Reconstruction of cochlea based on micro-CT and histological images of the human inner ear.

abstract：:Coronary CT angiography (CCTA) has become an important noninvasive imaging modality in the diagnosis of coronary artery disease (CAD). CCTA enables accurate evaluation of coronary artery stenosis. However, CCTA provides limited information on the physiological significance of stenotic lesions. A noninvasive "one-stop-...

journal_title：BioMed research international

authors： Xu L,Sun Z,Fan Z

更新日期：2015-01-01 00:00:00

abstract：:A Multilayered Multidisk Tablet (MLMDT) comprising two drug-loaded disks enveloped by three drug-free barrier layers was developed for use in chronotherapeutic disorders, employing two model drugs, theophylline and diltiazem HCl. The MLMDT was designed to achieve two pulses of drug release separated by a lag phase. Th...

journal_title：BioMed research international

authors： Khan Z,Choonara YE,Kumar P,du Toit LC,Ndesendo VM,Pillay V

更新日期：2013-01-01 00:00:00

abstract：:To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and ...

journal_title：BioMed research international

authors： Guo L,Yang S,Zhao Y,Zhang H,Wu Q,Chen F

更新日期：2014-01-01 00:00:00

abstract：:In renal cell carcinoma, chromophobe renal cell carcinoma (ChRCC) is a distinct subtype, whose clinical manifestations often lack specificity, and the molecular mechanisms of ChRCC tumorigenesis remain generally vague. The target of this study was to discover novel biomarkers involved in ChRCC by integrated bioinforma...

journal_title：BioMed research international

authors： Zhang W,Xu Y,Zhang J,Wu J

更新日期：2020-02-07 00:00:00

abstract：:High-grade gliomas are the main cause of death in children with brain tumours. Despite recent advances in cancer therapy, their prognosis remains poor and the treatment is still challenging. To date, surgery followed by radiotherapy and temozolomide is the standard therapy. However, increasing knowledge of glioma biol...

journal_title：BioMed research international

authors： Rizzo D,Ruggiero A,Martini M,Rizzo V,Maurizi P,Riccardi R

更新日期：2015-01-01 00:00:00

abstract：:Bone loss and fractures may call for the use of bone substituting materials, such as calcium phosphate cements (CPCs). CPCs can be degradable, and, to determine their limitations in terms of applications, their mechanical as well as chemical properties need to be evaluated over longer periods of time, under physiologi...

journal_title：BioMed research international

authors： Ajaxon I,Öhman C,Persson C

更新日期：2015-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2016/2643862.]. ...

journal_title：BioMed research international

authors： Cheng LG,He W,Zhang HX,Song Q,Ning B,Li HZ,He Y,Lin S

更新日期：2017-01-01 00:00:00

abstract：:Within-litter birth weight variation in multiparous animals has become a big issue due to high incidence of low birth weight neonates, which gives rise to high preweaning mortality and morbidity. Foetus with various birth weights is the outcome of diverse embryos competence which is affected by oocyte quality. Glucosa...

journal_title：BioMed research international

authors： Feng C,Yuan T,Wang S,Liu T,Tao S,Han D,Wang J

更新日期：2020-01-08 00:00:00

abstract：:The aim of this study is to inform about the development of a new semispherical surgical instrument for the bipolar multielectrode radiofrequency liver ablation. Present tools are universal; however they have several disadvantages such as ablation of healthy tissue, numerous needle punctures, and, therefore, longer op...

journal_title：BioMed research international

authors： Vavra P,Penhaker M,Grepl J,Jurcikova J,Palecek J,Crha M,Nowakova J,Hasal M,Skrobankova M,Ostruszka P,Ihnat P,Delongova P,Salounova D,Habib NA,Zonca P

更新日期：2014-01-01 00:00:00

abstract：:Myosin VI (MVI) is a unique motor protein moving towards the minus end of actin filaments unlike other known myosins. Its important role has recently been postulated for striated muscle and myogenic cells. Since MVI functions through interactions of C-terminal globular tail (GT) domain with tissue specific partners, w...

