A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain.

abstract：:Epigenetic changes have major role in the normal development and programming of gene expression. Aberrant methylation results in carcinogenesis. The primary objective of our study is to determine whether primary tumor tissue and cultured tumor cells in 2D and 3D tissue culture systems have the same methylation signatu...

journal_title：BioMed research international

authors： Şükrüoğlu Erdoğan Ö,Kılıç Erciyas S,Bilir A,Buğra Tunçer Ş,Akdeniz Ödemiş D,Kurul S,Karanlık H,Cabıoğlu N,Yazıcı H

更新日期：2019-01-17 00:00:00

abstract：:Muscle mass and strength progressively decrease with age, which results in a condition known as sarcopenia. Sarcopenia would lead to physical disability, poor quality of life, and death. Therefore, much is expected of an effective intervention for sarcopenia. Epidemiologic, clinical, and laboratory evidence suggest an...

journal_title：BioMed research international

authors： Wagatsuma A,Sakuma K

更新日期：2014-01-01 00:00:00

abstract：Background:Several studies found that physicians develop a negative attitude toward biochemistry and genetics disciplines. Many medical schools adopt an integrated system-based curriculum supplemented with clinical correlations. Medical schools in Jordan switched to the integrated curriculum; however, studies that eval...

journal_title：BioMed research international

authors： Alfaqih MA,Khader YS,Bashir N,Nusair Z,Nuseir Q,Nusier M

更新日期：2019-11-13 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have bee...

journal_title：BioMed research international

authors： Jia Q,Deng Y,Qing H

更新日期：2014-01-01 00:00:00

abstract：:Asthma susceptibility genes are mapped to a region on human chromosome 5q31-q33, which contains a cluster of proinflammatory cytokine genes such as interleukin-13 (IL-13), which is associated with asthma. This study investigated the allele frequencies of two single nucleotide polymorphisms (SNPs) (-1111C>T and 4257C>A...

journal_title：BioMed research international

authors： Radhakrishnan AK,Raj VL,Tan LK,Liam CK

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Sarcopenia is the presence of low muscle mass and low muscle function. The aim of this study was to establish cutoffs for low muscle mass using three published methods and to compare the prevalence of sarcopenia in older Australians. METHODS:Gender specific cutoffs levels were identified for low muscle mass...

journal_title：BioMed research international

authors： Yu S,Appleton S,Adams R,Chapman I,Wittert G,Visvanathan T,Visvanathan R

更新日期：2014-01-01 00:00:00

abstract：:Bioadhesive nasal dosage forms are an attractive method for overcoming rapid mucociliary clearance transport in the nose and for delivering the drug directly to brain. The present study was designed to formulate chondroitin sulphate (CS) and chitosan (CH) nasal inserts employing zolmitriptan, an antimigraine drug. The...

journal_title：BioMed research international

authors： Kaur K,Kaur G

更新日期：2013-01-01 00:00:00

abstract：:Molecular imaging based personalized therapy has been a fascinating concept for individualized therapeutic strategy, which is able to attain the highest efficacy and reduce adverse effects in certain patients. Theranostics, which integrates diagnostic testing to detect molecular targets for particular therapeutic moda...

journal_title：BioMed research international

authors： Ahn BC

更新日期：2016-01-01 00:00:00

abstract：:Txndc9 (thioredoxin domain containing protein 9) has been shown to be involved in mammalian mitosis; however, its function in mammalian oocyte meiosis remains unclear. In this study, we initially found that Txndc9 is expressed during meiotic maturation of mouse oocytes and higher expression of Txndc9 mRNA and protein ...

journal_title：BioMed research international

authors： Ma F,Hou L,Yang L

更新日期：2017-01-01 00:00:00

abstract：:The framework of graph theory provides useful tools for investigating the neural substrates of neuropsychiatric disorders. Graph description measures may be useful as predictor variables in classification procedures. Here, we consider several centrality measures as predictor features in a classification algorithm to i...

journal_title：BioMed research international

authors： dos Santos Siqueira A,Biazoli Junior CE,Comfort WE,Rohde LA,Sato JR

更新日期：2014-01-01 00:00:00

abstract：:Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS. In this study, we aimed to explore the regulatory mechanisms of mi...

journal_title：BioMed research international

authors： Zhang YH,Chen AL,Yu RQ,Jia BB,Ye DN,Wang M,Mei YZ,Fang GD,Jiang SY,Zhou Q,Zhang B

