Abstract:
:Novel and more effective treatment strategies against multiple myeloma (MM) have significantly prolonged patients' survival and raised interest in the depth of response and its association with clinical outcome. Minimal residual disease (MRD) has emerged as one of the most relevant prognostic factors in MM and should be included in a new definition of complete response (CR). Although further standardization is still required, MRD monitoring should be applied in prospective clinical trials as a sensitive tool to compare and evaluate the efficacy of different treatment strategies, particularly in the consolidation and maintenance settings, and implement individualized therapy-monitoring approaches. Here, we review current definition of deep response in MM, advantages and limitations of current MRD assessment assays, clinical evidences for MRD monitoring as a prognostic tool for therapeutic decisions in MM, and challenges to develop uniform criteria for MRD monitoring.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Fulciniti M,Munshi NC,Martinez-Lopez Jdoi
10.1155/2015/832049subject
Has Abstractpub_date
2015-01-01 00:00:00pages
832049eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract::Exclusive enteral nutrition (EEN) has been proven to be effective and safe in treating pediatric Crohn's disease (CD). EEN induces pediatric CD remission possibly through three pathways: (1) direct anti-inflammatory effects, (2) improved epithelial barrier function, and (3) modulation of the gut microbiota. Recent stu...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/8102589
更新日期:2017-01-01 00:00:00
abstract::Rabbit hemorrhagic disease (RHD) is an acute, high fatal contagious disease induced by rabbit hemorrhagic disease virus (RHDV) with acute severe hepatic injury and causes huge economic loss worldwide. In order to develop an effective and reliable drug to treat this disease in clinic, a prescription formulated with bai...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5201790
更新日期:2019-04-04 00:00:00
abstract::The application of chemotherapeutic drug adriamycin (ADR) in cancer therapy is limited by its side effects like high toxicity and insolubility. Nanomedicine offers new hope for overcoming the shortcomings. But how to increase in vivo stability and to control intracellular drug release is a key issue for nano-based for...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/987404
更新日期:2015-01-01 00:00:00
abstract::The exosomes are derived from mesenchymal stem cells (MSCs) and may be potentially used as an alternative for cell therapy, for treating diabetic wounds, and aid in angiogenesis. This study, aimed to investigate whether exosomes originated from bone marrow-derived MSCs (BMSCs) preconditioned by deferoxamine (DFO-Exos)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9742765
更新日期:2019-05-05 00:00:00
abstract::Preterm birth remains the most prevalent cause of neonatal morbidity. This study aimed to evaluate the diagnostic value of SDF-1α, resistin, secretory RAGE (sRAGE), and endogenous secretory RAGE (esRAGE) in preterm labor. A total of 211 pregnant women participated in the study. Group A contained 72 women between 22 an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2719460
更新日期:2016-01-01 00:00:00
abstract::Host jump can result in deadly pandemic events when avian influenza A viruses broaden their host specificity and become able to infect mammals, including humans. Haemagglutinin-the major capsid protein in influenza A viruses-is subjected to high rate mutations, of which several occur at its "head": the receptor-bindin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3870508
更新日期:2018-05-17 00:00:00
abstract::Tuberculosis (TB) is a dangerous infectious disease characterized by a tight interplay between mycobacteria and host cells in granulomatous lesions (granulomas) during the latent, asymptomatic stage of infection. Mycobacterium-host cell relationships were analyzed in granulomas obtained from various organs of BALB/c m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/948131
更新日期:2015-01-01 00:00:00
abstract::Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth. Unfortunately, the results obtained by these studies are still contradictory. In order to bet...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/161508
更新日期:2015-01-01 00:00:00
abstract::Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potenti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6456031
更新日期:2016-01-01 00:00:00
abstract::Human liver cancer has emerged as a serious health concern in the world, associated with poorly available therapies. The Berberis genus contains vital medicinal plants with miraculous healing properties and a wide range of bioactivities. In this study, different crude extracts of B. lycium Royle were prepared and scre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8256809
更新日期:2020-10-14 00:00:00
abstract:Background:It is unclear whether computer navigation can improve the accuracy and reliability of targeted lower limb alignment correction following open-wedge high tibial osteotomy (HTO). This meta-analysis was designed to compare the accuracy and reliability of limb alignment correction between computer navigated and ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2017/3803457
更新日期:2017-01-01 00:00:00
abstract:Objective:Biomaterial research for soft tissue augmentation is an increasing topic in aesthetic medicine. Hyaluronic acid (HA) fillers are widely used for their low invasiveness and easy application to correct aesthetic defects or traumatic injuries. Some complications as acute or chronic inflammation can occur in pati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8676343
更新日期:2020-05-21 00:00:00
abstract:Background:The chromobox (CBX) proteins CBX2, CBX4, CBX6, CBX7, and CBX8, also known as Polycomb (Pc) proteins, are canonical components of the Polycomb repressive complex 1 (PRC1). Abundant evidence indicates that abnormal expression of Pc proteins is associated with a variety of tumors, but their role in the pathogen...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2019/6436825
更新日期:2019-05-09 00:00:00
abstract::Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/720514
更新日期:2013-01-01 00:00:00
