Abstract:
Objective:The NOCTURNIN gene links nutrient absorption and metabolism to the circadian clock. Shift workers are at a heightened risk of overweight and of developing obesity and metabolic syndrome. This study investigates the diurnal variation of NOCTURNIN in healthy volunteers and its expression levels in rotational shift and daytime workers. Methods:NOCTURNIN expression levels were evaluated in peripheral blood lymphocytes from 15 healthy volunteers at 4-hour intervals for 24 h. Metabolic parameters and NOCTURNIN expression were measured in workers engaged in shift and daytime work. Results:In the group of volunteers NOCTURNIN expression showed diurnal variation, with a peak at 8:00 AM. NOCTURNIN expression was higher in shift workers than in daytime workers. Multivariate analysis confirmed the role of shift work as an independent factor affecting NOCTURNIN expression. Notably, its level correlated directly with body mass index and inversely with total energy expenditure. Conclusions:Measuring NOCTURNIN expression levels in human peripheral blood lymphocytes can improve investigations on the relationship between changes in circadian rhythm and metabolic disorders. Shift workers show higher NOCTURNIN levels than daytime workers.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Bracci M,Copertaro A,Ciarapica V,Barbaresi M,Esposito S,Albanesi A,Valentino M,Ledda C,Rapisarda V,Santarelli Ldoi
10.1155/2019/7582734subject
Has Abstractpub_date
2019-07-31 00:00:00pages
7582734eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
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