Potent anti-inflammatory activity of carbohydrate polymer with oxide of zinc.

Abstract:

:Pebisut is a biological adhesive composed of naturally occurring carbohydrates combined with zinc oxide (ZnO) initially used as a coadjutant for healing of anastomoses. Likewise some works demonstrated that carbohydrate complexes exerts anti-inflammatory activity and it is widely known that ZnO modulate inflammation. However, the direct effects of Pebisut on isolated cells and acute inflammatory responses remained to be investigated. The present study evaluated anti-inflammatory effect of Pebisut using lipopolysaccharide (LPS) stimulated human mononuclear cells, chemotaxis, and cell infiltration in vivo in a murine model of peritonitis. Our data show that human cells treated with different dilutions of Pebisut release less IL-6, IL-1 β , and IL-8 after LPS stimuli compared with the control treated cells. In addition, Pebisut lacked chemotactic activity in human mononuclear cells but was able to reduce chemotaxis towards CCL2, CCL5, and CXCL12 that are representative mononuclear cells chemoattractants. Finally, in a murine model of peritonitis, we found less number of macrophages (F4/80(+)) and T lymphocytes (CD3(+)) in peritoneal lavages from animals treated with Pebisut. Our results suggest that Pebisut has anti-inflammatory activity, which might have a beneficial effect during anastomoses healing or wounds associated with excessive inflammation.

journal_name

Biomed Res Int

authors

Moreno-Eutimio MA,Nieto-Velázquez NG,Espinosa-Monroy L,Torres-Ramos Y,Montoya-Estrada A,Cueto J,Hicks JJ,Acosta-Altamirano G

doi

10.1155/2014/712312

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

712312

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

临床试验,杂志文章
  • Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-β and IGF signaling.

    abstract::This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of struct...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/502093

    authors: Lee C,Jia Z,Rahmatpanah F,Zhang Q,Zi X,McClelland M,Mercola D

    更新日期:2014-01-01 00:00:00

  • Palmar Ulnar Artery Perforator Free Flap for Fingertip Reconstruction: Anatomical and Clinical Study.

    abstract:Background:Fingertips are a common site for hand injuries. The ideal substitute for fingertip pulp is tissue that matches texturally with minimal donor site morbidity. We described anatomical findings from cadaveric studies and the reliability of the palmar ulnar artery perforator (PUAP) free flap techniques for the re...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2862879

    authors: Pak CS,Jeon JI,Myung Y,Lee YK,Kim BJ,Jeong JH,Kim BK

    更新日期:2018-05-09 00:00:00

  • Automatic detection and quantification of acute cerebral infarct by fuzzy clustering and histographic characterization on diffusion weighted MR imaging and apparent diffusion coefficient map.

    abstract::Determination of the volumes of acute cerebral infarct in the magnetic resonance imaging harbors prognostic values. However, semiautomatic method of segmentation is time-consuming and with high interrater variability. Using diffusion weighted imaging and apparent diffusion coefficient map from patients with acute infa...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/963032

    authors: Tsai JZ,Peng SJ,Chen YW,Wang KW,Wu HK,Lin YY,Lee YY,Chen CJ,Lin HJ,Smith EE,Yeh PS,Hsin YL

    更新日期:2014-01-01 00:00:00

  • The Potential of Hibiscus sabdariffa Linn in Inducing Glucagon-Like Peptide-1 via SGLT-1 and GLPR in DM Rats.

    abstract:Background:Glucagon-like peptide 1 (GLP-1) hormone is an incretin hormone that is secreted in the ileum and plays a role in the pancreas to increase insulin secretion, stimulate proliferation, and prevent pancreatic β-cell apoptosis. Currently, diabetes mellitus (DM) treatment based on GLP-1 work is being developed, fo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/8724824

    authors: Kartinah NT,Fadilah F,Ibrahim EI,Suryati Y

    更新日期:2019-11-11 00:00:00

  • Artificial Liver and Renal Support System for Cynomolgus Monkeys with Surgery-Induced Acute Renal Failure: A Preclinical Study.