journal_title：BioMed research international

authors： Karolczak J,Sobczak M,Skowronek K,Rędowicz MJ

更新日期：2015-01-01 00:00:00

abstract：:A 35 KDa protein referred to as F3 was purified from the seeds of Borreria hispida by precipitation with 80% ammonium sulphate and gel filtration on Sephadex G-100 column. RP-HPLC analysis of protein fraction (F3) on an analytical C-18 column produced a single peak, detected at 220 nm. F3 showed an apparent molecular ...

journal_title：BioMed research international

authors： Rupachandra S,Sarada DV

更新日期：2014-01-01 00:00:00

abstract：:The aim of the study was to determine whether different sleep stages, especially REM sleep, affect QT interval duration and variability in male patients without obstructive sleep apnea (OSA). Polysomnographic recordings of 30 patients were analyzed. Beat-to-beat QT interval variability was calculated using QTV index (...

journal_title：BioMed research international

authors： Viigimae M,Karai D,Pirn P,Pilt K,Meigas K,Kaik J

更新日期：2015-01-01 00:00:00

abstract：:Hypoxia plays an essential role in orchestrating Epithelial-mesenchymal transition and promoting metastasis of colorectal cancer. However, the underlying mechanisms are still not well elucidated. Here, we present that hypoxic exposure causes endoplasmic reticulum stress and activates the unfolded protein response path...

journal_title：BioMed research international

authors： Zheng H,Wu Y,Guo T,Liu F,Xu Y,Cai S

更新日期：2020-01-27 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are unique in their capacity to give rise to all mature cells of the immune system. For years, HSC transplantation has been used for treatment of genetic and neoplastic diseases of the hematopoietic and immune systems. The sourcing of HSCs from human umbilical cord blood has salient adv...

journal_title：BioMed research international

authors： Biancotti JC,Town T

更新日期：2013-01-01 00:00:00

abstract：:Lower back pain is the leading cause of disability worldwide. Discogenic pain secondary to intervertebral disc degeneration is a significant cause of low back pain. Disc degeneration is a complex multifactorial process. Animal models are essential to furthering understanding of the degenerative process and testing pot...

journal_title：BioMed research international

authors： Daly C,Ghosh P,Jenkin G,Oehme D,Goldschlager T

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess the value of ecological momentary assessment in evaluating physical activity among children, adolescents, and adults. It also determines whether ecological momentary assessment fulfills the criteria of validity, reliability, objectivity, norms, and standardization appli...

journal_title：BioMed research international

authors： Marszalek J,Morgulec-Adamowicz N,Rutkowska I,Kosmol A

更新日期：2014-01-01 00:00:00

abstract：:This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra's algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network. The gene...

journal_title：BioMed research international

authors： Zhang J,Jiang M,Yuan F,Feng KY,Cai YD,Xu X,Chen L

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to compare the prevalence of different virulence factor (VF) genes in extended-spectrum beta-lactamase (ESBL) producing Escherichia coli strains isolated from the Baltic Sea region. A total of 432 strains of phenotypically ESBL positive E. coli were collected from 20 institutions located in E...

journal_title：BioMed research international

authors： Lillo J,Pai K,Balode A,Makarova M,Huik K,Kõljalg S,Ivanova M,Kaftyreva L,Miciuleviciene J,Naaber P,Parv K,Pavelkovich A,Rööp T,Toompere K,Suzhaeva L,Sepp E

更新日期：2014-01-01 00:00:00

abstract：:Age is an independent risk factor of cardiovascular disease, even in the absence of other traditional factors. Emerging evidence in experimental animal and human models has emphasized a central role for two main mechanisms of age-related cardiovascular disease: oxidative stress and inflammation. Excess reactive oxygen...

journal_title：BioMed research international

authors： Wu J,Xia S,Kalionis B,Wan W,Sun T

更新日期：2014-01-01 00:00:00

abstract：:The aging process causes a number of changes in the skin, including oxidative stress and dyschromia. The kojic acid (KA) is iron chelator employed in treatment of skin aging, and inhibits tyrosinase, promotes depigmentation. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can mod...

journal_title：BioMed research international

authors： Gonçalez ML,Corrêa MA,Chorilli M

更新日期：2013-01-01 00:00:00

abstract：:There has been a remarkable interest in finding lipid inhibitors from natural products to replace synthetic compounds, and a variety of oriental medicinal herbs are reported to have biological activity with regard to lipid inhibition. Buginawa (Bugi) is a novel combined formula that contains twelve medicinal herbs wit...

