Differential expression of immunogenic proteins on virulent Mycobacterium tuberculosis clinical isolates.

Abstract:

:Molecular epidemiology has revealed that Mycobacterium tuberculosis (Mtb), formerly regarded as highly conserved species, displays a considerable degree of genetic variability that can influence the outcome of the disease as well as the innate and adaptive immune response. Recent studies have demonstrated that Mtb families found worldwide today differ in pathology, transmissibility, virulence, and development of immune response. By proteomic approaches seven proteins that were differentially expressed between a local clinical isolate from Latin-American-Mediterranean (LAM) and from Haarlem (H) lineages were identified. In order to analyze the immunogenic ability, recombinant Rv2241, Rv0009, Rv0407, and Rv2624c proteins were produced for testing specific antibody responses. We found that these proteins induced humoral immune responses in patients with drug-sensitive and drug-resistant tuberculosis with substantial cross-reactivity among the four proteins. Moreover, such reactivity was also correlated with anti-Mtb-cell surface IgM, but not with anti-ManLAM, anti-PPD, or anti-Mtb-surface IgG antibodies. Therefore, the present results describe new Mtb antigens with potential application as biomarkers of TB.

journal_name

Biomed Res Int

authors

Schierloh P,Klepp L,Vazquez C,Rocha RV,Blanco FC,Balboa L,López B,Ritacco V,Bigi F,Sasiain Mdel C

doi

10.1155/2014/741309

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

741309

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

杂志文章
  • A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain.

    abstract::Diosmin has been widely used to treat patients with vascular pain for its potent anti-inflammatory and analgesic effects. To evaluate the therapeutic effects of Diosmin in the treatment of radicular pain, we conducted an investigator-initiated, randomized, active-controlled noninferiority trial between January 1, 2009...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2017/6875968

    authors: Wang Y,Fang X,Ye L,Li Y,Shi H,Cao Y

    更新日期:2017-01-01 00:00:00

  • Modulation of the rat hepatic cytochrome P4501A subfamily using biotin supplementation.

    abstract::Studies have found that biotin favors glucose and lipid metabolism, and medications containing biotin have been developed. Despite the use of biotin as a pharmacological agent, few studies have addressed toxicity aspects including the possible interaction with cytochrome P450 enzyme family. This study analyzed the eff...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/627907

    authors: Ronquillo-Sánchez MD,Camacho-Carranza R,Fernandez-Mejia C,Hernández-Ojeda S,Elinos-Baez M,Espinosa-Aguirre JJ

    更新日期:2013-01-01 00:00:00

  • Mineral and Phytochemical Profiles and Antioxidant Activity of Herbal Material from Two Temperate Astragalus Species.

    abstract::Only a few species of the large Astragalus genus, widely used for medicinal purposes, have been thoroughly studied for phytochemical composition. The aim of our research was to investigate the rarely studied species A. glycyphyllos L. and A. cicer L. for the distribution of mineral elements and phytochemicals in whole...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6318630

    authors: Butkutė B,Dagilytė A,Benetis R,Padarauskas A,Cesevičienė J,Olšauskaitė V,Lemežienė N

    更新日期:2018-01-21 00:00:00

  • In Vivo Imaging of Neutrophil Extracellular Traps (NETs): Visualization Methods and Outcomes.

    abstract::Neutrophils comprise the first line of innate immune defense during a host-pathogen interaction. They attack microorganisms directly through three different methods, of which, phagocytosis and degranulation have been known and well-studied for decades. The formation of neutrophil extracellular traps (NETs) is the thir...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/4192745

    authors: Alasmari SZ

    更新日期:2020-02-01 00:00:00

  • Clinical evaluation of CyberKnife in the treatment of vestibular schwannomas.

    abstract:OBJECTIVE:This study assessed the posttreatment tumor control and auditory function of vestibular schwannoma (VS) patients after CyberKnife (CK) and analyzed the possible prognostic factors of hearing loss. METHODS:We retrospectively studied 117 VS patients, with Gardner-Robertson (GR) classification grades I to IV, w...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/297093

    authors: Tsai JT,Lin JW,Lin CM,Chen YH,Ma HI,Jen YM,Chen YH,Ju DT

    更新日期:2013-01-01 00:00:00

  • A neural network model can explain ventriloquism aftereffect and its generalization across sound frequencies.

