Abstract:
:Txndc9 (thioredoxin domain containing protein 9) has been shown to be involved in mammalian mitosis; however, its function in mammalian oocyte meiosis remains unclear. In this study, we initially found that Txndc9 is expressed during meiotic maturation of mouse oocytes and higher expression of Txndc9 mRNA and protein occurred in germinal vesicle (GV) stage. By using confocal scanning, we observed that Txndc9 localized at both nucleus and cytoplasm, especially at spindle microtubules. Specific depletion of Txndc9 by siRNA in mouse oocyte resulted in decreasing the rate of first polar body extrusion and increasing abnormal spindle assemble. Moreover, knockdown of Txndc9 in germinal vesicle (GV) stage oocytes led to higher level of reactive oxygen species (ROS) and lower level of antioxidant glutathione (GSH) as compared with control oocytes, which indicated that Txndc9 may be involved in mediating the redox balance. In summary, our results demonstrated that Txndc9 is crucial for mouse oocyte maturation by regulating spindle assembly, polar body extrusion, and redox status.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Ma F,Hou L,Yang Ldoi
10.1155/2017/6265890subject
Has Abstractpub_date
2017-01-01 00:00:00pages
6265890eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract::Rauwolfia tetraphylla L. is an important medicinal plant species which is well known for its pharmaceutically important alkaloids. In the present study, we are reporting about its conservation by in vitro clonal multiplication through the standardized protocol of indirect regeneration by using leaf and stem based call...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3698742
更新日期:2019-04-11 00:00:00
abstract::To protect against the environmental pollution, the present research was undertaken to enumerate the Bacterial Technologies (BTs) on the restoration of polluted urban rivers, that is, Fenghu-Song Yang River (FSR) and Xuxi River (XXR). Experimental research accounted for the physiochemical parameters (pH; temperature; ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/241769
更新日期:2015-01-01 00:00:00
abstract::The history of polyglutamine diseases dates back approximately 20 years to the discovery of a polyglutamine repeat in the androgen receptor of SBMA followed by the identification of similar expansion mutations in Huntington's disease, SCA1, DRPLA, and the other spinocerebellar ataxias. This common molecular feature of...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/701758
更新日期:2014-01-01 00:00:00
abstract:Methods:The implantation sites, fetus resorption, and abnormal fetuses were studied in pregnant mice treated with different doses of BaP by oral gavage from day 1 to day 10 of gestation. Additionally, apoptosis and related signaling pathway, and the migration and invasion of trophoblasts, were assessed before and after...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8983494
更新日期:2020-10-16 00:00:00
abstract:PURPOSE:To develop a dual energy imaging method to improve the accuracy of electron density measurement with a cone-beam CT (CBCT) device. MATERIALS AND METHODS:The imaging system is the XVI CBCT system on Elekta Synergy linac. Projection data were acquired with the high and low energy X-ray, respectively, to set up a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/858907
更新日期:2015-01-01 00:00:00
abstract::This study introduced a combined computational fluid dynamics (CFD) and echocardiography methodology to simulate blood flow in the single right ventricle (SRV) and normal ventricles to study the intraventricular flow. Derived from echocardiographic image loops, CFD-based three-dimensional (3D) flow models of normal su...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1042038
更新日期:2018-01-16 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are al...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4574509
更新日期:2020-04-06 00:00:00
abstract::Carbonic anhydrases (CAs) are enzymes that catalyse the reversible hydration of CO2 to bicarbonate. CA XII is considered a potential biomarker of tumor cells and a promising target for specific therapies. The aim of the current study was to develop new monoclonal antibodies (MAbs) against human recombinant CA XII and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/309307
更新日期:2014-01-01 00:00:00
abstract:Background:Large scalp defects, especially those complicated by calvarial defects, titanium mesh exposure, or cerebrospinal fluid (CSF) leak, pose a challenge for the neurosurgeon and plastic surgeon. Here, we describe our experience of reconstructing the complex scalp defect with free flap transfer. Methods:From Octo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2748219
更新日期:2020-01-10 00:00:00
abstract::The hallucal sesamoid bones (HSBs), having an important role in reducing load per unit area on the first metatarsal head, can be injured commonly which also affected the first metatarsophalangeal joint and the surrounding structure. Meanwhile, differences among each HSB type may be a major factor affecting the occurre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9658916
更新日期:2020-06-26 00:00:00
abstract::ELABELA (ELA) is considered to be implicated in the pathophysiology of preeclampsia (PE), since ELA-deficient mice exhibited PE-like symptoms and infusion of exogenous ELA normalized the gestational hypertension (GH) and proteinuria. However, no evidence show that circulating ELA is deficient in early placental develo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2051701
更新日期:2020-09-28 00:00:00
abstract:AIM:Cardiac rehabilitation (CR) is an important part of heart failure (HF) treatment. The aim of this paper was to evaluate if thoracic fluid content (TFC) measured by impedance cardiography (ICG) is a useful parameter for predicting the outcome of CR. METHODS:Fifty HF patients underwent clinical and noninvasive haemo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/595369
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Frail older people are often unable to undertake high-intensity exercise programmes. Chair-based exercises (CBEs) are used as an alternative, for which health benefits are uncertain. OBJECTIVE:To examine the effects of CBE programmes for frail older people through a systematic review of existing literatur...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/309506
更新日期:2013-01-01 00:00:00