journal_title：BioMed research international

authors： Park YJ,Seo DW,Ju JY,Cha YY,An HJ

更新日期：2019-07-30 00:00:00

abstract：:Adiponectin (APN) is an adipokine secreted from adipose tissue and exhibits biological functions such as microcirculation-regulating, hearing-protective, and antiapoptotic. However, the effect of APN on the apoptosis of spiral arterial smooth muscle cells (SMCs) under hypoxic conditions in vitro is not clear. We used ...

journal_title：BioMed research international

authors： Xiao J,Zhang Y,Zhang W,Zhang L,Li L,Si J,Li X,Ma K

更新日期：2020-10-10 00:00:00

abstract：Objective:Mounting evidence has elaborated the implication of long noncoding RNAs (lncRNAs) in tumorigenesis of several cancers, including glioma. However, little was known about the mechanism of lncRNA maternally expressed gene 3 (MEG3) in the development and progression of glioma. This work is designed to explore the...

journal_title：BioMed research international

authors： Gong X,Huang MY

更新日期：2020-01-11 00:00:00

abstract：:The purpose of this study was to assess the impact of 3 months of aromatase inhibition together with progestin add-back on ovarian endometrioma size. This prospective cohort study was performed at University Medical Center (UC San Diego). Women trying to conceive were excluded. After informed consent, all women were t...

journal_title：BioMed research international

authors： Agarwal SK,Foster WG

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study is to evaluate the therapeutic effects of human umbilical cord-derived mesenchymal stem cells (hUC-MSC) activated by curcumin (CUR) on PC12 cells induced by 1-methyl-4-phenylpyridinium ion (MPP+), a cell model of Parkinson's disease (PD). The supernatant of hUC-MSC and hUC-MSC activated by 5 ...

journal_title：BioMed research international

authors： Jinfeng L,Yunliang W,Xinshan L,Yutong W,Shanshan W,Peng X,Xiaopeng Y,Zhixiu X,Qingshan L,Honglei Y,Xia C,Hongwei W,Bingzhen C

更新日期：2016-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2012/853879.]. ...

journal_title：BioMed research international

authors： Shirasu N,Yamada H,Shibaguchi H,Kuroki M,Kuroki M

更新日期：2015-01-01 00:00:00

abstract：:The availability of an active substance through the skin depends basically on two consecutive steps: the release of this substance from the vehicle and its subsequent permeation through the skin. Hence, studies on the specific properties of vehicles, such as their rheological behavior, are of great interest in the fie...

journal_title：BioMed research international

authors： Isaac VL,Chiari-Andréo BG,Marto JM,Moraes JD,Leone BA,Corrêa MA,Ribeiro HM

更新日期：2015-01-01 00:00:00

abstract：:Ultrasound tomography (UST) image segmentation is fundamental in breast density estimation, medicine response analysis, and anatomical change quantification. Existing methods are time consuming and require massive manual interaction. To address these issues, an automatic algorithm based on GrabCut (AUGC) is proposed i...

journal_title：BioMed research international

authors： Wu S,Yu S,Zhuang L,Wei X,Sak M,Duric N,Hu J,Xie Y

更新日期：2017-01-01 00:00:00

abstract：:Constitutive activation of Akt is believed to be an oncogenic signal in multiple myeloma and is associated with poor patient prognosis and resistance to available treatment. The stability of Akt proteins is regulated by phosphorylating the highly conserved turn motif (TM) of these proteins and the chaperone protein HS...

journal_title：BioMed research international

authors： Zhang Y,Fu Y,Zhang F,Liu J

更新日期：2014-01-01 00:00:00

abstract：:Angiogenesis plays a decisive role in the growth and spread of cancer and angiopoietin-2 (Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. The aim of this study was to introduce a computational simulation approach to screen aptamers with high binding ability for Ang2. We carried out...

journal_title：BioMed research international

authors： Hu WP,Kumar JV,Huang CJ,Chen WY

更新日期：2015-01-01 00:00:00