Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment.

Abstract:

:High-grade gliomas are the main cause of death in children with brain tumours. Despite recent advances in cancer therapy, their prognosis remains poor and the treatment is still challenging. To date, surgery followed by radiotherapy and temozolomide is the standard therapy. However, increasing knowledge of glioma biology is starting to impact drug development towards targeted therapies. The identification of agents directed against molecular targets aims at going beyond the traditional therapeutic approach in order to develop a personalized therapy and improve the outcome of pediatric high-grade gliomas. In this paper, we critically review the literature regarding the genetic abnormalities implicated in the pathogenesis of pediatric malignant gliomas and the current development of molecularly targeted therapies. In particular, we analyse the impact of molecular biology on the prognosis and treatment of pediatric high-grade glioma, comparing it to that of adult gliomas.

journal_name

Biomed Res Int

authors

Rizzo D,Ruggiero A,Martini M,Rizzo V,Maurizi P,Riccardi R

doi

10.1155/2015/215135

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

215135

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

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