abstract::An excessive pulmonary inflammatory response could explain the poor prognosis of chronic obstructive pulmonary disease (COPD) patients submitted to invasive mechanical ventilation. The aim of this study was to evaluate the response to normal tidal volume mechanical ventilation in an elastase-induced murine model of pu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5721293
更新日期:2018-12-19 00:00:00
abstract::Reactive oxygen species (ROS) damage macromolecules and cellular components in nearly all kinds of cells and often generate toxic intracellular byproducts. In this work, aldehyde generation derived from the Escherichia coli membrane oxidation as well as membrane fatty acid profiles, protein oxidation, and bacterial re...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/563756
更新日期:2013-01-01 00:00:00
abstract::The ability of Aspergillus niger strain to reduce organic and mineral pollution as well as the toxicity of two tannery wastewaters, the unhairing effluent (UE) and the final effluent (FE), taken from a local Tunisian tannery and under nonsterile conditions, was studied. Raw effluents show alkaline pH ≥11; thus experim...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9020178
更新日期:2019-06-03 00:00:00
abstract::The myostatin (MSTN) is a known negative growth regulator of skeletal muscle. The mutated myostatin showed a double-muscular phenotype having a positive significance for the farmed animals. Consequently, adequate information is not available in the teleosts, including farmed rohu carp, Labeo rohita. In the absence of ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7562368
更新日期:2016-01-01 00:00:00
abstract::The laser speckle contrast imaging (LSCI) is proved to be a reliable tool in flap monitoring in general surgery; however, it has not been evaluated in oral surgery yet. We applied the LSCI to compare the effect of a xenogeneic collagen matrix (Geistlich Mucograft®) to connective tissue grafts (CTG) on the microcircula...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/4042902
更新日期:2017-01-01 00:00:00
abstract::The new chemokine Prokineticin 2 (PROK2) and its receptors (PKR1 and PKR2) have a role in inflammatory pain and immunomodulation. Here we identified PROK2 as a critical mediator of neuropathic pain in the chronic constriction injury (CCI) of the sciatic nerve in mice and demonstrated that blocking the prokineticin rec...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/301292
更新日期:2015-01-01 00:00:00
abstract::Asthma susceptibility genes are mapped to a region on human chromosome 5q31-q33, which contains a cluster of proinflammatory cytokine genes such as interleukin-13 (IL-13), which is associated with asthma. This study investigated the allele frequencies of two single nucleotide polymorphisms (SNPs) (-1111C>T and 4257C>A...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/981012
更新日期:2013-01-01 00:00:00
abstract::Lung cancer consists of two main subtypes: small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) that are classified according to their physiological phenotypes. In this study, we have developed a network-based approach to identify molecular biomarkers that can distinguish SCLC from NSCLC. By identifyin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/685303
更新日期:2015-01-01 00:00:00
abstract::Bone integrity abnormality and imbalance between bone formation by osteoblasts and bone resorption by osteoclasts are known to result in metabolic bone diseases such as osteoporosis. Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteoblasts but reduced ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/919374
更新日期:2013-01-01 00:00:00
abstract::Non-VKA oral anticoagulants (NOACs) have now widely reached the lucrative market of anticoagulation. While the marketing authorization holders claimed that no routine monitoring is required and that these compounds can be given at fixed doses, several evidences arisen from the literature tend to demonstrate the opposi...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/345138
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:End-stage renal disease (ESRD) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). OBJECTIVES:To analyze the outcome and prognostic factors of renal transplantation in patients with ESRD due to SLE from January 1986 to December 2013 in a single center. RESU...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/746192
更新日期:2014-01-01 00:00:00
abstract:Background:The aims of this study were to explore the characteristics of left ventricular (LV) functional changes in subjects with or without acute mountain sickness (AMS) and their associations with AMS incidence. Methods:A total of 589 healthy men were enrolled and took a trip from Chengdu (500 m, above sea level (a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6028747
更新日期:2020-11-10 00:00:00
abstract::Finding an optimal set of discriminative features is still a crucial but challenging task in biomedical science. The complexity of the task is intensified when any of the two scenarios arise: a highly dimensioned dataset and a small sample-sized dataset. The first scenario poses a big challenge to existing machine lea...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8506365
更新日期:2020-08-17 00:00:00
abstract::MicroRNAs (miRNAs) family, which is involved in cancer development, proliferation, apoptosis, and drug resistance, is a group of noncoding RNAs that modulate the expression of oncogenes and antioncogenes. Doxorubicin is an active cytotoxic agent for breast cancer treatment, but the acquisition of doxorubicin resistanc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/373574
更新日期:2015-01-01 00:00:00
abstract::This study investigates the mechanism underlying the improving effect of zinc on fertility in obese rats using proteomics. The effects of three different doses of ZnSO4 on spermatogenesis and hormone levels were studied. Testicular spermatogenesis was observed by HE staining. Serum estrogen and testosterone levels wer...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9876363
更新日期:2020-05-04 00:00:00
abstract::Contrast-induced nephropathy (CIN) remains a leading cause of iatrogenic acute kidney injury, as the usage of contrast media for imaging and intravascular intervention keeps expanding. Diabetes is an important predisposing factor for CIN, particularly in patients with renal functional impairment. Renal hypoxia, combin...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/123589
更新日期:2013-01-01 00:00:00
abstract::Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/720514
更新日期:2013-01-01 00:00:00