Abstract:
:Reactive oxygen species (ROS) damage macromolecules and cellular components in nearly all kinds of cells and often generate toxic intracellular byproducts. In this work, aldehyde generation derived from the Escherichia coli membrane oxidation as well as membrane fatty acid profiles, protein oxidation, and bacterial resistance to oxidative stress elicitors was evaluated. Studies included wild-type cells as well as cells exhibiting a modulated monounsaturated fatty acid (MUFA) ratio. The hydroxyaldehyde 4-hydroxy 2-nonenal was found to be most likely produced by E. coli, whose levels are dependent upon exposure to oxidative stress elicitors. Aldehyde amounts and markers of oxidative damage decreased upon exposure to E. coli containing low MUFA ratios, which was paralleled by a concomitant increase in resistance to ROS-generating compounds. MUFAs ratio, lipid peroxidation, and aldehyde generation were found to be directly related; that is, the lower the MUFAs ratio, the lower the peroxide and aldehyde generation levels. These results provide additional evidence about MUFAs being targets for membrane lipid oxidation and their relevance in aldehyde generation.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Pradenas GA,Díaz-Vásquez WA,Pérez-Donoso JM,Vásquez CCdoi
10.1155/2013/563756subject
Has Abstractpub_date
2013-01-01 00:00:00pages
563756eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract::The present study was designed to evaluate the cardioprotective effect of sesamol against doxorubicin-induced cardiomyopathy in rats. In this study, the cardioprotective effect of sesamol against doxorubicin induced cardiomyopathy in experimental rats was evaluated at the dosage of 50 mg/kg bw. Doxorubicin was adminis...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/934239
更新日期:2013-01-01 00:00:00
abstract:Objectives:To evaluate the role of short-term low-dose glucocorticoids in mild COVID-19 patients. Methods:We conducted a retrospective, cross-sectional, single-center study in Kunming, China. A total of 33 mild COVID-19 cases were divided into two treatment groups (with and without glucocorticoids, methylprednisolone,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2854186
更新日期:2020-09-23 00:00:00
abstract::We discuss some aspects of the fluid dynamics of vitreous substitutes in the vitreous chamber, focussing on the flow induced by rotations of the eye bulb. We use simple, yet not trivial, theoretical models to highlight mechanical concepts that are relevant to understand the dynamics of vitreous substitutes and also to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/672926
更新日期:2014-01-01 00:00:00
abstract:Background:The aim of this study was to assess changes in skin microbiota of wrestlers during training sessions and to determine the sensitivity of hemolytic bacterial isolates to antiseptics. Methods:The main skin bacterial isolates obtained from the skin of 15 wrestlers were identified by cultivation method, with th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9843781
更新日期:2019-01-10 00:00:00
abstract::Metastasis is the leading cause of lung cancer-associated death. Downregulated expression of E-cadherin followed by epithelial-mesenchymal transition (EMT) is critical for metastasis initiation in lung cancer. BTBD7 plays essential roles in lung cancer metastasis, but the mechanisms remain unknown. This study aimed to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5937635
更新日期:2019-11-27 00:00:00
abstract::Bacterial biofilms are communities of microorganisms attached to a surface. Biofilm formation is critical not only for environmental survival but also for successful infection. Helicobacter pylori is one of the most common causes of bacterial infection in humans. Some studies demonstrated that this microorganism has b...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/914791
更新日期:2015-01-01 00:00:00
abstract::Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the co...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1462802
更新日期:2018-09-12 00:00:00
abstract::This study described a TaqMan based real-time fluorescent quantitative PCR (qPCR) method to detect porcine cytomegalovirus (PCMV) infection, targeting the conserved region of the DNA polymerase (DPOL) gene. The standard curve showed a linear regression relationship with a coefficient of 0.999 and a slope of y = -3.249...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5673145
更新日期:2020-01-10 00:00:00
abstract:Objective:This study evaluated the bioactivity and physicochemical properties of three commercial calcium silicate-based endodontic materials (MTA, EndoSequence Root Repair Material putty, and Biodentine™). Material and Methods. Horizontal sections of 3 mm thickness from 18 root canals of human teeth were subjected to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9576930
更新日期:2020-05-22 00:00:00
abstract::Glioma of infiltrative nature is challenging for surgeons to achieve tumor-specific and maximal resection. Raman spectroscopy provides structural information on the targeted materials as vibrational shifts. We utilized Raman spectroscopy to distinguish invasive tumors from normal tissues. Spectra obtained from replica...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/860241
更新日期:2014-01-01 00:00:00
abstract:Objective:It is sometimes difficult to obtain complete/partial response of large hepatocellular carcinoma (HCC) nodules by trans-arterial chemoembolization/embolization (TACE/TAE). The aim is retrospective investigation of tumor response of large HCC nodules (>7 cm) treated by the new TACE technique, repeated alternate...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9289321
更新日期:2020-01-19 00:00:00
abstract:OBJECTIVES:CD57 is normally found on NK-cells, but little is known about its expression in prostatic tissue. METHODS:We investigated CD57 expression by immunohistochemistry using tissue microarrays containing 3262 prostate cancers (PCa), lymph node metastases, and benign prostatic tissue. The results were compared wit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/356427
更新日期:2014-01-01 00:00:00
abstract::Triglyceride-glucose index (TyG index) is associated with type 2 diabetes mellitus (T2DM), but research on this relationship is limited in Japan. The purpose of this study was to evaluate the correlation between TyG index and the risk of T2DM in the Japanese population. Here, 12732 participants were selected from the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2947067
更新日期:2020-12-11 00:00:00
