The Coumarin Derivative 5'-Hydroxy Auraptene Suppresses Osteoclast Differentiation via Inhibiting MAPK and c-Fos/NFATc1 Pathways.

abstract：OBJECTIVE:To determine the histopathological differences after varicocele repair in testicular tissue in males with nonobstructive azoospermia. METHODS:Between 2009 and 2014, 45 men with complete azoospermia and palpable varicocele, presenting with primary infertility of at least 1 year, undergoing varicocele repair a...

journal_title：BioMed research international

authors： Ustuner M,Yilmaz H,Yavuz U,Ciftci S,Saribacak A,Aynur BS,Yasar H,Culha MM

更新日期：2015-01-01 00:00:00

abstract：:Background. Increased metal ion levels following total hip arthroplasty (THA) with metal-on-metal bearings are a highly debated topic. Local soft tissue reactions with chronic pain and systemic side effects such as neuropathy are described. The aim of the current study was to determine the serum metal ion concentratio...

journal_title：BioMed research international

authors： Maurer-Ertl W,Pranckh-Matzke D,Friesenbichler J,Bratschitsch G,Holzer LA,Maier M,Leithner A

更新日期：2017-01-01 00:00:00

abstract：:Polyetheretherketone (PEEK), which has biomechanical performance similar to that of human cancellous bone, is used widely as a spinal implant material. However, its bioinertness and hydrophobic surface properties result in poor osseointegration. This study applies a novel modification method, arc ion plating (AIP), th...

journal_title：BioMed research international

authors： Tsou HK,Chi MH,Hung YW,Chung CJ,He JL

更新日期：2015-01-01 00:00:00

abstract：:The endoscopic and histopathological findings detected in Sparus aurata experimentally infected with third-stage Anisakis larvae without intermediate host are evaluated and discussed. In six fish, live nematode larvae were introduced by gastroscopy into the stomach. The first observation by endoscope, 15 days after ch...

journal_title：BioMed research international

authors： Marino F,Lanteri G,Passantino A,De Stefano C,Costa A,Gaglio G,Macrì F

更新日期：2013-01-01 00:00:00

abstract：:Small intestinal bacterial overgrowth (SIBO) is associated with chronic gastrointestinal diseases and structural/functional abnormalities of the gastrointestinal tract. SIBO's association with clinical characteristics is unclear. This study investigates the association between clinical factors and SIBO according to la...

journal_title：BioMed research international

authors： Newberry C,Tierney A,Pickett-Blakely O

更新日期：2016-01-01 00:00:00

abstract：:In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Se...

journal_title：BioMed research international

authors： Wattanathorn J,Prabsattroo T,Somsapt P,Sritragool O,Thukham-Mee W,Muchimapura S

更新日期：2018-10-25 00:00:00

abstract：:In spite of the declining incidence of gastric cancer (GC) in recent years, the mortality rate is still high. The asymptomatic nature and nonspecific clinical manifestations combined with the lack of efficient screening programs delay the diagnosis of GC. Therefore, the prevalence of advanced gastric cancer (AGC) has ...

journal_title：BioMed research international

authors： Xu W,Beeharry MK,Liu W,Yan M,Zhu Z

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To assess whether high-molecular-weight proteins excretion predicts outcome and therapy-responsiveness in patients with FSGS and nephrotic syndrome. RESEARCH DESIGN AND METHODS:Thirty-eight patients measured at biopsy fractional excretion of IgG (FEIgG) and urinary α2-macroglobulin/creatinine ratio ( α m/C)....

journal_title：BioMed research international

authors： Bazzi C,Rizza V,Casellato D,Stivali G,Rachele G,Napodano P,Gallieni M,D'Amico G

更新日期：2013-01-01 00:00:00

abstract：:To overcome the issues connected to the use of autologous vascular grafts and artificial materials for reconstruction of small diameter (<6 mm) blood vessels, this study aimed to develop acellular matrix- (AM-) based vascular grafts. Rat iliac arteries were decellularized by a detergent-enzymatic treatment, whereas en...

journal_title：BioMed research international

authors： Dall'Olmo L,Zanusso I,Di Liddo R,Chioato T,Bertalot T,Guidi E,Conconi MT

更新日期：2014-01-01 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) patients often develop bone metastases (BM), and the overall survival for these patients is usually perishing. However, a model with high accuracy for predicting the survival of NSCLC with BM is still lacking. Here, we aimed to establish a model based on artificial intelligence for p...