    abstract::Renal dysfunction is one of the most common complications of liver cirrhosis and is associated with increased morbidity and mortality. However, no available technology can simultaneously support liver and renal function in these patients. The aim of this study was to evaluate the safety and efficacy of an artificial l...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7456898

    authors: Feng L,He G,Cai L,Fu C,Li Y,Weng J,Huo X,Peng Q,Gao Y

    更新日期:2018-05-24 00:00:00

  • The use of hyaluronic acid after tendon surgery and in tendinopathies.

    abstract::Viscosupplementation with hyaluronic acid is safe and effective in the management of osteoarthritis, but its use in the treatment of tendon disorders has received less attention. The aim of this review is to summarize the current knowledge on this topic, evaluating experimental and clinical trials. A search of English...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/783632

    authors: Abate M,Schiavone C,Salini V

    更新日期:2014-01-01 00:00:00

  • Reproducibility of NMR analysis of urine samples: impact of sample preparation, storage conditions, and animal health status.

    abstract:INTRODUCTION:Spectroscopic analysis of urine samples from laboratory animals can be used to predict the efficacy and side effects of drugs. This employs methods combining (1)H NMR spectroscopy with quantification of biomarkers or with multivariate data analysis. The most critical steps in data evaluation are analytical...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/878374

    authors: Schreier C,Kremer W,Huber F,Neumann S,Pagel P,Lienemann K,Pestel S

    更新日期:2013-01-01 00:00:00

  • Prosexual Effect of Chrysactinia mexicana A. Gray (Asteraceae), False Damiana, in a Model of Male Sexual Behavior.

    abstract::Chrysactinia mexicana A. Gray (Asteraceae) and Turnera diffusa Willd (Turneraceae) are employed in traditional medicine as aphrodisiacs; however, there is no scientific evidence supporting the prosexual properties of C. mexicana. The aim of this study was to determine whether an aqueous extract of C. mexicana (Cm) sti...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2987917

    authors: Estrada-Reyes R,Ferreyra-Cruz OA,Jiménez-Rubio G,Hernández-Hernández OT,Martínez-Mota L

    更新日期:2016-01-01 00:00:00

  • Silencing ELMO3 Inhibits the Growth, Invasion, and Metastasis of Gastric Cancer.

    abstract::ELMO3 is a member of the engulfment and cell motility (ELMO) protein family, which plays a vital role in the process of chemotaxis and metastasis of tumor cells. However, remarkably little is known about the role of ELMO3 in cancer. The present study was conducted to investigate the function and role of ELMO3 in gastr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3764032

    authors: Hu Y,Yu Q,Zhong Y,Shen W,Zhou X,Liu X,Xu M,Zhou N,Min W,Gao D

    更新日期:2018-09-24 00:00:00

  • Effect of Anti-TNF Antibodies on Clinical Response in Rheumatoid Arthritis Patients: A Meta-Analysis.

    abstract::Background. Antitumor necrosis factor (anti-TNF) drugs have been applied for rheumatoid arthritis (RA) treatment; however, patients having anti-drug antibodies (ADAbs) do not benefit from these drugs. The meta-analysis aims to comprehensively assess the relationship between ADAb positive (ADAb+) and anti-TNF response ...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2016/7185708

    authors: Wu C,Wang S,Xian P,Yang L,Chen Y,Mo X

    更新日期:2016-01-01 00:00:00

  • Facial vibrotactile stimulation activates the parasympathetic nervous system: study of salivary secretion, heart rate, pupillary reflex, and functional near-infrared spectroscopy activity.

    abstract::We previously found that the greatest salivation response in healthy human subjects is produced by facial vibrotactile stimulation of 89 Hz frequency with 1.9 μ m amplitude (89 Hz-S), as reported by Hiraba et al. (2012, 20011, and 2008). We assessed relationships between the blood flow to brain via functional near-inf...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/910812

    authors: Hiraba H,Inoue M,Gora K,Sato T,Nishimura S,Yamaoka M,Kumakura A,Ono S,Wakasa H,Nakayama E,Abe K,Ueda K

