Differentially expressed microRNAs in maternal plasma for the noninvasive prenatal diagnosis of Down syndrome (trisomy 21).

Abstract:

OBJECTIVES:Most developmental processes are under the control of small regulatory RNAs called microRNAs (miRNAs). We hypothesize that different fetal developmental processes might be reflected by extracellular miRNAs in maternal plasma and may be utilized as biomarkers for the noninvasive prenatal diagnosis of chromosomal aneuploidies. In this proof-of-concept study, we report on the identification of extracellular miRNAs in maternal plasma of Down syndrome (DS) pregnancies. METHODS:Using high-throughput quantitative PCR (HT-qPCR), 1043 miRNAs were investigated in maternal plasma via comparison of seven DS pregnancies with age and fetal sex matched controls. RESULTS:Six hundred and ninety-five miRNAs were identified. Thirty-six significantly differentially expressed mature miRNAs were identified as potential biomarkers. Hierarchical cluster analysis of these miRNAs resulted in the clear discrimination of DS from euploid pregnancies. Gene targets of the differentially expressed miRNAs were enriched in signaling pathways such as mucin type-O-glycans, ECM-receptor interactions, TGF-beta, and endocytosis, which have been previously associated with DS. CONCLUSIONS:miRNAs are promising and stable biomarkers for a broad range of diseases and may allow a reliable, cost-efficient diagnostic tool for the noninvasive prenatal diagnosis of DS.

journal_name

Biomed Res Int

authors

Kamhieh-Milz J,Moftah RF,Bal G,Futschik M,Sterzer V,Khorramshahi O,Burow M,Thiel G,Stuke-Sontheimer A,Chaoui R,Kamhieh-Milz S,Salama A

doi

10.1155/2014/402475

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

402475

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

杂志文章
  • Silencing ELMO3 Inhibits the Growth, Invasion, and Metastasis of Gastric Cancer.

    abstract::ELMO3 is a member of the engulfment and cell motility (ELMO) protein family, which plays a vital role in the process of chemotaxis and metastasis of tumor cells. However, remarkably little is known about the role of ELMO3 in cancer. The present study was conducted to investigate the function and role of ELMO3 in gastr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3764032

    authors: Hu Y,Yu Q,Zhong Y,Shen W,Zhou X,Liu X,Xu M,Zhou N,Min W,Gao D

    更新日期:2018-09-24 00:00:00

  • Comparisons of Jaw Line and Face Line after Mandibular Setback: Intraoral Vertical Ramus versus Sagittal Split Ramus Osteotomies.

    abstract:Background:This study investigates the differences in the lateral profile and frontal appearance after sagittal split ramus osteotomy (SSRO) and intraoral vertical ramus osteotomy (IVRO) procedures for the correction of mandibular prognathism. Methods:Sixty patients (30 SSRO and 30 IVRO) underwent mandibular setback s...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/1375085

    authors: Chen CM,Tseng YC,Ko EC,Chen MY,Chen KJ,Cheng JH

    更新日期:2018-12-18 00:00:00

  • Circulating Irisin Level and Thyroid Dysfunction: A Systematic Review and Meta-Analysis.

    abstract::Both thyroid hormones and irisin have profound influences on the metabolism of the human body. Based on their similarities, several studies have been conducted to explore changes in irisin levels in patients with hypothyroidism and hyperthyroidism. This study was conducted in accordance with the PRISMA statement and t...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/2182735

    authors: Shan D,Zou L,Liu X,Cai Y,Dong R,Hu Y

    更新日期:2020-10-28 00:00:00

  • The Effect of Altitude on Intraocular Pressure in Vitrectomized Eyes with Sulfur Hexafluoride Tamponade by the Friedenwald Method: Rabbit Animal Model.

