Abstract:
:The aim of this study was to analyze periprocedural and mid-term effect of clopidogrel on platelet function using the VerifyNow P2Y12 point-of-care assay in patients undergoing TAVI. Platelet reactivity was measured at the beginning of the procedure after 300 mg clopidogrel bolus administration and during the follow-up (at 1 month after the procedure) in 52 patients undergoing TAVI using the Medtronic CoreValve prosthesis (Medtronic CoreValve). A cutoff value of 240 PRU was used to identify nonresponders to clopidogrel treatment with high residual platelet reactivity (HRPR). Baseline HRPR was identified in 80% of patients and in 72% of patients during 6-month follow-up. There was no significant difference in the pharmacodynamic effects of clopidogrel on platelet reactivity from baseline to 6-months follow-up (297 ± 57 vs. 275 ± 62; P = 0.058). Ischemic event occurred only in 3 patients (5.8%) from the study group. In conclusion, majority of patients undergoing TAVI had high residual platelet reactivity after pretreatment with 300 mg of clopidogrel and during the 6-month follow-up at dual antiplatelet treatment. The noneffectiveness of clopidogrel in the TAVI population raises the question of the routine use of dual antiplatelet treatment in this setting.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Tousek P,Kocka V,Sulzenko J,Bednar F,Linkova H,Widimsky Pdoi
10.1155/2013/386074subject
Has Abstractpub_date
2013-01-01 00:00:00pages
386074eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract::Rabbit hemorrhagic disease (RHD) is an acute, high fatal contagious disease induced by rabbit hemorrhagic disease virus (RHDV) with acute severe hepatic injury and causes huge economic loss worldwide. In order to develop an effective and reliable drug to treat this disease in clinic, a prescription formulated with bai...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5201790
更新日期:2019-04-04 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2013/878374
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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更新日期:2020-03-23 00:00:00
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doi:10.1155/2014/261745
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7279036
更新日期:2018-07-26 00:00:00
abstract:Background:Statins are commonly used in the secondary prevention of coronary artery disease. Studies have shown that the rate of statin use is low among patients with coronary artery disease. In this study, we aimed to investigate the reasons for poor patient compliance with statin treatment. Methods:A total of 504 pa...
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doi:10.1155/2018/8961690
更新日期:2018-06-07 00:00:00
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pub_type: 杂志文章
doi:10.1155/2016/6068437
更新日期:2016-01-01 00:00:00
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doi:10.1155/2020/1395304
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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doi:10.1155/2020/1487593
更新日期:2020-10-17 00:00:00
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pub_type: 杂志文章
doi:10.1155/2016/9612437
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/642063
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4628592
更新日期:2016-01-01 00:00:00
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更新日期:2018-03-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00