Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate.

Abstract:

:The aim of this study was to investigate the potential of microparticles based on biocompatible phytolipids [Softisan® 154 (SF) (hydrogenated palm oil) and super-refined sunseed oil (SO)] and polyethylene glycol- (PEG-) 4000 to improve intravaginal delivery of miconazole nitrate (MN) for effective treatment of vulvovaginal candidiasis (VVC). Lipid matrices (LMs) consisting of rational blends of SF and SO with or without PEG-4000 were prepared by fusion and characterized and employed to formulate MN-loaded solid lipid microparticles (SLMs) by melt-homogenization. The SLMs were characterized for physicochemical properties, anticandidal activity, and stability. Spherical discrete microparticles with good physicochemical properties and mean diameters suitable for vaginal drug delivery were obtained. Formulations based on SO:SF (1:9) and containing highest concentrations of PEG-4000 (4 %w/w) and MN (3.0 %w/w) were stable and gave highest encapsulation efficiency (83.05-87.75%) and inhibition zone diameter (25.87±0.94-26.33±0.94 mm) and significantly (p<0.05) faster and more powerful fungicidal activity regarding killing rate constant values (7.10 x 10-3-1.09 x 10-2 min-1) than commercial topical solution of MN (Fungusol®) (8.00 x 10-3 min-1) and pure MN sample (5.160 x 10-3 min-1). This study has shown that MN-loaded SLMs based on molecularly PEGylated lipid matrices could provide a better option to deal with VVC.

journal_name

Biomed Res Int

authors

Kenechukwu FC,Attama AA,Ibezim EC,Nnamani PO,Umeyor CE,Uronnachi EM,Momoh MA,Akpa PA,Ozioko AC

doi

10.1155/2018/3714329

subject

Has Abstract

pub_date

2018-06-06 00:00:00

pages

3714329

eissn

2314-6133

issn

2314-6141

journal_volume

2018

pub_type

杂志文章
  • Can the Diagnostics of Triangular Fibrocartilage Complex Lesions Be Improved by MRI-Based Soft-Tissue Reconstruction? An Imaging-Based Workup and Case Presentation.

    abstract::Introduction. The triangular fibrocartilage complex (TFCC) provides both mobility and stability of the radiocarpal joint. TFCC lesions are difficult to diagnose due to the complex anatomy. The standard treatment for TFCC lesions is arthroscopy, posing surgery-related risks onto the patients. This feasibility study aim...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/5870875

    authors: Hammer N,Hirschfeld U,Strunz H,Werner M,Wolfskämpf T,Löffler S

    更新日期:2017-01-01 00:00:00

  • Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men.

    abstract::Background. Advancing age, chronic inflammation, oxidative damage, and disorders of lipid metabolism are positively linked to the late-life cognitive impairment. Serum biomarkers may be associated with the cognitive status in older men. Methods. 440 old male subjects with different cognitive functions were recruited t...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/481621

    authors: Ma C,Li J,Bao Z,Ruan Q,Yu Z

    更新日期:2015-01-01 00:00:00

  • The Quantified Level of Circulating Prostate Stem Cell Antigen mRNA relative to GAPDH Level Is a Clinically Significant Indictor for Predicting Biochemical Recurrence in Prostate Cancer Patients after Radical Prostatectomy.

    abstract::The study quantified the relative absolute PSCA level in relation to the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) level in the peripheral blood of 478 hormone-naive prostate cancer (PC) patients who underwent radical prostatectomy from 2005 to 2012 and evaluated its prognostic significance as a risk factor for...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/292454

    authors: Kim SH,Park WS,Lee SJ,Choi MK,Yeon SM,Joo JN,Ko A,Lee ES,Joung JY,Seo HK,Chung J,Lee KH

    更新日期:2015-01-01 00:00:00

  • Expression Pattern of G-Protein-Coupled Estrogen Receptor in Myometrium of Uteri with and without Adenomyosis.

    abstract:Objective:To compare the expression of G-protein-coupled estrogen receptor (GPER) in the junctional zone and outer myometrium of the proliferative and secretory phases of women with and without adenomyosis. Methods:A total of 76 women were included in this study, 42 with adenomyosis (proliferative phase, n = 23; secre...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/5974693

    authors: Li JJ,Duan H,Wang S,Sun FQ,Gan L,Tang YQ,Xu Q,Li TC

    更新日期:2017-01-01 00:00:00

  • Silencing ELMO3 Inhibits the Growth, Invasion, and Metastasis of Gastric Cancer.