    abstract::The aim of this study is to assess the change in intraocular pressure after a road trip, in eyes with different levels of filling with gas tamponade. Five rabbit eyes were subject to pars plana vitrectomy and gas tamponade (filling percentage: 25%, 50%, and 100% of nonexpansile SF6, 100% saline solution, and 100% room...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7326160

    authors: Fromow-Guerra J,Solís-Vivanco A,Velez-Montoya R,Perez-Reguera A,Quiroz-Mercado H,Meza-de Regil A,Papa-Oliva G,Morales-Cantón V

    更新日期:2016-01-01 00:00:00

  • Varicocele Repair Improves Testicular Histology in Men with Nonobstructive Azoospermia.

    abstract:OBJECTIVE:To determine the histopathological differences after varicocele repair in testicular tissue in males with nonobstructive azoospermia. METHODS:Between 2009 and 2014, 45 men with complete azoospermia and palpable varicocele, presenting with primary infertility of at least 1 year, undergoing varicocele repair a...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2015/709452

    authors: Ustuner M,Yilmaz H,Yavuz U,Ciftci S,Saribacak A,Aynur BS,Yasar H,Culha MM

    更新日期:2015-01-01 00:00:00

  • Whole-Exome Sequencing Identified a Novel Compound Heterozygous Mutation of LRRC6 in a Chinese Primary Ciliary Dyskinesia Patient.

    abstract::Primary ciliary dyskinesia (PCD) is a clinical rare peculiar disorder, mainly featured by respiratory infection, tympanitis, nasosinusitis, and male infertility. Previous study demonstrated it is an autosomal recessive disease and by 2017 almost 40 pathologic genes have been identified. Among them are the leucine-rich...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/1854269

    authors: Liu L,Luo H

    更新日期:2018-01-08 00:00:00

  • Remote effects of lower limb ischemia-reperfusion: impaired lung, unchanged liver, and stimulated kidney oxidative capacities.

    abstract::Remote organ impairments are frequent and increase patient morbidity and mortality after lower limb ischemia-reperfusion (IR). We challenged the hypothesis that lower limb IR might also impair lung, renal, and liver mitochondrial respiration. Two-hour tourniquet-induced ischemia was performed on both hindlimbs, follow...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/392390

    authors: Mansour Z,Charles AL,Kindo M,Pottecher J,Chamaraux-Tran TN,Lejay A,Zoll J,Mazzucotelli JP,Geny B

    更新日期:2014-01-01 00:00:00

  • Freeze-drying of plant tissue containing HBV surface antigen for the oral vaccine against hepatitis B.

    abstract::The aim of this study was to develop a freeze-drying protocol facilitating successful processing of plant material containing the small surface antigen of hepatitis B virus (S-HBsAg) while preserving its VLP structure and immunogenicity. Freeze-drying of the antigen in lettuce leaf tissue, without any isolation or pur...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/485689

    authors: Czyż M,Dembczyński R,Marecik R,Wojas-Turek J,Milczarek M,Pajtasz-Piasecka E,Wietrzyk J,Pniewski T

    更新日期:2014-01-01 00:00:00

  • Automated Classification of Lung Cancer Types from Cytological Images Using Deep Convolutional Neural Networks.

    abstract::Lung cancer is a leading cause of death worldwide. Currently, in differential diagnosis of lung cancer, accurate classification of cancer types (adenocarcinoma, squamous cell carcinoma, and small cell carcinoma) is required. However, improving the accuracy and stability of diagnosis is challenging. In this study, we d...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/4067832

    authors: Teramoto A,Tsukamoto T,Kiriyama Y,Fujita H

    更新日期:2017-01-01 00:00:00

  • Identification of Candidate Genes and MicroRNAs for Acute Myocardial Infarction by Weighted Gene Coexpression Network Analysis.

    abstract:Background:Identification of potential molecular targets of acute myocardial infarction is crucial to our comprehensive understanding of the disease mechanism. However, studies of gene coexpression analysis via jointing multiple microarray data of acute myocardial infarction still remain restricted. Methods:Microarray...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5742608

    authors: Li Y,He XN,Li C,Gong L,Liu M

    更新日期:2019-02-11 00:00:00

  • A Cross-Sectional Study on the Association of Patterns and Physical Risk Factors with Musculoskeletal Disorders among Academicians in Saudi Arabia.