更新日期：2021-01-05 00:00:00

abstract：:The presence of acquired mutations within the JAK2, CALR, and MPL genes in the majority of patients with myeloproliferative neoplasms (MPN) affords the opportunity to utilise these mutations as markers of minimal residual disease (MRD). Reduction of the mutated allele burden has been reported in response to a number o...

journal_title：BioMed research international

authors： Haslam K,Langabeer SE

更新日期：2016-01-01 00:00:00

abstract：:Ureteroplasty using onlay grafts or flaps emerged as an innovative procedure for the management of proximal and midureteral strictures. Autologous grafts or flaps used commonly in ureteroplasty include the oral mucosae, bladder mucosae, ileal mucosae, and appendiceal mucosae. Oral mucosa grafts, especially buccal muco...

journal_title：BioMed research international

authors： Xiong S,Wang J,Zhu W,Yang K,Ding G,Li X,Eun DD

更新日期：2020-07-27 00:00:00

abstract：:The monoexponential model is widely used in quantitative biomedical imaging. Notable applications include apparent diffusion coefficient (ADC) imaging and pharmacokinetics. The application of ADC imaging to the detection of malignant tissue has in turn prompted several studies concerning optimal experiment design for ...

journal_title：BioMed research international

authors： Alipoor M,Maier SE,Gu IY,Mehnert A,Kahl F

更新日期：2015-01-01 00:00:00

abstract：Objective:Biomaterial research for soft tissue augmentation is an increasing topic in aesthetic medicine. Hyaluronic acid (HA) fillers are widely used for their low invasiveness and easy application to correct aesthetic defects or traumatic injuries. Some complications as acute or chronic inflammation can occur in pati...

journal_title：BioMed research international

authors： Cannella V,Altomare R,Leonardi V,Russotto L,Di Bella S,Mira F,Guercio A

更新日期：2020-05-21 00:00:00

abstract：:Fibrosarcomas are rare malignant mesenchymal tumors originating from fibroblasts. Importantly, fibrosarcoma cells were shown to have a high content and turnover of extracellular matrix (ECM) components including hyaluronan (HA), proteoglycans, collagens, fibronectin, and laminin. ECMs are complicated structures that s...

journal_title：BioMed research international

authors： Nikitovic D,Kouvidi K,Karamanos NK,Tzanakakis GN

更新日期：2013-01-01 00:00:00

abstract：:Therapeutic approach for Alzheimer's disease (AD) is still deficient. To find active compounds from herbal medicine is of interest in the alleviation of AD symptoms. This study aimed to investigate the protective effects of Tanshinone IIA (TIIA) on memory performance and synaptic plasticity in a transgenic AD model at...

journal_title：BioMed research international

authors： Li F,Han G,Wu K

更新日期：2016-01-01 00:00:00

abstract：Purpose:In this study, we examined whether the associations between working hours, job satisfaction, and work-life balance are mediated by occupational stress. In addition, we tested whether perceived time control helps moderate the effects of working hours and occupational stress. Methodology:Questionnaires were admi...

journal_title：BioMed research international

authors： Hsu YY,Bai CH,Yang CM,Huang YC,Lin TT,Lin CH

更新日期：2019-06-23 00:00:00

abstract：:Genome-wide association studies (GWAS) have extensively analyzed single SNP effects on a wide variety of common and complex diseases and found many genetic variants associated with diseases. However, there is still a large portion of the genetic variants left unexplained. This missing heritability problem might be due...

journal_title：BioMed research international

authors： Lee S,Kim Y,Kwon MS,Park T

更新日期：2015-01-01 00:00:00

abstract：Background:Adverse drug reactions (ADRs) are the known cause of morbidity and mortality, resulting in increased hospitalization, healthcare costs, complications, and decreased adherence in patients with depression. This study is aimed at evaluating adverse drug reactions due to antidepressants among patients with depre...

journal_title：BioMed research international

authors： Sankhi S,Marasine NR,Sankhi S,Lamichhane R

更新日期：2020-11-16 00:00:00

abstract：:Remote organ impairments are frequent and increase patient morbidity and mortality after lower limb ischemia-reperfusion (IR). We challenged the hypothesis that lower limb IR might also impair lung, renal, and liver mitochondrial respiration. Two-hour tourniquet-induced ischemia was performed on both hindlimbs, follow...