    abstract::ELMO3 is a member of the engulfment and cell motility (ELMO) protein family, which plays a vital role in the process of chemotaxis and metastasis of tumor cells. However, remarkably little is known about the role of ELMO3 in cancer. The present study was conducted to investigate the function and role of ELMO3 in gastr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3764032

    authors: Hu Y,Yu Q,Zhong Y,Shen W,Zhou X,Liu X,Xu M,Zhou N,Min W,Gao D

    更新日期:2018-09-24 00:00:00

  • CD57 expression in incidental, clinically manifest, and metastatic carcinoma of the prostate.

    abstract:OBJECTIVES:CD57 is normally found on NK-cells, but little is known about its expression in prostatic tissue. METHODS:We investigated CD57 expression by immunohistochemistry using tissue microarrays containing 3262 prostate cancers (PCa), lymph node metastases, and benign prostatic tissue. The results were compared wit...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/356427

    authors: Wangerin H,Kristiansen G,Schlomm T,Stephan C,Gunia S,Zimpfer A,Weichert W,Sauter G,Erbersdobler A

    更新日期:2014-01-01 00:00:00

  • Morphometric and statistical analysis of the palmaris longus muscle in human and non-human primates.

    abstract::The palmaris longus is considered a phylogenetic degenerate metacarpophalangeal joint flexor muscle in humans, a small vestigial forearm muscle; it is the most variable muscle in humans, showing variation in position, duplication, slips and could be reverted. It is frequently studied in papers about human anatomical v...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/178906

    authors: Aversi-Ferreira RA,Bretas RV,Maior RS,Davaasuren M,Paraguassú-Chaves CA,Nishijo H,Aversi-Ferreira TA

    更新日期:2014-01-01 00:00:00

  • Age dependent differences in collagen alignment of glutaraldehyde fixed bovine pericardium.

    abstract::Bovine pericardium is used for heart valve leaflet replacement where the strength and thinness are critical properties. Pericardium from neonatal animals (4-7 days old) is advantageously thinner and is considered as an alternative to that from adult animals. Here, the structures of adult and neonatal bovine pericardiu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/189197

    authors: Sizeland KH,Wells HC,Higgins J,Cunanan CM,Kirby N,Hawley A,Mudie ST,Haverkamp RG

    更新日期:2014-01-01 00:00:00

  • Autologous stem cell transplantation in elderly patients with multiple myeloma: past, present, and future.

    abstract::High-dose melphalan (200 mg/m(2)) as conditioning regimen followed by autologous stem cell transplantation (ASCT) rescue has been established as a standard treatment for patients with multiple myeloma (MM) younger than 65 years of age. However, the role of ASCT in elderly patients older than 65 years remains controver...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/394792

    authors: Ozaki S,Shimizu K

    更新日期:2014-01-01 00:00:00

  • CD40 Ligand Deficient C57BL/6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens.

    abstract::Individuals with X-HIGM syndrome fail to express functional CD40 ligand; consequently they cannot mount effective protective antibody responses against pathogenic bacteria. We evaluated, compared, and characterized the humoral immune response of wild type (WT) and C57-CD40L deficient (C57-CD40L(-/-)) mice infected wit...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/679850

    authors: Lopez-Saucedo C,Bernal-Reynaga R,Zayas-Jahuey J,Galindo-Gomez S,Shibayama M,Garcia-Galvez C,Estrada-Parra S,Estrada-Garcia T

    更新日期:2015-01-01 00:00:00

  • Effects of Raloxifene on the Proliferation and Apoptosis of Human Aortic Valve Interstitial Cells.

    abstract::We aimed to explore the effects of raloxifene (RAL) on the proliferation and apoptosis of human aortic valve interstitial cells (AVICs). Different concentrations of RAL were used to act on AVICs. MTS kit is used to test the effects of different concentrations of RAL on the proliferation of AVICs. Cell cycle and apopto...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/5473204

    authors: Fu Z,Luo B,Li M,Peng B,Wang Z

    更新日期:2016-01-01 00:00:00

  • Trunk and shoulder kinematic and kinetic and electromyographic adaptations to slope increase during motorized treadmill propulsion among manual wheelchair users with a spinal cord injury.

    abstract::The main objective was to quantify the effects of five different slopes on trunk and shoulder kinematics as well as shoulder kinetic and muscular demands during manual wheelchair (MWC) propulsion on a motorized treadmill. Eighteen participants with spinal cord injury propelled their MWC at a self-selected constant spe...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/636319

    authors: Gagnon D,Babineau AC,Champagne A,Desroches G,Aissaoui R

    更新日期:2015-01-01 00:00:00

  • Carbapenem-Resistant Klebsiella pneumoniae Infections among ICU Admission Patients in Central China: Prevalence and Prediction Model.