    abstract:Background:Musculoskeletal disorders (MSDs) are considered one of the most common health issues in working population and have a high social and economic impact. This study is aimed at determining the MSD patterns and associated risk factors among higher education academicians in Saudi Arabia. Methods:A cross-sectiona...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8930968

    authors: Algarni FS,Kachanathu SJ,AlAbdulwahab SS

    更新日期:2020-08-15 00:00:00

  • Brain-Derived Neurotropic Factor Val66Met Polymorphism and Posttraumatic Stress Disorder among Survivors of the 1998 Dongting Lake Flood in China.

    abstract:OBJECTIVE:This study mainly aimed to explore the association between brain-derived neurotropic factor (BDNF) Val66Met polymorphism and posttraumatic stress disorder (PTSD) among flood survivors in China. METHODS:Individuals who experienced the 1998 Dongting Lake flood in Southeast Huarong, China, were enrolled in this...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2017/4569698

    authors: Dai W,Kaminga AC,Wu X,Wen SW,Tan H,Yan J,Deng J,Lai Z,Liu A

    更新日期:2017-01-01 00:00:00

  • Environmental epidemiology of intestinal schistosomiasis in Uganda: population dynamics of biomphalaria (gastropoda: planorbidae) in Lake Albert and Lake Victoria with observations on natural infections with digenetic trematodes.

    abstract::This study documented the population dynamics of Biomphalaria and associated natural infections with digenetic trematodes, along the shores of Lake Albert and Lake Victoria, recording local physicochemical factors. Over a two-and-a-half-year study period with monthly sampling, physicochemical factors were measured at ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/717261

    authors: Rowel C,Fred B,Betson M,Sousa-Figueiredo JC,Kabatereine NB,Stothard JR

    更新日期:2015-01-01 00:00:00

  • Modeling Clinical States and Metabolic Rhythms in Bioarcheology.

    abstract::Bioarcheology is cross disciplinary research encompassing the study of human remains. However, life's activities have, up till now, eluded bioarcheological investigation. We hypothesized that growth lines in hair might archive the biologic rhythms, growth rate, and metabolism during life. Computational modeling predic...

    journal_title:BioMed research international

    pub_type: 历史文章,杂志文章

    doi:10.1155/2015/818724

    authors: Qualls C,Bianucci R,Spilde MN,Phillips G,Wu C,Appenzeller O

    更新日期:2015-01-01 00:00:00

  • Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?

    abstract:OBJECTIVE:Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/673018

    authors: Södergren A,Karp K,Bengtsson C,Möller B,Rantapää-Dahlqvist S,Wållberg-Jonsson S

    更新日期:2015-01-01 00:00:00

  • The Use and Effectiveness of Triple Multiplex System for Coding Region Single Nucleotide Polymorphism in Mitochondrial DNA Typing of Archaeologically Obtained Human Skeletons from Premodern Joseon Tombs of Korea.

    abstract::Previous study showed that East Asian mtDNA haplogroups, especially those of Koreans, could be successfully assigned by the coupled use of analyses on coding region SNP markers and control region mutation motifs. In this study, we tried to see if the same triple multiplex analysis for coding regions SNPs could be also...

    journal_title:BioMed research international

    pub_type: 历史文章,杂志文章

    doi:10.1155/2015/850648

    authors: Oh CS,Lee SD,Kim YS,Shin DH

    更新日期:2015-01-01 00:00:00

  • Antiosteoclastic activity of milk thistle extract after ovariectomy to suppress estrogen deficiency-induced osteoporosis.

    abstract::Bone integrity abnormality and imbalance between bone formation by osteoblasts and bone resorption by osteoclasts are known to result in metabolic bone diseases such as osteoporosis. Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteoblasts but reduced ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/919374

    authors: Kim JL,Kim YH,Kang MK,Gong JH,Han SJ,Kang YH

    更新日期:2013-01-01 00:00:00

  • Modulation of Intrathymic Sphingosine-1-Phosphate Levels Promotes Escape of Immature Thymocytes to the Periphery with a Potential Proinflammatory Role in Chagas Disease.