    abstract::Exposure to synchronous but spatially disparate auditory and visual stimuli produces a perceptual shift of sound location towards the visual stimulus (ventriloquism effect). After adaptation to a ventriloquism situation, enduring sound shift is observed in the absence of the visual stimulus (ventriloquism aftereffect)...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/475427

    authors: Magosso E,Cona F,Ursino M

    更新日期:2013-01-01 00:00:00

  • Microelectrical Impedance Spectroscopy for the Differentiation between Normal and Cancerous Human Urothelial Cell Lines: Real-Time Electrical Impedance Measurement at an Optimal Frequency.

    abstract:PURPOSE:To distinguish between normal (SV-HUC-1) and cancerous (TCCSUP) human urothelial cell lines using microelectrical impedance spectroscopy (μEIS). MATERIALS AND METHODS:Two types of μEIS devices were designed and used in combination to measure the impedance of SV-HUC-1 and TCCSUP cells flowing through the channe...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8748023

    authors: Park Y,Kim HW,Yun J,Seo S,Park CJ,Lee JZ,Lee JH

    更新日期:2016-01-01 00:00:00

  • Ten-Year Surgical Outcomes and Prognostic Factors for French-Door Laminoplasty in the Treatment of Multilevel Cervical Spondylotic Myelopathy.

    abstract:Objective:To analyze the ten-year surgical outcomes and postoperative complications of French-Door laminoplasty (FDL) in the management of multilevel cervical spondylotic myelopathy (MCSM) and analyze the prognostic factors for FDL in treating MCSM. Methods:64 patients with MCSM, who were operated by FDL, were include...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3627071

    authors: Chen G,Liu X,Chen N,Chen B,Zou X,Wei F,Liu S

    更新日期:2020-05-06 00:00:00

  • Evaluation of granulocyte colony-stimulating factor effects on treatment-resistant thin endometrium in women undergoing in vitro fertilization.

    abstract::The aim of the study was to assess the granulocyte colony-stimulating factor (G-CSF) effects on unresponsive thin (<7 mm) endometrium in women undergoing in vitro fertilization (IVF). We included thirty-seven subjects who had thin unresponsive endometrium on the day of triggering ovulation. These patients also failed ...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2014/913235

    authors: Kunicki M,Łukaszuk K,Woclawek-Potocka I,Liss J,Kulwikowska P,Szczyptańska J

    更新日期:2014-01-01 00:00:00

  • Mean 5-year clinical and radiographic outcomes of cementless total hip arthroplasty in patients under the age of 30.

    abstract::We performed a retrospective review of 40 consecutive modern cementless THAs with 65-month mean followup in 34 patients under the age of 30 primarily for diagnoses other than inflammatory arthritis. We found acceptable functional improvement and radiographic outcomes at mean 5-year followup. We found a high transfusio...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/649506

    authors: Gililland JM,Anderson LA,Erickson J,Pelt CE,Peters CL

    更新日期:2013-01-01 00:00:00

  • Specific Binding Peptides from Rv3632: A Strategy for Blocking Mycobacterium tuberculosis Entry to Target Cells?

    abstract::Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb, i.e., the aetiological agent); the WHO has established this disease as high priority due to its ensuing mortality. Mtb uses a range of mechanisms for preventing its elimination by an infected host; new, viable alternatives for blocking th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/8680935

    authors: Sánchez-Barinas CD,Ocampo M,Tabares L,Bermúdez M,Patarroyo MA,Patarroyo ME

    更新日期:2019-04-14 00:00:00

  • Circulating microRNAs and kallikreins before and after radical prostatectomy: are they really prostate cancer markers?

    abstract::The aim of our study was to monitor serum levels of two miRNAs (miR-21 and miR-141) and three KLKs (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy, in order to characterize their fluctuations after surgery. 38 patients with prostate cancer were included. miR-21 and miR-141 were quant...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/241780

    authors: Egidi MG,Cochetti G,Serva MR,Guelfi G,Zampini D,Mechelli L,Mearini E

    更新日期:2013-01-01 00:00:00

  • Characterization Method for 3D Substructure of Nuclear Cell Based on Orthogonal Phase Images.

    abstract::A set of optical models associated with blood cells are introduced in this paper. All of these models are made up of different parts possessing symmetries. The wrapped phase images as well as the unwrapped ones from two orthogonal directions related to some of these models are obtained by simulation technique. Because...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/917640

    authors: Ji Y,Liang M,Hua T,Xu Y,Xin Z,Wang Y

    更新日期:2015-01-01 00:00:00

  • The role of oxidative stress and inflammation in cardiovascular aging.

