Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer.

abstract：:Introduction. NOTCH pathway and TP53 protein are involved in the development of fibrosis and autoimmune disorders, respectively. The aim of this study was to evaluate the role of single nucleotide polymorphisms (SNPs) of NOTCH3 and TP53 genes and serum anti-TP53 antibodies with the susceptibility, clinical subset of s...

journal_title：BioMed research international

authors： Zmorzyński S,Wojcierowska-Litwin M,Kowal M,Michalska-Jakubus M,Styk W,Filip AA,Walecka I,Krasowska D

更新日期：2020-02-25 00:00:00

abstract：:In order to understand disease pathogenesis, improve medical diagnosis, or discover effective drug targets, it is important to identify significant genes deeply involved in human disease. For this purpose, many earlier approaches attempted to prioritize candidate genes using gene expression profiles or SNP genotype da...

journal_title：BioMed research international

authors： Che J,Shin M

更新日期：2015-01-01 00:00:00

abstract：AIM:To evaluate the impact of SPARC on female sexual function. METHODS:151 women with a mean age of 60 ± 11.90 and SUI had a complete urodynamic investigation and underwent SPARC operation. 98 women completed the validated female sexual function index questionnaire (FSFI) at baseline and 94 women at follow-up. A minim...

journal_title：BioMed research international

authors： Al-Ali BM,Shamloul R,Hutterer GC,Puchwein E,Pummer K,Avian A,Primus G

更新日期：2013-01-01 00:00:00

abstract：:Introduction. Luteolin, a falconoid compound in many Chinese herbs and formula, plays important roles in cardiovascular diseases. The underlying mechanism of luteolin remains to be further elaborated. Methods. A model of hydrogen peroxide- (H2O2-) induced H9C2 cells apoptosis was established. Cell viabilities were exa...

journal_title：BioMed research international

authors： Chang H,Li C,Huo K,Wang Q,Lu L,Zhang Q,Wang Y,Wang W

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to analyze periprocedural and mid-term effect of clopidogrel on platelet function using the VerifyNow P2Y12 point-of-care assay in patients undergoing TAVI. Platelet reactivity was measured at the beginning of the procedure after 300 mg clopidogrel bolus administration and during the follow-u...

journal_title：BioMed research international

authors： Tousek P,Kocka V,Sulzenko J,Bednar F,Linkova H,Widimsky P

更新日期：2013-01-01 00:00:00

abstract：Background:The aim of this article is to present a short review of noninvasive, nonpharmacological treatment methods used in somatic illnesses that fall under the umbrella of approach called behavioral medicine. Methods:The narrative review method was applied in the study. Science paper databases, including PubMed, ha...

journal_title：BioMed research international

authors： Białkowska J,Juranek J,Wojtkiewicz J

更新日期：2020-11-03 00:00:00

abstract：:Despite many advances in the diagnosis and treatment of colorectal cancer (CRC), its incidence and mortality rates continue to make an impact worldwide and in some countries rates are mounting. Over the past decade, liquid biopsies have been the object of fundamental and clinical research with regard to the different ...

journal_title：BioMed research international

authors： Christou N,Meyer J,Popeskou S,David V,Toso C,Buchs N,Liot E,Robert J,Ris F,Mathonnet M

更新日期：2019-12-04 00:00:00

abstract：:Uterine fibroids (UFs) are benign tumors of the reproductive tract, arising from smooth muscle cells of the uterus. Steroid hormones, estrogen, and progesterone are considered to be the most important links in the pathophysiology of UFs. Alpha-tocopherol (AT) is the most active form of vitamin E. What is important as ...

journal_title：BioMed research international

authors： Ciebiera M,Szymańska-Majchrzak J,Sentkowska A,Kilian K,Rogulski Z,Nowicka G,Jakiel G,Tomaszewski P,Włodarczyk M

更新日期：2018-07-24 00:00:00

abstract：:Maintaining regular blood pressure control usually requires multidrug regimens rather than monotherapy. The objective of this study was to describe the effectiveness and safety of an angiotensin-converting enzyme inhibitor and a nondihydropyridine calcium channel blocker in a single-tablet combination in patients with...

journal_title：BioMed research international

authors： Atalar E,Eskin F,Tugtekin HB,Karabulut A,Kanyilmaz S,Kirbiyik H,Ozyildiz AG

更新日期：2020-09-05 00:00:00

abstract：Background:The purpose of this study was to examine the physical activity patterns and health-related fitness levels of adolescents within the Juvenile Justice System. Methods:Participants included 68 adolescents (Mean age = 17.1 ± 1.0 years) in two secure Juvenile Justice correctional facilities in the Western USA. M...

