Abstract:
:Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potential associated risk factors, the serologic prevalence of T. cruzi, and the presence of T. cruzi-Leishmania sp. mixed infection in a region of the northwest of Argentina. Methods. Cross-sectional studies were conducted to detect TL prevalence and T. cruzi seroprevalence. A case-control study was conducted to examine leishmaniasis risk factors. Results. Prevalence of TL was 0.17%, seroprevalence of T. cruzi infection was 9.73%, and mixed infection proportion-within the leishmaniasic patients group-was 16.67%. The risk factors associated with TL transmission were sex, age, exposure to bites at work, staying outdoors more than 10 hours/day, bathing in the river, and living with people who had lesions or were infected during the study. Discussion. The endemic pattern of TL seems to involve exposure of patients to vectors in wild as well as peridomestic environment. Cases of T. cruzi infection are apparently due to migration. Therefore, a careful epidemiological surveillance is necessary due to the contraindication of antimonial administration to chagasic patients.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Hoyos CL,Cajal SP,Juarez M,Marco JD,Alberti D'Amato AM,Cayo M,Torrejón I,Cimino RO,Diosque P,Krolewiecki AJ,Nasser JR,Gil JFdoi
10.1155/2016/6456031subject
Has Abstractpub_date
2016-01-01 00:00:00pages
6456031eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
杂志文章abstract::Heat shock proteins 70 and heat shock proteins 90 (Hsp70/90) have been implicated in many crucial steps of carcinogenesis: stabilizing oncogenic proteins, inhibiting programmed cell death and replicative senescence, induction of tumor angiogenesis, and activation of the invasion and metastasis. Plenty of cancer relate...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/239164
更新日期:2014-01-01 00:00:00
abstract::The purpose of this study was to offer a new insight into the microstructure changes during in vitro lipolysis of five lipid-based drug delivery formulations belonging to different lipid formulation types. Five lipid-based formulations of indomethacin were investigated using an in vitro lipolysis model. During lipolys...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2364317
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:End-stage renal disease (ESRD) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). OBJECTIVES:To analyze the outcome and prognostic factors of renal transplantation in patients with ESRD due to SLE from January 1986 to December 2013 in a single center. RESU...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/746192
更新日期:2014-01-01 00:00:00
abstract::To better understand the molecular mechanism for the pathogenesis of follicular thyroid carcinoma (FTC), this study aimed at identifying key miRNAs and their target genes associated with FTC, as well as analyzing their interactions. Based on the gene microarray data GSE82208 and microRNA dataset GSE62054, the differen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2725192
更新日期:2019-03-28 00:00:00
abstract::The present study deals with the enzymatic synthesis of biodiesel by transesterification of Jatropha oil (Jatropha curcas L.) with ethanol in a solvent-free system. Seven commercial lipase preparations immobilized by covalent attachment on epoxy-polysiloxane-polyvinyl alcohol composite (epoxy-SiO2-PVA) were tested as ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1404567
更新日期:2016-01-01 00:00:00
abstract::In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6452965
更新日期:2018-10-25 00:00:00
abstract::The impact of a premature elevation of serum progesterone level, the day of hCG administration in patients under controlled ovarian stimulation during IVF procedure, on human endometrial receptivity is still debated. In the present study, we investigated the endometrial gene expression profile shifts during the prerec...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/951937
更新日期:2014-01-01 00:00:00
abstract::Despite many advances in the diagnosis and treatment of colorectal cancer (CRC), its incidence and mortality rates continue to make an impact worldwide and in some countries rates are mounting. Over the past decade, liquid biopsies have been the object of fundamental and clinical research with regard to the different ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/5953036
更新日期:2019-12-04 00:00:00
abstract::Pediatric myelodysplastic syndrome (MDS) is an uncommon disease and little is known about the molecular alterations of its development and evolution to acute myeloid leukemia (AML). The Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PCR2). It is a histone methyltransferas...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2019/3176565
更新日期:2019-12-10 00:00:00
abstract:Purpose:To evaluate the effects of intravitreal ranibizumab (IVR) treatment on the blood flow of the optic nerve head (ONH) and of retinal vessels of the peripapillary region of eyes with diabetic macular edema (DME) assessed using laser speckle flowgraphy (LSFG). Methods:Forty eyes of 30 patients treated with IVR for...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9496242
更新日期:2020-02-10 00:00:00
abstract:Background:Promoting health-enhancing physical activity following rehabilitation is a well-known challenge. This study analysed the barriers to leisure time activity among low back pain patients. Methods:A subset of 192 low back pain patients who participated in a randomized controlled trial promoting physical activit...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6925079
更新日期:2017-01-01 00:00:00
abstract:Introduction:The purpose of this study was to investigate the difference in surgical outcomes between symptomatic and asymptomatic patients with primary hyperparathyroidism (PHPT) and between patients with high serum calcium and those with normal blood calcium, as well as to explore the epidemiological trend of PHPT in...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/2150159
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:An elevated neutrophil-to-lymphocyte ratio (NLR) has been suggested to be associated with a poor prognosis in several cancers. We evaluated the utility of an elevated NLR as a biomarker to predict the prognosis of metastatic castration-resistant prostate cancer (mCRPC) patients treated with ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7538647
更新日期:2017-01-01 00:00:00
abstract::The endoscopic and histopathological findings detected in Sparus aurata experimentally infected with third-stage Anisakis larvae without intermediate host are evaluated and discussed. In six fish, live nematode larvae were introduced by gastroscopy into the stomach. The first observation by endoscope, 15 days after ch...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/701828
