Abstract:
:Approximately 40% of patients admitted to the medical intensive care unit (ICU) require mechanical ventilation. An accurate prediction of successful extubation in patients is a key clinical problem in ICU due to the fact that the successful extubation is highly associated with prolonged ICU stay. The prolonged ICU stay is also associated with increasing cost and mortality rate in healthcare system. This study is retrospective in the aspect of ICU. Hence, a total of 41 patients were selected from the largest academic medical center in Taiwan. Our experimental results show that predicting successful rate of 87.8% is obtained from the proposed predicting function. Based on several types of statistics analysis, including logistic regression analysis, discriminant analysis, and bootstrap method, three major successful extubation predictors, namely, rapid shallow breathing index, respiratory rate, and minute ventilation, are revealed. The prediction of successful extubation function is proposed for patients, ICU, physicians, and hospital for reference.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Tu CS,Chang CH,Chang SC,Lee CS,Chang CTdoi
10.1155/2018/6820975subject
Has Abstractpub_date
2018-01-04 00:00:00pages
6820975eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
杂志文章abstract::Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/905215
更新日期:2015-01-01 00:00:00
abstract:Purpose:High tibial osteotomy (HTO) has been adopted as an effective surgery for medial degeneration of the osteoarthritis (OA) knee. However, satisfactory outcomes necessitate the precise creation and distraction of osteotomized wedges and the use of intraoperative X-ray images to continually monitor the wedge-related...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9246529
更新日期:2018-05-08 00:00:00
abstract:BACKGROUND:Aquaporin (AQP) 3 and AQP 5 are involved in tumorigenesis and tumor progression of several tumor types. AIM:To investigate expression patterns and clinical significance of AQP3 and AQP5 in hepatocellular carcinoma (HCC). METHODS:Immunohistochemistry was performed to detect the expression of AQP3 and AQP5 i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/206525
更新日期:2013-01-01 00:00:00
abstract:Background:Preeclampsia (PE) is a pregnancy-specific hypertension syndrome and is one of the leading causes of maternal and perinatal morbidity and mortality. Long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in many diseases, including preeclampsia. The present study is aimed at identifying t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1673486
更新日期:2020-06-05 00:00:00
abstract::The relationship between oxidative stress and miRNA changes in placenta as a potential mechanism involved in preeclampsia (PE) is not fully elucidated. We investigated the impact of oxidative stress on miRNAs and mRNA expression profiles of genes associated with PE in villous 3A first trimester trophoblast cells expos...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/257090
更新日期:2015-01-01 00:00:00
abstract::The exosomes are derived from mesenchymal stem cells (MSCs) and may be potentially used as an alternative for cell therapy, for treating diabetic wounds, and aid in angiogenesis. This study, aimed to investigate whether exosomes originated from bone marrow-derived MSCs (BMSCs) preconditioned by deferoxamine (DFO-Exos)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9742765
更新日期:2019-05-05 00:00:00
abstract::A 35 KDa protein referred to as F3 was purified from the seeds of Borreria hispida by precipitation with 80% ammonium sulphate and gel filtration on Sephadex G-100 column. RP-HPLC analysis of protein fraction (F3) on an analytical C-18 column produced a single peak, detected at 220 nm. F3 showed an apparent molecular ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/179836
更新日期:2014-01-01 00:00:00
abstract::This study was performed to assess the efficacy and safety of a topical diclofenac solution in patients with knee osteoarthritis (OA). PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases were searched for randomized controlled trials until June 2020. The WOMAC pain, stiffness, physical function subs...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1758071
更新日期:2020-11-24 00:00:00
abstract::Peroxisome proliferators-activated receptor (PPAR) gene family members exhibit distinct patterns of distribution in tissues and differ in functions. The purpose of this study is to investigate the evolutionary impacts on diversity functions of PPAR members and the regulatory differences on gene expression patterns. 63...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/613910
更新日期:2015-01-01 00:00:00
abstract::Sericin is a natural protein component of silks of silkworm and has potential utility in multiple areas such as pharmacological, cosmetics, and biotechnological industries. However, the understanding of its toxicological safety is still limited. This study evaluated the safety of water-extract sericin from silkworm (B...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9689386
更新日期:2020-11-05 00:00:00
abstract:PURPOSE:(1) To evaluate a new acquisition protocol of (18)F-choline (FCH) PET/CT for prostate cancer patients (PC), (2) to review acquisition (18)F-choline PET/CT methodology, and (3) to propose a standardized acquisition protocol on FCH PET/CT in PC patients. MATERIALS:100 consecutive PC patients (mean age 70.5 years...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/215650
更新日期:2014-01-01 00:00:00
abstract::Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving su...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3656574
更新日期:2016-01-01 00:00:00
abstract::The ultrasound imaging is one of the most common schemes to detect diseases in the clinical practice. There are many advantages of ultrasound imaging such as safety, convenience, and low cost. However, reading ultrasound imaging is not easy. To support the diagnosis of clinicians and reduce the load of doctors, many u...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/5137904
更新日期:2018-03-04 00:00:00