    abstract:Objective:To investigate the prevalence of infections due to carbapenem-resistant Klebsiella pneumoniae (CRKP) among ICU admission patients in central China and develop a reliable prediction model. Methods:Five hundred and seven consecutive ICU admission patients with Klebsiella pneumoniae (KP) infection were enrolled...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9767313

    authors: Li Y,Shen H,Zhu C,Yu Y

    更新日期:2019-03-27 00:00:00

  • T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF-κB.

    abstract::Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by bone loss. Degree of inflammation has been identified as an important initiator of skeletal damage in RA. Iguratimod (T-614) is an anti-inflammatory agent which has been reported to show the inhibitory effect of bone destruction in RA. Ho...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4901591

    authors: Song J,Liu H,Zhu Q,Miao Y,Wang F,Yang F,Cheng W,Xi Y,Niu X,He D,Chen G

    更新日期:2018-02-19 00:00:00

  • Role of NADPH oxidase-mediated reactive oxygen species in podocyte injury.

    abstract::Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/839761

    authors: Chen S,Meng XF,Zhang C

    更新日期:2013-01-01 00:00:00

  • Glutamine/glutamate metabolism studied with magnetic resonance spectroscopic imaging for the characterization of adrenal nodules and masses.

    abstract:PURPOSE:To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). MATERIALS AND METHODS:Institutional review board approval...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2013/835385

    authors: Goldman SM,Nunes TF,Melo HJ,Dalavia C,Szejnfeld D,Kater C,Andreoni C,Szejnfeld J,Ajzen SA

    更新日期:2013-01-01 00:00:00

  • A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress.

    abstract::One of the most important tasks of a living organism is to maintain its genetic integrity with respect to stress. Endoplasmic reticulum (ER) has a crucial role in sensing cellular homeostasis by controlling metabolism, proteostasis, and several signaling processes. ER stressors can induce autophagy-dependent survival;...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/319589

    authors: Holczer M,Márton M,Kurucz A,Bánhegyi G,Kapuy O

    更新日期:2015-01-01 00:00:00

  • Chronic dietary supplementation of 4% figs on the modification of oxidative stress in Alzheimer's disease transgenic mouse model.

    abstract::We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test. AD Tg mice on con...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/546357

    authors: Subash S,Essa MM,Al-Asmi A,Al-Adawi S,Vaishnav R

    更新日期:2014-01-01 00:00:00

  • The importance of the ionic product for water to understand the physiology of the acid-base balance in humans.

    abstract::Human plasma is an aqueous solution that has to abide by chemical rules such as the principle of electrical neutrality and the constancy of the ionic product for water. These rules define the acid-base balance in the human body. According to the electroneutrality principle, plasma has to be electrically neutral and th...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/695281

    authors: Adeva-Andany MM,Carneiro-Freire N,Donapetry-García C,Rañal-Muíño E,López-Pereiro Y

    更新日期:2014-01-01 00:00:00

  • Effects of Combined Use of Ultrasonic Bone Scalpel and Hemostatic Matrix on Perioperative Blood Loss and Surgical Duration in Degenerative Thoracolumbar Spine Surgery.

    abstract::How to decrease intraoperative bleeding, shorten surgical time, and increase safety in spinal surgery is an important issue. Ultrasonic bone removers and FloSeal have been proven to increase safety, reduce the surgical duration, and decrease intraoperative bleeding in skull base surgery. Therefore, we aimed to compare...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6286258

    authors: Chen HT,Hsu CC,Lu ML,Chen SH,Chen JM,Wu RW

    更新日期:2019-05-19 00:00:00

  • LAP TGF-Beta Subset of CD4(+)CD25(+)CD127(-) Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients.

    abstract::Lung cancer is the leading cause of cancer death worldwide. Adenocarcinoma, the most commonly diagnosed histologic type of lung cancer, is associated with smoking. Cigarette smoke promotes inflammation on the airways, which might be mediated by Th17 cells. This inflammatory environment may contribute to tumor developm...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/430943

    authors: Islas-Vazquez L,Prado-Garcia H,Aguilar-Cazares D,Meneses-Flores M,Galicia-Velasco M,Romero-Garcia S,Camacho-Mendoza C,Lopez-Gonzalez JS

    更新日期:2015-01-01 00:00:00

  • Cerebral Ischemic Postconditioning Plays a Neuroprotective Role through Regulation of Central and Peripheral Glutamate.