    更新日期:2014-01-01 00:00:00

  • Salivary MicroRNAs for Early Detection of Head and Neck Squamous Cell Carcinoma: A Case-Control Study in the High Altitude Mestizo Ecuadorian Population.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with the highest incidence worldwide. HNSCC is often diagnosed at advanced stages, incurring significant high mortality and morbidity. The use of saliva, as a noninvasive tool for the diagnosis of cancer, has recently increased. Salivary mic...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9792730

    authors: Salazar-Ruales C,Arguello JV,López-Cortés A,Cabrera-Andrade A,García-Cárdenas JM,Guevara-Ramírez P,Peralta P,Leone PE,Paz-Y-Miño C

    更新日期:2018-11-21 00:00:00

  • Neuroinflammatory Gene Expression Pattern Is Similar between Allergic Rhinitis and Atopic Dermatitis but Distinct from Atopic Asthma.

    abstract:Methods:In the study, we included 86 children diagnosed with atopic asthma (n = 25), allergic rhinitis (n = 20), and atopic dermatitis (n = 20) and healthy control subjects (n = 21) of Caucasian origin from the Polish population. The blood leukocyte expression of 31 genes involved in neuroinflammatory response (neurotr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7196981

    authors: Sobkowiak P,Langwiński W,Nowakowska J,Wojsyk-Banaszak I,Szczepankiewicz D,Jenerowicz D,Wasilewska E,Bręborowicz A,Szczepankiewicz A

    更新日期:2020-06-10 00:00:00

  • Comparison of Arthroscopic Partial Meniscectomy to Physical Therapy following Degenerative Meniscus Tears: A Systematic Review and Meta-analysis.

    abstract:Objective:To compare the effectiveness of arthroscopic partial meniscectomy (APM) and physical therapy (PT) for degenerative meniscus tears. Method:We conducted a literature search through PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. Randomized controlled trials in adults...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2020/1709415

    authors: Li J,Zhu W,Gao X,Li X

    更新日期:2020-03-03 00:00:00

  • Assessment of Mycobacterium bovis deleted in p27-p55 virulence operon as candidate vaccine against tuberculosis in animal models.

    abstract::A Mycobacterium bovis knockout in p27-p55 operon was tested as an antituberculosis experimental vaccine in animal models. The mutant MbΔp27-p55 was significantly more attenuated in nude mice than its parental strain but more virulent than BCG Pasteur. Challenge experiments in mice and guinea pigs using M. bovis or M. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/951978

    authors: Bianco MV,Clark S,Blanco FC,Garbaccio S,García E,Cataldi AA,Williams A,Bigi F

    更新日期:2014-01-01 00:00:00

  • Rare Mutations in AHDC1 in Patients with Obstructive Sleep Apnea.

    abstract:Objectives:Obstructive sleep apnea (OSA) is a common disorder influenced by genetic and environmental factors. Mutations of AT-hook DNA-binding motif containing 1 (AHDC1) gene have been implicated which could cause rare syndromes presenting OSA. This study aims to investigate some rare mutations of AHDC1 in Chinese Han...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5907361

    authors: Yang S,Li K,Zhu MM,Yuan XD,Jiao XL,Yang YY,Li J,Li L,Zhang HN,Du YH,Wei YX,Qin YW

    更新日期:2019-10-13 00:00:00

  • Identification of Deleterious Mutations in Myostatin Gene of Rohu Carp (Labeo rohita) Using Modeling and Molecular Dynamic Simulation Approaches.

    abstract::The myostatin (MSTN) is a known negative growth regulator of skeletal muscle. The mutated myostatin showed a double-muscular phenotype having a positive significance for the farmed animals. Consequently, adequate information is not available in the teleosts, including farmed rohu carp, Labeo rohita. In the absence of ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7562368

    authors: Rasal KD,Chakrapani V,Patra SK,Mohapatra SD,Nayak S,Jena S,Sundaray JK,Jayasankar P,Barman HK

