Abstract:
:Background. Antitumor necrosis factor (anti-TNF) drugs have been applied for rheumatoid arthritis (RA) treatment; however, patients having anti-drug antibodies (ADAbs) do not benefit from these drugs. The meta-analysis aims to comprehensively assess the relationship between ADAb positive (ADAb+) and anti-TNF response in RA patients. Methods. Observational studies comparing different clinical response between ADAb+ and ADAb negative groups were included. Odds ratio (OR) with its corresponding 95% confidence interval (CI) was used as effect size. Subgroup analyses stratified by TNF inhibitor types and assay methods for ADAb detection were performed. Results. Totally, 10 eligible studies containing 1806 subjects were included. ADAb+ was significantly associated with reduced anti-TNF response to RA at all the time points after follow-up (P < 0.001). Subgroup analysis also supported this significant association (P < 0.05), except for enzyme-linked immunosorbent assay (ELISA) group at 3 months, infliximab (INF) and enzyme-linked immunosorbent assay (ELISA) groups at 6 months, and Immunological Multi-Parameter Chip Technology (IMPACT) group at 12 months. Conclusion. ADAb+ was significantly associated with reduced clinical response in RA patients, and other alternatives should be considered in RA patients presenting ADAb+.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Wu C,Wang S,Xian P,Yang L,Chen Y,Mo Xdoi
10.1155/2016/7185708subject
Has Abstractpub_date
2016-01-01 00:00:00pages
7185708eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
杂志文章,meta分析,评审abstract::Eccentric exercise is characterized by initial unfavorable effects such as subcellular muscle damage, pain, reduced fiber excitability, and initial muscle weakness. However, stretch combined with overload, as in eccentric contractions, is an effective stimulus for inducing physiological and neural adaptations to train...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/193741
更新日期:2015-01-01 00:00:00
abstract:Background:Spinal cord injury (SCI) is often associated with long-term impairments related to functional limitations in the sensorimotor system. The use of virtual reality (VR) technology may lead to increased motivation and engagement, besides allowing a wide range of possible tasks/exercises to be implemented in reha...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7106951
更新日期:2019-11-13 00:00:00
abstract:Background:As the important components in polycomb repressive complexes 1 (PRC1) and heterochromatin protein 1 (HP1), Chromobox (CBX) family members are involved in epigenetic regulatory function, transcriptional repression, and other cellular metabolisms. Increasing studies have indicated significant associations betw...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5306509
更新日期:2020-11-05 00:00:00
abstract:Objectives:Obstructive sleep apnea (OSA) is a common disorder influenced by genetic and environmental factors. Mutations of AT-hook DNA-binding motif containing 1 (AHDC1) gene have been implicated which could cause rare syndromes presenting OSA. This study aims to investigate some rare mutations of AHDC1 in Chinese Han...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5907361
更新日期:2019-10-13 00:00:00
abstract:Objective:The NOCTURNIN gene links nutrient absorption and metabolism to the circadian clock. Shift workers are at a heightened risk of overweight and of developing obesity and metabolic syndrome. This study investigates the diurnal variation of NOCTURNIN in healthy volunteers and its expression levels in rotational sh...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7582734
更新日期:2019-07-31 00:00:00
abstract::Non-VKA oral anticoagulants (NOACs) have now widely reached the lucrative market of anticoagulation. While the marketing authorization holders claimed that no routine monitoring is required and that these compounds can be given at fixed doses, several evidences arisen from the literature tend to demonstrate the opposi...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/345138
更新日期:2015-01-01 00:00:00
abstract::It is of great importance to prepare multifunctional scaffolds combining good mechanical strength, bioactivity, and drug delivery ability for bone tissue engineering. In this study, nanosized mesoporous bioglass/poly(lactic-co-glycolic acid) composite-coated calcium silicate scaffolds, named NMBG-PLGA/CS, were success...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/323046
更新日期:2014-01-01 00:00:00
abstract::Cardiovascular disease (CVD) is the most common cause of death in the world. Recent studies have shown an association between adrenal insufficiency (AI) and increased cardiovascular risk (CVR). Patients with AI receive glucocorticoid (GC) replacement therapy which can lead to varying levels of blood cortisol. It was s...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/3691913
更新日期:2017-01-01 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is one of the most common cancers in the world. Our aim is to identify prognostic biomarkers that contribute to the progression of early stage ccRCC and clarify the mechanism. Here, the mRNA microarray expression profile of ccRCC samples was obtained from Gene Expression Omnibus...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2064582
更新日期:2020-10-29 00:00:00
abstract::Purpose. To compare the results of extracorporeal shock wave therapy (ESWT) for insertional Achilles tendinopathy (IAT) with or without Haglund's deformity. Methods. Between September 2014 and May 2015, all patients who underwent ESWT were retrospectively enrolled in this study. A total of 67 patients were available f...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6315846
更新日期:2016-01-01 00:00:00
abstract::Nuclear factor-kappa B (NF-κB) is the key part of multiple signal transduction of inflammation in the pathogenesis of diabetic nephropathy (DN). The ubiquitin-proteasome system is extensively involved in the regulation of the NF-κB pathway. Cylindromatosis (CYLD) has deubiquitinase activity and acts as a negative regu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3982906
更新日期:2017-01-01 00:00:00
abstract::Large amounts of various biological networks exist for representing different types of interaction data, such as genetic, metabolic, gene regulatory, and protein-protein relationships. Recent approaches on biological network study are based on different mathematical concepts. It is necessary to construct a uniform fra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7457131
更新日期:2017-01-01 00:00:00
abstract::Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving su...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3656574
更新日期:2016-01-01 00:00:00
