Abstract:
Objective:To investigate the prevalence of infections due to carbapenem-resistant Klebsiella pneumoniae (CRKP) among ICU admission patients in central China and develop a reliable prediction model. Methods:Five hundred and seven consecutive ICU admission patients with Klebsiella pneumoniae (KP) infection were enrolled in this retrospective multicenter case-control study from January 2014 to June 2018. The prevalence and antimicrobial susceptibility pattern were analyzed. Multivariate analysis was performed by logistic regression modeling to determine the risk factors. A prediction model was developed and verified using data from six hospitals in central China. Results:Of the total 507 isolates of KP, 244 (48.1%) strains were carbapenem resistant. The majority of these isolates were from sputum (30.9%) and blood (20.9%) samples. Tigecycline had good activity against CRKP (95.5%). The most common sequence type (ST) of CRKP was ST11 (84.4%), and 98.6% of them had the blaKPC-2 antimicrobial resistance gene. Thirteen variables were identified as independent risk factors for CRKP infection, including KP colonization or infection in the preceding year (OR=3.32, 95% CI 2.01-4.38), CD4/CD8 ratio <1 (OR=2.98, 95% CI 2.02-4.19), and parenteral nutrition ⩾48 h (OR=1.88, 95% CI 1.22-3.04). The model developed to predict CRKP infection was effective, with an area under the receiver-operating characteristic curve of 0.854 (95% CI 0.821-0.884, p<0.001). Conclusions:ST11 carrying the blaKPC-2 antimicrobial resistance gene was the most common type of CRKP among the ICU admission patients in central China. The model demonstrated excellent predictive performance and exhibited good discrimination.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Li Y,Shen H,Zhu C,Yu Ydoi
10.1155/2019/9767313subject
Has Abstractpub_date
2019-03-27 00:00:00pages
9767313eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章abstract::Porcine circovirus virus type II (PCV2) is the etiology of postweaning multisystemic wasting syndrome (PMWS), porcine dermatitis, nephropathy syndrome (PDNS), and necrotizing pneumonia. Rapid diagnosis tool for detection of PCV2 plays an important role in the disease control and eradication program. Recombinase polyme...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8403642
更新日期:2017-01-01 00:00:00
abstract::MicroRNAs (miRs) are small noncoding RNA molecules and recently have demonstrated that altered expression and functions are their tight association with ulcerative colitis (UC). Previous microarray study reported that miR-214 was downregulated in the sigmoid colon of patients with active UC, but the roles of miR-214 i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8524972
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/810734
更新日期:2013-01-01 00:00:00
abstract:Objective:To investigate the effects of arteriovenous thrombolysis combined with mechanical thrombectomy on clinical efficacy, neurological function, and the changes of nerve injury markers of acute cerebral infarct (ACI) patients. Methods:A total of 143 cases with ACI admitted to our hospital from June 2017 to June 2...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9743075
更新日期:2020-10-09 00:00:00
abstract::Detection of single based genetic mutation by using oligonucleotide probes is one of the common methods of detecting single nucleotide polymorphisms at known loci. In this paper, we demonstrated a hybridization system which included a buffer solution that produced selective salt-induced effect and a locked nucleic aci...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/391070
更新日期:2015-01-01 00:00:00
abstract::We developed a new product called titanium-prepared platelet-rich fibrin (T-PRF). The T-PRF method is based on the hypothesis that titanium may be more effective in activating platelets than the silica activators used with glass tubes in Chouckroun's leukocyte- and platelet-rich fibrin (L-PRF) method. In this study, w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/209548
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/2139834
更新日期:2019-11-26 00:00:00
abstract:Objective:It is sometimes difficult to obtain complete/partial response of large hepatocellular carcinoma (HCC) nodules by trans-arterial chemoembolization/embolization (TACE/TAE). The aim is retrospective investigation of tumor response of large HCC nodules (>7 cm) treated by the new TACE technique, repeated alternate...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9289321
更新日期:2020-01-19 00:00:00
abstract::Nowadays, several screening strategies are available to prevent cervical cancer, but inadequate resources, sociocultural barriers, and sampling issues impede their success in low-income countries. To overcome these issues, this study aimed to evaluate the performance of human papillomavirus (HPV) testing from dried ur...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/283036
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/5926470
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8052143
更新日期:2020-08-13 00:00:00
abstract::Healthcare professionals undergo high levels of occupational stress as a result of their working conditions. Thus, the aim of this study is to develop a model that focuses on healthcare professionals so as to analyze the influence that job demands, control, social support, and recognition have on the likelihood that a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4673047
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9065181
更新日期:2018-09-24 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6352858
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/3691913
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1395304
更新日期:2020-11-09 00:00:00
abstract::Long-term application and extensive use of synthetic insecticides have resulted in accumulating their residues in food, milk, water, and soil and cause adverse health effects to human and ecosystems. Therefore, application of natural insecticides in agriculture and public health sectors has been increased as alternati...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/4308054
更新日期:2018-10-16 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/627126
更新日期:2014-01-01 00:00:00
abstract::In this paper, differences between multichannel EEG signals of artists and nonartists were analyzed during visual perception and mental imagery of some paintings and at resting condition using approximate entropy (ApEn). It was found that ApEn is significantly higher for artists during the visual perception and the me...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/764382
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8812974
更新日期:2020-11-22 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/648040
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/754012
更新日期:2014-01-01 00:00:00
abstract:Purpose:To evaluate the diagnostic performance of deep learning with a multichannel fusion three-dimensional convolutional neural network (MCF-3DCNN) in the differentiation of the pathologic grades of hepatocellular carcinoma (HCC) based on dynamic contrast-enhanced magnetic resonance images (DCE-MR images). Methods a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9783106
更新日期:2019-04-28 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/6258248
更新日期:2019-06-13 00:00:00
abstract:Background:To improve the efficacy of regenerative treatment for gingival recessions, the autologous platelet concentrates (APCs) combined with coronally advanced flap (CAF) have been investigated. However, few studies systematically assess the complementary effect of APCs in periodontal regeneration. The present study...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/2587245
更新日期:2019-07-25 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/651879
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/896432
更新日期:2015-01-01 00:00:00
abstract::This study described a TaqMan based real-time fluorescent quantitative PCR (qPCR) method to detect porcine cytomegalovirus (PCMV) infection, targeting the conserved region of the DNA polymerase (DPOL) gene. The standard curve showed a linear regression relationship with a coefficient of 0.999 and a slope of y = -3.249...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5673145
更新日期:2020-01-10 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8273581
更新日期:2018-12-27 00:00:00
abstract::The epilepsies are a heterogeneous group of neurological disorders and syndromes characterised by recurrent, involuntary, paroxysmal seizure activity, which is often associated with a clinicoelectrical correlate on the electroencephalogram. The diagnosis of epilepsy is usually made by a neurologist but can be difficul...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/986736
更新日期:2015-01-01 00:00:00