Abstract:
:Purpose of this paper is to analyze different species' proportion of nontuberculosis mycobacteria (NTM) and susceptibility to clarithromycin of different species. 278 clinical NTM isolates were identified into species by using 16S rRNA, rpoB and hsp65. Then clarithromycin susceptibility testing against different species was done separately, using microplate Alamar Blue assay. Finally, resistance isolates' erm(41) of M. abscessus were sequenced in order to analyze mechanisms for clarithromycin resistant. In this test, 131 isolates (47%) belonged to M. avium complex (MAC), and 70 isolates (25%) belonged to M. abscessus. Nearly all the M. abscessus subsp. abscessus resistant to clarithromycin had T28 in erm(41). However, all the M. abscessus subsp. abscessus susceptible to clarithromycin had C28 in erm(41). In this study, we find that MAC was the most common pathogens of NTM, and the second one was M. abscessus. However, M. chelonei, M. fuerth, and M. gordon were rare. Clarithromycin had a good inhibition activity against all the NTM species except M. abscessus subsp. abscessus. The erm(41) genotype is of high relevance to clarithromycin resistance.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Nie W,Duan H,Huang H,Lu Y,Chu Ndoi
10.1155/2015/506598subject
Has Abstractpub_date
2015-01-01 00:00:00pages
506598eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract::Acute nonspecific, or primary, mesenteric lymphadenitis is a self-limiting inflammatory condition affecting the mesenteric lymph nodes, whose presentation mimics appendicitis or intussusception. It typically occurs in children, adolescents, and young adults. White blood count and C-reactive protein are of limited usef...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/9784565
更新日期:2017-01-01 00:00:00
abstract::Alterations in muscle protein turnover of the unaffected side of stroke patients could contribute to physical disability. We investigated whether hypercatabolic activity occurred in unaffected arm muscle and whether supplemented essential amino acids (EAAs) could limit muscle hypercatabolism (MH). Thirty-eight dysphag...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/964365
更新日期:2014-01-01 00:00:00
abstract::The effect of Cordyceps militaris (CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC si...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/102918
更新日期:2013-01-01 00:00:00
abstract:Background:The purpose of this study was to evaluate the association between the non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio and the risk of coronary artery disease (CAD). We also explored the potential role of non-HDL-C/HDL-C in the prognosis of CAD. Meth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7146028
更新日期:2020-03-07 00:00:00
abstract::A 35 KDa protein referred to as F3 was purified from the seeds of Borreria hispida by precipitation with 80% ammonium sulphate and gel filtration on Sephadex G-100 column. RP-HPLC analysis of protein fraction (F3) on an analytical C-18 column produced a single peak, detected at 220 nm. F3 showed an apparent molecular ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/179836
更新日期:2014-01-01 00:00:00
abstract::Epidemiological studies have proven an association between consumption of polyphenols and prevention of Alzheimer's disease, the most common form of dementia characterized by extracellular deposition of amyloid beta plaques. The aim of this study is pharmacological screening of the aqueous alcohol extract of Markhamia...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/843263
更新日期:2014-01-01 00:00:00
abstract::Among the different signaling molecules released during reactive gliosis occurring in Alzheimer's disease (AD), the astrocyte-derived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease. The use of pharmacological tools targeting S100B may be crucial to embank its effects and some ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/508342
更新日期:2015-01-01 00:00:00
abstract::We have developed a new "drug" and approach that appear to be effective in reducing arterial age. This "drug" represents a low, subtherapeutic dose of statin and sartan and particularly their low-dose combination. The improvement of arterial wall characteristics, also reflecting in a decrease of arterial age, was achi...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/235709
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to evaluate the safety and effectiveness of percutaneous transluminal angioplasty and stenting (PTAS) for intracranial atherosclerotic disease (ICAD) by conducting a meta-analysis. Two independent observers searched PubMed, EMBASE, and Cochrane Library for relevant studies up to 31 December 2...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2017/3258681
更新日期:2017-01-01 00:00:00
abstract::The perceived risk of nonremunerated blood donation (NRBD) is one of the most important factors which hinder the Chinese public from donating blood. To understand deeply and measure scientifically the public's perceived risk of NRBD, in this paper the qualitative and quantitative methods were used to explore the const...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/302043
更新日期:2015-01-01 00:00:00
abstract::We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test. AD Tg mice on con...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/546357
更新日期:2014-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are al...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4574509
更新日期:2020-04-06 00:00:00
abstract::The success rate of oral implants is lower in type 2 diabetes mellitus (T2DM) patients than in nondiabetic subjects; functional impairment of bone marrow-derived mesenchymal stem cells (BMSCs) is an important underlying cause. Many factors in the blood can act on BMSCs to regulate their biological functions and influe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7626215
更新日期:2020-06-07 00:00:00
abstract:Background:The pathogenesis of abdominal aortic aneurysm (AAA) is characterized by atherosclerosis with chronic inflammation in the aortic wall. Montelukast is a selective cys-LT 1 receptor antagonist that can suppress atherosclerotic diseases. We evaluated the in vitro properties of montelukast and its in vivo activit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9104680