    abstract::Age is an independent risk factor of cardiovascular disease, even in the absence of other traditional factors. Emerging evidence in experimental animal and human models has emphasized a central role for two main mechanisms of age-related cardiovascular disease: oxidative stress and inflammation. Excess reactive oxygen...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/615312

    authors: Wu J,Xia S,Kalionis B,Wan W,Sun T

    更新日期:2014-01-01 00:00:00

  • Novel insights on nutrient management of sarcopenia in elderly.

    abstract::Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of muscle mass and strength. The more rationale approach to delay the progression of sarcopenia is based on the combination of proper nutrition, possibly associated with the use of dietary supplements and a regular exercise program. ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/524948

    authors: Rondanelli M,Faliva M,Monteferrario F,Peroni G,Repaci E,Allieri F,Perna S

    更新日期:2015-01-01 00:00:00

  • The Prevalence and Replication Capacity of a Tibetan Dominant HBV Strain, C/D Recombinant.

    abstract::This study aimed to estimate the distribution of hepatitis B virus (HBV) C/D recombinant in Han and Tibet patients with chronic hepatitis B (CHB) and then learn such strain's replication capacity in vivo. A total of 331 serum samples were collected from Han outpatients from Sichuan Province and Tibetan outpatients fro...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/8415907

    authors: Du L,Liu M,Liu M,Zhou T,Cheng X,Liu C,Tang H

    更新日期:2017-01-01 00:00:00

  • Identification of Candidate Genes and MicroRNAs for Acute Myocardial Infarction by Weighted Gene Coexpression Network Analysis.

    abstract:Background:Identification of potential molecular targets of acute myocardial infarction is crucial to our comprehensive understanding of the disease mechanism. However, studies of gene coexpression analysis via jointing multiple microarray data of acute myocardial infarction still remain restricted. Methods:Microarray...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5742608

    authors: Li Y,He XN,Li C,Gong L,Liu M

    更新日期:2019-02-11 00:00:00

  • Effect of Chronic Kidney Disease on Changes in Vasopressin System Expression in the Kidney Cortex in Rats with Nephrectomy.

    abstract::It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy. The study was performed on 4 groups of Sprague ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2607928

    authors: Czarzasta K,Cudnoch-Jedrzejewska A,Niemczyk L,Wrzesien R,Tkaczyk M,Puchalska L,Saracyn M,Zmudzki W,Niemczyk S

    更新日期:2018-06-14 00:00:00

  • Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis.

    abstract::Natural products are valuable sources for drug discovery because they have a wide variety of useful chemical components and biological properties. A quick reevaluation of the potential therapeutic properties of established natural products was made possible by the recent development of the methodology and improvement ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6716547

    authors: Jeon YJ,Shin JI,Lee S,Lee YG,Kim JB,Kwon HC,Kim SH,Kim I,Lee K,Han YS

    更新日期:2018-08-01 00:00:00

  • Biochemical and Molecular Phylogenetic Study of Agriculturally Useful Association of a Nitrogen-Fixing Cyanobacterium and Nodule Sinorhizobium with Medicago sativa L.

    abstract::Seed inoculation with bacterial consortium was found to increase legume yield, providing a higher growth than the standard nitrogen treatment methods. Alfalfa plants were inoculated by mono- and binary compositions of nitrogen-fixing microorganisms. Their physiological and biochemical properties were estimated. Inocul...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/202597

    authors: Karaushu EV,Lazebnaya IV,Kravzova TR,Vorobey NA,Lazebny OE,Kiriziy DA,Olkhovich OP,Taran NY,Kots SY,Popova AA,Omarova E,Koksharova OA

    更新日期:2015-01-01 00:00:00

  • Chronic traumatic encephalopathy and suicide: a systematic review.

    abstract::Traumatic brain injury (TBI) is a global health concern, and the recent literature reports that a single mild TBI can result in chronic traumatic encephalopathy (CTE). It has been suggested that CTE may lead to death by suicide, raising important prevention, treatment, and policy implications. Thus, we conducted a sys...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2013/424280

    authors: Wortzel HS,Shura RD,Brenner LA

    更新日期:2013-01-01 00:00:00

  • Effects of Direct Current Administration on Hyperhidrosis Disease Severity Scale in Patients with Axillary Hyperhidrosis.