abstract::Correlation of parametrized image texture features (ITF) analyses conducted in different regions of interest (ROIs) overcomes limitations and reliably reflects image quality. The aim of this study is to propose a nonparametrical method and classify the quality of a magnetic resonance (MR) image that has undergone cont...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3706581
更新日期:2019-11-20 00:00:00
abstract::Coronal decompensation is a common complication in Lenke 1 or 2 AIS patients after selective thoracic fusion (STF). However, the majority who developed immediately postoperative coronal decompensation experienced improvement and the related factors are not fully understood. The aim of this retrospective study was to i...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/3476425
更新日期:2018-12-09 00:00:00
abstract:OBJECTIVE:This study mainly aimed to explore the association between brain-derived neurotropic factor (BDNF) Val66Met polymorphism and posttraumatic stress disorder (PTSD) among flood survivors in China. METHODS:Individuals who experienced the 1998 Dongting Lake flood in Southeast Huarong, China, were enrolled in this...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/4569698
更新日期:2017-01-01 00:00:00
abstract:Background:The aims of this study were to explore the characteristics of left ventricular (LV) functional changes in subjects with or without acute mountain sickness (AMS) and their associations with AMS incidence. Methods:A total of 589 healthy men were enrolled and took a trip from Chengdu (500 m, above sea level (a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6028747
更新日期:2020-11-10 00:00:00
abstract::Uraemia and long-term peritoneal dialysis (PD) can lead to fibrotic thickening of the peritoneal membrane, which may limit its dialytic function. Peritoneal fibrosis is associated with the appearance of myofibroblasts and expansion of extracellular matrix. The extent of contribution of resident peritoneal fibroblasts ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/134708
更新日期:2015-01-01 00:00:00
abstract:Purpose:Accumulated evidence suggests that reproductive factors are related to different breast cancer subtypes, but most studies on these relationships are mainly focused on middle-aged and older patients, and it remains unclear how reproductive factors impact different subtypes of breast cancer in young women. Metho...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5931529
更新日期:2020-04-06 00:00:00
abstract::Early recovery from muscular injury is crucial for elite athletes. Hyperbaric oxygen therapy (HBOT) has been reported to be beneficial in terms of accelerating cell recovery and tissue repair, which are considered to be helpful for eliminating fatigue and recovering stamina. This study was performed to evaluate the ef...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/6289380
更新日期:2019-05-29 00:00:00
abstract::The VAD (vincristine-doxorubicin-dexamethasone) regimen has been used for decades to treat multiple myeloma (MM). Based on reports that vascular endothelial growth factor- (VEGF-) mediated angiogenesis is critical for MM pathogenesis, the antiangiogenic compound thalidomide has been added to VAD (T-VAD). However, it r...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2018/3936706
更新日期:2018-11-11 00:00:00
abstract::Aim. To explore the effects of curcumin on phosphate carrier (PiC) and its role in protection against doxorubicin induced myocyte toxicity. Methods. Using H9c2 cell line, the cardiotoxic effect of doxorubicin and its mitigation by curcumin were studied. H9c2 cells were cultured with doxorubicin and/or curcumin at vari...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1980763
更新日期:2016-01-01 00:00:00
abstract::Plantar fasciitis is a cause of chronic pain under the heel and bottom of the foot. One of the treatments to reduce pain consists of using plantar orthoses to address specific imbalances during foot placement or gait. The aim of the present study was to determine if reduction of pain with a treatment based on plantar ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/3594150
更新日期:2018-12-12 00:00:00
abstract::Nutrient overload leads to impaired muscle oxidative capacity and insulin sensitivity. However, comparative analyses of the effects of dietary manipulation on skeletal muscles with different fiber composition are lacking. This study aimed to investigate the selective adaptations in the soleus and tibialis anterior mus...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/569623
更新日期:2014-01-01 00:00:00
abstract::No pharmacological treatment is currently available to protect brain from neuronal damage after ischemic stroke. Recent studies found that enkephalin may play an important role in neuron regeneration. We assembled a homogeneous size vesicle constituted by transferrin, exosomes, and enkephalin. Immunofluorescence assay...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4273290
更新日期:2019-03-04 00:00:00
abstract::Quercetin, a natural flavonol existing in many food resources, has been reported to be an effective antimicrobial and anti-inflammatory agent for restricting the inflammation in periodontitis. In this study, we aimed to investigate the anti-inflammatory effects of quercetin on Porphyromonas gingivalis (P. gingivalis) ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6282635
更新日期:2019-08-20 00:00:00
abstract::Introduction. Given its efficacy and safety, NexoBrid™ (NXB) has become part of our therapeutic options in burns treatment with satisfactory results. However, no cost analysis comparing NXB to the standard of care (SOC) has been carried out as of today. Aim. To assess the cost of treatment with NXB and compare it to t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9567498
更新日期:2017-01-01 00:00:00
abstract::A new exopolysaccharide preparation isolated from stationary cultures of the white rot fungus Ganoderma applanatum (GpEPS) was tested in terms of its bioactive properties including its cytotoxic and immunostimulatory effect. The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/743812
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Sarcoidosis is a multisystemic granulomatous disorder characterized by multiple noncaseating granulomas involving intrathoracic lymph nodes and lung parenchyma. Recently, the use of anti-tumor necrosis factor alpha (anti-TNFα) agents has been introduced for therapy of chronic and refractory sarcoidosis wit...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/401341
更新日期:2015-01-01 00:00:00