mg/kg via intraperitoneal (ip) route; group III, administered DOX+SA 20...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3921796
更新日期:2020-03-10 00:00:00
abstract::The recombinant catalase-peroxidase HPI from E. coli was used as an alternative enzyme in polymerization reactions for the production of (-) epicatechin oligomers and their biological activity was characterized. The enzyme was prepared in two forms: a purified and an immobilized form. Both were tested for their activi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3828627
更新日期:2018-04-23 00:00:00
abstract:AIM:Gastrointestinal mucositis is a frequent complication of antineoplastic chemotherapy, but the effects of chemotherapy on mucosal defense mechanisms remain poorly understood. We studied the effects of cisplatin on mucin, one of the principal defense factors of the gastrointestinal mucosa, and evaluated the efficacy ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/276186
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Human mesenchymal stromal cells (hMSCs) exhibit the potential to accelerate bone healing by enhanced osteogenic differentiation. Interleukin-1β is highly expressed during fracture healing and has been demonstrated to exert a significant impact on the differentiation behaviour of hMSCs. Here, we investigate...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/714230
更新日期:2015-01-01 00:00:00
abstract:Objective:Comparison of outcomes between RIRS with vacuum-assisted ureteral access sheath (V-UAS) and MPCNL in the treatment of renal stone. Materials and Methods:28 patients with 2-4 cm renal stone were treated using RIRS with 14/16 F V-UAS. The outcomes were compared to those who underwent MPCNL with 16 F Amplatz sh...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8052013
更新日期:2020-05-14 00:00:00
abstract::Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/720514
更新日期:2013-01-01 00:00:00
abstract:Objective:To explore multiscale integrated analysis methods in identifying key regulators of esophageal cancer (ESCA). Methods:We downloaded the ESCA dataset from The Cancer Genome Atlas (TCGA) database, which contained RNA-seq data, miRNA-seq data, methylation data, and clinical phenotype information. Then, we combin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5603958
更新日期:2020-08-12 00:00:00
abstract:BACKGROUND:Aquaporin (AQP) 3 and AQP 5 are involved in tumorigenesis and tumor progression of several tumor types. AIM:To investigate expression patterns and clinical significance of AQP3 and AQP5 in hepatocellular carcinoma (HCC). METHODS:Immunohistochemistry was performed to detect the expression of AQP3 and AQP5 i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/206525
更新日期:2013-01-01 00:00:00
abstract::MicroRNAs (miRNAs) family, which is involved in cancer development, proliferation, apoptosis, and drug resistance, is a group of noncoding RNAs that modulate the expression of oncogenes and antioncogenes. Doxorubicin is an active cytotoxic agent for breast cancer treatment, but the acquisition of doxorubicin resistanc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/373574
更新日期:2015-01-01 00:00:00
abstract::The cyprinid genus Pteronotropis is endemic to southeastern Gulf of Mexico and Atlantic Ocean of North America. Never before has the genus been demonstrated to be monophyletic. We investigate both the phylogenetic relationships and the phylogeography of some species in the genus using mitochondrial ND2 sequences. In n...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/675260
更新日期:2015-01-01 00:00:00
abstract::In recent years, new prognostic indexes (PIs) for chronic lymphocytic leukemia (CLL), which include clinical, biological, and genetic variables, have been validated, highlighting the MD Anderson Cancer Center prognostic index (MDACC PI), the CLL-international prognostic index (CLL-IPI), and the Barcelona-Brno biomarke...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9506979
更新日期:2018-03-15 00:00:00
abstract::Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1) and 2 (IDH2) have been associated with good prognosis for patients with brain neoplasias and have been commonly found together with mutated TP53 gene. To determine the prevalence of IDH1, IDH2, and TP53 mutations and their impact on overall surviva...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/654727
更新日期:2014-01-01 00:00:00
abstract:Background:Doublecortin-like kinase 1 (DCLK1) has been universally identified as a cancer stem cell (CSC) marker and is found to be overexpressed in many types of cancers including breast cancer. However, there is little data regarding the functional role of DCLK1 in breast cancer metastasis. In the present study, we s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1061979
更新日期:2019-05-15 00:00:00
abstract::DNA-binding proteins often play important role in various processes within the cell. Over the last decade, a wide range of classification algorithms and feature extraction techniques have been used to solve this problem. In this paper, we propose a novel DNA-binding protein prediction method called HMMBinder. HMMBinde...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4590609
更新日期:2017-01-01 00:00:00
abstract::Renal dysfunction is one of the most common complications of liver cirrhosis and is associated with increased morbidity and mortality. However, no available technology can simultaneously support liver and renal function in these patients. The aim of this study was to evaluate the safety and efficacy of an artificial l...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7456898
更新日期:2018-05-24 00:00:00
abstract:Purpose:Fractures are common among all types of paediatric injuries, with differences in incidence over time. Here, we present the epidemiologic features of traumatic fractures in a population of youth ≤ 18 years of age who were admitted to our university-affiliated hospitals from 2002 to 2010. Methods:We retrospectiv...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/8019063
更新日期:2019-02-20 00:00:00
abstract::Here we wanted to investigate predictive value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in the diagnosis of brucellosis. Thirty-two brucellosis patients diagnosed with positive serum agglutination test and thirty-two randomized healthy subjects were enrolled in this study retrospectivel...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/210502
更新日期:2015-01-01 00:00:00
abstract::To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/782490
更新日期:2014-01-01 00:00:00