更新日期:2019-05-27 00:00:00
abstract::Body weight supported locomotor training uses neuroplasticity principles to improve recovery following a spinal cord injury (SCI). Steady state locomotion using the same body weight support (BWS) percent was compared in 7 males (42.6 ± 4.29 years) with incomplete SCI and matched (gender, age) noninjured controls (42.7...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/632765
更新日期:2014-01-01 00:00:00
abstract::Cancer is known to have unique metabolic features such as Warburg effect. Current cancer therapy has moved forward from cytotoxic treatment to personalized, targeted therapies, with some that could lead to specific metabolic changes, potentially monitored by imaging methods. In this paper we addressed the important as...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/625095
更新日期:2014-01-01 00:00:00
abstract:Background:A deficiency in steroid 5α-reductase type 2 is an autosomal recessive disorder. Affected individuals manifested ambiguous genitalia, which is caused by decreased dihydrotestosterone (DHT) synthesis in the fetus. Methods:We analyzed 25 patients with 5α-reductase deficiency in China. Seventeen of the 25 patie...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1789514
更新日期:2020-06-09 00:00:00
abstract::Exposure to a variety of environmental factors such as salinity, drought, metal toxicity, extreme temperature, air pollutants, ultraviolet-B (UV-B) radiation, pesticides, and pathogen infection leads to subject oxidative stress in plants, which in turn affects multiple biological processes via reactive oxygen species ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/9732325
更新日期:2019-05-08 00:00:00
abstract:BACKGROUND:Perimesencephalic nonaneurysmal subarachnoid hemorrhage (PM-NASAH) is characterized by a benign course compared with aneurysmal SAH. While vasospasm (VS) after aneurysmal SAH is considered responsible for serious complications, VS post-PM-NASAH is not well documented. Our purpose was to characterize the inci...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/371063
更新日期:2013-01-01 00:00:00
abstract::Gravity is crucial for spatial perception, postural equilibrium, and movement generation. The vestibular apparatus is the main sensory system involved in monitoring gravity. Hair cells in the vestibular maculae respond to gravitoinertial forces, but they cannot distinguish between linear accelerations and changes of h...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/615854
更新日期:2014-01-01 00:00:00
abstract::Surgical flaps are frequently affected by ischemia/reperfusion (I/R) injury. Calcium-sensing receptor (CaSR) and stromal cell-derived factor-1α (SDF-1α) are closely associated with myocardial I/R injury. This study was performed to evaluate the feasibility of applying SDF-1α to counteract CaSR activation-mediated I/R ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8945850
更新日期:2018-01-11 00:00:00
abstract::Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence o...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/901941
更新日期:2014-01-01 00:00:00
abstract:Methods:This prospective single-blinded clinical trial included 72 ASA I-II stage children aged 1-36 months with cCHD who were scheduled to undergo TTE under sedation. Children were assigned to group A (n = 37) with a previous history of cardiac surgery and group B (n = 35) with no history of cardiac surgery. Doses of ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1349432
更新日期:2020-12-12 00:00:00
abstract::Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense infiltrati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1267038
更新日期:2018-10-08 00:00:00
abstract::Acute kidney injury (AKI) is associated with an increased risk of developing advanced chronic kidney disease (CKD). Yet, effective interventions to prevent this conversion are unavailable for clinical practice. In this study, we examined the beneficial effects of Tanshinone IIA on renal fibrosis in a mouse model of fo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/867140
更新日期:2015-01-01 00:00:00
abstract::The energy generated by an extremely low frequency electromagnetic field (ELF-EMF) is too weak to directly induce genotoxicity. However, it is reported that an extremely low frequency magnetic field (ELF-MF) is related to DNA strand breakage and apoptosis. The testes that conduct spermatogenesis through a dynamic cell...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/567183
更新日期:2014-01-01 00:00:00
abstract::Preoperative 5-fluorouracil- (5-FU-) based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, the effect of 5-FU-based chemoradiotherapy on CRC is limited due to the development of chemoradiation resistance (CRR), and the molecular mechanisms underlying this resistance are...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8421614
更新日期:2017-01-01 00:00:00
abstract::The impairment of wound healing in diabetic patients is an important clinical problem affecting millions of patients worldwide. Various clinical and basic science studies show that stem cell therapy, as a regenerative medical therapy, can be a good solution. In this paper, we begin with an introduction of the cellular...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/462179
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:This study aimed to investigate the shear displacement between the body and backrest/seat, range of motion (ROM), and force acting on the lower limb joints during sit-stand-sit transitions by operating an electric-powered standing wheelchair. METHODS AND MATERIALS:The amounts of sliding along the backrest and ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/236486
更新日期:2014-01-01 00:00:00
abstract::A Mycobacterium bovis knockout in p27-p55 operon was tested as an antituberculosis experimental vaccine in animal models. The mutant MbΔp27-p55 was significantly more attenuated in nude mice than its parental strain but more virulent than BCG Pasteur. Challenge experiments in mice and guinea pigs using M. bovis or M. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/951978
更新日期:2014-01-01 00:00:00