abstract::Presynaptic and postsynaptic neurotoxins are proteins which act at the presynaptic and postsynaptic membrane. Correctly predicting presynaptic and postsynaptic neurotoxins will provide important clues for drug-target discovery and drug design. In this study, we developed a theoretical method to discriminate presynapti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3267325
更新日期:2017-01-01 00:00:00
abstract::Nuclear factor-kappa B (NF-κB) is the key part of multiple signal transduction of inflammation in the pathogenesis of diabetic nephropathy (DN). The ubiquitin-proteasome system is extensively involved in the regulation of the NF-κB pathway. Cylindromatosis (CYLD) has deubiquitinase activity and acts as a negative regu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3982906
更新日期:2017-01-01 00:00:00
abstract::Protein structure prediction (PSP) is computationally a very challenging problem. The challenge largely comes from the fact that the energy function that needs to be minimised in order to obtain the native structure of a given protein is not clearly known. A high resolution 20 × 20 energy model could better capture th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/924137
更新日期:2013-01-01 00:00:00
abstract:Objective:We identified differentially expressed microRNAs (DEMs) between esophageal carcinoma (ESCA) tissues and normal esophageal tissues. We then constructed a novel three-miRNA signature to predict the prognosis of ESCA patients using bioinformatics analysis. Materials and Methods. We combined two microarray profil...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5973082
更新日期:2020-02-10 00:00:00
abstract::The chromosomal changes accompanying bivalve evolution are an area about which few reports have been published. To improve our understanding on chromosome evolution in Veneridae, ribosomal RNA gene clusters were mapped by fluorescent in situ hybridization (FISH) to chromosomes of five species of venerid clams (Venerup...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/754012
更新日期:2014-01-01 00:00:00
abstract::MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes. Their deregulation is thus often causative of human malignancies, including cancers. Numerous studies have implicated microRNAs in the different steps of tumorigenesis including initiation, progression, metastasis, and ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/642916
更新日期:2014-01-01 00:00:00
abstract::RAW264.7 is a macrophage strain derived from mice tumour and shows a significant ability in antigen uptake. Real-time quantitative PCR (RT-qPCR) is one of the most commonly used methods in gene studies and requires suitable reference genes to normalize and quantitate the expression of gene of interest with sensitivity...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6131879
更新日期:2019-05-16 00:00:00
abstract::Endothelial-to-mesenchymal transition (EndMT) emerges as an important source of fibroblasts. MicroRNA let-7 exhibits anti-EndMT effects and fibroblast growth factor (FGF) receptor has been shown to be an important in microRNA let-7 expression. The endogenous antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/696475
更新日期:2014-01-01 00:00:00
abstract::Ureteroplasty using onlay grafts or flaps emerged as an innovative procedure for the management of proximal and midureteral strictures. Autologous grafts or flaps used commonly in ureteroplasty include the oral mucosae, bladder mucosae, ileal mucosae, and appendiceal mucosae. Oral mucosa grafts, especially buccal muco...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6178286
更新日期:2020-07-27 00:00:00
abstract:OBJECTIVE:Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/673018
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the value of ecological momentary assessment in evaluating physical activity among children, adolescents, and adults. It also determines whether ecological momentary assessment fulfills the criteria of validity, reliability, objectivity, norms, and standardization appli...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/915172
更新日期:2014-01-01 00:00:00
abstract:Objective:This study evaluated the bioactivity and physicochemical properties of three commercial calcium silicate-based endodontic materials (MTA, EndoSequence Root Repair Material putty, and Biodentine™). Material and Methods. Horizontal sections of 3 mm thickness from 18 root canals of human teeth were subjected to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9576930
更新日期:2020-05-22 00:00:00
abstract:Objectives:Obstructive sleep apnea (OSA) is a common disorder influenced by genetic and environmental factors. Mutations of AT-hook DNA-binding motif containing 1 (AHDC1) gene have been implicated which could cause rare syndromes presenting OSA. This study aims to investigate some rare mutations of AHDC1 in Chinese Han...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5907361
更新日期:2019-10-13 00:00:00
abstract::Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death. In this review, we first focus on colorectal carcinogenesis and on the genetic and epigenetic alterations involved...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/7354260
更新日期:2017-01-01 00:00:00
abstract::This study was undertaken to evaluate the effect of 3D printed polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) scaffold containing bone demineralized and decellularized extracellular matrix (bdECM) and human recombinant bone morphogenetic protein-2 (rhBMP-2) on bone regeneration. Scaffolds were divided into PCL/...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2876135
更新日期:2018-02-27 00:00:00
abstract::Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the co...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1462802
更新日期:2018-09-12 00:00:00
abstract::Small renal masses have been diagnosed increasingly in recent decades, allowing surgical treatment by partial nephrectomy. This treatment option is associated with better renal function preservation, in comparison with radical nephrectomy. However, for obtaining a bloodless field during surgery, occlusion of renal art...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/8575398
更新日期:2019-02-07 00:00:00