Abstract:
INTRODUCTION AND OBJECTIVES:An elevated neutrophil-to-lymphocyte ratio (NLR) has been suggested to be associated with a poor prognosis in several cancers. We evaluated the utility of an elevated NLR as a biomarker to predict the prognosis of metastatic castration-resistant prostate cancer (mCRPC) patients treated with cabazitaxel (CBZ). METHODS:We analyzed 47 patients who received CBZ chemotherapy for mCRPC in our institutions. The NLR was calculated using the neutrophil and lymphocyte counts before CBZ chemotherapy. We determined the NLR cut-off value based on the sensitivity and specificity levels derived from area under the receiver operator characteristic curves for death. A multivariate analysis was performed to investigate the association between the NLR and the prognosis. RESULTS:The median overall survival (OS) after CBZ was 10.0 months (range: 6.3-13.2). The median OS was shorter in patients with a high NLR (≥3.83) than in those with a low NLR (<3.83) (5.8 versus 13.2 months, p = 0.018). In the multivariate analysis, the NLR, patient age, and lymph node (LN) metastasis were independent predictors of the OS (hazard ratio 3.01, p = 0.030; hazard ratio 3.10, p = 0.029; hazard ratio 12.38, p = 0.001, resp.). CONCLUSIONS:NLR might be a useful prognostic biomarker in mCRPC patients treated with CBZ.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Uemura K,Kawahara T,Yamashita D,Jikuya R,Abe K,Tatenuma T,Yokomizo Y,Izumi K,Teranishi JI,Makiyama K,Yumura Y,Kishida T,Udagawa K,Kobayashi K,Miyoshi Y,Yao M,Uemura Hdoi
10.1155/2017/7538647subject
Has Abstractpub_date
2017-01-01 00:00:00pages
7538647eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract:Background:The aim of this study was to investigate the potential mechanisms by which chronic unpredictable mild stress (CMS) might induce cardiovascular disease. Methods:Twenty male Sprague-Dawley rats (weighing 180-250 g) were divided into the CMS group (CMS for 3 weeks) and control group (n = 10/group). Sucrose sol...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8697913
更新日期:2018-03-07 00:00:00
abstract:PURPOSE:To evaluate tumor structure in children with diffuse intrinsic pontine glioma (DIPG) using histogram analyses of mean diffusivity (MD), determine potential treatment and corticosteroid-related effects on MD, and monitor changes in MD distributions over time. MATERIALS AND METHODS:DTI was performed on a 1.5T GE...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/647356
更新日期:2014-01-01 00:00:00
abstract::The application of chemotherapeutic drug adriamycin (ADR) in cancer therapy is limited by its side effects like high toxicity and insolubility. Nanomedicine offers new hope for overcoming the shortcomings. But how to increase in vivo stability and to control intracellular drug release is a key issue for nano-based for...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/987404
更新日期:2015-01-01 00:00:00
abstract::To compare the clinical efficacy and radiological outcome of treating 4-level cervical spondylotic myelopathy (CSM) with either anterior cervical discectomy and fusion (ACDF) or "skip" corpectomy and fusion, 48 patients with 4-level CSM who had undergone ACDF or SCF at our hospital were analyzed retrospectively betwee...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/513906
更新日期:2015-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by bone loss. Degree of inflammation has been identified as an important initiator of skeletal damage in RA. Iguratimod (T-614) is an anti-inflammatory agent which has been reported to show the inhibitory effect of bone destruction in RA. Ho...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4901591
更新日期:2018-02-19 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/153419
更新日期:2013-01-01 00:00:00
abstract::Although disorders of the stomatognathic system are common, the mechanisms involved are unknown. Our objective was to study the changes in the masseter muscles after unilateral exodontia. Molar extraction was performed on Wistar rats (left side), and the animals were sacrificed after either 14 or 26 days. The masseter...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/563463
更新日期:2014-01-01 00:00:00
abstract::The nonnucleoside reverse transcriptase inhibitors, used for the treatment of HIV infections, are reported to have low bioavailability pertaining to high first-pass metabolism, high protein binding, and enzymatic metabolism. They also show low permeability across blood brain barrier. The CNS is reported to be the most...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5984014
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1497213
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/138060
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2640684
更新日期:2019-04-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/649750
更新日期:2015-01-01 00:00:00