abstract:Objective:To compare the expression of G-protein-coupled estrogen receptor (GPER) in the junctional zone and outer myometrium of the proliferative and secretory phases of women with and without adenomyosis. Methods:A total of 76 women were included in this study, 42 with adenomyosis (proliferative phase, n = 23; secre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5974693
更新日期:2017-01-01 00:00:00
abstract::Rauwolfia tetraphylla L. is an important medicinal plant species which is well known for its pharmaceutically important alkaloids. In the present study, we are reporting about its conservation by in vitro clonal multiplication through the standardized protocol of indirect regeneration by using leaf and stem based call...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3698742
更新日期:2019-04-11 00:00:00
abstract::Lycium barbarum is a famous plant in the traditional Chinese medicine. The plant is known to have health-promoting bioactive components. The properties of Lycium barbarum berries cultivated in Umbria (Italy) and their effect on human hepatocellular carcinoma cells (HepG2) have been investigated in this work. The obtai...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7529521
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To estimate localization and the period up to the appearance of small hyperreflective round-shaped droplets using spectral-domain optical coherence tomography (SD-OCT) after pars plana vitrectomy with silicone oil tamponade. METHODS:A retrospective observational study included 24 patients who had undergone par...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/372045
更新日期:2014-01-01 00:00:00
abstract:Results:The VMAT plans showed superior to PTV dose conformity index (CI), homogeneity index (HI), protection of the ipsilateral lung, monitor units (MUs), and maximum dose (Dmax) to the contralateral breast compared with TSP and 9FIMRT plans. The TSP provided better protection for Dmean of the heart and left ventricle ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2020/7131590
更新日期:2020-03-26 00:00:00
abstract:OBJECTIVES:Most developmental processes are under the control of small regulatory RNAs called microRNAs (miRNAs). We hypothesize that different fetal developmental processes might be reflected by extracellular miRNAs in maternal plasma and may be utilized as biomarkers for the noninvasive prenatal diagnosis of chromoso...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/402475
更新日期:2014-01-01 00:00:00
abstract::Post-Kala-Azar Dermal Leishmaniasis (PKDL) remains a major public health threat in Bangladesh. A cross-sectional study was carried out in Surya Kanta Kala azar Research Centre (SKKRC), Mymensingh, from January 2012 to July 2013 to evaluate the health seeking behaviour and the length of delay of PKDL management. The co...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/314543
更新日期:2015-01-01 00:00:00
abstract::In orthopaedic surgery and sports medicine, the knee joint has traditionally been considered the workhorse. The reconstruction of every damaged element in this joint is crucial in achieving the surgeon's goal to restore the knee function and prevent degeneration towards osteoarthritis. In the last fifteen years, the f...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/890630
更新日期:2014-01-01 00:00:00
abstract:Aim:To evaluate thiol/disulphide homeostasis as a new indicator of oxidative stress in AKI patients and to determine the effect of HD on antioxidant balance and oxidative stress through plasma thiols. Methods:This study was performed in patients aged between 12 months and 18 years prospectively who underwent hemodialy...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1898671
更新日期:2018-09-25 00:00:00
abstract::The current developments of the new biological drugs targeting interleukin 5 (IL-5) and IL-5 receptor allowed to expand the treatment options for severe hypereosinophilic asthma. Clinicians will then be able to choose between antibodies targeting either circulating IL-5 or its receptor expressed on eosinophils and bas...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/5698212
更新日期:2018-11-05 00:00:00
abstract::Cervical cancer is one of the malignant tumors that seriously threaten women's health. The mechanism of development needs to be deeply studied. In recent years, lncRNA has been identified as one of the important factors affecting the malignant progression of tumors. In this study, we illustrated the important mechanis...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4351671
更新日期:2020-01-03 00:00:00
abstract:Objective:This study evaluated the bioactivity and physicochemical properties of three commercial calcium silicate-based endodontic materials (MTA, EndoSequence Root Repair Material putty, and Biodentine™). Material and Methods. Horizontal sections of 3 mm thickness from 18 root canals of human teeth were subjected to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9576930
更新日期:2020-05-22 00:00:00
abstract::Background. For development of individualized treatment on a routine basis, transfer of patients' tumor tissue in a xenograft model (i.e., generation of patient-derived xenografts (PDX)) is desirable for molecular, biochemical, or functional analyses. Drawbacks are dissatisfactory tumor take rates, the necessity of fa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1715053
更新日期:2016-01-01 00:00:00
abstract::VEGF-NO axis uncoupling is an important pathogenesis for DN. Reduced β2GPI could play a part in VEGF signaling pathway and has a protective effect on diabetic vascular disease. This study investigates the effect of reduced β2GPI on glomerular mesangial cells VEGF-NO axis uncoupling induced by high glucose. Compared to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5484731
更新日期:2018-07-18 00:00:00
abstract::Here we aimed to develop a capillary electrophoresis-based high-throughput multiplex polymerase chain reaction (PCR) system for the simultaneous detection of nine pathogens in swine. Nine pairs of specific primers and a set of universal primers were designed; the multiplex PCR was established. The specificity and cros...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7243909
更新日期:2017-01-01 00:00:00
abstract::The similarity-based retrieval of lung nodule computed tomography (CT) images is an important task in the computer-aided diagnosis of lung lesions. It can provide similar clinical cases for physicians and help them make reliable clinical diagnostic decisions. However, when handling large-scale lung images with a gener...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3162649
更新日期:2016-01-01 00:00:00
abstract:Purpose:To evaluate the diagnostic performance of deep learning with a multichannel fusion three-dimensional convolutional neural network (MCF-3DCNN) in the differentiation of the pathologic grades of hepatocellular carcinoma (HCC) based on dynamic contrast-enhanced magnetic resonance images (DCE-MR images). Methods a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9783106
更新日期:2019-04-28 00:00:00