journal_title：BioMed research international

authors： Brusseau TA,Burns RD,Hannon JC

更新日期：2018-07-15 00:00:00

abstract：:High-grade gliomas are the main cause of death in children with brain tumours. Despite recent advances in cancer therapy, their prognosis remains poor and the treatment is still challenging. To date, surgery followed by radiotherapy and temozolomide is the standard therapy. However, increasing knowledge of glioma biol...

journal_title：BioMed research international

authors： Rizzo D,Ruggiero A,Martini M,Rizzo V,Maurizi P,Riccardi R

更新日期：2015-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking, are major lung diseases affecting millions of individuals worldwide. The generated gas mixture of smoking is proved to contain about 4,500 components such as carbon monoxide, nicotine, oxidants, fine particulate matter, and aldeh...

journal_title：BioMed research international

authors： Hou W,Hu S,Li C,Ma H,Wang Q,Meng G,Guo T,Zhang J

更新日期：2019-06-24 00:00:00

abstract：:A cross-sectional study was carried out to determine the arsenic (As) and cadmium (Cd) concentrations in blood, urine, and drinking water as well as the health implications on 100 residents in an urban and a rural community. Results showed the blood As, urinary Cd, DNA damage, and water As and Cs were significantly (P...

journal_title：BioMed research international

authors： Zailina H,Najibah H,Aiezzati AN,Praveena SM,Patimah I

更新日期：2014-01-01 00:00:00

abstract：Objective:To investigate the prevalence of infections due to carbapenem-resistant Klebsiella pneumoniae (CRKP) among ICU admission patients in central China and develop a reliable prediction model. Methods:Five hundred and seven consecutive ICU admission patients with Klebsiella pneumoniae (KP) infection were enrolled...

journal_title：BioMed research international

authors： Li Y,Shen H,Zhu C,Yu Y

更新日期：2019-03-27 00:00:00

abstract：:Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb, i.e., the aetiological agent); the WHO has established this disease as high priority due to its ensuing mortality. Mtb uses a range of mechanisms for preventing its elimination by an infected host; new, viable alternatives for blocking th...

journal_title：BioMed research international

authors： Sánchez-Barinas CD,Ocampo M,Tabares L,Bermúdez M,Patarroyo MA,Patarroyo ME

更新日期：2019-04-14 00:00:00

abstract：:This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of struct...

journal_title：BioMed research international

authors： Lee C,Jia Z,Rahmatpanah F,Zhang Q,Zi X,McClelland M,Mercola D

更新日期：2014-01-01 00:00:00

abstract：:MicroRNAs (miRs) are small noncoding RNA molecules and recently have demonstrated that altered expression and functions are their tight association with ulcerative colitis (UC). Previous microarray study reported that miR-214 was downregulated in the sigmoid colon of patients with active UC, but the roles of miR-214 i...

journal_title：BioMed research international

authors： Li JA,Wang YD,Wang K,Wang ZL,Jia DY,Yang BY,Xiong CB

更新日期：2017-01-01 00:00:00

abstract：:A role of pro- and antioxidants for reducing rectal cancer (RC) incidence in operative, preoperative, and postoperative treatments is still disputable and controversial. The redox state of venous blood and tissues of blood vessels of 60 patients with RC (T2-4N0-2M0G2) and 20 donors is studied by means of the conventio...

journal_title：BioMed research international

authors： Burlaka AP,Vovk AV,Burlaka AA,Gafurov MR,Iskhakova KB,Lukin SN

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Sarcopenia is the presence of low muscle mass and low muscle function. The aim of this study was to establish cutoffs for low muscle mass using three published methods and to compare the prevalence of sarcopenia in older Australians. METHODS:Gender specific cutoffs levels were identified for low muscle mass...

journal_title：BioMed research international

authors： Yu S,Appleton S,Adams R,Chapman I,Wittert G,Visvanathan T,Visvanathan R

更新日期：2014-01-01 00:00:00

abstract：:The insula is believed to be associated with touch-evoked effects. In this work, functional MRI was applied to investigate the network model of insula function when 20 normal subjects received tactile stimulation over segregated areas. Data analysis was performed with SPM8 and Conn toolbox. Activations in the contrala...

journal_title：BioMed research international

authors： Wei P,Bao R

更新日期：2013-01-01 00:00:00

abstract：Background:Focal hyperhidrosis mostly affects the axillae, hands, feet, and face. For the management, several techniques are used. The aim of this study was to investigate the effects of direct current administration on the hyperhidrosis disease severity scale (HDSS) in patients with axillary hyperhidrosis that have va...

