Abstract:
:Diabetes mellitus (DM) is one of the major metabolic disorders that is currently threatening the world. DM is seen associated with obesity and diabetic retinopathy (DR). In the present paper we tried to evaluate the relationship between the three aliments at the gene level and further performed the molecular docking to identify the common drug for all the three diseases. We have adopted several software programs such as Phenopedia, VennViewer, and CDOCKER to accomplish the objective. Our results revealed six genes that commonly associated and are involved in the signalling pathway. Furthermore, evaluation of common gene association from the selected set of genes projected the presence of SIRT1 in all the three aliments. Therefore, we targeted protein 4KXQ which was produced from the gene SIRT1 and challenged it with eight phytochemicals, adopting the CDOCKER. C1 compound has displayed highest -CDOCKER energy and -CDOCKER interaction energy of 43.6905 and 43.3953, respectively. Therefore, this compound is regarded as the most potential lead molecule.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Rampogu S,Rampogu Lemuel Mdoi
10.1155/2016/6068437subject
Has Abstractpub_date
2016-01-01 00:00:00pages
6068437eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
杂志文章abstract:INTRODUCTION:The aim of our work was to investigate the causal connection between M1 and M2 macrophage phenotypes occurrence and prostate cancer, their correlation with tumor extension (ECE), and biochemical recurrence (BR). PATIENT AND METHODS:Clinical and pathological data were prospectively gathered from 93 patient...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/486798
更新日期:2014-01-01 00:00:00
abstract::It has been reported that many modifications occur with the increase of oxidative stress during storage in erythrocytes. In order to delay these negative changes, we evaluated whether the addition of substances likely to protect antioxidant capacity in stored blood would be useful. Therefore, we investigated the effec...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3057384
更新日期:2016-01-01 00:00:00
abstract::Mental rotation task (MRT) incorporates elements of spatial abilities, important in many professions, with people of both genders involved. Importantly, these are the areas where spatial tasks might be performed for long time periods; thus adverse effects of mental fatigue are highly unwanted. Substantial variation of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/741758
更新日期:2014-01-01 00:00:00
abstract::Autoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life. These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiolog...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/367359
更新日期:2014-01-01 00:00:00
abstract::A reliable in vivo imaging method to localize transplanted cells and monitor their viability would enable a systematic investigation of cell therapy. Most stem cell transplantation studies have used immunohistological staining, which does not provide information about the migration of transplanted cells in vivo in the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/231805
更新日期:2015-01-01 00:00:00
abstract::Stem cells are biological cells that can self-renew and can differentiate into multiple cell lineages. Stem cell-based therapy is emerging as a promising alternative therapeutic option for various disorders. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are isolated from various tissues and can b...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/6104738
更新日期:2019-01-29 00:00:00
abstract::The objective of this study was to investigate the iontophoretic delivery of lidocaine hydrochloride through porcine skin and to compare the effects of modulated alternating and direct current iontophoresis. Continuous and modulated iontophoresis was applied for one hour and two hours (0-1 h and 4-5th h) using a 1% w/...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/537941
更新日期:2014-01-01 00:00:00
abstract:Background:To improve the efficacy of regenerative treatment for gingival recessions, the autologous platelet concentrates (APCs) combined with coronally advanced flap (CAF) have been investigated. However, few studies systematically assess the complementary effect of APCs in periodontal regeneration. The present study...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/2587245
更新日期:2019-07-25 00:00:00
abstract::Owing to its hydrophilicity, negative charge, small size, and labile degradation by endogenous nucleases, small interfering RNA (siRNA) delivery must be achieved by a carrier system. In this study, cationic copolymers composed of low-molecular-weight polyethylenimine and polythiophenes were synthesized and evaluated a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/406389
更新日期:2015-01-01 00:00:00
abstract:Background:Influenza virus mainly causes acute respiratory infections in humans. However, the diagnosis of influenza is not accurate based on clinical evidence, as the symptoms of flu are similar to other respiratory virus. The lateral-flow assay is a rapid method to detect influenza virus. But the effectiveness of the...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3969868
更新日期:2020-09-08 00:00:00
abstract::Hitherto, limited clinical impact has been achieved in the treatment of glioblastoma (GBMs). Although phytochemicals found in medicinal herbs can provide mankind with new therapeutic remedies, single agent intervention has failed to bring the expected outcome in clinical trials. Therefore, combinations of several agen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/260210
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/7268308.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/5151645
更新日期:2018-07-05 00:00:00
abstract::ELABELA (ELA) is considered to be implicated in the pathophysiology of preeclampsia (PE), since ELA-deficient mice exhibited PE-like symptoms and infusion of exogenous ELA normalized the gestational hypertension (GH) and proteinuria. However, no evidence show that circulating ELA is deficient in early placental develo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2051701
更新日期:2020-09-28 00:00:00