journal_title：BioMed research international

authors： Mansour Z,Charles AL,Kindo M,Pottecher J,Chamaraux-Tran TN,Lejay A,Zoll J,Mazzucotelli JP,Geny B

更新日期：2014-01-01 00:00:00

abstract：:MicroRNAs are small noncoding RNAs, involved in the regulation of many cellular processes in plants. Hundreds of miRNAs have been identified in cassava by various techniques, yet these identifications were constrained by a lack of miRNA templates and the narrow range of conditions in transcriptome study. In this resea...

journal_title：BioMed research international

authors： Yawichai A,Kalapanulak S,Thammarongtham C,Saithong T

更新日期：2019-06-19 00:00:00

abstract：:Big data bioinformatics aims at drawing biological conclusions from huge and complex biological datasets. Added value from the analysis of big data, however, is only possible if the data is accompanied by accurate metadata annotation. Particularly in high-throughput experiments intelligent approaches are needed to kee...

journal_title：BioMed research international

authors： Friedrich A,Kenar E,Kohlbacher O,Nahnsen S

更新日期：2015-01-01 00:00:00

abstract：:Both human adipose tissue-derived mesenchymal stem cells (ASCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs) have been explored as attractive mesenchymal stem cells (MSCs) sources, but very few parallel comparative studies of these two cell types have been made. We designed a side-by-side comparative st...

journal_title：BioMed research international

authors： Hu L,Hu J,Zhao J,Liu J,Ouyang W,Yang C,Gong N,Du L,Khanal A,Chen L

更新日期：2013-01-01 00:00:00

abstract：Background:Oxidative stress is an important factor during age-related cataract formation. Apoptosis and autophagy induced by oxidative stress have been reported as key factors in age-related cataract. In our research, we investigated the role of let-7c-3p in the regulation of autophagy and apoptosis during the formatio...

journal_title：BioMed research international

authors： Li T,Huang Y,Zhou W,Yan Q

更新日期：2020-03-16 00:00:00

abstract：:Activity-dependent plasticity as a result of reorganization of neural circuits is a fundamental characteristic of the central nervous system that occurs simultaneously in multiple sites. In this study, we established the effects of subthreshold transcranial magnetic stimulation (TMS) over the primary motor cortex regi...

journal_title：BioMed research international

authors： Hajela N,Mummidisetty CK,Smith AC,Knikou M

更新日期：2013-01-01 00:00:00

abstract：Background:The purpose of this study was to examine the physical activity patterns and health-related fitness levels of adolescents within the Juvenile Justice System. Methods:Participants included 68 adolescents (Mean age = 17.1 ± 1.0 years) in two secure Juvenile Justice correctional facilities in the Western USA. M...

journal_title：BioMed research international

authors： Brusseau TA,Burns RD,Hannon JC

更新日期：2018-07-15 00:00:00

abstract：:The use of anaesthetic drugs in the treatment of oral aphthosis is one of the pharmaceutical possibilities that a doctor can use for the most painful forms. Normally, Lidocaine or Diclofenac is used to treat this disease, but they can be used for a very limited time and so they are of little practical use. In this stu...

journal_title：BioMed research international

authors： Gasparini G,Saponaro G,Gasparini D,Foresta E,Azzuni C,Adduci A,Boniello R,Moro A,De Angelis P,Di Nardo F,Damato G,Doneddu P,Todaro M,Garagiola U,Pelo S

更新日期：2018-03-11 00:00:00

abstract：Objective:To retrospectively investigate computed tomographic (CT) quantitative analysis of ground-glass opacity (GGO) volume percentage and morphologic features of resected lung adenocarcinomas according to epidermal growth factor receptor (EGFR) mutation status and subtypes. Methods:Amplification refractory mutation...

journal_title：BioMed research international

authors： Wang H,Guo H,Wang Z,Shan B,Lin J

更新日期：2019-03-06 00:00:00

abstract：BACKGROUND:The aims of this study were to evaluate the complications that occur after trauma and the characteristics of individuals who develop complications, to identify potential risk factors that increase their incidence, and finally to investigate the relationship between complications and mortality. METHODS:We di...

journal_title：BioMed research international

authors： Mondello S,Cantrell A,Italiano D,Fodale V,Mondello P,Ang D

更新日期：2014-01-01 00:00:00