    abstract::The sphingosine-1-phosphate (S1P) system regulates both thymic and lymph nodes T cell egress which is essential for producing and maintaining the recycling T cell repertoire. Infection with the protozoan parasite Trypanosoma cruzi induces a hormonal systemic deregulation that has impact in the thymic S1P homeostasis t...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/709846

    authors: Flávia Nardy A,Santos L,Freire-de-Lima CG,Morrot A

    更新日期:2015-01-01 00:00:00

  • How Should Disaster Base Hospitals Prepare for Dialysis Therapy after Earthquakes? Introduction of Double Water Piping Circuits Provided by Well Water System.

    abstract::After earthquakes, continuing dialysis for patients with ESRD and patients suffering from crush syndrome is the serious problem. In this paper, we analyzed the failure of the provision of dialysis services observed in recent disasters and discussed how to prepare for disasters to continue dialysis therapy. Japan has f...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/9647156

    authors: Ikegaya N,Seki G,Ohta N

    更新日期:2016-01-01 00:00:00

  • Functional development of the circadian clock in the zebrafish pineal gland.

    abstract::The zebrafish constitutes a powerful model organism with unique advantages for investigating the vertebrate circadian timing system and its regulation by light. In particular, the remarkably early and rapid development of the zebrafish circadian system has facilitated exploring the factors that control the onset of ci...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/235781

    authors: Ben-Moshe Z,Foulkes NS,Gothilf Y

    更新日期:2014-01-01 00:00:00

  • Circulating Exosomal miRNAs as Novel Biomarkers for Stable Coronary Artery Disease.

    abstract::Exosomal miRNAs are currently being explored as a novel class of biomarkers in cardiovascular diseases. However, few reports have focused on the value of circulating exosomal miRNAs as biomarkers for stable coronary artery disease (SCAD). Here, we aimed to investigate whether miRNAs involved in cardiovascular diseases...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3593962

    authors: Zhang P,Liang T,Chen Y,Wang X,Wu T,Xie Z,Luo J,Yu Y,Yu H

    更新日期:2020-12-11 00:00:00

  • Txndc9 Is Required for Meiotic Maturation of Mouse Oocytes.

    abstract::Txndc9 (thioredoxin domain containing protein 9) has been shown to be involved in mammalian mitosis; however, its function in mammalian oocyte meiosis remains unclear. In this study, we initially found that Txndc9 is expressed during meiotic maturation of mouse oocytes and higher expression of Txndc9 mRNA and protein ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/6265890

    authors: Ma F,Hou L,Yang L

    更新日期:2017-01-01 00:00:00

  • Short-Term Lifestyle Strategies for Sustaining Cognitive Status.

    abstract::Cognitive decline impacts older adults, particularly their independence. The goal of this project was to increase understanding of how short-term, everyday lifestyle options, including physical activity, help an older adult sustain cognitive independence. Using a secondary analysis of lifestyle choices, we drew on a d...

    journal_title:BioMed research international

    pub_type: 杂志文章,多中心研究

    doi:10.1155/2016/7405748

    authors: Howard EP,Morris JN,Steel K,Strout KA,Fries BE,Moore A,Garms-Homolová V

    更新日期:2016-01-01 00:00:00

  • The Use of a Hypoallergenic Dermal Matrix for Wrapping in Peripheral Nerve Lesions Regeneration: Functional and Quantitative Morphological Analysis in an Experimental Animal Model.

    abstract:Introduction:The aim of this research was to test, in an animal model, the nerve regeneration technique with a hypoallergenic acellular dermal matrix used to wrap the microsurgical neural suture. Materials and Methods:Two groups of rats received the cut of limb right median nerves. The regeneration technique considers...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/4750624

    authors: Colonna MR,Fazio A,Costa AL,Galletti F,Lo Giudice R,Galletti B,Galletti C,Lo Giudice G,Dell'Aversana Orabona G,Papalia I,Ronchi G,Geuna S