    abstract::Following cerebral ischemia/reperfusion (I/R) injury, a series of pathophysiological processes are stimulated in both the central nervous system (CNS) and the periphery, including, but not limited to, the peripheral immune and endocrine systems and underregulation of the neuroendocrine-immune network. Glutamate (Glu) ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2018/6316059

    authors: You J,Feng L,Xin M,Ma D,Feng J

    更新日期:2018-07-19 00:00:00

  • PPARδ agonist GW501516 inhibits PDGF-stimulated pulmonary arterial smooth muscle cell function related to pathological vascular remodeling.

    abstract::Pulmonary arterial hypertension (PAH) is a severe and progressive disease, a key feature of which is pulmonary vascular remodeling. Growth factors, cytokines, and lipid mediators are involved in this remodeling process. Recent reports suggest that the peroxisome proliferator-activated receptors (PPARs) play important ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/903947

    authors: Liu G,Li X,Li Y,Tang X,Xu J,Li R,Hao P,Sun Y

    更新日期:2013-01-01 00:00:00

  • A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain.

    abstract::Diosmin has been widely used to treat patients with vascular pain for its potent anti-inflammatory and analgesic effects. To evaluate the therapeutic effects of Diosmin in the treatment of radicular pain, we conducted an investigator-initiated, randomized, active-controlled noninferiority trial between January 1, 2009...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2017/6875968

    authors: Wang Y,Fang X,Ye L,Li Y,Shi H,Cao Y

    更新日期:2017-01-01 00:00:00

  • Palmar Ulnar Artery Perforator Free Flap for Fingertip Reconstruction: Anatomical and Clinical Study.

    abstract:Background:Fingertips are a common site for hand injuries. The ideal substitute for fingertip pulp is tissue that matches texturally with minimal donor site morbidity. We described anatomical findings from cadaveric studies and the reliability of the palmar ulnar artery perforator (PUAP) free flap techniques for the re...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2862879

    authors: Pak CS,Jeon JI,Myung Y,Lee YK,Kim BJ,Jeong JH,Kim BK

    更新日期:2018-05-09 00:00:00

  • The effects of single-dose rectal midazolam application on postoperative recovery, sedation, and analgesia in children given caudal anesthesia plus bupivacaine.

    abstract:BACKGROUND:This study aimed to compare the effects of rectal midazolam addition after applying bupivacaine and caudal anesthesia on postoperative analgesia time, the need for additional analgesics, postoperative recovery, and sedation and to find out its adverse effects in children having lower abdominal surgery. METH...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/127548

    authors: Saylan S,Eroglu A,Dohman D

    更新日期:2014-01-01 00:00:00

  • Study of the polycarbonate-urethane/metal contact in different positions during gait cycle.

    abstract::Nowadays, a growing number of young and more active patients receive hip replacement. More strenuous activities in such patients involve higher friction and wear rates, with friction on the bearing surface being crucial to ensure arthroplasty survival in the long term. Over the last years, the polycarbonate-urethane h...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/548968

    authors: Gabarre S,Herrera A,Mateo J,Ibarz E,Lobo-Escolar A,Gracia L

    更新日期:2014-01-01 00:00:00

  • Clinical Results and Serum Metal Ion Concentrations following Ceramic-on-Metal Total Hip Arthroplasty at a Mean Follow-Up of 60 Months.

    abstract::Background. Increased metal ion levels following total hip arthroplasty (THA) with metal-on-metal bearings are a highly debated topic. Local soft tissue reactions with chronic pain and systemic side effects such as neuropathy are described. The aim of the current study was to determine the serum metal ion concentratio...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/3726029

    authors: Maurer-Ertl W,Pranckh-Matzke D,Friesenbichler J,Bratschitsch G,Holzer LA,Maier M,Leithner A

    更新日期:2017-01-01 00:00:00

  • Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot.

    abstract:Objective:The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at p...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6383906

    authors: Cui M,Gao Y,Zhao Y,Pang H,Chen L,Wang Z,Zhao L,Li M

    更新日期:2020-06-21 00:00:00

  • Resveratrol ameliorates motor neuron degeneration and improves survival in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

    abstract::Resveratrol has recently been used as a supplemental treatment for several neurological and nonneurological diseases. It is not known whether resveratrol has neuroprotective effect on amyotrophic lateral sclerosis (ALS). To assess the effect of resveratrol on the disease, we tested this agent on an ALS model of SOD1(G...

    journal_title:BioMed research international

    pub_type: 杂志文章,收录出版

    doi:10.1155/2014/483501

    authors: Song L,Chen L,Zhang X,Li J,Le W

    更新日期:2014-01-01 00:00:00