Diffusion tensor histogram analysis of pediatric diffuse intrinsic pontine glioma.

Abstract:

PURPOSE:To evaluate tumor structure in children with diffuse intrinsic pontine glioma (DIPG) using histogram analyses of mean diffusivity (MD), determine potential treatment and corticosteroid-related effects on MD, and monitor changes in MD distributions over time. MATERIALS AND METHODS:DTI was performed on a 1.5T GE scanner. Regions of interest included the entire FLAIR-defined tumor. MD data were used to calculate histograms. Patterns in MD distributions were evaluated and fitted using a two-normal mixture model. Treatment-related effects were evaluated using the R (2) statistic for linear mixed models and Cox proportional hazards models. RESULTS:12 patients with DIPG underwent one or more DTI exams. MD histogram distributions varied among patients. Over time, histogram peaks became shorter and broader (P = 0.0443). Two-normal mixture fitting revealed large lower curve proportions that were not associated with treatment response or outcome. Corticosteroid use affected MD histograms and was strongly associated with larger, sharper peaks (R(2) = 0.51, P = 0.0028). CONCLUSIONS:MD histograms of pediatric DIPG show significant interpatient and intratumoral differences and quantifiable changes in tumor structure over time. Corticosteroids greatly affected MD and must be considered a confounding factor when interpreting MD results in the context of treatment response.

journal_name

Biomed Res Int

authors

Steffen-Smith EA,Sarlls JE,Pierpaoli C,Shih JH,Bent RS,Walker L,Warren KE

doi

10.1155/2014/647356

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

647356

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

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