    更新日期:2019-06-17 00:00:00

  • Epithelial-mesenchymal transition regulated by EphA2 contributes to vasculogenic mimicry formation of head and neck squamous cell carcinoma.

    abstract:PURPOSE:Vasculogenic mimicry (VM) was related to invasion and metastasis of head and neck squamous cell carcinoma (HNSCC) patients. This study was designed to investigate the role of EphA2 in VM formation of HNSCC. METHODS:The SiRNA technique was used to knock down the expression of EphA2 in vitro. The ability of cell...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/803914

    authors: Wang W,Lin P,Sun B,Zhang S,Cai W,Han C,Li L,Lu H,Zhao X

    更新日期:2014-01-01 00:00:00

  • Combinational Effect of Rumex tingitanus (Polygonaceae) Hexane Extract and Bacillus thuringiensis  δ-Endotoxin against Spodoptera littoralis (Lepidoptera: Noctuidae).

    abstract::The increasing insect resistance against Bacillus thuringiensis delta-endotoxins is a serious problem which makes it urgent to look for new eco-friendly strategies. Combining these toxins with other biomolecules is one of the promising strategies against insect pests. In this work, we evaluated the bioinsecticidal pot...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3895834

    authors: Mhalla D,Ben Farhat-Touzri D,Tounsi S,Trigui M

    更新日期:2018-08-08 00:00:00

  • Dosimetric Comparison of Three Radiotherapy Techniques in Irradiation of Left-Sided Breast Cancer Patients after Radical Mastectomy.

    abstract:Results:The VMAT plans showed superior to PTV dose conformity index (CI), homogeneity index (HI), protection of the ipsilateral lung, monitor units (MUs), and maximum dose (Dmax) to the contralateral breast compared with TSP and 9FIMRT plans. The TSP provided better protection for Dmean of the heart and left ventricle ...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2020/7131590

    authors: Hu J,Han G,Lei Y,Xu X,Ge W,Ruan C,Chang S,Zhang A,Li X

    更新日期:2020-03-26 00:00:00

  • In Vitro Anticancer Potential of Berberis lycium Royle Extracts against Human Hepatocarcinoma (HepG2) Cells.

    abstract::Human liver cancer has emerged as a serious health concern in the world, associated with poorly available therapies. The Berberis genus contains vital medicinal plants with miraculous healing properties and a wide range of bioactivities. In this study, different crude extracts of B. lycium Royle were prepared and scre...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8256809

    authors: Mustafa K,Mohamed H,Shah AM,Yu S,Akhlaq M,Xiao H,Li S,Naz T,Nosheen S,Bai X,Song Y

    更新日期:2020-10-14 00:00:00

  • Isorhamnetin Induces Melanoma Cell Apoptosis via the PI3K/Akt and NF-κB Pathways.

    abstract::Malignant melanoma is characterized by its bad prognosis for aggressiveness, drug resistance, and early metastasis. Isorhamnetin (3'-methoxy-3,4',5,7-tetrahydroxyflavone; IH) is a natural flavonoid that has been investigated for its antitumor effects in breast cancer, colon cancer, and gastric cancer through inducing ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/1057943

    authors: Duan R,Liang X,Chai B,Zhou Y,Du H,Suo Y,Chen Z,Li Q,Huang X

    更新日期:2020-05-05 00:00:00

  • Late adherent human bone marrow stromal cells form bone and restore the hematopoietic microenvironment in vivo.

    abstract::Bone marrow stromal cells (BMSCs) are a valuable resource for skeletal regenerative medicine because of their osteogenic potential. In spite of the very general term "stem cell," this population of cells is far from homogeneous, and different BMSCs clones have greatly different phenotypic properties and, therefore, po...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/790842

    authors: Vianna VF,Bonfim DC,Cavalcanti Ados S,Fernandes MC,Kahn SA,Casado PL,Lima IC,Murray SS,Murray EJ,Duarte ME

    更新日期:2013-01-01 00:00:00