    更新日期:2016-01-01 00:00:00

  • The Effect of Stroke Subtypes on Baroreceptor Sensitivity, a Predict for Acute Stroke Outcome.

    abstract:Background:Reduced baroreflex sensitivity (BRS) has been reported in patients with acute cardiovascular events. We tested the hypothesis that BRS varies in different subtypes of acute ischemic stroke (AIS) and that BRS is a predictor of clinical outcomes. Methods:We examined autonomic parameters in 34 patients with AI...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/7614828

    authors: Tsai WC,Lin HC,Lai YR,Hsu CW,Huang CC,Wang HC,Su CM,Su YJ,Lin WC,Cheng BC,Chang WN,Lu CH,Tsai NW

    更新日期:2019-04-18 00:00:00

  • Regenerative repair of damaged meniscus with autologous adipose tissue-derived stem cells.

    abstract::Mesenchymal stem cells (MSCs) are defined as pluripotent cells found in numerous human tissues, including bone marrow and adipose tissue. Such MSCs, isolated from bone marrow and adipose tissue, have been shown to differentiate into bone and cartilage, along with other types of tissues. Therefore, MSCs represent a pro...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/436029

    authors: Pak J,Lee JH,Lee SH

    更新日期:2014-01-01 00:00:00

  • Status of Human Papillomavirus Infection in the Ethnic Population in Yunnan Province, China.

    abstract::HPV genotypes have distinct distributions among various ethnic populations worldwide. In December 2013, 237 and 159 cervical samples were collected from Hani and Han ethnic women, respectively, in Mojiang, a rural county in southern Yunnan. The overall HPV infection rate (21.1%) among the Hani women was significantly ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/314815

    authors: Baloch Z,Yue L,Yuan T,Feng Y,Tai W,Liu Y,Wang B,Li X,Liu L,Zhang AM,Wu X,Xia X

    更新日期:2015-01-01 00:00:00

  • Oxidative stress, prooxidants, and antioxidants: the interplay.

    abstract::Oxidative stress is a normal phenomenon in the body. Under normal conditions, the physiologically important intracellular levels of reactive oxygen species (ROS) are maintained at low levels by various enzyme systems participating in the in vivo redox homeostasis. Therefore, oxidative stress can also be viewed as an i...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/761264

    authors: Rahal A,Kumar A,Singh V,Yadav B,Tiwari R,Chakraborty S,Dhama K

    更新日期:2014-01-01 00:00:00

  • Effect of Chronic Kidney Disease on Changes in Vasopressin System Expression in the Kidney Cortex in Rats with Nephrectomy.

    abstract::It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy. The study was performed on 4 groups of Sprague ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2607928

    authors: Czarzasta K,Cudnoch-Jedrzejewska A,Niemczyk L,Wrzesien R,Tkaczyk M,Puchalska L,Saracyn M,Zmudzki W,Niemczyk S

    更新日期:2018-06-14 00:00:00

  • Protective Effects of Paricalcitol on Peritoneal Remodeling during Peritoneal Dialysis.

    abstract::Peritoneal dialysis (PD) is associated with structural and functional alterations of the peritoneal membrane, consisting of fibrosis, angiogenesis, and loss of ultrafiltration capacity. Vitamin D receptor activation (VDRA) plays an important role in mineral metabolism and inflammation, but also antiangiogenic and anti...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/468574

    authors: Stavenuiter AW,Farhat K,Vila Cuenca M,Schilte MN,Keuning ED,Paauw NJ,ter Wee PM,Beelen RH,Vervloet MG

    更新日期:2015-01-01 00:00:00

  • Individual IOL surface topography analysis by the WaveMaster Reflex UV.

