Abstract:
:The aim of this study was to investigate the potential of microparticles based on biocompatible phytolipids [Softisan® 154 (SF) (hydrogenated palm oil) and super-refined sunseed oil (SO)] and polyethylene glycol- (PEG-) 4000 to improve intravaginal delivery of miconazole nitrate (MN) for effective treatment of vulvovaginal candidiasis (VVC). Lipid matrices (LMs) consisting of rational blends of SF and SO with or without PEG-4000 were prepared by fusion and characterized and employed to formulate MN-loaded solid lipid microparticles (SLMs) by melt-homogenization. The SLMs were characterized for physicochemical properties, anticandidal activity, and stability. Spherical discrete microparticles with good physicochemical properties and mean diameters suitable for vaginal drug delivery were obtained. Formulations based on SO:SF (1:9) and containing highest concentrations of PEG-4000 (4 %w/w) and MN (3.0 %w/w) were stable and gave highest encapsulation efficiency (83.05-87.75%) and inhibition zone diameter (25.87±0.94-26.33±0.94 mm) and significantly (p<0.05) faster and more powerful fungicidal activity regarding killing rate constant values (7.10 x 10-3-1.09 x 10-2 min-1) than commercial topical solution of MN (Fungusol®) (8.00 x 10-3 min-1) and pure MN sample (5.160 x 10-3 min-1). This study has shown that MN-loaded SLMs based on molecularly PEGylated lipid matrices could provide a better option to deal with VVC.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Kenechukwu FC,Attama AA,Ibezim EC,Nnamani PO,Umeyor CE,Uronnachi EM,Momoh MA,Akpa PA,Ozioko ACdoi
10.1155/2018/3714329subject
Has Abstractpub_date
2018-06-06 00:00:00pages
3714329eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
杂志文章abstract::Introduction. The triangular fibrocartilage complex (TFCC) provides both mobility and stability of the radiocarpal joint. TFCC lesions are difficult to diagnose due to the complex anatomy. The standard treatment for TFCC lesions is arthroscopy, posing surgery-related risks onto the patients. This feasibility study aim...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5870875
更新日期:2017-01-01 00:00:00
abstract::Background. Advancing age, chronic inflammation, oxidative damage, and disorders of lipid metabolism are positively linked to the late-life cognitive impairment. Serum biomarkers may be associated with the cognitive status in older men. Methods. 440 old male subjects with different cognitive functions were recruited t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/481621
更新日期:2015-01-01 00:00:00
abstract::The study quantified the relative absolute PSCA level in relation to the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) level in the peripheral blood of 478 hormone-naive prostate cancer (PC) patients who underwent radical prostatectomy from 2005 to 2012 and evaluated its prognostic significance as a risk factor for...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/292454
更新日期:2015-01-01 00:00:00
abstract:Objective:To compare the expression of G-protein-coupled estrogen receptor (GPER) in the junctional zone and outer myometrium of the proliferative and secretory phases of women with and without adenomyosis. Methods:A total of 76 women were included in this study, 42 with adenomyosis (proliferative phase, n = 23; secre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5974693
更新日期:2017-01-01 00:00:00
abstract::ELMO3 is a member of the engulfment and cell motility (ELMO) protein family, which plays a vital role in the process of chemotaxis and metastasis of tumor cells. However, remarkably little is known about the role of ELMO3 in cancer. The present study was conducted to investigate the function and role of ELMO3 in gastr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3764032
更新日期:2018-09-24 00:00:00
abstract:OBJECTIVES:CD57 is normally found on NK-cells, but little is known about its expression in prostatic tissue. METHODS:We investigated CD57 expression by immunohistochemistry using tissue microarrays containing 3262 prostate cancers (PCa), lymph node metastases, and benign prostatic tissue. The results were compared wit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/356427
更新日期:2014-01-01 00:00:00
abstract::The palmaris longus is considered a phylogenetic degenerate metacarpophalangeal joint flexor muscle in humans, a small vestigial forearm muscle; it is the most variable muscle in humans, showing variation in position, duplication, slips and could be reverted. It is frequently studied in papers about human anatomical v...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/178906
更新日期:2014-01-01 00:00:00
abstract::Bovine pericardium is used for heart valve leaflet replacement where the strength and thinness are critical properties. Pericardium from neonatal animals (4-7 days old) is advantageously thinner and is considered as an alternative to that from adult animals. Here, the structures of adult and neonatal bovine pericardiu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/189197
更新日期:2014-01-01 00:00:00
abstract::High-dose melphalan (200 mg/m(2)) as conditioning regimen followed by autologous stem cell transplantation (ASCT) rescue has been established as a standard treatment for patients with multiple myeloma (MM) younger than 65 years of age. However, the role of ASCT in elderly patients older than 65 years remains controver...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/394792
更新日期:2014-01-01 00:00:00
abstract::Individuals with X-HIGM syndrome fail to express functional CD40 ligand; consequently they cannot mount effective protective antibody responses against pathogenic bacteria. We evaluated, compared, and characterized the humoral immune response of wild type (WT) and C57-CD40L deficient (C57-CD40L(-/-)) mice infected wit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/679850
更新日期:2015-01-01 00:00:00
abstract::We aimed to explore the effects of raloxifene (RAL) on the proliferation and apoptosis of human aortic valve interstitial cells (AVICs). Different concentrations of RAL were used to act on AVICs. MTS kit is used to test the effects of different concentrations of RAL on the proliferation of AVICs. Cell cycle and apopto...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5473204
更新日期:2016-01-01 00:00:00
abstract::The main objective was to quantify the effects of five different slopes on trunk and shoulder kinematics as well as shoulder kinetic and muscular demands during manual wheelchair (MWC) propulsion on a motorized treadmill. Eighteen participants with spinal cord injury propelled their MWC at a self-selected constant spe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/636319