journal_title：BioMed research international

authors： Şener S,Karakoç Y

更新日期：2019-10-31 00:00:00

abstract：Objective:To characterize and evaluate CT and MRI features of extremity soft tissue adult fibrosarcoma. Methods:CT and MRI images from 10 adult patients with pathologically proven fibrosarcomas were retrospectively analyzed with regard to tumor location, size, number, shape, margins, attenuation, signal intensity, and...

journal_title：BioMed research international

authors： Wang H,Nie P,Dong C,Li J,Huang Y,Hao D,Xu W

更新日期：2018-03-06 00:00:00

abstract：PURPOSE:Fusarium, Aspergillus, and Dematiaceous are the most common fungal species causing keratitis in tropical countries. Herein we report a prospective study on fungal keratitis caused by these three fungal species. METHODOLOGY:A prospective investigation was undertaken to evaluate eyes with presumed fungal keratit...

journal_title：BioMed research international

authors： Gajjar DU,Pal AK,Ghodadra BK,Vasavada AR

更新日期：2013-01-01 00:00:00

abstract：:The pathogenesis of intractable epilepsy is not fully clear. In recent years, both animal and clinical trials have shown that the expression of ATP-binding cassette (ABC) transporters is increased in patients with intractable epilepsy; additionally, epileptic seizures can lead to an increase in the number of sites tha...

journal_title：BioMed research international

authors： Xiong J,Mao DA,Liu LQ

更新日期：2015-01-01 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) patients often develop bone metastases (BM), and the overall survival for these patients is usually perishing. However, a model with high accuracy for predicting the survival of NSCLC with BM is still lacking. Here, we aimed to establish a model based on artificial intelligence for p...

journal_title：BioMed research international

authors： Huang Z,Hu C,Chi C,Jiang Z,Tong Y,Zhao C

更新日期：2020-06-27 00:00:00

abstract：:High-dose melphalan (200 mg/m(2)) as conditioning regimen followed by autologous stem cell transplantation (ASCT) rescue has been established as a standard treatment for patients with multiple myeloma (MM) younger than 65 years of age. However, the role of ASCT in elderly patients older than 65 years remains controver...

journal_title：BioMed research international

authors： Ozaki S,Shimizu K

更新日期：2014-01-01 00:00:00

abstract：:This study described a TaqMan based real-time fluorescent quantitative PCR (qPCR) method to detect porcine cytomegalovirus (PCMV) infection, targeting the conserved region of the DNA polymerase (DPOL) gene. The standard curve showed a linear regression relationship with a coefficient of 0.999 and a slope of y = -3.249...

journal_title：BioMed research international

authors： Chen R,Chen Q,Wu X,Che Y,Wang C,Wang L,Yan S,Zhou L

更新日期：2020-01-10 00:00:00

abstract：Objective:ANGPTL7 is a member of the angiogenin-like protein family. Compared to other members, ANGPTL7 is the least known. Recent studies have explored the relationship between ANGPTL7 and multiple pathological processes and diseases. However, there is no research about ANGPTL7 in neonates. This study was designed to ...

journal_title：BioMed research international

authors： Xia X,Ren Z,Yan L,Zheng X,Yang H,Kang M,Yan H,Zhong Z,Xu F,Miao J,Wang J,Li Y,Wei W,Yang J

更新日期：2020-11-27 00:00:00

abstract：Background:Currently, effective genetic markers are limited to predict the clinical outcome of melanoma. High-throughput multiomics sequencing data have provided a valuable approach for the identification of genes associated with cancer prognosis. Method:The multidimensional data of melanoma patients, including clinic...

journal_title：BioMed research international

authors： Gao Y,Li Y,Niu X,Wu Y,Guan X,Hong Y,Chen H,Song B

更新日期：2020-05-08 00:00:00

abstract：:Pebisut is a biological adhesive composed of naturally occurring carbohydrates combined with zinc oxide (ZnO) initially used as a coadjutant for healing of anastomoses. Likewise some works demonstrated that carbohydrate complexes exerts anti-inflammatory activity and it is widely known that ZnO modulate inflammation. ...

journal_title：BioMed research international

authors： Moreno-Eutimio MA,Nieto-Velázquez NG,Espinosa-Monroy L,Torres-Ramos Y,Montoya-Estrada A,Cueto J,Hicks JJ,Acosta-Altamirano G

更新日期：2014-01-01 00:00:00