Abstract:
:Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking, are major lung diseases affecting millions of individuals worldwide. The generated gas mixture of smoking is proved to contain about 4,500 components such as carbon monoxide, nicotine, oxidants, fine particulate matter, and aldehydes. These components were considered to be the principle factor driving the pathogenesis and progression of pulmonary disease. A large proportion of lung cancer patients showed a history of COPD, which demonstrated that there might be a close relationship between COPD and lung cancer. In the early stages of smoking, lung barrier provoked protective response and DNA repair are likely to suppress these changes to a certain extent. In the presence of long-term smoking exposure, these mechanisms seem to be malfunctioned and lead to disease progression. The infiltration of inflammatory cells to mucosa, submucosa, and glandular tissue caused by inhaled cigarette smoke is responsible for the destruction of matrix, blood supply shortage, and epithelial cell death. Conversely, cancer cells have the capacity to modulate the proliferation of epithelial cells and produce of new vascular networks. Comprehension understanding of mechanisms responsible for both pathologies is necessary for the prevention and treatment of COPD and lung cancer. In this review, we will summarize related articles and give a glance of possible mechanism between cigarette smoking induced COPD and lung cancer.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Hou W,Hu S,Li C,Ma H,Wang Q,Meng G,Guo T,Zhang Jdoi
10.1155/2019/2025636subject
Has Abstractpub_date
2019-06-24 00:00:00pages
2025636eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章,评审abstract:Purpose:To investigate the pachymetry distribution of central cornea and morphologic changes in subclinical keratoconus with normal biomechanics and determine their potential benefit for the screening of very early keratoconus. Methods:This retrospective comparative study was performed in 33 clinically unaffected eyes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1748579
更新日期:2019-11-19 00:00:00
abstract:OBJECTIVE:Fever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/939783
更新日期:2015-01-01 00:00:00
abstract::Tumourigenesis is a mutation accumulation process, which is likely to start with a mutated founder cell. The evolutionary nature of tumor development makes phylogenetic models suitable for inferring tumor evolution through genetic variation data. Copy number variation (CNV) is the major genetic marker of the genome wi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5482750
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/1953076
更新日期:2017-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the first most common neurodegenerative disease. Despite a large amount of research, the pathogenetic mechanism of AD has not yet been clarified. The two hallmarks of the pathology of AD are the extracellular senile plaques (SPs) of aggregated amyloid-beta (Aβ) peptide and the accumulation ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/796869
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abstract::Cystic change in metastatic lymph nodes of papillary thyroid carcinoma (PTC) is a diagnostic challenge for fine needle aspiration (FNA) because of the scant cellularity. The aim of this study was to evaluate the measurement of thyroglobulin in fine needle aspirate (Tg-FNA) for detecting metastatic PTC in patients with...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8905916
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2536272
更新日期:2020-05-02 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8582901
更新日期:2018-05-02 00:00:00
abstract::The current data are still inconclusive in terms of a genetic component involved in the susceptibility to renal cell carcinoma. Our aim was to evaluate 40 selected candidate polymorphisms for potential association with clear cell renal cell carcinoma (ccRCC) based on independent group of 167 patients and 200 healthy c...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/860405
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abstract::Macleaya cordata extract is of great scientific and practical interest to researchers, due to its antimicrobial and anti-inflammatory responses within experimental animals. This study was designed to determine the diarrhea score and innate immunity of growing piglets after they had received Macleaya cordata extract su...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1069585
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:In order to establish inspection routines for individual intraocular lenses (IOLs), their surfaces have to be measured separately. Currently available measurement devices lack this functionality. The purpose of this study is to evaluate a new topography measurement device based on wavefront analysis for measuri...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/363742
更新日期:2013-01-01 00:00:00
abstract::Giardia duodenalis is a small intestinal protozoan parasite of several terrestrial vertebrates. This work aims to assess the genotypic variability of Giardia duodenalis isolates from cattle, sheep and pigs in the Southeast of Brazil, by comparing the standard characterization between glutamate dehydrogenase (gdh) and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/875048
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:The aim of this study is to describe the robotic assisted transfer device (RATD) and an initial focus group evaluation by end users. The purpose of the device is to aid in the transfers of people with disabilities to and from their electric powered wheelchair (EPW) onto other surfaces. The device can be used fo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/198476
更新日期:2015-01-01 00:00:00
abstract::Coronary CT angiography (CCTA) has become an important noninvasive imaging modality in the diagnosis of coronary artery disease (CAD). CCTA enables accurate evaluation of coronary artery stenosis. However, CCTA provides limited information on the physiological significance of stenotic lesions. A noninvasive "one-stop-...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/435737