更新日期:2013-01-01 00:00:00
abstract::A search for novel and more efficient therapeutic modalities of inflammatory bowel disease (IBD) is one of the most important tasks of contemporary medicine. The anti-inflammatory action of nicotine in IBD might be therapeutic, but its toxicity due to off-target and nonreceptor effects limited its use and prompted a s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/609086
更新日期:2014-01-01 00:00:00
abstract::Acute kidney injury (AKI) is associated with an increased risk of developing advanced chronic kidney disease (CKD). Yet, effective interventions to prevent this conversion are unavailable for clinical practice. In this study, we examined the beneficial effects of Tanshinone IIA on renal fibrosis in a mouse model of fo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/867140
更新日期:2015-01-01 00:00:00
abstract::Triple-negative breast cancer (TNBC) has a significant clinical relevance of being associated with a shorter median time to relapse and death and does not respond to endocrine therapy or other available targeted agents. Increased aggressiveness of this tumor, as well as resistance to standard drug therapies, may be as...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/158682
更新日期:2015-01-01 00:00:00
abstract::Despite the rapid progression of cancer pharmacotherapy, the high drug resistance of pancreatic ductal adenocarcinoma (PDA) makes it one of the most lethal malignancies. Therefore, there are high expectations associated with experimental therapies, such as electrochemotherapy (ECT). This technique involves the applica...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7364539
更新日期:2018-03-19 00:00:00
abstract::The aim of this study was to investigate the influence of a topically administered hygienic preparation containing a 3% ethanolic extract of Brazilian green propolis (EEP-B) on oral microflora spectrum changes in a group of patients who underwent common oral surgery procedures. Two gel samples were compared: the teste...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/869575
更新日期:2015-01-01 00:00:00
abstract::Diabetic patients are at risk for spontaneous foot ulcers, chronic wounds, infections, and tissue necrosis. Current theories suggest that the development and progression of diabetic foot ulcers are mainly caused by arteriosclerosis and peripheral neuropathy. Tissue necrosis plays a primordial role in the progression o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/490964
更新日期:2013-01-01 00:00:00
abstract::Fluconazole is a broad-spectrum triazole antifungal that is well-established as the first-line treatment for Candida albicans infections. Despite its extensive use, reports on its genotoxic/mutagenic effects are controversial; therefore, further studies are needed to better clarify such effects. African green monkey k...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6271547
更新日期:2018-11-01 00:00:00
abstract::High mobility group box 1 (HMGB1) is an ubiquitous protein that plays different roles in the nucleus, cytoplasm, and extracellular space. It is an important DAMP molecule that allows communication between damaged or tumor cells and the immune system. Tumor cells exploit HMGB1's ability to activate intracellular pathwa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/512027
更新日期:2015-01-01 00:00:00
abstract::Mitochondrial uncoupling protein 2 (UCP2) is suggested to have a role in the development of nonalcoholic steatohepatitis (NASH). However, the mechanism remains unclear. Autophagy is an important mediator of many pathological responses. This study aims to investigate the relationship between UCP2 and hepatoma cells aut...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/810401
更新日期:2014-01-01 00:00:00
abstract::Several studies report that the OPG is an important candidate gene in the pathogenesis of osteoporosis. This study aimed to detect the potential association of OPG gene polymorphisms with osteoporosis in postmenopausal women. We recruited 928 subjects containing 463 with primary postmenopausal osteoporosis and 465 hea...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/320828
更新日期:2014-01-01 00:00:00
abstract::Recently, an important topic of the acquired immunodeficiency syndrome (AIDS) had been published in 2013. In this report, the expression of the IFN-induced myxovirus resistance 2 (MX2) had been defined the function to kill the human immunodeficiency virus (HIV). The screening from the Traditional Chinese Medicine (TCM...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/871576
更新日期:2014-01-01 00:00:00
abstract::The microbial resistance of fungi and bacteria is currently considered a major public health problem. Esters derived from cinnamic acid have a broad spectrum of pharmacological properties that include antimicrobial activity. In this study, a collection of structurally related 4-chlorocinnamic acid esters was prepared ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3941242
更新日期:2019-04-23 00:00:00
abstract::IL-1 family includes IL-38 (IL-1F10) and the subfamily of IL-36 and is the central mediators of inflammatory diseases, including pustular psoriasis, atopic dermatitis, rheumatoid arthritis, and gut inflammation. The purpose of the study was to evaluate on tissue of the patients with inflammatory bowel disease (IBD), t...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/5140691
更新日期:2018-12-10 00:00:00
abstract:Background:Pyroptosis, a novel form of inflammatory programmed cell death, was recently found to be a cause of mucosal barrier defect. In our pervious study, CD147 expression was documented to increase in intestinal tissue of inflammatory bowel disease (IBD). Objective:The aim of this study was to determine the functi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5341247
更新日期:2020-06-30 00:00:00
abstract:BACKGROUND:Macrosomia has become a worldwide problem with the rapid economic growth in the past few years. However, the detailed mechanism of how the macrosomia happened remains unknown. Growing evidence indicates that miRNAs are involved in maintaining metabolic homeostasis. We hypothesized that serum miRNAs are poten...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/394125
更新日期:2014-01-01 00:00:00
abstract::Hypolactasia, or intestinal lactase deficiency, affects more than half of the world population. Currently, xylose quantification in urine after gaxilose oral administration for the noninvasive diagnosis of hypolactasia is performed with the hand-operated nonautomatable phloroglucinol reaction. This work demonstrates t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8421418
更新日期:2017-01-01 00:00:00