abstract:BACKGROUND:Physical activity is associated with reduced mortality and morbidity. Cardiac rehabilitation (CR) is an effective intervention for patients with cardiovascular disease (CVD). Unfortunately, women are less likely to engage in, or sustain, regular physical activity. Objectives were to (1) describe women's guid...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/121030
更新日期:2013-01-01 00:00:00
abstract::Lung cancer consists of two main subtypes: small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) that are classified according to their physiological phenotypes. In this study, we have developed a network-based approach to identify molecular biomarkers that can distinguish SCLC from NSCLC. By identifyin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/685303
更新日期:2015-01-01 00:00:00
abstract::Abnormal metabolism is another cancer hallmark. The two most characterized altered metabolic pathways are high rates of glycolysis and glutaminolysis, which are natural targets for cancer therapy. Currently, a number of newer compounds to block glycolysis and glutaminolysis are being developed; nevertheless, lonidamin...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/690492
更新日期:2015-01-01 00:00:00
abstract::A Mycobacterium bovis knockout in p27-p55 operon was tested as an antituberculosis experimental vaccine in animal models. The mutant MbΔp27-p55 was significantly more attenuated in nude mice than its parental strain but more virulent than BCG Pasteur. Challenge experiments in mice and guinea pigs using M. bovis or M. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/951978
更新日期:2014-01-01 00:00:00
abstract::This study aimed to analyse the diversity of the Campylobacter jejuni population in broilers and to evaluate the major source of contamination in poultry meat. Eight rearing cycles over one year provided samples from three different broiler farms processed at the same slaughterhouse. A total of 707 C. jejuni were isol...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/859845
更新日期:2015-01-01 00:00:00
abstract::We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/419805
更新日期:2014-01-01 00:00:00
abstract::Oil palm (Elaeis guineensis Jacq) is one of the major sources of edible oil. Reducing the effect of Ganoderma, main cause of basal stem rot (BSR) on oil palm, is the main propose of this study. Understanding the oil palm defense mechanism against Ganoderma infection through monitoring changes in the secondary metaboli...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1494157
更新日期:2018-03-12 00:00:00
abstract::Prostate cancer is a life-threatening and highly heterogeneous malignancy. In the past decade, circulating tumor cells (CTCs) have been suggested to play a critical role in the occurrence and progression of prostate cancer. In particular, as the "seed" of the cancer metastasis cascade, CTCs determine numerous biologic...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2021/6230826
更新日期:2021-01-08 00:00:00
abstract::Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the co...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1462802
更新日期:2018-09-12 00:00:00
abstract::Tissue regeneration has become a promising treatment for craniomaxillofacial bone defects such as alveolar clefts. This study sought to assess the efficacy of lateral ramus cortical plate with buccal fat pad derived mesenchymal stem cells (BFSCs) in treatment of human alveolar cleft defects. Ten patients with unilater...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6560234
更新日期:2017-01-01 00:00:00
abstract::Background. Findings on the association between posttransplant anemia (PTA) and mortality in posttransplant patients are scarce. This study explored whether PTA shortly after kidney transplantation (KT) predicts mortality at up to 10 years' follow-up, stratified for chronic kidney disease (CKD) stages. Methods. PTA wa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6987240
更新日期:2017-01-01 00:00:00
abstract::Significant positive effects, particularly on psychological state in patients who completed the follow-up pulmonary rehabilitation programs, are indicated by a large number of studies. Yet, a remarkable proportion of selected patients drop out from these programs. In this study, we investigated existing differences on...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/401326
更新日期:2014-01-01 00:00:00
abstract::Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potenti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6456031
更新日期:2016-01-01 00:00:00
abstract:Materials and Methods:Various aqueous extracts were prepared from this plant and preadministered per os to albino mice 3 h before APAP administration, once daily for one week. Animals from the normal group were given only distilled water while those from negative control received only APAP 250 mg/kg. After treatment, m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3807234
更新日期:2020-08-31 00:00:00
abstract::Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by an impairment of corneal sensory innervation, characterized by decreased or absent corneal sensitivity resulting in epithelial keratopathy, ulceration, and perforation. The aetiopathogenesis of corneal sensory innervation impairment in ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/805876
更新日期:2015-01-01 00:00:00
abstract::Electrospun scaffolds provide a dense framework of nanofibers with pore sizes and fiber diameters that closely resemble the architecture of native extracellular matrix. However, it generates limited three-dimensional structures of relevant physiological thicknesses. 3D printing allows digitally controlled fabrication ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6956794
更新日期:2017-01-01 00:00:00
abstract::The phytochemical substances, coumarin derivatives, have demonstrated antiresorptive bone effects by suppressing osteoclast differentiation in vitro and in vivo. Recently, we have identified 5'-hydroxy auraptene (5'-HA), a coumarin derivative isolated from Lotus lalambensis Schweinf, as a novel stimulator for osteobla...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9395146
更新日期:2019-12-28 00:00:00