Abstract:
:The receptor activator of NF-κB (RANK) pathway is involved in bone health as well as breast cancer (BC) pathogenesis and progression. Whereas the therapeutic implication of this pathway is established for the treatment of osteoporosis and bone metastases, the application in adjuvant BC is currently investigated. As genetic variants in this pathway have been described to influence bone health, aim of this study was the prognostic relevance of genetic variants in RANK and RANKL. Single nucleotide polymorphisms in RANK(L) (rs1054016/rs1805034/rs35211496) were genotyped and analyzed with regard to bone metastasis-free survival (BMFS), disease-free survival, and overall survival for a retrospective cohort of 1251 patients. Cox proportional hazard models were built to examine the prognostic influence in addition to commonly established prognostic factors. The SNP rs1054016 seems to influence BMFS. Patients with two minor alleles had a more favorable prognosis than patients with at least one common allele (HR 0.37 (95% CI: 0.17, 0.84)), whereas other outcome parameters remained unaffected. rs1805034 and rs35211496 had no prognostic relevance. The effect of rs1054016(RANKL) adds to the evidence that the RANK pathway plays a role in BC pathogenesis and progression with respect to BMFS, emphasizing the connection between BC and bone health.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Hein A,Bayer CM,Schrauder MG,Häberle L,Heusinger K,Strick R,Ruebner M,Lux MP,Renner SP,Schulz-Wendtland R,Ekici AB,Hartmann A,Beckmann MW,Fasching PAdoi
10.1155/2014/842452subject
Has Abstractpub_date
2014-01-01 00:00:00pages
842452eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
临床试验,杂志文章,多中心研究abstract:UNLABELLED:Isoniazid (INH), a key agent in the treatment of tuberculosis (TB), is metabolized primarily by the genetically polymorphic N-acetyltransferase 2 (NAT2) enzyme. Patients treated with INH can be classified as fast, intermediate, and slow acetylators. The objective of this study was to explore the relationship...
journal_title:BioMed research international
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