    abstract:Background:Focal hyperhidrosis mostly affects the axillae, hands, feet, and face. For the management, several techniques are used. The aim of this study was to investigate the effects of direct current administration on the hyperhidrosis disease severity scale (HDSS) in patients with axillary hyperhidrosis that have va...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2019/3232015

    authors: Şener S,Karakoç Y

    更新日期:2019-10-31 00:00:00

  • Spider silk as guiding biomaterial for human model neurons.

    abstract::Over the last years, a number of therapeutic strategies have emerged to promote axonal regeneration. An attractive strategy is the implantation of biodegradable and nonimmunogenic artificial scaffolds into injured peripheral nerves. In previous studies, transplantation of decellularized veins filled with spider silk f...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/906819

    authors: Roloff F,Strauß S,Vogt PM,Bicker G,Radtke C

    更新日期:2014-01-01 00:00:00

  • Progesterone and mental rotation task: is there any effect?

    abstract::Mental rotation task (MRT) incorporates elements of spatial abilities, important in many professions, with people of both genders involved. Importantly, these are the areas where spatial tasks might be performed for long time periods; thus adverse effects of mental fatigue are highly unwanted. Substantial variation of...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/741758

    authors: Noreika D,Griškova-Bulanova I,Alaburda A,Baranauskas M,Grikšienė R

    更新日期:2014-01-01 00:00:00

  • Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neuroendocrine Tumors (ROHHADNET) Syndrome: A Systematic Review.

    abstract:Background and Aim:ROHHADNET (rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, neuroendocrine tumor) syndrome is a rare disease with grave outcome. Although early recognition is essential, prompt diagnosis may be challenging due to its extreme rarity. This study aimed to systematically r...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/1250721

    authors: Lee JM,Shin J,Kim S,Gee HY,Lee JS,Cha DH,Rim JH,Park SJ,Kim JH,Uçar A,Kronbichler A,Lee KH,Shin JI

    更新日期:2018-11-21 00:00:00

  • Prediction and Prevention of Acute Kidney Injury after Cardiac Surgery.

    abstract::The incidence of acute kidney injury after cardiac surgery (CS-AKI) ranges from 33% to 94% and is associated with a high incidence of morbidity and mortality. The etiology is suggested to be multifactorial and related to almost all aspects of perioperative management. Numerous studies have reported the risk factors an...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/2985148

    authors: Shin SR,Kim WH,Kim DJ,Shin IW,Sohn JT

    更新日期:2016-01-01 00:00:00

  • The importance of the ionic product for water to understand the physiology of the acid-base balance in humans.

    abstract::Human plasma is an aqueous solution that has to abide by chemical rules such as the principle of electrical neutrality and the constancy of the ionic product for water. These rules define the acid-base balance in the human body. According to the electroneutrality principle, plasma has to be electrically neutral and th...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/695281

    authors: Adeva-Andany MM,Carneiro-Freire N,Donapetry-García C,Rañal-Muíño E,López-Pereiro Y

    更新日期:2014-01-01 00:00:00

  • HIV risk perception among HIV negative or status-unknown men who have sex with men in China.

    abstract:OBJECTIVE:To evaluate HIV risk perception and its associated factors among Chinese MSM. METHODS:A cross-sectional study was conducted among MSM with an HIV negative or unknown status in Beijing, China, between 2011 and 2012. A questionnaire interview was conducted and a blood sample was collected for HIV and syphilis ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/232451

    authors: Fan W,Yin L,Qian HZ,Li D,Shao Y,Vermund SH,Ruan Y,Zhang Z

    更新日期:2014-01-01 00:00:00

  • MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39.

    abstract::Emerging evidence shows that microRNAs (miRNAs) play important roles in the regulation of various biological and pathologic processes in human cancers and the aberrant expression of miRNAs contributes to the tumor development. In this study, our findings indicate that miR-451 is significantly overexpressed in pancreat...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2381482

    authors: Guo R,Gu J,Zhang Z,Wang Y,Gu C

    更新日期:2017-01-01 00:00:00

  • Longitudinal Patterns of Stability and Change in Tenacious Goal Pursuit and Flexible Goal Adjustment among Older People over a 9-Year Period.

    abstract::Using the dual-process model of assimilative-tenacity (TGP) and accommodative-flexibility (FGA), the study aims to identify trajectories of TGP and FGA over five time points within a 9-year period, explore the relationships between the trajectories of TGP and FGA, and explore if participants from distinct TGP and FGA ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/8017541

    authors: Martinent G,Bailly N,Ferrand C,Gana K,Giraudeau C,Joulain M

    更新日期:2017-01-01 00:00:00