journal_title：BioMed research international

authors： Huang Z,Hu C,Chi C,Jiang Z,Tong Y,Zhao C

更新日期：2020-06-27 00:00:00

abstract：:Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is a mitochondrial inner membrane protein and plays an important role in mitochondrial ATP production and biogenesis. High expression levels of LETM1 have been correlated with numerous human malignancies. This study explored the clinicopathological sign...

journal_title：BioMed research international

authors： Chen L,Yang Y,Liu S,Piao L,Zhang Y,Lin Z,Li Z

更新日期：2014-01-01 00:00:00

abstract：:Myofascial pain syndrome is characterized by pain and a limited range of joint motion caused by muscle contracture related to motor-end-plate dysfunction and the presence of myofascial trigger points (MTrPs). It is the most frequent cause of musculoskeletal pain, with a worldwide prevalence varying between 13.7% and 4...

journal_title：BioMed research international

authors： Wada JT,Akamatsu F,Hojaij F,Itezerote A,Scarpa JC,Andrade M,Jacomo A

更新日期：2020-01-22 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) inhibitors have proven to be successful agents in inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached clinical trial testing for treatment in different cancers, and, recently, Olaparib (AZD2281) has gained both United States Food and Drug Admini...

journal_title：BioMed research international

authors： Murata S,Zhang C,Finch N,Zhang K,Campo L,Breuer EK

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:The 7th (2009) edition of the AJCC melanoma staging system incorporates tumor (Breslow) thickness, MR, and ulceration in stratifying T1 primary melanomas. Compared to the prior 6th (2001) edition, MR has replaced CL for thin melanomas. OBJECTIVE:We sought to identify and report differences of the classificatio...

journal_title：BioMed research international

authors： Chu VH,Tetzlaff MT,Torres-Cabala CA,Prieto VG,Bassett R Jr,Gershenwald JE,McLemore MS,Ivan D,Wang WL,Ross MI,Curry JL

更新日期：2013-01-01 00:00:00

abstract：:Interactions between proteins and drugs, which can lead to formation of stable drug-protein complexes, have important implications on several processes related to human health. These interactions can affect, for instance, free concentration, biological activity, and metabolism of the drugs in the blood stream. Here, w...

journal_title：BioMed research international

authors： Gorza FD,Pedro GC,Trescher TF,da Silva RJ,Silva JR,de Souza NC

更新日期：2014-01-01 00:00:00

abstract：:The presence of acquired mutations within the JAK2, CALR, and MPL genes in the majority of patients with myeloproliferative neoplasms (MPN) affords the opportunity to utilise these mutations as markers of minimal residual disease (MRD). Reduction of the mutated allele burden has been reported in response to a number o...

journal_title：BioMed research international

authors： Haslam K,Langabeer SE

更新日期：2016-01-01 00:00:00

abstract：:Correlation of parametrized image texture features (ITF) analyses conducted in different regions of interest (ROIs) overcomes limitations and reliably reflects image quality. The aim of this study is to propose a nonparametrical method and classify the quality of a magnetic resonance (MR) image that has undergone cont...

journal_title：BioMed research international

authors： Obuchowicz R,Piórkowski A,Urbanik A,Strzelecki M

更新日期：2019-11-20 00:00:00

abstract：:Introduction. The aim of the present study was to determine the closeness of agreement between a self-reported and an objective measure of physical activity in low back pain patients and healthy controls. Beyond, influencing factors on overestimation were identified. Methods. 27 low back pain patients and 53 healthy c...

journal_title：BioMed research international

authors： Schaller A,Rudolf K,Dejonghe L,Grieben C,Froboese I

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Hypoxia-induced autophagy and muscle wasting occur in several environmental and pathological conditions. However, the molecular mechanisms underlying the effects of the hypoxia-mimetic agent CoCl2 on autophagy and muscle atrophy are still unclear. METHODS:C2C12 myotubes were exposed to increasing concentrat...

journal_title：BioMed research international

authors： Chen R,Jiang T,She Y,Xu J,Li C,Zhou S,Shen H,Shi H,Liu S

更新日期：2017-01-01 00:00:00

abstract：:Prior to the "onset of hearing," developing cochlear inner hair cells (IHCs) and primary auditory neurons undergo experience-independent activity, which is thought to be important in retaining and refining neural connections in the absence of sound. One of the major hypotheses regarding the origin of such activity inv...

journal_title：BioMed research international

authors： Dayaratne MW,Vlajkovic SM,Lipski J,Thorne PR

更新日期：2014-01-01 00:00:00

abstract：:We applied a metabolomic approach to monitor the modifications occurring in goat vitreous humor (VH) metabolite composition at different times (0, 6, 12, 18, and 24 hours) after death. The (1)H-NMR analysis of the VH samples was performed for the simultaneous determination of several metabolites (i.e., the metabolite ...