    abstract:PURPOSE:In order to establish inspection routines for individual intraocular lenses (IOLs), their surfaces have to be measured separately. Currently available measurement devices lack this functionality. The purpose of this study is to evaluate a new topography measurement device based on wavefront analysis for measuri...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/363742

    authors: Kannengießer M,Langenbucher A,Janunts E

    更新日期:2013-01-01 00:00:00

  • A 12-Week Assessment of the Treatment of White Spot Lesions with CPP-ACP Paste and/or Fluoride Varnish.

    abstract::This 12-week clinical study evaluated the impact of 10% CPP-ACP and 5% sodium fluoride varnish regimes on the regression of nonorthodontic white spot lesions (WSLs). The study included 21 children with 101 WSLs who were randomised into four treatment regimes: weekly clinical applications of fluoride varnish for the fi...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2016/8357621

    authors: Güçlü ZA,Alaçam A,Coleman NJ

    更新日期:2016-01-01 00:00:00

  • Improving Physical Fitness of Children with Intellectual and Developmental Disabilities through an Adapted Rhythmic Gymnastics Program in China.

    abstract:Background:Health-related physical fitness is vital for children with intellectual and developmental disabilities (IDD) to gain healthier lives. The adapted rhythmic gymnastics (ARG) program was designed for children with IDD and is aimed at testing the effects of the exercise program on children's physical fitness. M...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2345607

    authors: Xu C,Yao M,Kang M,Duan G

    更新日期:2020-08-10 00:00:00

  • Corrigendum to "Tabu Search and Machine-Learning Classification of Benign and Malignant Proliferative Breast Lesions".

    abstract::[This corrects the article DOI: 10.1155/2020/4671349.]. ...

    journal_title:BioMed research international

    pub_type: 杂志文章,已发布勘误

    doi:10.1155/2020/7638969

    authors: Dhahri H,Rahmany I,Mahmood A,Al Maghayreh E,Elkilani W

    更新日期:2020-06-30 00:00:00

  • Induction of apoptotic effects of antiproliferative protein from the seeds of Borreria hispida on lung cancer (A549) and cervical cancer (HeLa) cell lines.

    abstract::A 35 KDa protein referred to as F3 was purified from the seeds of Borreria hispida by precipitation with 80% ammonium sulphate and gel filtration on Sephadex G-100 column. RP-HPLC analysis of protein fraction (F3) on an analytical C-18 column produced a single peak, detected at 220 nm. F3 showed an apparent molecular ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/179836

    authors: Rupachandra S,Sarada DV

    更新日期:2014-01-01 00:00:00

  • Error-Correcting Output Codes in Classification of Human Induced Pluripotent Stem Cell Colony Images.

    abstract::The purpose of this paper is to examine how well the human induced pluripotent stem cell (hiPSC) colony images can be classified using error-correcting output codes (ECOC). Our image dataset includes hiPSC colony images from three classes (bad, semigood, and good) which makes our classification task a multiclass probl...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/3025057

    authors: Joutsijoki H,Haponen M,Rasku J,Aalto-Setälä K,Juhola M

    更新日期:2016-01-01 00:00:00

  • Determinants of Neonatal Jaundice among Neonates Admitted to Neonatal Intensive Care Unit in Public General Hospitals of Central Zone, Tigray, Northern Ethiopia, 2019: a Case-Control Study.

    abstract:Background:Neonatal jaundice is common a clinical problem worldwide. Globally, every year, about 1.1 million babies develop severe hyperbilirubinemia with or without bilirubin encephalopathy and the vast majority reside in sub-Saharan Africa and South Asia. Strategies and information on determinants of neonatal jaundic...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4743974

    authors: Asefa GG,Gebrewahid TG,Nuguse H,Gebremichael MW,Birhane M,Zereabruk K,Zemicheal TM,Hailay A,Abrha WA,Hadera SA,Hailu AG,Beyene BH,Dagnazgi EA,Tekulu FG,Welay F

    更新日期:2020-10-21 00:00:00