更新日期:2015-01-01 00:00:00
abstract::The pathogenesis of intractable epilepsy is not fully clear. In recent years, both animal and clinical trials have shown that the expression of ATP-binding cassette (ABC) transporters is increased in patients with intractable epilepsy; additionally, epileptic seizures can lead to an increase in the number of sites tha...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/194541
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5246350
更新日期:2020-02-27 00:00:00
abstract::Circulating cell-free DNA has been recognized as an accurate marker for the diagnosis of prostate cancer, whereas the role of urine cell-free DNA (UCF DNA) has never been evaluated in this setting. It is known that normal apoptotic cells produce highly fragmented DNA while cancer cells release longer DNA. We thus veri...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/270457
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Varicocele is associated with high levels of DNA damage in spermatozoa due to oxidative stress and elevated levels of sperm DNA fragmentation, which has been currently proposed to be an essential additional diagnostic test to be recommended for patients with clinical varicocele. The aim of this study was to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/695713
更新日期:2014-01-01 00:00:00
abstract::Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The h...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/236745
更新日期:2015-01-01 00:00:00
abstract::In consequence of the key role of factor Xa in the clotting cascade and absence of its activity in the processes that do not affect coagulation, this protein is an attractive target for development of new blood coagulation inhibitors. Factor Xa is more effective and convenient target for creation of anticoagulants tha...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/120802
更新日期:2015-01-01 00:00:00
abstract::The mycotoxin zearalenone (ZEN) is a frequent contaminant of animal feeds, but its effects on fish have not yet been investigated extensively. In order to fill this gap a feeding trial with juvenile carp was conducted. Three groups of fish were fed feeds contaminated with ZEN at three concentrations (low: 332 μg kg(-1...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/420702
更新日期:2015-01-01 00:00:00
abstract::Stem cell implantation has been utilized for the repair of spinal cord injury; however, it shows unsatisfactory performance in repairing large scale lesion of an organ. We hypothesized that dental follicle cells (DFCs), which possess multipotential capability, could reconstruct spinal cord defect (SCD) in combination ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/197183
更新日期:2015-01-01 00:00:00
abstract::Previous studies have shown the therapeutic properties of ginseng and ginsenosides on hyperactive and impulsive behaviors in several psychiatric diseases. Herein, we investigated the effect of Panax ginseng Meyer (PG) on hyperactive/impulsive behaviors in a manic-like animal model, sleep deprivation (SD) rats. Male ra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3636874
更新日期:2020-10-17 00:00:00
abstract::A large number of occupational exposure limit values (OELs) are based on avoiding of sensory irritation of the eyes and the upper respiratory tract. In order to investigate the chemosensory effect range of a chemical, odor and sensory irritation thresholds (lateralization thresholds, LTs) can be assessed. Humidity aff...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/6015761
更新日期:2016-01-01 00:00:00
abstract::This study was performed to assess the efficacy and safety of a topical diclofenac solution in patients with knee osteoarthritis (OA). PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases were searched for randomized controlled trials until June 2020. The WOMAC pain, stiffness, physical function subs...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1758071
更新日期:2020-11-24 00:00:00
abstract::The quantitative and reproducible analysis of the standard body movement in Tai Chi Chuan (TCC) was performed in this study. We aimed to provide a reference of the upper extremities for standardizing TCC practice. Microsoft Kinect was used to record the motion during the practice of TCC. The preparation form and eight...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2538765
更新日期:2018-01-29 00:00:00
abstract::The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field and made it possible to carry out functional studies on model organisms. Insects including Drosophila are classical and still popular models to study autophagy, starting from the 1960s. This rev...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/273473
更新日期:2014-01-01 00:00:00
abstract::Understanding the mechanism behind the structure of the internal cellular clock can lead to advances in the knowledge of origins of pairs of monozygotic twins and higher order multiples as well as other biological phenomena. To gain insight into this mechanism, we analyze possible cell labeling schemes that model an o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/628092
更新日期:2015-01-01 00:00:00
abstract::Panax ginseng Meyer, a valuable medicinal plant, is severely threatened by rusty root, a condition that greatly affects its yield and quality. Studies investigating the relationship between soil microbial community composition and rusty roots are vital for the production of high-quality ginseng. Here, high-throughput ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8018525
更新日期:2020-01-15 00:00:00
abstract::Selenium is an essential trace element, which has certain antioxidant properties. Na2SeO3 is toxic, and its use is limited. SeMet, as an organic selenium, is less toxic than Na2SeO3. In this experiment, different concentrations of Na2SeO3 and SeMet were added to MEA and PDA media to observe the effect of selenium on t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2368245
更新日期:2020-04-26 00:00:00