Heat shock proteins at the crossroads between cancer and Alzheimer's disease.

Abstract:

:Heat shock proteins 70 and heat shock proteins 90 (Hsp70/90) have been implicated in many crucial steps of carcinogenesis: stabilizing oncogenic proteins, inhibiting programmed cell death and replicative senescence, induction of tumor angiogenesis, and activation of the invasion and metastasis. Plenty of cancer related proteins have the ability of regulating the expression of Hsp70/90 through heat shock factor 1. Cancer and Alzheimer's disease (AD) have plenty of overlapping regions in molecular genetics and cell biology associated with Hsp70/90. The Hsp70, as a protein stabilizer, has a cellular protection against neurodegeneration of the central nervous system, while Hsp90 promote neurodegenerative disorders indirectly through regulating the expression of Hsp70 and other chaperones. All these make existing anticancer drugs target Hsp70/90 which might be used in AD therapy.

journal_name

Biomed Res Int

authors

Wang H,Tan MS,Lu RC,Yu JT,Tan L

doi

10.1155/2014/239164

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

239164

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

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