更新日期:2015-01-01 00:00:00
abstract:Objective:To investigate the prevalence of infections due to carbapenem-resistant Klebsiella pneumoniae (CRKP) among ICU admission patients in central China and develop a reliable prediction model. Methods:Five hundred and seven consecutive ICU admission patients with Klebsiella pneumoniae (KP) infection were enrolled...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9767313
更新日期:2019-03-27 00:00:00
abstract::Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by bone loss. Degree of inflammation has been identified as an important initiator of skeletal damage in RA. Iguratimod (T-614) is an anti-inflammatory agent which has been reported to show the inhibitory effect of bone destruction in RA. Ho...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4901591
更新日期:2018-02-19 00:00:00
abstract::Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/839761
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). MATERIALS AND METHODS:Institutional review board approval...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/835385
更新日期:2013-01-01 00:00:00
abstract::One of the most important tasks of a living organism is to maintain its genetic integrity with respect to stress. Endoplasmic reticulum (ER) has a crucial role in sensing cellular homeostasis by controlling metabolism, proteostasis, and several signaling processes. ER stressors can induce autophagy-dependent survival;...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/319589
更新日期:2015-01-01 00:00:00
abstract::We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test. AD Tg mice on con...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/546357
更新日期:2014-01-01 00:00:00
abstract::Human plasma is an aqueous solution that has to abide by chemical rules such as the principle of electrical neutrality and the constancy of the ionic product for water. These rules define the acid-base balance in the human body. According to the electroneutrality principle, plasma has to be electrically neutral and th...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/695281
更新日期:2014-01-01 00:00:00
abstract::How to decrease intraoperative bleeding, shorten surgical time, and increase safety in spinal surgery is an important issue. Ultrasonic bone removers and FloSeal have been proven to increase safety, reduce the surgical duration, and decrease intraoperative bleeding in skull base surgery. Therefore, we aimed to compare...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6286258
更新日期:2019-05-19 00:00:00
abstract::Lung cancer is the leading cause of cancer death worldwide. Adenocarcinoma, the most commonly diagnosed histologic type of lung cancer, is associated with smoking. Cigarette smoke promotes inflammation on the airways, which might be mediated by Th17 cells. This inflammatory environment may contribute to tumor developm...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/430943
更新日期:2015-01-01 00:00:00
abstract::Following cerebral ischemia/reperfusion (I/R) injury, a series of pathophysiological processes are stimulated in both the central nervous system (CNS) and the periphery, including, but not limited to, the peripheral immune and endocrine systems and underregulation of the neuroendocrine-immune network. Glutamate (Glu) ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/6316059
更新日期:2018-07-19 00:00:00
abstract::Pulmonary arterial hypertension (PAH) is a severe and progressive disease, a key feature of which is pulmonary vascular remodeling. Growth factors, cytokines, and lipid mediators are involved in this remodeling process. Recent reports suggest that the peroxisome proliferator-activated receptors (PPARs) play important ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/903947
更新日期:2013-01-01 00:00:00
abstract::Diosmin has been widely used to treat patients with vascular pain for its potent anti-inflammatory and analgesic effects. To evaluate the therapeutic effects of Diosmin in the treatment of radicular pain, we conducted an investigator-initiated, randomized, active-controlled noninferiority trial between January 1, 2009...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6875968
更新日期:2017-01-01 00:00:00
abstract:Background:Fingertips are a common site for hand injuries. The ideal substitute for fingertip pulp is tissue that matches texturally with minimal donor site morbidity. We described anatomical findings from cadaveric studies and the reliability of the palmar ulnar artery perforator (PUAP) free flap techniques for the re...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2862879
更新日期:2018-05-09 00:00:00
abstract:BACKGROUND:This study aimed to compare the effects of rectal midazolam addition after applying bupivacaine and caudal anesthesia on postoperative analgesia time, the need for additional analgesics, postoperative recovery, and sedation and to find out its adverse effects in children having lower abdominal surgery. METH...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/127548
更新日期:2014-01-01 00:00:00
abstract::Nowadays, a growing number of young and more active patients receive hip replacement. More strenuous activities in such patients involve higher friction and wear rates, with friction on the bearing surface being crucial to ensure arthroplasty survival in the long term. Over the last years, the polycarbonate-urethane h...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/548968
更新日期:2014-01-01 00:00:00
abstract::Background. Increased metal ion levels following total hip arthroplasty (THA) with metal-on-metal bearings are a highly debated topic. Local soft tissue reactions with chronic pain and systemic side effects such as neuropathy are described. The aim of the current study was to determine the serum metal ion concentratio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3726029
更新日期:2017-01-01 00:00:00
abstract:Objective:The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at p...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6383906
更新日期:2020-06-21 00:00:00
abstract::Resveratrol has recently been used as a supplemental treatment for several neurological and nonneurological diseases. It is not known whether resveratrol has neuroprotective effect on amyotrophic lateral sclerosis (ALS). To assess the effect of resveratrol on the disease, we tested this agent on an ALS model of SOD1(G...
journal_title:BioMed research international
pub_type: 杂志文章,收录出版
doi:10.1155/2014/483501
更新日期:2014-01-01 00:00:00