abstract:Introduction:Limitations in breeding source reduction practices, development of insecticide resistance in mosquitoes, and ill effects of chemical controlling methods on human and ecosystem health have motivated Sri Lankan authorities working for dengue control to seek for alternative, ecofriendly, and sustainable appro...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8759459
更新日期:2018-12-03 00:00:00
abstract::Novel and more effective treatment strategies against multiple myeloma (MM) have significantly prolonged patients' survival and raised interest in the depth of response and its association with clinical outcome. Minimal residual disease (MRD) has emerged as one of the most relevant prognostic factors in MM and should ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/832049
更新日期:2015-01-01 00:00:00
abstract::Primary open angle glaucoma (POAG) is a multifactorial disease characterized by progressive retinal ganglion cell death and visual field loss. It is known that alterations in intraocular pressure (IOP), blood pressure (BP), and ocular perfusion pressure (OPP) can play a significant role in the pathogenesis of the dise...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/141905
更新日期:2015-01-01 00:00:00
abstract::Febrile seizures (FS) are the most common neurological disorder in childhood and are a great stress for parents due to their dramatic clinical appearance. Using test for determination of homozygously recessive characteristics in humans (HRC test) we analyzed presence, distribution, and individual combination of 20 sel...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7845904
更新日期:2018-07-05 00:00:00
abstract::Following cerebral ischemia/reperfusion (I/R) injury, a series of pathophysiological processes are stimulated in both the central nervous system (CNS) and the periphery, including, but not limited to, the peripheral immune and endocrine systems and underregulation of the neuroendocrine-immune network. Glutamate (Glu) ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/6316059
更新日期:2018-07-19 00:00:00
abstract:Background:Health-related physical fitness is vital for children with intellectual and developmental disabilities (IDD) to gain healthier lives. The adapted rhythmic gymnastics (ARG) program was designed for children with IDD and is aimed at testing the effects of the exercise program on children's physical fitness. M...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2345607
更新日期:2020-08-10 00:00:00
abstract::Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long no...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/2405351
更新日期:2018-05-22 00:00:00
abstract::Studies have found that biotin favors glucose and lipid metabolism, and medications containing biotin have been developed. Despite the use of biotin as a pharmacological agent, few studies have addressed toxicity aspects including the possible interaction with cytochrome P450 enzyme family. This study analyzed the eff...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/627907
更新日期:2013-01-01 00:00:00
abstract::Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats. Three-week-old male rats were randomly divided into 2 groups: control (C; n = 14)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2494067
更新日期:2017-01-01 00:00:00
abstract::Background. Findings on the association between posttransplant anemia (PTA) and mortality in posttransplant patients are scarce. This study explored whether PTA shortly after kidney transplantation (KT) predicts mortality at up to 10 years' follow-up, stratified for chronic kidney disease (CKD) stages. Methods. PTA wa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6987240
更新日期:2017-01-01 00:00:00
abstract::A novel approach for selecting a rectangular template around periocular region optimally potential for human recognition is proposed. A comparatively larger template of periocular image than the optimal one can be slightly more potent for recognition, but the larger template heavily slows down the biometric system by ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/481431
更新日期:2013-01-01 00:00:00
abstract::In continuance of our search for anticancer agents, we report herein the synthesis and anticancer activity of some novel oxadiazole analogues. The compounds were screened for anticancer activity as per National Cancer Institute (NCI US) protocol on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and br...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/814984
更新日期:2014-01-01 00:00:00
abstract::Blood pressure is the most important, modifiable risk factor for cardiovascular diseases. Lifestyle factors and also workload are the main, potential risk factors for the development of hypertension. This study focused on the early detection of unknown hypertension by screening employees in the hotel and restaurant in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6820160
更新日期:2018-04-08 00:00:00
abstract::A role of pro- and antioxidants for reducing rectal cancer (RC) incidence in operative, preoperative, and postoperative treatments is still disputable and controversial. The redox state of venous blood and tissues of blood vessels of 60 patients with RC (T2-4N0-2M0G2) and 20 donors is studied by means of the conventio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4848652
更新日期:2018-08-13 00:00:00
abstract:Background:Sympathetic sprouting in the dorsal root ganglion (DRG) following nerve injuries had been proved to induce adult neuropathic pain. However, it is unclear whether the abnormal sprouting occurs in infant nerve injury. Methods:L5 spinal nerve ligation (SNL) or sham surgery was performed on adult rats and 10-da...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9165475
更新日期:2020-06-16 00:00:00
abstract::The impact of a premature elevation of serum progesterone level, the day of hCG administration in patients under controlled ovarian stimulation during IVF procedure, on human endometrial receptivity is still debated. In the present study, we investigated the endometrial gene expression profile shifts during the prerec...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/951937
更新日期:2014-01-01 00:00:00
abstract::The aim of this study was to develop a freeze-drying protocol facilitating successful processing of plant material containing the small surface antigen of hepatitis B virus (S-HBsAg) while preserving its VLP structure and immunogenicity. Freeze-drying of the antigen in lettuce leaf tissue, without any isolation or pur...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/485689
更新日期:2014-01-01 00:00:00