journal_title：BioMed research international

authors： Rosa MF,Scano P,Noto A,Nioi M,Sanna R,Paribello F,De-Giorgio F,Locci E,d'Aloja E

更新日期：2015-01-01 00:00:00

abstract：:One of the biggest obstetric challenges is the diagnosis and management of a short cervix as cervical length has an inverse relationship with risk of preterm birth. A cervical cerclage is a surgical procedure to reduce the risk of preterm birth and can be placed in an elective or emergency setting. This is a retrospec...

journal_title：BioMed research international

authors： Vasudeva N,Reddington C,Bogdanska M,De Luca L

更新日期：2018-09-30 00:00:00

abstract：Background:Spinal cord injury (SCI) is often associated with long-term impairments related to functional limitations in the sensorimotor system. The use of virtual reality (VR) technology may lead to increased motivation and engagement, besides allowing a wide range of possible tasks/exercises to be implemented in reha...

journal_title：BioMed research international

authors： de Araújo AVL,Neiva JFO,Monteiro CBM,Magalhães FH

更新日期：2019-11-13 00:00:00

abstract：:N6-methyladenosine (m6A) plays an important role in many cancers. However, few studies have examined the role of m6A in colorectal CRC. To examine the effect of m6A on CRC, we studied the genome of 591 CRC cases from The Cancer Genome Atlas (TCGA). The relationship between the messenger RNA (mRNA) expression, copy num...

journal_title：BioMed research international

authors： Zhang Q,Cai Y,Kurbatov V,Khan SA,Lu L,Zhang Y,Johnson CH

更新日期：2020-12-19 00:00:00

abstract：:Plant-associated bacteria provide important services to host plants. Environmental factors such as cultivar type and pedoclimatic conditions contribute to shape their diversity. However, whether these environmental factors may influence the plant growth promoting (PGP) potential of the root-associated bacteria is not ...

journal_title：BioMed research international

authors： Marasco R,Rolli E,Fusi M,Cherif A,Abou-Hadid A,El-Bahairy U,Borin S,Sorlini C,Daffonchio D

更新日期：2013-01-01 00:00:00

abstract：:Extra-intestinal E. coli are emerging as a global threat due to their diffusion as opportunistic pathogens and, above all, to their wide set of antibiotic resistance determinants. There are still many gaps in our knowledge of their origin and spread pathways, although food animals have been adjudicated vehicles for pa...

journal_title：BioMed research international

authors： Caruso G,Giammanco A,Cardamone C,Oliveri G,Mascarella C,Capra G,Fasciana T

更新日期：2018-11-18 00:00:00

abstract：:Background. There has been a decline in emphasis of the value of physical examination in heart failure (HF) with increased reliance on cardiac imaging. We aim to study the clinical and prognostic significance of positive hepatojugular reflux (HJR) on discharge in patients hospitalized with HF. Methods. Using the ESCAP...

journal_title：BioMed research international

authors： Omar HR,Guglin M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. METHODS:Young children (≤ 5 years) with suspected TB were prospectively enrolled at a tertiary hospital...

journal_title：BioMed research international

authors： Jain SK,Ordonez A,Kinikar A,Gupte N,Thakar M,Mave V,Jubulis J,Dharmshale S,Desai S,Hatolkar S,Kagal A,Lalvani A,Gupta A,Bharadwaj R

更新日期：2013-01-01 00:00:00

abstract：:Surgical flaps are frequently affected by ischemia/reperfusion (I/R) injury. Calcium-sensing receptor (CaSR) and stromal cell-derived factor-1α (SDF-1α) are closely associated with myocardial I/R injury. This study was performed to evaluate the feasibility of applying SDF-1α to counteract CaSR activation-mediated I/R ...

journal_title：BioMed research international

authors： Song L,Gao LN,Wang J,Thapa S,Li Y,Zhong XB,Zhao HW,Xiang XR,Zhang FG,Ji P

更新日期：2018-01-11 00:00:00

abstract：:The Purkinje network is a specialized conduction system within the heart that ensures the proper activation of the ventricles to produce effective contraction. Its role during ventricular arrhythmias is less clear, but some experimental studies have suggested that the Purkinje network may significantly affect the gene...

journal_title：BioMed research international

authors： Liu BR,Cherry EM

更新日期：2015-01-01 00:00:00