abstract::Background. Stenotrophomonas maltophilia bacteremia (SMB) is the most perilous situation as compared to other types of S. maltophilia infection. The present study aimed to investigate the clinical features, distribution, drug resistance, and predictors of survival of SMB in a tertiary-care hospital of China. Methods. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4931501
更新日期:2019-12-09 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6875968
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1905987
更新日期:2017-01-01 00:00:00
abstract::The cyprinid genus Pteronotropis is endemic to southeastern Gulf of Mexico and Atlantic Ocean of North America. Never before has the genus been demonstrated to be monophyletic. We investigate both the phylogenetic relationships and the phylogeography of some species in the genus using mitochondrial ND2 sequences. In n...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/675260
更新日期:2015-01-01 00:00:00
abstract::Birt-Hogg-Dube syndrome (BHD, OMIM#135150) is a rare disease in clinic; it is characterized by skin fibrofolliculomas, pulmonary cysts with an increased risk of recurrent pneumothorax, renal cysts, and renal neoplasms. Previous studies have demonstrated that variants in folliculin (FLCN, NM_144997) are mainly responsi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8751384
更新日期:2017-01-01 00:00:00
abstract::To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/782490
更新日期:2014-01-01 00:00:00
abstract::SARS-CoV-2 pandemic and COVID-19 diffusion have recently become an international public health emergency. Cancer patients, as a frail population, are particularly exposed to the risk related to infections. The clinical decision-making process and the organizational workflow of radiotherapy department should be revised...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4892382
更新日期:2020-05-26 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/580460
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:(1) To evaluate a new acquisition protocol of (18)F-choline (FCH) PET/CT for prostate cancer patients (PC), (2) to review acquisition (18)F-choline PET/CT methodology, and (3) to propose a standardized acquisition protocol on FCH PET/CT in PC patients. MATERIALS:100 consecutive PC patients (mean age 70.5 years...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/215650
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/701828
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologou...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/940278
更新日期:2015-01-01 00:00:00
abstract::Gender affirmation surgery remains one of the greatest challenges in transgender medicine. In recent years, there have been continuous discussions on bioethical aspects in the treatment of persons with gender dysphoria. Gender reassignment is a difficult process, including not only hormonal treatment with possible sur...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/9652305
更新日期:2018-06-13 00:00:00
abstract::Spinal cord injured (SCI) individuals show an altered hemodynamic response to metaboreflex activation due to a reduced capacity to vasoconstrict the venous and arterial vessels below the level of the lesion. Exercise training was found to enhance circulating catecholamines and to improve cardiac preload and venous ton...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/893468
更新日期:2014-01-01 00:00:00
abstract::With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conventional drug deliv...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/263604
更新日期:2014-01-01 00:00:00
abstract::Introduction. The lateral lumbar interbody fusion (LLIF) surgical approach has potential advantages over other approaches but is associated with some unique neurologic risks due to the proximity of the lumbosacral plexus. The present study analyzed complications following LLIF surgical approach using a novel single fl...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2016/8450712
更新日期:2016-01-01 00:00:00
abstract::Variations in human genome (e.g., single nucleotide polymorphisms, SNPs) may be associated with hereditary diseases, their complications, comorbidities, and drug responses. Using Web service SNP_TATA_Comparator presented in our previous paper, here we analyzed immediate surroundings of known SNP markers of diseases an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8642703
更新日期:2016-01-01 00:00:00
abstract::Fungi are important soil components as both decomposers and plant symbionts and play a major role in ecological and biogeochemical processes. However, little is known about the richness and structure of fungal communities. DNA sequencing technologies allow for the direct estimation of microbial community diversity, av...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/972481
更新日期:2015-01-01 00:00:00
abstract::Light traps represent the most used attractive system to collect and monitor phlebotomine sand flies. Recent studies have suggested that light traps can be easily upgraded by the use of light-emitting diode (LED) with positive effects on trap design, weight, and battery life. However, scant data on the effect of diffe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6432637
更新日期:2018-06-27 00:00:00